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glycine receptor, alpha 1 subunit

Summary

Gene Symbol

Glra1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

14654

PubChem

14654

Alliance of Genome Resources

MGI:95747

Annotation

Keyword

Alternative splicing
Cell membrane
Cell projection
Chloride channel
Disease variant
Disulfide bond
Glycoprotein
Ligand-gated ion channel
Metal-binding
Postsynaptic cell membrane
Receptor
Reference proteome
Signal
Transmembrane helix
Zinc

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q64018	Glycine receptor 48 kDa subunit Glycine receptor strychnine-binding subunit
Q5NCT9

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 47 in total

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GO Term	Evidence Code	PMID
startle response	ISS
startle response	ISO
startle response	IMP	11275284 12380014 16964444 17114051 8406478 8733750 9087981
regulation of respiratory gaseous exchange by nervous system process	IMP	16800867
ion transport	ISS

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

synaptic transmission, glycinergic

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

neuropeptide signaling pathway

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to acid chemical [inference]

cellular response to amino acid stimulus

cellular response to inorganic substance [inference]

cellular response to metal ion [inference]

cellular response to zinc ion

cellular response to organic substance [inference]

cellular response to organonitrogen compound [inference]

cellular response to amino acid stimulus

cellular response to alcohol [inference]

cellular response to ethanol

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to amino acid stimulus

cellular response to oxygen-containing compound [inference]

cellular response to amino acid stimulus

cellular response to alcohol [inference]

cellular response to ethanol

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic anion transmembrane transport [inference]

chloride transmembrane transport

reproductive process [inference]

acrosome reaction

multicellular organismal process [inference]

system process [inference]

muscle system process [inference]

muscle contraction

nervous system process [inference]

regulation of respiratory gaseous exchange by nervous system process

sensory perception [inference]

sensory perception of light stimulus [inference]

visual perception

neuromuscular process

behavior [inference]

locomotory behavior [inference]

adult locomotory behavior [inference]

adult walking behavior

walking behavior [inference]

adult walking behavior

adult behavior [inference]

adult locomotory behavior [inference]

adult walking behavior

response to stimulus [inference]

response to external stimulus [inference]

startle response

reflex [inference]

righting reflex

response to endogenous stimulus [inference]

cellular response to endogenous stimulus [inference]

cellular response to organonitrogen compound [inference]

cellular response to amino acid stimulus

response to chemical [inference]

response to acid chemical [inference]

response to amino acid [inference]

cellular response to amino acid stimulus

cellular response to acid chemical [inference]

cellular response to amino acid stimulus

response to organic substance [inference]

response to organonitrogen compound [inference]

response to amino acid [inference]

cellular response to amino acid stimulus

cellular response to organonitrogen compound [inference]

cellular response to amino acid stimulus

cellular response to organic substance [inference]

cellular response to organonitrogen compound [inference]

cellular response to amino acid stimulus

cellular response to alcohol [inference]

cellular response to ethanol

response to alcohol

response to ethanol [inference]

cellular response to ethanol

cellular response to alcohol [inference]

cellular response to ethanol

response to inorganic substance [inference]

response to metal ion [inference]

response to zinc ion [inference]

cellular response to zinc ion

cellular response to metal ion [inference]

cellular response to zinc ion

cellular response to inorganic substance [inference]

cellular response to metal ion [inference]

cellular response to zinc ion

cellular response to chemical stimulus [inference]

cellular response to acid chemical [inference]

cellular response to amino acid stimulus

cellular response to inorganic substance [inference]

cellular response to metal ion [inference]

cellular response to zinc ion

cellular response to organic substance [inference]

cellular response to organonitrogen compound [inference]

cellular response to amino acid stimulus

cellular response to alcohol [inference]

cellular response to ethanol

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to amino acid stimulus

cellular response to oxygen-containing compound [inference]

cellular response to amino acid stimulus

cellular response to alcohol [inference]

cellular response to ethanol

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to amino acid [inference]

cellular response to amino acid stimulus

cellular response to organonitrogen compound [inference]

cellular response to amino acid stimulus

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to amino acid stimulus

response to oxygen-containing compound [inference]

response to amino acid [inference]

cellular response to amino acid stimulus

response to alcohol

response to ethanol [inference]

cellular response to ethanol

cellular response to alcohol [inference]

cellular response to ethanol

cellular response to oxygen-containing compound [inference]

cellular response to amino acid stimulus

cellular response to alcohol [inference]

cellular response to ethanol

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to acid chemical [inference]

cellular response to amino acid stimulus

cellular response to inorganic substance [inference]

cellular response to metal ion [inference]

cellular response to zinc ion

cellular response to organic substance [inference]

cellular response to organonitrogen compound [inference]

cellular response to amino acid stimulus

cellular response to alcohol [inference]

cellular response to ethanol

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to amino acid stimulus

cellular response to oxygen-containing compound [inference]

cellular response to amino acid stimulus

cellular response to alcohol [inference]

cellular response to ethanol

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport

monoatomic anion transport

chloride transport

chloride transmembrane transport

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic anion transport [inference]

chloride transport

chloride transmembrane transport

inorganic anion transmembrane transport [inference]

chloride transmembrane transport

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic anion transmembrane transport [inference]

chloride transmembrane transport

biological regulation [inference]

regulation of biological process [inference]

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

synaptic transmission, glycinergic

positive regulation of biological process [inference]

positive regulation of reproductive process [inference]

positive regulation of acrosome reaction

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of transmission of nerve impulse

negative regulation of multicellular organismal process [inference]

negative regulation of nervous system process [inference]

negative regulation of transmission of nerve impulse

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

neuropeptide signaling pathway

regulation of cell communication [inference]

negative regulation of cell communication [inference]

negative regulation of transmission of nerve impulse

regulation of transmission of nerve impulse [inference]

negative regulation of transmission of nerve impulse

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of transmission of nerve impulse

regulation of multicellular organismal process [inference]

regulation of respiratory gaseous exchange

regulation of respiratory system process [inference]

regulation of respiratory gaseous exchange by nervous system process

regulation of system process [inference]

regulation of nervous system process [inference]

negative regulation of nervous system process [inference]

negative regulation of transmission of nerve impulse

regulation of transmission of nerve impulse [inference]

negative regulation of transmission of nerve impulse

regulation of respiratory system process [inference]

regulation of respiratory gaseous exchange by nervous system process

negative regulation of multicellular organismal process [inference]

negative regulation of nervous system process [inference]

negative regulation of transmission of nerve impulse

regulation of reproductive process [inference]

regulation of acrosome reaction [inference]

positive regulation of acrosome reaction

positive regulation of reproductive process [inference]

positive regulation of acrosome reaction

regulation of biological quality [inference]

regulation of membrane potential

action potential [inference]

neuronal action potential

regulation of postsynaptic membrane potential [inference]

regulation of presynaptic membrane potential

Displaying entries **1 - 5** of 21 in total

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GO Term	Evidence Code	PMID
intracellular anatomical structure	IDA	17145751
plasma membrane	ISS
plasma membrane	ISO
external side of plasma membrane	IDA	17145751
membrane	IDA	1371219 17114051 9145798

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

chloride channel complex

transporter complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

chloride channel complex

cellular anatomical entity [inference]

intracellular anatomical structure

membrane

plasma membrane

plasma membrane region [inference]

synaptic membrane [inference]

cell junction [inference]

synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection

dendrite

perikaryon

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle

intracellular organelle [inference]

intracellular membrane-bounded organelle

cell body [inference]

neuronal cell body

neuron projection terminus [inference]

axon terminus [inference]

calyx of Held

side of membrane [inference]

external side of plasma membrane

presynapse [inference]

axon terminus [inference]

calyx of Held

Displaying entries **1 - 5** of 22 in total

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GO Term	Evidence Code	PMID
transmembrane signaling receptor activity	IEA
excitatory extracellular ligand-gated monoatomic ion channel activity	IBA
chloride channel activity	IBA
zinc ion binding	ISS
zinc ion binding	ISO

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

monoatomic anion channel activity [inference]

chloride channel activity

extracellularly glycine-gated chloride channel activity

ligand-gated monoatomic anion channel activity [inference]

extracellularly glycine-gated chloride channel activity

ligand-gated monoatomic ion channel activity [inference]

extracellular ligand-gated monoatomic ion channel activity [inference]

excitatory extracellular ligand-gated monoatomic ion channel activity

extracellularly glycine-gated ion channel activity

extracellularly glycine-gated chloride channel activity

inhibitory extracellular ligand-gated monoatomic ion channel activity [inference]

extracellularly glycine-gated chloride channel activity

transmitter-gated monoatomic ion channel activity [inference]

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

ligand-gated monoatomic anion channel activity [inference]

extracellularly glycine-gated chloride channel activity

ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential

monoatomic anion transmembrane transporter activity [inference]

monoatomic anion channel activity [inference]

chloride channel activity

extracellularly glycine-gated chloride channel activity

ligand-gated monoatomic anion channel activity [inference]

extracellularly glycine-gated chloride channel activity

chloride transmembrane transporter activity [inference]

chloride channel activity

extracellularly glycine-gated chloride channel activity

inorganic molecular entity transmembrane transporter activity [inference]

inorganic anion transmembrane transporter activity [inference]

chloride transmembrane transporter activity [inference]

chloride channel activity

extracellularly glycine-gated chloride channel activity

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity [inference]

monoatomic anion channel activity [inference]

chloride channel activity

extracellularly glycine-gated chloride channel activity

ligand-gated monoatomic anion channel activity [inference]

extracellularly glycine-gated chloride channel activity

ligand-gated monoatomic ion channel activity [inference]

extracellular ligand-gated monoatomic ion channel activity [inference]

excitatory extracellular ligand-gated monoatomic ion channel activity

extracellularly glycine-gated ion channel activity

extracellularly glycine-gated chloride channel activity

inhibitory extracellular ligand-gated monoatomic ion channel activity [inference]

extracellularly glycine-gated chloride channel activity

transmitter-gated monoatomic ion channel activity [inference]

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

ligand-gated monoatomic anion channel activity [inference]

extracellularly glycine-gated chloride channel activity

ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential

gated channel activity [inference]

ligand-gated channel activity [inference]

ligand-gated monoatomic ion channel activity [inference]

extracellular ligand-gated monoatomic ion channel activity [inference]

excitatory extracellular ligand-gated monoatomic ion channel activity

extracellularly glycine-gated ion channel activity

extracellularly glycine-gated chloride channel activity

inhibitory extracellular ligand-gated monoatomic ion channel activity [inference]

extracellularly glycine-gated chloride channel activity

transmitter-gated monoatomic ion channel activity [inference]

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

ligand-gated monoatomic anion channel activity [inference]

extracellularly glycine-gated chloride channel activity

ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential

transmitter-gated channel activity [inference]

transmitter-gated monoatomic ion channel activity [inference]

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

salt transmembrane transporter activity [inference]

chloride transmembrane transporter activity [inference]

chloride channel activity

extracellularly glycine-gated chloride channel activity

binding [inference]

protein binding [inference]

identical protein binding

small molecule binding [inference]

organic acid binding [inference]

carboxylic acid binding [inference]

amino acid binding [inference]

glycine binding

alkanesulfonate binding [inference]

taurine binding

ion binding [inference]

anion binding [inference]

carboxylic acid binding [inference]

amino acid binding [inference]

glycine binding

alkanesulfonate binding [inference]

taurine binding

cation binding [inference]

glycine binding

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

protein-containing complex binding

sulfur compound binding [inference]

alkanesulfonate binding [inference]

taurine binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity

neurotransmitter receptor activity [inference]

transmitter-gated channel activity [inference]

transmitter-gated monoatomic ion channel activity [inference]

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

postsynaptic neurotransmitter receptor activity [inference]

neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential [inference]

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

gamma-aminobutyric acid receptor

Functional Category

E: Amino acid transport and metabolism
T: Signal transduction mechanisms
X: Mobilome: prophages, transposons

Displaying **all 7** entries
Gene Ontology
chloride channel activity
chloride transmembrane transport
excitatory extracellular ligand-gated monoatomic ion channel activity
extracellular ligand-gated monoatomic ion channel activity
monoatomic ion channel activity
monoatomic ion transport
transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

Displaying **all 8** entries
InterPro
Gamma-aminobutyric acid A receptor/Glycine receptor alpha
Neuronal acetylcholine receptor
Neurotransmitter-gated ion-channel ligand-binding domain superfamily
Neurotransmitter-gated ion-channel ligand-binding domain
Neurotransmitter-gated ion-channel transmembrane domain superfamily
Neurotransmitter-gated ion-channel transmembrane domain
Neurotransmitter-gated ion-channel, conserved site
Neurotransmitter-gated ion-channel

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0060695	hyperekplexia	Alliance of Genome Resources
DOID:0060696	hyperekplexia 1	Alliance of Genome Resources

Ortholog

Displaying entries **41 - 50** of 72 in total

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Species	Gene ID	Orthologous MAtrix
Melopsittacus undulatus	101877896	MELUD09679
Chrysemys picta bellii	101932156	CHRPI36574
Ictidomys tridecemlineatus	101959519	ICTTR11543
Chinchilla lanigera	102024428	CHILA02172
Capra hircus	102169587	CAPHI27140
Myotis lucifugus	102423073	MYOLU05223
Pelodiscus sinensis	102447313	PELSI16092
Vicugna pacos	102528919	VICPA05372
Chlorocebus sabaeus	103244821	CHLSB11134
Carlito syrichta	103250962	CARSF17085

GlyTouCan

GlyComb

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UniCarb-DR

LM-GlycoRepo

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OrthoDB (Group)

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Acknowledgements