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alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B

Summary

Gene Symbol

MGAT5B

Aliases

FLJ25132
GnT-IX
GnT-VB

Organism

Homo sapiens (human)

External Links

NCBI Gene

146664

GGDB ID

gg131

HGNC

24140

mRNA

NM_144677

map

17q25.3

Protein

NP_653278

OMIM

612441

KEGG Gene ID

hsa:146664

PubChem

146664

Alliance of Genome Resources

HGNC:24140

Annotation

Keyword

Alternative splicing
Disulfide bond
Glycoprotein
Glycosyltransferase
Golgi apparatus
Manganese
Metal-binding
Reference proteome
Signal-anchor
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q3V5L5	Alpha-mannoside beta-1,6-N-acetylglucosaminyltransferase B GlcNAc-T Vb Mannoside acetylglucosaminyltransferase 5B N-acetylglucosaminyl-transferase Vb N-acetylglucosaminyltransferase IX

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	PMID
protein N-linked glycosylation	IBA
protein O-linked glycosylation via serine	IDA	19846580

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein N-linked glycosylation

protein O-linked glycosylation [inference]

protein O-linked glycosylation via serine

peptidyl-amino acid modification [inference]

peptidyl-serine modification [inference]

protein O-linked glycosylation via serine

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein N-linked glycosylation

protein O-linked glycosylation [inference]

protein O-linked glycosylation via serine

peptidyl-amino acid modification [inference]

peptidyl-serine modification [inference]

protein O-linked glycosylation via serine

glycosylation [inference]

macromolecule glycosylation [inference]

protein glycosylation [inference]

protein N-linked glycosylation

protein O-linked glycosylation [inference]

protein O-linked glycosylation via serine

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein N-linked glycosylation

protein O-linked glycosylation [inference]

protein O-linked glycosylation via serine

peptidyl-amino acid modification [inference]

peptidyl-serine modification [inference]

protein O-linked glycosylation via serine

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation [inference]

protein N-linked glycosylation

protein O-linked glycosylation [inference]

protein O-linked glycosylation via serine

peptidyl-amino acid modification [inference]

peptidyl-serine modification [inference]

protein O-linked glycosylation via serine

macromolecule glycosylation [inference]

protein glycosylation [inference]

protein N-linked glycosylation

protein O-linked glycosylation [inference]

protein O-linked glycosylation via serine

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein N-linked glycosylation

protein O-linked glycosylation [inference]

protein O-linked glycosylation via serine

peptidyl-amino acid modification [inference]

peptidyl-serine modification [inference]

protein O-linked glycosylation via serine

Displaying **all 2** entries
GO Term	Evidence Code	PMID
Golgi apparatus	IBA
Golgi membrane	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protein binding	IPI	23088713
manganese ion binding	IDA	19846580
alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity	IBA IDA	19846580

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

UDP-glycosyltransferase activity [inference]

acetylglucosaminyltransferase activity [inference]

alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity

hexosyltransferase activity [inference]

acetylglucosaminyltransferase activity [inference]

alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity

catalytic activity, acting on a protein [inference]

catalytic activity, acting on a glycoprotein [inference]

alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

manganese ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 3** entries
Gene Ontology
alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity
protein N-linked glycosylation
transferase activity

Displaying 1 entry
InterPro
Glycosyltransferase family 18

GlycoGene Database (GGDB)

GGDB ID

gg131

Gene Symbol

MGAT5B

Reactions

Displaying 1 entry
Donor	Acceptor	Reducing terminal(Acceptor)	Product	Reducing terminal(Product)	Reference
UDP-GlcNAc	G39213VZ	Asn-X	G10219AA	Asn-X	12941944

Displaying **all 4** entries
Donor	Acceptor	Reducing terminal(Acceptor)	Product	Reducing terminal(Product)	Reference
UDP-GlcNAc	G39213VZ	Asn-X	G10219AA	Asn-X	12941944
UDP-GlcNAc	G85856KC	O-benzyl	G56868BH	O-benzyl	19846580
UDP-GlcNAc	G39213VZ	Asialo-galacto-biantennary	G83717YJ	Asialo-galacto-biantennary	19846580
UDP-GlcNAc	G85856KC	Ac-VEP[T*]AV-NH2[alpha]-dystroglycan	G56868BH	Ac-VEP[T*]AV-NH2[alpha]-dystroglycan	19846580

Displaying 1 entry
Donor	Acceptor	Reducing terminal(Acceptor)	Reference
UDP-GlcNAc	G49108TO		19846580

Orthologous Gene

Displaying **all 2** entries
Species	Protein	mRNA
Rattus norvegicus	XP_221136	XM_221136
Mus musculus	NP_766536	NM_172948

KEGG BRITE Database

Orthology

K09661

Name

mannosyl alpha-1,6-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B [EC:2.4.1.-]

References

12941944

Reactions

Displaying **all 6** entries
KEGG Reaction	Enzyme	Acceptor	Product
R07621	2.4.1.-	G85856KC	G56868BH
R07622	2.4.1.-	G39213VZ	G10219AA
R07625	2.4.1.-	G88380UG	G83717YJ
R07623	2.4.1.-	G39213VZ	G88380UG
R05991	2.4.1.155	G29011JC	G20030CU
R07624	2.4.1.-	G10219AA	G83717YJ

Rhea

RHEA:16921

UDP-N-acetyl-α-D-glucosamine

H⁺ + UDP

Enzyme

2.4.1.155

PMID

Ortholog

Displaying entries **11 - 20** of **107** in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Callithrix jacchus	100411284		CALJA36396
Ailuropoda melanoleuca	100474282		AILME13624
Xenopus tropicalis	100487001	Xenbase:XB-GENE-987716
Sus scrofa	100516218		PIGXX01769
Meleagris gallopavo	100538548		MELGA06610
Loxodonta africana	100672358		LOXAF07182
Oreochromis niloticus	100696723		ORENI62186
Oreochromis niloticus	100708112		ORENI56391
Cavia porcellus	100723796		CAVPO20165
Cricetulus griseus	100771275		CRIGR05312

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Other Information

Tools

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Summary

External Links

Annotation

OrthoDB (Group)

GlycoGene Database (GGDB)

KEGG BRITE Database

International Collaboration

Acknowledgements