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Guidelines

MIRAGE

cystatin B

Summary

Gene Symbol

CSTB

Organism

Homo sapiens (human)

External Links

NCBI Gene

1476

PubChem

1476

Alliance of Genome Resources

HGNC:2482

JoGo

CSTB

TogoVar

CSTB

Annotation

Keyword

3D-structure
Acetylation
Cytoplasm
Direct protein sequencing
Disease variant
Epilepsy
Neurodegeneration
Nucleus
Proteomics identification
Reference proteome
Thiol protease inhibitor

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q76LA1	Stefin-B
P04080	CPI-B Liver thiol proteinase inhibitor Stefin-B

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
adult locomotory behavior	IEA
negative regulation of peptidase activity	IDA	6203523
negative regulation of proteolysis	IDA	3488317

GO Hierarchy

biological process

multicellular organismal process [inference]

behavior [inference]

locomotory behavior [inference]

adult locomotory behavior

adult behavior [inference]

adult locomotory behavior

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis

negative regulation of peptidase activity

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis

negative regulation of peptidase activity

regulation of nitrogen compound metabolic process [inference]

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis

negative regulation of peptidase activity

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis

negative regulation of peptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis

negative regulation of peptidase activity

regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis

negative regulation of peptidase activity

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis

negative regulation of peptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis

negative regulation of peptidase activity

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis

negative regulation of peptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis

negative regulation of peptidase activity

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis

negative regulation of peptidase activity

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis

negative regulation of peptidase activity

regulation of molecular function [inference]

negative regulation of molecular function [inference]

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of peptidase activity

regulation of catalytic activity [inference]

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of peptidase activity

regulation of hydrolase activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of peptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity

Displaying entries **1 - 5** of 13 in total

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2

3

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GO Term	Evidence Code	PMID
extracellular region	TAS
extracellular space	IDA	3488317
extracellular space	HDA	23580065
nucleus	IDA	11139332
nucleolus	IDA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

external encapsulating structure [inference]

extracellular matrix [inference]

collagen-containing extracellular matrix

membrane-enclosed lumen [inference]

organelle lumen [inference]

vesicle lumen [inference]

cytoplasmic vesicle lumen [inference]

secretory granule lumen

intracellular organelle lumen [inference]

cytoplasmic vesicle lumen [inference]

secretory granule lumen

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

nucleus

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

nucleolus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular non-membrane-bounded organelle [inference]

nucleolus

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
protease binding	IDA	11514663
protease binding	IPI	6203523
RNA binding	HDA	22658674
endopeptidase inhibitor activity	IDA	3053245
cysteine-type endopeptidase inhibitor activity	IDA	3488317 6203523

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

enzyme binding [inference]

protease binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

RNA binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity

cysteine-type endopeptidase inhibitor activity

peptidase regulator activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity

cysteine-type endopeptidase inhibitor activity

endopeptidase regulator activity [inference]

endopeptidase inhibitor activity

cysteine-type endopeptidase inhibitor activity

molecular function inhibitor activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity

cysteine-type endopeptidase inhibitor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

cystatin A

Functional Category

J: Translation, ribosomal structure and biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
endopeptidase inhibitor activity

Displaying **all 4** entries
InterPro
Cystatin domain
Cystatin superfamily
Proteinase inhibitor I25, cystatin, conserved site
Proteinase inhibitor I25A, stefin

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0111452	progressive myoclonus epilepsy 1A	Alliance of Genome Resources
DOID:3535	Unverricht-Lundborg syndrome	Alliance of Genome Resources

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025