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guanine nucleotide binding protein, alpha 12

Summary

Gene Symbol

Gna12

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

14673

PubChem

14673

Alliance of Genome Resources

MGI:95767

Annotation

Keyword

3D-structure
Cell membrane
Cytoplasm
GTP-binding
Magnesium
Metal-binding
Palmitate
Phosphoprotein
Reference proteome
Transducer

Proteins

Displaying 1 entry
UniProt	Protein Name
P27600

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 21 in total

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GO Term	Evidence Code	PMID
in utero embryonic development	IGI	12077299
G protein-coupled receptor signaling pathway	ISA	2508088
G protein-coupled receptor signaling pathway	ISO	29453251
G protein-coupled receptor signaling pathway	TAS	9305907
adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IBA

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

adenylate cyclase-modulating G protein-coupled receptor signaling pathway

intracellular signal transduction

small GTPase mediated signal transduction [inference]

Ras protein signal transduction [inference]

Rho protein signal transduction

cellular developmental process [inference]

cell differentiation

multicellular organismal process [inference]

multicellular organism development [inference]

embryo development [inference]

embryo development ending in birth or egg hatching [inference]

chordate embryonic development [inference]

in utero embryonic development

developmental process [inference]

anatomical structure morphogenesis [inference]

embryonic morphogenesis [inference]

embryonic digit morphogenesis

anatomical structure development [inference]

multicellular organism development [inference]

embryo development [inference]

embryo development ending in birth or egg hatching [inference]

chordate embryonic development [inference]

in utero embryonic development

cellular developmental process [inference]

cell differentiation

response to stimulus [inference]

response to chemical [inference]

response to xenobiotic stimulus

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein dephosphorylation [inference]

positive regulation of phosphoprotein phosphatase activity

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of dephosphorylation [inference]

positive regulation of phosphatase activity [inference]

positive regulation of phosphoprotein phosphatase activity

positive regulation of protein dephosphorylation [inference]

positive regulation of phosphoprotein phosphatase activity

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein dephosphorylation [inference]

positive regulation of phosphoprotein phosphatase activity

regulation of catabolic process [inference]

regulation of protein catabolic process [inference]

regulation of proteasomal protein catabolic process [inference]

regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of ubiquitin-dependent protein catabolic process [inference]

regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of dephosphorylation [inference]

positive regulation of phosphatase activity [inference]

positive regulation of phosphoprotein phosphatase activity

positive regulation of protein dephosphorylation [inference]

positive regulation of phosphoprotein phosphatase activity

regulation of phosphorus metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of dephosphorylation [inference]

positive regulation of phosphatase activity [inference]

positive regulation of phosphoprotein phosphatase activity

positive regulation of protein dephosphorylation [inference]

positive regulation of phosphoprotein phosphatase activity

regulation of phosphate metabolic process [inference]

regulation of dephosphorylation [inference]

regulation of phosphatase activity [inference]

positive regulation of phosphatase activity [inference]

positive regulation of phosphoprotein phosphatase activity

regulation of phosphoprotein phosphatase activity [inference]

positive regulation of phosphoprotein phosphatase activity

regulation of protein dephosphorylation [inference]

positive regulation of protein dephosphorylation [inference]

positive regulation of phosphoprotein phosphatase activity

regulation of phosphoprotein phosphatase activity [inference]

positive regulation of phosphoprotein phosphatase activity

positive regulation of dephosphorylation [inference]

positive regulation of phosphatase activity [inference]

positive regulation of phosphoprotein phosphatase activity

positive regulation of protein dephosphorylation [inference]

positive regulation of phosphoprotein phosphatase activity

positive regulation of phosphate metabolic process [inference]

positive regulation of dephosphorylation [inference]

positive regulation of phosphatase activity [inference]

positive regulation of phosphoprotein phosphatase activity

positive regulation of protein dephosphorylation [inference]

positive regulation of phosphoprotein phosphatase activity

regulation of nitrogen compound metabolic process [inference]

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein dephosphorylation [inference]

positive regulation of phosphoprotein phosphatase activity

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

regulation of proteolysis involved in protein catabolic process [inference]

regulation of proteasomal protein catabolic process [inference]

regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of ubiquitin-dependent protein catabolic process [inference]

regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of protein modification process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein dephosphorylation [inference]

positive regulation of phosphoprotein phosphatase activity

regulation of protein dephosphorylation [inference]

positive regulation of protein dephosphorylation [inference]

positive regulation of phosphoprotein phosphatase activity

regulation of phosphoprotein phosphatase activity [inference]

positive regulation of phosphoprotein phosphatase activity

regulation of protein catabolic process [inference]

regulation of proteasomal protein catabolic process [inference]

regulation of proteasomal ubiquitin-dependent protein catabolic process

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein dephosphorylation [inference]

positive regulation of phosphoprotein phosphatase activity

regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein dephosphorylation [inference]

positive regulation of phosphoprotein phosphatase activity

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

regulation of proteolysis involved in protein catabolic process [inference]

regulation of proteasomal protein catabolic process [inference]

regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of ubiquitin-dependent protein catabolic process [inference]

regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of protein modification process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein dephosphorylation [inference]

positive regulation of phosphoprotein phosphatase activity

regulation of protein dephosphorylation [inference]

positive regulation of protein dephosphorylation [inference]

positive regulation of phosphoprotein phosphatase activity

regulation of phosphoprotein phosphatase activity [inference]

positive regulation of phosphoprotein phosphatase activity

regulation of protein catabolic process [inference]

regulation of proteasomal protein catabolic process [inference]

regulation of proteasomal ubiquitin-dependent protein catabolic process

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein dephosphorylation [inference]

positive regulation of phosphoprotein phosphatase activity

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

regulation of proteolysis involved in protein catabolic process [inference]

regulation of proteasomal protein catabolic process [inference]

regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of ubiquitin-dependent protein catabolic process [inference]

regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of protein modification process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein dephosphorylation [inference]

positive regulation of phosphoprotein phosphatase activity

regulation of protein dephosphorylation [inference]

positive regulation of protein dephosphorylation [inference]

positive regulation of phosphoprotein phosphatase activity

regulation of phosphoprotein phosphatase activity [inference]

positive regulation of phosphoprotein phosphatase activity

regulation of protein catabolic process [inference]

regulation of proteasomal protein catabolic process [inference]

regulation of proteasomal ubiquitin-dependent protein catabolic process

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein dephosphorylation [inference]

positive regulation of phosphoprotein phosphatase activity

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of TOR signaling

regulation of locomotion [inference]

negative regulation of locomotion [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of smooth muscle cell migration [inference]

negative regulation of vascular associated smooth muscle cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of fibroblast migration

regulation of smooth muscle cell migration [inference]

negative regulation of smooth muscle cell migration [inference]

negative regulation of vascular associated smooth muscle cell migration

regulation of vascular associated smooth muscle cell migration [inference]

negative regulation of vascular associated smooth muscle cell migration

negative regulation of cell migration [inference]

negative regulation of smooth muscle cell migration [inference]

negative regulation of vascular associated smooth muscle cell migration

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of smooth muscle cell migration [inference]

negative regulation of vascular associated smooth muscle cell migration

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein dephosphorylation [inference]

positive regulation of phosphoprotein phosphatase activity

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of dephosphorylation [inference]

positive regulation of phosphatase activity [inference]

positive regulation of phosphoprotein phosphatase activity

positive regulation of protein dephosphorylation [inference]

positive regulation of phosphoprotein phosphatase activity

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein dephosphorylation [inference]

positive regulation of phosphoprotein phosphatase activity

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of dephosphorylation [inference]

positive regulation of phosphatase activity [inference]

positive regulation of phosphoprotein phosphatase activity

positive regulation of protein dephosphorylation [inference]

positive regulation of phosphoprotein phosphatase activity

negative regulation of biological process [inference]

negative regulation of locomotion [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of smooth muscle cell migration [inference]

negative regulation of vascular associated smooth muscle cell migration

negative regulation of cellular process [inference]

negative regulation of cell population proliferation [inference]

negative regulation of smooth muscle cell proliferation [inference]

negative regulation of vascular associated smooth muscle cell proliferation

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of smooth muscle cell migration [inference]

negative regulation of vascular associated smooth muscle cell migration

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of TOR signaling

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of cell morphogenesis [inference]

regulation of cell shape

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

adenylate cyclase-modulating G protein-coupled receptor signaling pathway

intracellular signal transduction

small GTPase mediated signal transduction [inference]

Ras protein signal transduction [inference]

Rho protein signal transduction

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of TOR signaling

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of dephosphorylation [inference]

positive regulation of phosphatase activity [inference]

positive regulation of phosphoprotein phosphatase activity

positive regulation of protein dephosphorylation [inference]

positive regulation of phosphoprotein phosphatase activity

regulation of phosphorus metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of dephosphorylation [inference]

positive regulation of phosphatase activity [inference]

positive regulation of phosphoprotein phosphatase activity

positive regulation of protein dephosphorylation [inference]

positive regulation of phosphoprotein phosphatase activity

regulation of phosphate metabolic process [inference]

regulation of dephosphorylation [inference]

regulation of phosphatase activity [inference]

positive regulation of phosphatase activity [inference]

positive regulation of phosphoprotein phosphatase activity

regulation of phosphoprotein phosphatase activity [inference]

positive regulation of phosphoprotein phosphatase activity

regulation of protein dephosphorylation [inference]

positive regulation of protein dephosphorylation [inference]

positive regulation of phosphoprotein phosphatase activity

regulation of phosphoprotein phosphatase activity [inference]

positive regulation of phosphoprotein phosphatase activity

positive regulation of dephosphorylation [inference]

positive regulation of phosphatase activity [inference]

positive regulation of phosphoprotein phosphatase activity

positive regulation of protein dephosphorylation [inference]

positive regulation of phosphoprotein phosphatase activity

positive regulation of phosphate metabolic process [inference]

positive regulation of dephosphorylation [inference]

positive regulation of phosphatase activity [inference]

positive regulation of phosphoprotein phosphatase activity

positive regulation of protein dephosphorylation [inference]

positive regulation of phosphoprotein phosphatase activity

regulation of cell population proliferation [inference]

negative regulation of cell population proliferation [inference]

negative regulation of smooth muscle cell proliferation [inference]

negative regulation of vascular associated smooth muscle cell proliferation

regulation of smooth muscle cell proliferation [inference]

negative regulation of smooth muscle cell proliferation [inference]

negative regulation of vascular associated smooth muscle cell proliferation

regulation of vascular associated smooth muscle cell proliferation [inference]

negative regulation of vascular associated smooth muscle cell proliferation

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of dephosphorylation [inference]

positive regulation of phosphatase activity [inference]

positive regulation of phosphoprotein phosphatase activity

positive regulation of protein dephosphorylation [inference]

positive regulation of phosphoprotein phosphatase activity

negative regulation of cellular process [inference]

negative regulation of cell population proliferation [inference]

negative regulation of smooth muscle cell proliferation [inference]

negative regulation of vascular associated smooth muscle cell proliferation

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of smooth muscle cell migration [inference]

negative regulation of vascular associated smooth muscle cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of fibroblast migration

regulation of smooth muscle cell migration [inference]

negative regulation of smooth muscle cell migration [inference]

negative regulation of vascular associated smooth muscle cell migration

regulation of vascular associated smooth muscle cell migration [inference]

negative regulation of vascular associated smooth muscle cell migration

negative regulation of cell migration [inference]

negative regulation of smooth muscle cell migration [inference]

negative regulation of vascular associated smooth muscle cell migration

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of smooth muscle cell migration [inference]

negative regulation of vascular associated smooth muscle cell migration

regulation of biological quality [inference]

regulation of molecular function [inference]

positive regulation of molecular function [inference]

positive regulation of catalytic activity [inference]

positive regulation of hydrolase activity [inference]

positive regulation of phosphatase activity [inference]

positive regulation of phosphoprotein phosphatase activity

regulation of catalytic activity [inference]

positive regulation of catalytic activity [inference]

positive regulation of hydrolase activity [inference]

positive regulation of phosphatase activity [inference]

positive regulation of phosphoprotein phosphatase activity

regulation of hydrolase activity [inference]

regulation of phosphatase activity [inference]

positive regulation of phosphatase activity [inference]

positive regulation of phosphoprotein phosphatase activity

regulation of phosphoprotein phosphatase activity [inference]

positive regulation of phosphoprotein phosphatase activity

positive regulation of hydrolase activity [inference]

positive regulation of phosphatase activity [inference]

positive regulation of phosphoprotein phosphatase activity

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
cytoplasm	IBA
cytoplasm	IEA
heterotrimeric G-protein complex	TAS	10037795 9305907
heterotrimeric G-protein complex	IBA
lateral plasma membrane	ISO

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

plasma membrane protein complex [inference]

heterotrimeric G-protein complex

catalytic complex [inference]

GTPase complex [inference]

heterotrimeric G-protein complex

cellular anatomical entity [inference]

cytoplasm

membrane [inference]

plasma membrane region [inference]

cell projection membrane [inference]

brush border membrane

lateral plasma membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection

cell body [inference]

neuronal cell body

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	PMID
GTPase activity	ISA	2508088
GTPase activity	TAS	9305907
GTPase activity	IBA
G protein activity	ISS
G protein activity	ISO

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

GTPase activity

G protein activity

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

G protein-coupled receptor binding [inference]

dopamine receptor binding [inference]

D5 dopamine receptor binding

enzyme binding [inference]

phosphatase binding [inference]

protein phosphatase binding [inference]

protein phosphatase 2A binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

guanyl nucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

GTP binding

cation binding [inference]

metal ion binding

protein-containing complex binding [inference]

G-protein beta/gamma-subunit complex binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

guanyl nucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleoside triphosphate binding [inference]

GTP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

molecular function regulator activity [inference]

G protein activity

enzyme regulator activity [inference]

enzyme activator activity [inference]

phosphatase activator activity [inference]

protein phosphatase activator activity

phosphatase regulator activity [inference]

phosphatase activator activity [inference]

protein phosphatase activator activity

protein phosphatase regulator activity

protein phosphatase activator activity

molecular function activator activity [inference]

enzyme activator activity [inference]

phosphatase activator activity [inference]

protein phosphatase activator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

G alpha

Functional Category

E: Amino acid transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
G protein-coupled receptor binding
G-protein beta/gamma-subunit complex binding
GTP binding
adenylate cyclase-modulating G protein-coupled receptor signaling pathway
guanyl nucleotide binding
nucleotide binding

Displaying **all 3** entries
InterPro
G protein alpha subunit, helical insertion
Guanine nucleotide binding protein (G-protein), alpha subunit
P-loop containing nucleoside triphosphate hydrolase

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements