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notum, palmitoleoyl-protein carboxylesterase

Summary

Gene Symbol

NOTUM

Organism

Homo sapiens (human)

External Links

NCBI Gene

147111

PubChem

147111

Alliance of Genome Resources

HGNC:27106

Annotation

Keyword

3D-structure
Glycoprotein
Phosphoprotein
Reference proteome
Secreted
Serine esterase
Signal
Wnt signaling pathway

Proteins

Displaying 1 entry
UniProt	Protein Name
Q6P988	hNOTUM

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
Wnt signaling pathway	IEA
negative regulation of Wnt signaling pathway	IDA	25731175
regulation of bone mineralization	IDA	30622831
regulation of bone mineralization	IMP	30622831
bone development	IMP	30622831

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein catabolic process [inference]

lipoprotein catabolic process [inference]

protein depalmitoleylation

protein modification process [inference]

protein deacylation [inference]

protein depalmitoleylation

lipoprotein metabolic process [inference]

lipoprotein catabolic process [inference]

protein depalmitoleylation

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

lipoprotein catabolic process [inference]

protein depalmitoleylation

catabolic process [inference]

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

lipoprotein catabolic process [inference]

protein depalmitoleylation

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

lipoprotein catabolic process [inference]

protein depalmitoleylation

primary metabolic process [inference]

protein metabolic process [inference]

protein catabolic process [inference]

lipoprotein catabolic process [inference]

protein depalmitoleylation

protein modification process [inference]

protein deacylation [inference]

protein depalmitoleylation

lipoprotein metabolic process [inference]

lipoprotein catabolic process [inference]

protein depalmitoleylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

lipoprotein catabolic process [inference]

protein depalmitoleylation

protein metabolic process [inference]

protein catabolic process [inference]

lipoprotein catabolic process [inference]

protein depalmitoleylation

protein modification process [inference]

protein deacylation [inference]

protein depalmitoleylation

lipoprotein metabolic process [inference]

lipoprotein catabolic process [inference]

protein depalmitoleylation

macromolecule modification [inference]

protein modification process [inference]

protein deacylation [inference]

protein depalmitoleylation

macromolecule deacylation [inference]

protein deacylation [inference]

protein depalmitoleylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein catabolic process [inference]

lipoprotein catabolic process [inference]

protein depalmitoleylation

protein modification process [inference]

protein deacylation [inference]

protein depalmitoleylation

lipoprotein metabolic process [inference]

lipoprotein catabolic process [inference]

protein depalmitoleylation

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

lipoprotein catabolic process [inference]

protein depalmitoleylation

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

lipoprotein catabolic process [inference]

protein depalmitoleylation

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

lipoprotein catabolic process [inference]

protein depalmitoleylation

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Wnt signaling pathway

developmental process [inference]

anatomical structure development [inference]

animal organ development [inference]

bone development

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway

negative regulation of canonical Wnt signaling pathway

regulation of Wnt signaling pathway [inference]

negative regulation of Wnt signaling pathway

negative regulation of canonical Wnt signaling pathway

regulation of canonical Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway

negative regulation of canonical Wnt signaling pathway

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway

negative regulation of canonical Wnt signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway

negative regulation of canonical Wnt signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway

negative regulation of canonical Wnt signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway

negative regulation of canonical Wnt signaling pathway

regulation of Wnt signaling pathway [inference]

negative regulation of Wnt signaling pathway

negative regulation of canonical Wnt signaling pathway

regulation of canonical Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway

negative regulation of canonical Wnt signaling pathway

regulation of developmental process [inference]

regulation of multicellular organismal development [inference]

regulation of biomineral tissue development [inference]

regulation of bone mineralization

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Wnt signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway

negative regulation of canonical Wnt signaling pathway

regulation of Wnt signaling pathway [inference]

negative regulation of Wnt signaling pathway

negative regulation of canonical Wnt signaling pathway

regulation of canonical Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway

negative regulation of canonical Wnt signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway

negative regulation of canonical Wnt signaling pathway

regulation of multicellular organismal process [inference]

regulation of ossification [inference]

regulation of bone mineralization

regulation of multicellular organismal development [inference]

regulation of biomineral tissue development [inference]

regulation of bone mineralization

Displaying **all 2** entries
GO Term	Evidence Code	PMID
extracellular region	TAS
endoplasmic reticulum lumen	TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular region

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endoplasmic reticulum lumen

Displaying **all 5** entries
GO Term	Evidence Code	PMID
phospholipase C activity	TAS
protein binding	IPI	32296183
protein-containing complex destabilizing activity	IEA
palmitoleyl hydrolase activity	IDA	25731175
palmitoleyl hydrolase activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

lipase activity [inference]

phospholipase activity [inference]

phospholipase C activity

phosphoric ester hydrolase activity [inference]

phosphoric diester hydrolase activity [inference]

phospholipase C activity

carboxylic ester hydrolase activity [inference]

palmitoleyl hydrolase activity

binding [inference]

protein binding

protein-containing complex destabilizing activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

PI-PLC X domain-containing protein

Functional Category

I: Lipid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
hydrolase activity

Displaying 1 entry
InterPro
Pectinacetylesterase/NOTUM

Ortholog

Displaying entries **1 - 10** of 64 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	39751	Xenbase:XB-GENE-996986
Mus musculus	77583	Xenbase:XB-GENE-996986	MOUSE05122
Xenopus tropicalis	147111	Xenbase:XB-GENE-996986
Rattus norvegicus	303743		RATNO02096
Xenopus tropicalis	444338	Xenbase:XB-GENE-996986
Canis lupus familiaris	483374		CANLF18334
Drosophila melanogaster	566040	FB:FBgn0044028
Danio rerio	570510	Xenbase:XB-GENE-996986	DANRE32478
Monodelphis domestica	100029923		MONDO11066
Ornithorhynchus anatinus	100079087		ORNAN00246