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prolyl 3-hydroxylase 3

Summary

Gene Symbol

P3h3

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

14789

PubChem

14789

Alliance of Genome Resources

MGI:1315208

Annotation

Keyword

Coiled coil
Dioxygenase
Endoplasmic reticulum
Glycoprotein
Iron
Metal-binding
Reference proteome
Repeat
Signal
TPR repeat
Vitamin C

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8CG70	Leprecan-like protein 2 Protein B

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
negative regulation of cell population proliferation	ISO
negative regulation of cell population proliferation	IEA
peptidyl-lysine hydroxylation	IMP	28115524
collagen metabolic process	IBA
collagen biosynthetic process	IMP	28115524

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein hydroxylation [inference]

peptidyl-lysine hydroxylation

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

peptidyl-lysine hydroxylation

biosynthetic process [inference]

collagen biosynthetic process

collagen metabolic process

collagen biosynthetic process

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein hydroxylation [inference]

peptidyl-lysine hydroxylation

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

peptidyl-lysine hydroxylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein hydroxylation [inference]

peptidyl-lysine hydroxylation

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

peptidyl-lysine hydroxylation

macromolecule modification [inference]

protein modification process [inference]

protein hydroxylation [inference]

peptidyl-lysine hydroxylation

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

peptidyl-lysine hydroxylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein hydroxylation [inference]

peptidyl-lysine hydroxylation

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

peptidyl-lysine hydroxylation

biological regulation [inference]

regulation of biological process [inference]

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

regulation of cellular process [inference]

regulation of cell population proliferation [inference]

negative regulation of cell population proliferation

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

Displaying **all 3** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum	IBA
endoplasmic reticulum	IEA
catalytic complex	IMP	27119146

GO Hierarchy

cellular component

protein-containing complex [inference]

catalytic complex

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying **all 5** entries
GO Term	Evidence Code	PMID
iron ion binding	IEA
protein binding	IPI	27119146
procollagen-proline 3-dioxygenase activity	IBA
procollagen-proline 3-dioxygenase activity	IEA
L-ascorbic acid binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [inference]

2-oxoglutarate-dependent dioxygenase activity [inference]

peptidyl-proline dioxygenase activity [inference]

procollagen-proline dioxygenase activity [inference]

procollagen-proline 3-dioxygenase activity

peptidyl-proline 3-dioxygenase activity [inference]

procollagen-proline 3-dioxygenase activity

dioxygenase activity [inference]

2-oxoglutarate-dependent dioxygenase activity [inference]

peptidyl-proline dioxygenase activity [inference]

procollagen-proline dioxygenase activity [inference]

procollagen-proline 3-dioxygenase activity

peptidyl-proline 3-dioxygenase activity [inference]

procollagen-proline 3-dioxygenase activity

catalytic activity, acting on a protein [inference]

peptidyl-proline dioxygenase activity [inference]

procollagen-proline dioxygenase activity [inference]

procollagen-proline 3-dioxygenase activity

peptidyl-proline 3-dioxygenase activity [inference]

procollagen-proline 3-dioxygenase activity

binding [inference]

protein binding

carbohydrate binding [inference]

monosaccharide binding [inference]

L-ascorbic acid binding

small molecule binding [inference]

vitamin binding [inference]

L-ascorbic acid binding

organic acid binding [inference]

carboxylic acid binding [inference]

L-ascorbic acid binding

monosaccharide binding [inference]

L-ascorbic acid binding

heterocyclic compound binding [inference]

L-ascorbic acid binding

ion binding [inference]

anion binding [inference]

carboxylic acid binding [inference]

L-ascorbic acid binding

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

iron ion binding

organic cyclic compound binding [inference]

L-ascorbic acid binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Prolyl 3-hydroxylase 3

Functional Category

L: Replication, recombination and repair
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 8** entries
Gene Ontology
L-ascorbic acid binding
collagen metabolic process
dioxygenase activity
iron ion binding
metal ion binding
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
oxidoreductase activity
procollagen-proline 3-dioxygenase activity

Displaying **all 5** entries
InterPro
Oxoglutarate/iron-dependent dioxygenase
Prolyl 3-hydroxylase
Prolyl 4-hydroxylase alpha subunit, Fe(2+) 2OG dioxygenase domain
Prolyl 4-hydroxylase, alpha subunit
Tetratricopeptide-like helical domain superfamily

Ortholog

Displaying entries **1 - 10** of 74 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	10536	Xenbase:XB-GENE-5901520	HUMAN10786
Xenopus tropicalis	14789	Xenbase:XB-GENE-5901520
Rattus norvegicus	297595		RATNO31585
Danio rerio	553311		DANRE10739
Monodelphis domestica	100016121		MONDO35139
Equus caballus	100060032		HORSE37533
Sus scrofa	100156539		PIGXX26300
Taeniopygia guttata	100221140		TAEGU10413
Oryctolagus cuniculus	100344567		RABIT12322
Callithrix jacchus	100385724		CALJA45437