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glutamate receptor, metabotropic 1

Summary

Gene Symbol

Grm1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

14816

PubChem

14816

Alliance of Genome Resources

MGI:1351338

Annotation

Keyword

Alternative splicing
Cell membrane
Disulfide bond
G-protein coupled receptor
Glycoprotein
Phosphoprotein
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P97772
Q3V0U2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
regulation of sensory perception of pain	IDA	11356865
cellular response to electrical stimulus	IMP	21052544
sensory perception of pain	IMP	11356865
positive regulation of MAPK cascade	IDA	11356865
phospholipase C-activating G protein-coupled glutamate receptor signaling pathway	ISO ISS

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

synaptic signaling via neuropeptide

signal transduction [inference]

cell surface receptor signaling pathway [inference]

glutamate receptor signaling pathway [inference]

G protein-coupled glutamate receptor signaling pathway

phospholipase C-activating G protein-coupled glutamate receptor signaling pathway

G protein-coupled receptor signaling pathway

phospholipase C-activating G protein-coupled receptor signaling pathway

phospholipase C-activating G protein-coupled glutamate receptor signaling pathway

G protein-coupled glutamate receptor signaling pathway

phospholipase C-activating G protein-coupled glutamate receptor signaling pathway

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

calcium-mediated signaling

cellular response to stimulus [inference]

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to electrical stimulus

transmembrane transport [inference]

import across plasma membrane [inference]

amino acid import across plasma membrane [inference]

L-glutamate import across plasma membrane

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

amino acid import across plasma membrane [inference]

L-glutamate import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport [inference]

L-glutamate import across plasma membrane

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

sensory perception [inference]

sensory perception of pain

behavior [inference]

locomotory behavior

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis [inference]

regulation of cytosolic calcium ion concentration [inference]

regulation of postsynaptic cytosolic calcium ion concentration

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis [inference]

regulation of cytosolic calcium ion concentration [inference]

regulation of postsynaptic cytosolic calcium ion concentration

monoatomic cation homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis [inference]

regulation of cytosolic calcium ion concentration [inference]

regulation of postsynaptic cytosolic calcium ion concentration

calcium ion homeostasis [inference]

intracellular calcium ion homeostasis [inference]

regulation of cytosolic calcium ion concentration [inference]

regulation of postsynaptic cytosolic calcium ion concentration

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis [inference]

regulation of cytosolic calcium ion concentration [inference]

regulation of postsynaptic cytosolic calcium ion concentration

inorganic ion homeostasis [inference]

calcium ion homeostasis [inference]

intracellular calcium ion homeostasis [inference]

regulation of cytosolic calcium ion concentration [inference]

regulation of postsynaptic cytosolic calcium ion concentration

response to stimulus [inference]

response to abiotic stimulus [inference]

response to electrical stimulus [inference]

cellular response to electrical stimulus

cellular response to abiotic stimulus [inference]

cellular response to electrical stimulus

cellular response to stimulus [inference]

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to electrical stimulus

localization [inference]

establishment of localization [inference]

transport [inference]

transmembrane transport [inference]

import across plasma membrane [inference]

amino acid import across plasma membrane [inference]

L-glutamate import across plasma membrane

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

amino acid import across plasma membrane [inference]

L-glutamate import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport [inference]

L-glutamate import across plasma membrane

organic substance transport [inference]

organic anion transport [inference]

carboxylic acid transport [inference]

dicarboxylic acid transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport [inference]

L-glutamate import across plasma membrane

amino acid transport [inference]

amino acid transmembrane transport [inference]

amino acid import across plasma membrane [inference]

L-glutamate import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport [inference]

L-glutamate import across plasma membrane

acidic amino acid transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport [inference]

L-glutamate import across plasma membrane

L-amino acid transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport [inference]

L-glutamate import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport [inference]

L-glutamate import across plasma membrane

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

amino acid import across plasma membrane [inference]

L-glutamate import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport [inference]

L-glutamate import across plasma membrane

organic acid transport [inference]

carboxylic acid transport [inference]

dicarboxylic acid transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport [inference]

L-glutamate import across plasma membrane

amino acid transport [inference]

amino acid transmembrane transport [inference]

amino acid import across plasma membrane [inference]

L-glutamate import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport [inference]

L-glutamate import across plasma membrane

acidic amino acid transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport [inference]

L-glutamate import across plasma membrane

L-amino acid transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport [inference]

L-glutamate import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport [inference]

L-glutamate import across plasma membrane

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

amino acid import across plasma membrane [inference]

L-glutamate import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport [inference]

L-glutamate import across plasma membrane

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

amino acid import across plasma membrane [inference]

L-glutamate import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport [inference]

L-glutamate import across plasma membrane

nitrogen compound transport [inference]

amino acid transport [inference]

amino acid transmembrane transport [inference]

amino acid import across plasma membrane [inference]

L-glutamate import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport [inference]

L-glutamate import across plasma membrane

acidic amino acid transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport [inference]

L-glutamate import across plasma membrane

L-amino acid transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport [inference]

L-glutamate import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport [inference]

L-glutamate import across plasma membrane

amide transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport [inference]

L-glutamate import across plasma membrane

import into cell [inference]

amino acid import across plasma membrane [inference]

L-glutamate import across plasma membrane

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic transmission, glutamatergic

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

synaptic signaling via neuropeptide

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

glutamate receptor signaling pathway [inference]

G protein-coupled glutamate receptor signaling pathway

phospholipase C-activating G protein-coupled glutamate receptor signaling pathway

G protein-coupled receptor signaling pathway

phospholipase C-activating G protein-coupled receptor signaling pathway

phospholipase C-activating G protein-coupled glutamate receptor signaling pathway

G protein-coupled glutamate receptor signaling pathway

phospholipase C-activating G protein-coupled glutamate receptor signaling pathway

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

calcium-mediated signaling

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic transmission, glutamatergic

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of nervous system process [inference]

regulation of sensory perception [inference]

regulation of sensory perception of pain

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
Schaffer collateral - CA1 synapse	EXP IDA	11487615
postsynaptic membrane	ISO TAS	10936169
postsynaptic density membrane	IBA ISO
postsynaptic density	IDA	15579147
G protein-coupled receptor homodimeric complex	IEA ISO

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex [inference]

plasma membrane signaling receptor complex [inference]

G protein-coupled receptor complex [inference]

G protein-coupled receptor dimeric complex

G protein-coupled receptor homodimeric complex

membrane protein complex [inference]

plasma membrane protein complex [inference]

plasma membrane signaling receptor complex [inference]

G protein-coupled receptor complex [inference]

G protein-coupled receptor dimeric complex

G protein-coupled receptor homodimeric complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

synaptic membrane [inference]

postsynaptic specialization membrane [inference]

postsynaptic density membrane

cell junction [inference]

synapse [inference]

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection

neuron spine [inference]

dendritic spine

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

postsynaptic specialization [inference]

postsynaptic density

cell body [inference]

neuronal cell body

postsynapse [inference]

dendritic spine

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	15579147 18480293 9808458
glutamate receptor activity	ISO ISS
neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration	IBA
PLC activating G protein-coupled glutamate receptor activity	TAS	9185557
adenylate cyclase inhibiting G protein-coupled glutamate receptor activity	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding

transcription factor binding [inference]

DNA-binding transcription factor binding [inference]

RNA polymerase II-specific DNA-binding transcription factor binding [inference]

nuclear receptor binding [inference]

nuclear estrogen receptor binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity [inference]

G protein-coupled glutamate receptor activity [inference]

G protein-coupled neurotransmitter receptor activity [inference]

G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration

G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential

glutamate receptor activity

G protein-coupled glutamate receptor activity [inference]

neurotransmitter receptor activity [inference]

postsynaptic neurotransmitter receptor activity [inference]

neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration

G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration

G protein-coupled neurotransmitter receptor activity [inference]

G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

metabotropic glutamate receptor 1

Functional Category

J: Translation, ribosomal structure and biogenesis
O: Posttranslational modification, protein turnover, chaperones
P: Inorganic ion transport and metabolism

Displaying **all 6** entries
Gene Ontology
G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential
adenylate cyclase inhibiting G protein-coupled glutamate receptor activity
chemical synaptic transmission
neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration
phospholipase C-activating G protein-coupled glutamate receptor signaling pathway
regulation of synaptic transmission, glutamatergic

Displaying 1 entry
InterPro
GPCR family 3, C-terminal

Disease

Disease Ontology

Displaying **all 5** entries
DO ID	Disease Name	Source
DOID:0080062	autosomal recessive spinocerebellar ataxia 13	Alliance of Genome Resources
DOID:0080286	spinocerebellar ataxia 44	Alliance of Genome Resources
DOID:3328	temporal lobe epilepsy	Alliance of Genome Resources
DOID:6039	uveal melanoma	Alliance of Genome Resources
DOID:8923	skin melanoma	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of **135** in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	2911		HGNC:4593	HUMAN86911
Rattus norvegicus	24414	10116_1:000bec	RGD:2742	RATNO17072
Caenorhabditis elegans	172914		WB:WBGene00003233
Ovis aries	443101			SHEEP18865
Pan troglodytes	463049			PANTR39249
Canis lupus familiaris	484024			CANLF00186
Bos taurus	540485			BOVIN35938
Danio rerio	555576		ZFIN:ZDB-GENE-030131-7893	DANRE19671
Macaca mulatta	698736			MACMU34145
Taeniopygia guttata	751999			TAEGU20007

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements