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glycine N-methyltransferase

Summary

Gene Symbol

Gnmt

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

14711

PubChem

14711

Alliance of Genome Resources

MGI:1202304

Annotation

Keyword

3D-structure
Acetylation
Cytoplasm
Folate-binding
Methyltransferase
Phosphoprotein
Reference proteome
S-adenosyl-L-methionine

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9QXF8

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
methylation	ISO
S-adenosylmethionine metabolic process	IBA IDA ISO	15340920
one-carbon metabolic process	IBA IMP	17937387
glycine metabolic process	ISO
glycogen metabolic process	IMP	17937387

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

ribonucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

organonitrogen compound metabolic process [inference]

sulfur amino acid metabolic process [inference]

methionine metabolic process

amino acid metabolic process [inference]

alpha-amino acid metabolic process [inference]

aspartate family amino acid metabolic process [inference]

methionine metabolic process

serine family amino acid metabolic process [inference]

glycine metabolic process

cellular modified amino acid metabolic process [inference]

nucleoside metabolic process [inference]

ribonucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

methylation

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

sulfur amino acid metabolic process [inference]

methionine metabolic process

amino acid metabolic process [inference]

alpha-amino acid metabolic process [inference]

aspartate family amino acid metabolic process [inference]

methionine metabolic process

serine family amino acid metabolic process [inference]

glycine metabolic process

generation of precursor metabolites and energy [inference]

energy derivation by oxidation of organic compounds [inference]

energy reserve metabolic process [inference]

glycogen metabolic process

cellular modified amino acid metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

ribonucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

one-carbon metabolic process

sulfur compound metabolic process [inference]

sulfur amino acid metabolic process [inference]

methionine metabolic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

ribonucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

ribonucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

primary metabolic process [inference]

carbohydrate metabolic process [inference]

polysaccharide metabolic process [inference]

glucan metabolic process [inference]

glycogen metabolic process

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

ribonucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

amino acid metabolic process [inference]

alpha-amino acid metabolic process [inference]

aspartate family amino acid metabolic process [inference]

methionine metabolic process

serine family amino acid metabolic process [inference]

glycine metabolic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

sulfur amino acid metabolic process [inference]

methionine metabolic process

amino acid metabolic process [inference]

alpha-amino acid metabolic process [inference]

aspartate family amino acid metabolic process [inference]

methionine metabolic process

serine family amino acid metabolic process [inference]

glycine metabolic process

one-carbon metabolic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

ribonucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

polysaccharide metabolic process [inference]

glucan metabolic process [inference]

glycogen metabolic process

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

sulfur amino acid metabolic process [inference]

methionine metabolic process

amino acid metabolic process [inference]

alpha-amino acid metabolic process [inference]

aspartate family amino acid metabolic process [inference]

methionine metabolic process

serine family amino acid metabolic process [inference]

glycine metabolic process

macromolecule metabolic process [inference]

polysaccharide metabolic process [inference]

glucan metabolic process [inference]

glycogen metabolic process

S-adenosylmethionine metabolic process

carbohydrate derivative metabolic process [inference]

glycosyl compound metabolic process [inference]

nucleoside metabolic process [inference]

ribonucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

ribonucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

organonitrogen compound metabolic process [inference]

sulfur amino acid metabolic process [inference]

methionine metabolic process

amino acid metabolic process [inference]

alpha-amino acid metabolic process [inference]

aspartate family amino acid metabolic process [inference]

methionine metabolic process

serine family amino acid metabolic process [inference]

glycine metabolic process

cellular modified amino acid metabolic process [inference]

nucleoside metabolic process [inference]

ribonucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

sulfur amino acid metabolic process [inference]

methionine metabolic process

amino acid metabolic process [inference]

alpha-amino acid metabolic process [inference]

aspartate family amino acid metabolic process [inference]

methionine metabolic process

serine family amino acid metabolic process [inference]

glycine metabolic process

generation of precursor metabolites and energy [inference]

energy derivation by oxidation of organic compounds [inference]

energy reserve metabolic process [inference]

glycogen metabolic process

cellular modified amino acid metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

ribonucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

one-carbon metabolic process

sulfur compound metabolic process [inference]

sulfur amino acid metabolic process [inference]

methionine metabolic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

ribonucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

ribonucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process [inference]

purine ribonucleoside metabolic process [inference]

S-adenosylhomocysteine metabolic process

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein homooligomerization [inference]

protein homotetramerization

protein tetramerization [inference]

protein homotetramerization

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein homooligomerization [inference]

protein homotetramerization

protein tetramerization [inference]

protein homotetramerization

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of carbohydrate biosynthetic process [inference]

regulation of gluconeogenesis

regulation of small molecule metabolic process [inference]

regulation of glucose metabolic process [inference]

regulation of gluconeogenesis

regulation of primary metabolic process [inference]

regulation of carbohydrate metabolic process [inference]

regulation of glucose metabolic process [inference]

regulation of gluconeogenesis

regulation of carbohydrate biosynthetic process [inference]

regulation of gluconeogenesis

Displaying **all 3** entries
GO Term	Evidence Code	PMID
methyltransferase complex	ISO
cytosol	IBA ISO
cytoplasm	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

catalytic complex [inference]

transferase complex [inference]

methyltransferase complex

cellular anatomical entity [inference]

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
S-adenosylmethionine-dependent methyltransferase activity	ISO
S-adenosyl-L-methionine binding	IBA ISO
transferase activity	IEA
folic acid binding	ISO
glycine N-methyltransferase activity	IBA IDA ISO	15340920

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity

transferase activity, transferring one-carbon groups [inference]

methyltransferase activity

N-methyltransferase activity [inference]

glycine N-methyltransferase activity

S-adenosylmethionine-dependent methyltransferase activity

glycine N-methyltransferase activity

binding [inference]

protein binding [inference]

identical protein binding

amide binding [inference]

folic acid binding

small molecule binding [inference]

vitamin binding [inference]

folic acid binding

organic acid binding [inference]

carboxylic acid binding [inference]

folic acid binding

amino acid binding [inference]

glycine binding

heterocyclic compound binding [inference]

folic acid binding

ion binding [inference]

anion binding [inference]

carboxylic acid binding [inference]

folic acid binding

amino acid binding [inference]

glycine binding

cation binding [inference]

modified amino acid binding [inference]

folic acid binding

organic cyclic compound binding [inference]

folic acid binding

sulfur compound binding [inference]

S-adenosyl-L-methionine binding

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0111037	glycine N-methyltransferase deficiency	Alliance of Genome Resources
DOID:684	hepatocellular carcinoma	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 76 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	41561	FB:FBgn0038074
Callorhinchus milii	103187634		CALMI37181
Latimeria chalumnae	102360222		LATCH13172
Danio rerio	403338	ZFIN:ZDB-GENE-040227-1	DANRE13235
Ictalurus punctatus	108270118		ICTPU35862
Electrophorus electricus	113572147		ELEEL10946
Salmo salar	106561891		SALSA16023
Salmo trutta	115202816		SALTR77148
Gadus morhua	115535976		GADMO35491
Oreochromis niloticus	100706279		ORENI31665

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