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guanine nucleotide binding protein, alpha O

Summary

Gene Symbol

Gnao1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

14681

PubChem

14681

Alliance of Genome Resources

MGI:95775

Annotation

Keyword

3D-structure
Alternative splicing
Cell membrane
Direct protein sequencing
GTP-binding
Magnesium
Metal-binding
Myristate
Palmitate
Reference proteome
Transducer

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q543S2
P18872

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
vesicle docking involved in exocytosis	IMP	20622165
G protein-coupled receptor signaling pathway	ISO
G protein-coupled receptor signaling pathway	TAS	2508088
G protein-coupled receptor signaling pathway	IMP	9501252
adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IBA

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

adenylate cyclase-modulating G protein-coupled receptor signaling pathway

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting serotonin receptor signaling pathway

G protein-coupled serotonin receptor signaling pathway [inference]

adenylate cyclase-inhibiting serotonin receptor signaling pathway

dopamine receptor signaling pathway

membrane docking [inference]

organelle localization by membrane tethering [inference]

vesicle docking [inference]

vesicle docking involved in exocytosis

exocytic process [inference]

vesicle docking involved in exocytosis

multicellular organismal process [inference]

behavior [inference]

locomotory behavior

localization [inference]

organelle localization [inference]

organelle localization by membrane tethering [inference]

vesicle docking [inference]

vesicle docking involved in exocytosis

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

negative regulation of signaling [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

regulation of hormone secretion [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

regulation of peptide hormone secretion [inference]

regulation of insulin secretion [inference]

negative regulation of insulin secretion

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

postsynaptic modulation of chemical synaptic transmission

regulation of localization [inference]

regulation of transport [inference]

regulation of monoatomic ion transport [inference]

regulation of metal ion transport [inference]

regulation of calcium ion transport [inference]

negative regulation of calcium ion transport

negative regulation of monoatomic ion transport [inference]

negative regulation of calcium ion transport

regulation of secretion [inference]

regulation of peptide secretion [inference]

negative regulation of peptide secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

regulation of peptide hormone secretion [inference]

regulation of insulin secretion [inference]

negative regulation of insulin secretion

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

negative regulation of secretion [inference]

negative regulation of peptide secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

negative regulation of secretion by cell [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

negative regulation of protein secretion [inference]

negative regulation of insulin secretion

regulation of secretion by cell [inference]

regulation of hormone secretion [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

regulation of peptide hormone secretion [inference]

regulation of insulin secretion [inference]

negative regulation of insulin secretion

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

regulation of protein secretion [inference]

negative regulation of protein secretion [inference]

negative regulation of insulin secretion

regulation of insulin secretion [inference]

negative regulation of insulin secretion

negative regulation of secretion by cell [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

negative regulation of protein secretion [inference]

negative regulation of insulin secretion

negative regulation of transport [inference]

negative regulation of monoatomic ion transport [inference]

negative regulation of calcium ion transport

negative regulation of secretion [inference]

negative regulation of peptide secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

negative regulation of secretion by cell [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

negative regulation of protein secretion [inference]

negative regulation of insulin secretion

negative regulation of protein transport [inference]

negative regulation of protein secretion [inference]

negative regulation of insulin secretion

regulation of protein transport [inference]

regulation of protein secretion [inference]

negative regulation of protein secretion [inference]

negative regulation of insulin secretion

regulation of insulin secretion [inference]

negative regulation of insulin secretion

negative regulation of protein transport [inference]

negative regulation of protein secretion [inference]

negative regulation of insulin secretion

regulation of peptide transport [inference]

regulation of peptide secretion [inference]

negative regulation of peptide secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

regulation of peptide hormone secretion [inference]

regulation of insulin secretion [inference]

negative regulation of insulin secretion

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of protein secretion [inference]

negative regulation of protein secretion [inference]

negative regulation of insulin secretion

regulation of insulin secretion [inference]

negative regulation of insulin secretion

negative regulation of protein transport [inference]

negative regulation of protein secretion [inference]

negative regulation of insulin secretion

negative regulation of establishment of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of protein secretion [inference]

negative regulation of insulin secretion

negative regulation of protein localization [inference]

negative regulation of establishment of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of protein secretion [inference]

negative regulation of insulin secretion

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

negative regulation of secretion by cell [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

negative regulation of protein secretion [inference]

negative regulation of insulin secretion

negative regulation of protein localization [inference]

negative regulation of establishment of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of protein secretion [inference]

negative regulation of insulin secretion

negative regulation of transport [inference]

negative regulation of monoatomic ion transport [inference]

negative regulation of calcium ion transport

negative regulation of secretion [inference]

negative regulation of peptide secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

negative regulation of secretion by cell [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

negative regulation of protein secretion [inference]

negative regulation of insulin secretion

negative regulation of protein transport [inference]

negative regulation of protein secretion [inference]

negative regulation of insulin secretion

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

adenylate cyclase-modulating G protein-coupled receptor signaling pathway

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting serotonin receptor signaling pathway

G protein-coupled serotonin receptor signaling pathway [inference]

adenylate cyclase-inhibiting serotonin receptor signaling pathway

dopamine receptor signaling pathway

regulation of cell communication [inference]

negative regulation of cell communication [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

regulation of hormone secretion [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

regulation of peptide hormone secretion [inference]

regulation of insulin secretion [inference]

negative regulation of insulin secretion

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

postsynaptic modulation of chemical synaptic transmission

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

negative regulation of secretion by cell [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

negative regulation of protein secretion [inference]

negative regulation of insulin secretion

negative regulation of protein localization [inference]

negative regulation of establishment of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of protein secretion [inference]

negative regulation of insulin secretion

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of protein secretion [inference]

negative regulation of protein secretion [inference]

negative regulation of insulin secretion

regulation of insulin secretion [inference]

negative regulation of insulin secretion

negative regulation of protein transport [inference]

negative regulation of protein secretion [inference]

negative regulation of insulin secretion

negative regulation of establishment of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of protein secretion [inference]

negative regulation of insulin secretion

negative regulation of protein localization [inference]

negative regulation of establishment of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of protein secretion [inference]

negative regulation of insulin secretion

regulation of secretion by cell [inference]

regulation of hormone secretion [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

regulation of peptide hormone secretion [inference]

regulation of insulin secretion [inference]

negative regulation of insulin secretion

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

regulation of protein secretion [inference]

negative regulation of protein secretion [inference]

negative regulation of insulin secretion

regulation of insulin secretion [inference]

negative regulation of insulin secretion

negative regulation of secretion by cell [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

negative regulation of protein secretion [inference]

negative regulation of insulin secretion

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of blood circulation [inference]

regulation of heart contraction

regulation of biological quality [inference]

regulation of hormone levels [inference]

regulation of hormone secretion [inference]

negative regulation of hormone secretion [inference]

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

regulation of peptide hormone secretion [inference]

regulation of insulin secretion [inference]

negative regulation of insulin secretion

negative regulation of peptide hormone secretion [inference]

negative regulation of insulin secretion

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
cytoplasm	IBA
heterotrimeric G-protein complex	TAS	2508088
heterotrimeric G-protein complex	IBA
plasma membrane	ISO
plasma membrane	TAS

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

plasma membrane protein complex [inference]

heterotrimeric G-protein complex

catalytic complex [inference]

GTPase complex [inference]

heterotrimeric G-protein complex

cellular anatomical entity [inference]

cytoplasm

membrane

plasma membrane

plasma membrane region [inference]

synaptic membrane [inference]

cell junction [inference]

synapse [inference]

excitatory synapse [inference]

parallel fiber to Purkinje cell synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

dendrite

Displaying entries **1 - 5** of 19 in total

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GO Term	Evidence Code	PMID
GTPase activity	ISO
GTPase activity	TAS	2508088
GTPase activity	IBA
G protein activity	IDA	10926822
signaling receptor binding	ISO

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

GTPase activity

G protein activity

binding [inference]

protein binding

signaling receptor binding

G protein-coupled receptor binding [inference]

opioid receptor binding [inference]

mu-type opioid receptor binding

G protein-coupled serotonin receptor binding

neuropeptide receptor binding [inference]

corticotropin-releasing hormone receptor binding [inference]

corticotropin-releasing hormone receptor 1 binding

hormone receptor binding [inference]

peptide hormone receptor binding [inference]

corticotropin-releasing hormone receptor binding [inference]

corticotropin-releasing hormone receptor 1 binding

GTPase activating protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

guanyl nucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

GTP binding

cation binding [inference]

metal ion binding

protein-containing complex binding [inference]

G-protein beta/gamma-subunit complex binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

guanyl nucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleoside triphosphate binding [inference]

GTP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

molecular function regulator activity [inference]

G protein activity

molecular function activator activity [inference]

transporter activator activity [inference]

channel activator activity [inference]

potassium channel activator activity

transporter regulator activity [inference]

channel regulator activity [inference]

channel activator activity [inference]

potassium channel activator activity

ion channel regulator activity [inference]

potassium channel regulator activity [inference]

potassium channel activator activity

transporter activator activity [inference]

channel activator activity [inference]

potassium channel activator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

G alpha

Functional Category

E: Amino acid transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
G protein-coupled receptor binding
G-protein beta/gamma-subunit complex binding
GTP binding
adenylate cyclase-modulating G protein-coupled receptor signaling pathway
guanyl nucleotide binding
nucleotide binding

Displaying **all 3** entries
InterPro
G protein alpha subunit, helical insertion
Guanine nucleotide binding protein (G-protein), alpha subunit
P-loop containing nucleoside triphosphate hydrolase

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0080450	developmental and epileptic encephalopathy 17	Alliance of Genome Resources
DOID:0112276	neurodevelopmental disorder with involuntary movements	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 41 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Saccharomyces cerevisiae S288C	2770	SGD:S000001047
Saccharomyces cerevisiae S288C	2771	SGD:S000001047
Saccharomyces cerevisiae S288C	2773	SGD:S000001047
Homo sapiens	2775		HUMAN28327
Saccharomyces cerevisiae S288C	14677	SGD:S000001047
Saccharomyces cerevisiae S288C	14678	SGD:S000001047
Saccharomyces cerevisiae S288C	14679	SGD:S000001047
Xenopus tropicalis	14681	Xenbase:XB-GENE-921635
Saccharomyces cerevisiae S288C	346562	SGD:S000001047
Pan troglodytes	450173		PANTR12388

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Annotation

OrthoDB (Group)

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Acknowledgements