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lysophosphatidylcholine acyltransferase 3

Summary

Gene Symbol

Lpcat3

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

14792

PubChem

14792

Alliance of Genome Resources

MGI:1315211

Annotation

Keyword

Acetylation
Acyltransferase
Endoplasmic reticulum
Glycoprotein
Phospholipid biosynthesis
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q91V01	1-acylglycerophosphocholine O-acyltransferase 1-acylglycerophosphoethanolamine O-acyltransferase 1-acylglycerophosphoserine O-acyltransferase Lysophosphatidylcholine acyltransferase Lysophosphatidylcholine acyltransferase 3 Lysophosphatidylethanolamine acyltransferase Lysophosphatidylserine acyltransferase Membrane-bound O-acyltransferase domain-containing protein 5

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	PMID
very-low-density lipoprotein particle assembly	IMP	25806685
positive regulation of intestinal cholesterol absorption	IMP	26833026
endoplasmic reticulum membrane organization	IMP	28846071
regulation of cholesterol biosynthetic process	IMP	29395055
positive regulation of triglyceride transport	IMP	25806685 25898003

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

cellular modified amino acid metabolic process [inference]

phosphatidylserine metabolic process [inference]

phosphatidylserine acyl-chain remodeling

phosphatidylcholine metabolic process [inference]

organonitrogen compound biosynthetic process [inference]

phosphatidylcholine biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

organonitrogen compound biosynthetic process [inference]

phosphatidylcholine biosynthetic process

cellular metabolic process [inference]

cellular modified amino acid metabolic process [inference]

phosphatidylserine metabolic process [inference]

phosphatidylserine acyl-chain remodeling

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylserine metabolic process [inference]

phosphatidylserine acyl-chain remodeling

phosphatidylcholine metabolic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylserine metabolic process [inference]

phosphatidylserine acyl-chain remodeling

phosphatidylcholine metabolic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylserine metabolic process [inference]

phosphatidylserine acyl-chain remodeling

phosphatidylcholine metabolic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

lipid modification

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylserine metabolic process [inference]

phosphatidylserine acyl-chain remodeling

phosphatidylcholine metabolic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

primary metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylserine metabolic process [inference]

phosphatidylserine acyl-chain remodeling

phosphatidylcholine metabolic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

lipid modification

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylserine metabolic process [inference]

phosphatidylserine acyl-chain remodeling

phosphatidylcholine metabolic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylserine metabolic process [inference]

phosphatidylserine acyl-chain remodeling

phosphatidylcholine metabolic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

lipid modification

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylserine metabolic process [inference]

phosphatidylserine acyl-chain remodeling

phosphatidylcholine metabolic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylserine metabolic process [inference]

phosphatidylserine acyl-chain remodeling

phosphatidylcholine metabolic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

organonitrogen compound metabolic process [inference]

cellular modified amino acid metabolic process [inference]

phosphatidylserine metabolic process [inference]

phosphatidylserine acyl-chain remodeling

phosphatidylcholine metabolic process [inference]

organonitrogen compound biosynthetic process [inference]

phosphatidylcholine biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

organonitrogen compound biosynthetic process [inference]

phosphatidylcholine biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

cellular modified amino acid metabolic process [inference]

phosphatidylserine metabolic process [inference]

phosphatidylserine acyl-chain remodeling

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylserine metabolic process [inference]

phosphatidylserine acyl-chain remodeling

phosphatidylcholine metabolic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylserine metabolic process [inference]

phosphatidylserine acyl-chain remodeling

phosphatidylcholine metabolic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylserine metabolic process [inference]

phosphatidylserine acyl-chain remodeling

phosphatidylcholine metabolic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

lipid modification

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylserine metabolic process [inference]

phosphatidylserine acyl-chain remodeling

phosphatidylcholine metabolic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylcholine biosynthetic process

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein-lipid complex assembly [inference]

plasma lipoprotein particle assembly [inference]

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein-lipid complex assembly [inference]

plasma lipoprotein particle assembly [inference]

protein-lipid complex organization [inference]

protein-lipid complex assembly [inference]

plasma lipoprotein particle assembly [inference]

plasma lipoprotein particle organization [inference]

plasma lipoprotein particle assembly [inference]

membrane organization [inference]

endoplasmic reticulum membrane organization

multicellular organismal process [inference]

multicellular organismal-level homeostasis [inference]

homeostasis of number of cells [inference]

intestinal stem cell homeostasis

plasma lipoprotein particle organization [inference]

plasma lipoprotein particle assembly [inference]

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

homeostasis of number of cells [inference]

intestinal stem cell homeostasis

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of lipid biosynthetic process [inference]

regulation of steroid biosynthetic process [inference]

regulation of sterol biosynthetic process [inference]

regulation of cholesterol biosynthetic process

regulation of alcohol biosynthetic process [inference]

regulation of cholesterol biosynthetic process

regulation of small molecule metabolic process [inference]

regulation of cholesterol metabolic process [inference]

regulation of cholesterol biosynthetic process

regulation of alcohol biosynthetic process [inference]

regulation of cholesterol biosynthetic process

regulation of primary metabolic process [inference]

regulation of lipid metabolic process [inference]

regulation of steroid metabolic process [inference]

regulation of steroid biosynthetic process [inference]

regulation of sterol biosynthetic process [inference]

regulation of cholesterol biosynthetic process

regulation of cholesterol metabolic process [inference]

regulation of cholesterol biosynthetic process

regulation of lipid biosynthetic process [inference]

regulation of steroid biosynthetic process [inference]

regulation of sterol biosynthetic process [inference]

regulation of cholesterol biosynthetic process

regulation of localization [inference]

regulation of transport [inference]

regulation of lipid transport [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of intestinal cholesterol absorption

positive regulation of acylglycerol transport [inference]

positive regulation of triglyceride transport

positive regulation of intestinal lipid absorption [inference]

positive regulation of intestinal cholesterol absorption

regulation of sterol transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of intestinal cholesterol absorption

regulation of cholesterol transport [inference]

regulation of intestinal cholesterol absorption [inference]

positive regulation of intestinal cholesterol absorption

positive regulation of cholesterol transport [inference]

positive regulation of intestinal cholesterol absorption

regulation of acylglycerol transport [inference]

positive regulation of acylglycerol transport [inference]

positive regulation of triglyceride transport

regulation of triglyceride transport [inference]

positive regulation of triglyceride transport

regulation of intestinal lipid absorption [inference]

regulation of intestinal cholesterol absorption [inference]

positive regulation of intestinal cholesterol absorption

positive regulation of intestinal lipid absorption [inference]

positive regulation of intestinal cholesterol absorption

positive regulation of transport [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of intestinal cholesterol absorption

positive regulation of acylglycerol transport [inference]

positive regulation of triglyceride transport

positive regulation of intestinal lipid absorption [inference]

positive regulation of intestinal cholesterol absorption

positive regulation of intestinal absorption [inference]

positive regulation of intestinal lipid absorption [inference]

positive regulation of intestinal cholesterol absorption

regulation of intestinal absorption [inference]

positive regulation of intestinal absorption [inference]

positive regulation of intestinal lipid absorption [inference]

positive regulation of intestinal cholesterol absorption

regulation of intestinal lipid absorption [inference]

regulation of intestinal cholesterol absorption [inference]

positive regulation of intestinal cholesterol absorption

positive regulation of intestinal lipid absorption [inference]

positive regulation of intestinal cholesterol absorption

regulation of lipid localization [inference]

regulation of lipid transport [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of intestinal cholesterol absorption

positive regulation of acylglycerol transport [inference]

positive regulation of triglyceride transport

positive regulation of intestinal lipid absorption [inference]

positive regulation of intestinal cholesterol absorption

regulation of sterol transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of intestinal cholesterol absorption

regulation of cholesterol transport [inference]

regulation of intestinal cholesterol absorption [inference]

positive regulation of intestinal cholesterol absorption

positive regulation of cholesterol transport [inference]

positive regulation of intestinal cholesterol absorption

regulation of acylglycerol transport [inference]

positive regulation of acylglycerol transport [inference]

positive regulation of triglyceride transport

regulation of triglyceride transport [inference]

positive regulation of triglyceride transport

regulation of intestinal lipid absorption [inference]

regulation of intestinal cholesterol absorption [inference]

positive regulation of intestinal cholesterol absorption

positive regulation of intestinal lipid absorption [inference]

positive regulation of intestinal cholesterol absorption

positive regulation of lipid localization [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of intestinal cholesterol absorption

positive regulation of acylglycerol transport [inference]

positive regulation of triglyceride transport

positive regulation of intestinal lipid absorption [inference]

positive regulation of intestinal cholesterol absorption

positive regulation of biological process [inference]

positive regulation of transport [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of intestinal cholesterol absorption

positive regulation of acylglycerol transport [inference]

positive regulation of triglyceride transport

positive regulation of intestinal lipid absorption [inference]

positive regulation of intestinal cholesterol absorption

positive regulation of intestinal absorption [inference]

positive regulation of intestinal lipid absorption [inference]

positive regulation of intestinal cholesterol absorption

positive regulation of multicellular organismal process [inference]

positive regulation of digestive system process [inference]

positive regulation of intestinal absorption [inference]

positive regulation of intestinal lipid absorption [inference]

positive regulation of intestinal cholesterol absorption

positive regulation of lipid localization [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of intestinal cholesterol absorption

positive regulation of acylglycerol transport [inference]

positive regulation of triglyceride transport

positive regulation of intestinal lipid absorption [inference]

positive regulation of intestinal cholesterol absorption

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of response to endoplasmic reticulum stress

negative regulation of response to stimulus [inference]

negative regulation of defense response [inference]

negative regulation of inflammatory response

negative regulation of response to external stimulus [inference]

negative regulation of inflammatory response

negative regulation of response to endoplasmic reticulum stress

regulation of response to stimulus [inference]

regulation of response to external stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of inflammatory response

regulation of inflammatory response [inference]

negative regulation of inflammatory response

negative regulation of response to stimulus [inference]

negative regulation of defense response [inference]

negative regulation of inflammatory response

negative regulation of response to external stimulus [inference]

negative regulation of inflammatory response

negative regulation of response to endoplasmic reticulum stress

regulation of response to stress [inference]

regulation of defense response [inference]

negative regulation of defense response [inference]

negative regulation of inflammatory response

regulation of inflammatory response [inference]

negative regulation of inflammatory response

regulation of cellular response to stress [inference]

regulation of response to endoplasmic reticulum stress [inference]

negative regulation of response to endoplasmic reticulum stress

regulation of cellular process [inference]

negative regulation of cellular process [inference]

negative regulation of response to endoplasmic reticulum stress

regulation of cellular response to stress [inference]

regulation of response to endoplasmic reticulum stress [inference]

negative regulation of response to endoplasmic reticulum stress

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of digestive system process [inference]

positive regulation of digestive system process [inference]

positive regulation of intestinal absorption [inference]

positive regulation of intestinal lipid absorption [inference]

positive regulation of intestinal cholesterol absorption

regulation of intestinal absorption [inference]

positive regulation of intestinal absorption [inference]

positive regulation of intestinal lipid absorption [inference]

positive regulation of intestinal cholesterol absorption

regulation of intestinal lipid absorption [inference]

regulation of intestinal cholesterol absorption [inference]

positive regulation of intestinal cholesterol absorption

positive regulation of intestinal lipid absorption [inference]

positive regulation of intestinal cholesterol absorption

positive regulation of multicellular organismal process [inference]

positive regulation of digestive system process [inference]

positive regulation of intestinal absorption [inference]

positive regulation of intestinal lipid absorption [inference]

positive regulation of intestinal cholesterol absorption

regulation of plasma lipoprotein particle levels

Displaying **all 2** entries
GO Term	Evidence Code	PMID
membrane	IBA
endoplasmic reticulum membrane	IDA ISO ISS	18287005

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

organelle membrane [inference]

endoplasmic reticulum membrane

Displaying **all 4** entries
GO Term	Evidence Code	PMID
1-acylglycerophosphoethanolamine O-acyltransferase activity	IDA ISO	18287005 25898003
1-acylglycerophosphoserine O-acyltransferase activity	IDA ISO	18287005
1-acylglycerophosphocholine O-acyltransferase activity	IBA IDA IMP ISO	18287005 25898003
lysophospholipid acyltransferase activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

acyltransferase activity [inference]

acyltransferase activity, transferring groups other than amino-acyl groups [inference]

O-acyltransferase activity [inference]

lysophospholipid acyltransferase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

lysophospholipid acyltransferase 5

Functional Category

J: Translation, ribosomal structure and biogenesis
M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 5** entries
Gene Ontology
O-acyltransferase activity
lipid modification
lysophospholipid acyltransferase activity
phosphatidylcholine biosynthetic process
transferase activity

Displaying 1 entry
InterPro
Membrane bound O-acyl transferase, MBOAT

Ortholog

Displaying entries **1 - 10** of **112** in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	10162		HGNC:30244	HUMAN10866
Drosophila melanogaster	40093		FB:FBgn0026630
Caenorhabditis elegans	175339		WB:WBGene00020115
Rattus norvegicus	362434	10116_1:001c3f	RGD:1310223	RATNO30730
Pan troglodytes	451807			PANTR05015
Danio rerio	555566		ZFIN:ZDB-GENE-041111-232	DANRE11070
Macaca mulatta	714639			MACMU03300
Monodelphis domestica	100016730			MONDO34588
Equus caballus	100053035			HORSE37571
Ciona intestinalis	100186495			CIOIN00076

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OrthoDB (Group)

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Acknowledgements