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Guidelines

MIRAGE

dynein axonemal heavy chain 2

Summary

Gene Symbol

DNAH2

Organism

Homo sapiens (human)

External Links

NCBI Gene

146754

PubChem

146754

Alliance of Genome Resources

HGNC:2948

Annotation

Keyword

3D-structure
ATP-binding
Alternative splicing
Coiled coil
Cytoskeleton
Disease variant
Dynein
Flagellum
Microtubule
Motor protein
RNA editing
Reference proteome
Repeat
TPR repeat

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9P225	Axonemal beta dynein heavy chain 2 Ciliary dynein heavy chain 2 Dynein heavy chain domain-containing protein 3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
inner dynein arm assembly	IMP	30811583
cilium-dependent cell motility	IMP NAS	30811583 9256245
cilium movement involved in cell motility	IBA

GO Hierarchy

biological process

cellular process [inference]

microtubule-based process [inference]

microtubule-based movement [inference]

cilium movement [inference]

cilium movement involved in cell motility

cell motility [inference]

cilium or flagellum-dependent cell motility [inference]

cilium-dependent cell motility

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

axonemal dynein complex assembly [inference]

inner dynein arm assembly

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

axonemal dynein complex assembly [inference]

inner dynein arm assembly

Displaying entries **1 - 5** of 8 in total

1

2

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GO Term	Evidence Code	PMID
axoneme	IBA IDA	31178125
motile cilium	IDA	31178125
axonemal dynein complex	NAS	9256245
microtubule	IEA
9+2 motile cilium	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

microtubule associated complex [inference]

axonemal dynein complex

inner dynein arm

catalytic complex [inference]

axonemal dynein complex

inner dynein arm

cellular anatomical entity [inference]

axoneme

cell projection [inference]

plasma membrane bounded cell projection [inference]

cilium [inference]

9+2 motile cilium

sperm flagellum

organelle [inference]

membrane-bounded organelle [inference]

cilium [inference]

9+2 motile cilium

sperm flagellum

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

microtubule

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
ATP binding	IEA
dynein intermediate chain binding	IBA
dynein light intermediate chain binding	IBA
microtubule motor activity	NAS	9256245
ATP hydrolysis activity	IEA

GO Hierarchy

molecular function

cytoskeletal motor activity [inference]

microtubule motor activity

minus-end-directed microtubule motor activity

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

binding [inference]

protein binding [inference]

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ATP-dependent activity [inference]

microtubule motor activity

minus-end-directed microtubule motor activity

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0112163	spermatogenic failure 45	Alliance of Genome Resources

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Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: February 17, 2025