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protein disulfide isomerase associated 3

Summary

Gene Symbol

Pdia3

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

14827

PubChem

14827

Alliance of Genome Resources

MGI:95834

Annotation

Keyword

Acetylation
Adaptive immunity
Direct protein sequencing
Disulfide bond
Endoplasmic reticulum
Isomerase
Methylation
Phosphoprotein
Redox-active center
Reference proteome
Repeat
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
P27773	58 kDa glucose-regulated protein 58 kDa microsomal protein Disulfide isomerase ER-60 Endoplasmic reticulum resident protein 57 Endoplasmic reticulum resident protein 60

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
adaptive immune response	IEA
peptide antigen assembly with MHC class I protein complex	ISO
protein folding	IBA
response to endoplasmic reticulum stress	IBA
platelet aggregation	IMP	28576878

GO Hierarchy

biological process

immune system process [inference]

immune response [inference]

adaptive immune response

cellular process [inference]

protein folding

cell communication [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to nutrient [inference]

cellular response to vitamin [inference]

cellular response to vitamin D

cell adhesion [inference]

cell-cell adhesion [inference]

homotypic cell-cell adhesion [inference]

platelet aggregation

signal transduction [inference]

cell surface receptor signaling pathway [inference]

extrinsic apoptotic signaling pathway

apoptotic signaling pathway [inference]

extrinsic apoptotic signaling pathway

cellular response to stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to nutrient [inference]

cellular response to vitamin [inference]

cellular response to vitamin D

cellular response to stress [inference]

response to endoplasmic reticulum stress

cellular response to chemical stimulus [inference]

cellular response to nutrient [inference]

cellular response to vitamin [inference]

cellular response to vitamin D

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to interleukin-7

cellular response to lipid [inference]

cellular response to vitamin D

cellular response to organic cyclic compound [inference]

cellular response to vitamin D

cellular response to oxygen-containing compound [inference]

cellular response to vitamin D

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

peptide antigen assembly with MHC protein complex [inference]

peptide antigen assembly with MHC class I protein complex

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

peptide antigen assembly with MHC protein complex [inference]

peptide antigen assembly with MHC class I protein complex

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress

immune response [inference]

adaptive immune response

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels [inference]

response to nutrient [inference]

cellular response to nutrient [inference]

cellular response to vitamin [inference]

cellular response to vitamin D

response to vitamin [inference]

response to vitamin D [inference]

cellular response to vitamin D

cellular response to vitamin [inference]

cellular response to vitamin D

cellular response to nutrient levels [inference]

cellular response to nutrient [inference]

cellular response to vitamin [inference]

cellular response to vitamin D

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to nutrient [inference]

cellular response to vitamin [inference]

cellular response to vitamin D

cellular response to external stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to nutrient [inference]

cellular response to vitamin [inference]

cellular response to vitamin D

response to chemical [inference]

response to nutrient [inference]

cellular response to nutrient [inference]

cellular response to vitamin [inference]

cellular response to vitamin D

response to vitamin [inference]

response to vitamin D [inference]

cellular response to vitamin D

cellular response to vitamin [inference]

cellular response to vitamin D

response to organic substance [inference]

response to organic cyclic compound [inference]

response to vitamin D [inference]

cellular response to vitamin D

cellular response to organic cyclic compound [inference]

cellular response to vitamin D

response to lipid [inference]

response to vitamin D [inference]

cellular response to vitamin D

cellular response to lipid [inference]

cellular response to vitamin D

response to cytokine [inference]

cellular response to cytokine stimulus [inference]

cellular response to interleukin-7

response to interleukin-7 [inference]

cellular response to interleukin-7

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to interleukin-7

cellular response to lipid [inference]

cellular response to vitamin D

cellular response to organic cyclic compound [inference]

cellular response to vitamin D

cellular response to chemical stimulus [inference]

cellular response to nutrient [inference]

cellular response to vitamin [inference]

cellular response to vitamin D

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to interleukin-7

cellular response to lipid [inference]

cellular response to vitamin D

cellular response to organic cyclic compound [inference]

cellular response to vitamin D

cellular response to oxygen-containing compound [inference]

cellular response to vitamin D

response to oxygen-containing compound [inference]

response to vitamin D [inference]

cellular response to vitamin D

cellular response to oxygen-containing compound [inference]

cellular response to vitamin D

cellular response to stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to nutrient [inference]

cellular response to vitamin [inference]

cellular response to vitamin D

cellular response to stress [inference]

response to endoplasmic reticulum stress

cellular response to chemical stimulus [inference]

cellular response to nutrient [inference]

cellular response to vitamin [inference]

cellular response to vitamin D

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to interleukin-7

cellular response to lipid [inference]

cellular response to vitamin D

cellular response to organic cyclic compound [inference]

cellular response to vitamin D

cellular response to oxygen-containing compound [inference]

cellular response to vitamin D

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

regulation of apoptotic signaling pathway [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

regulation of extrinsic apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

positive regulation of protein folding

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

regulation of apoptotic signaling pathway [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

regulation of extrinsic apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

extrinsic apoptotic signaling pathway

apoptotic signaling pathway [inference]

extrinsic apoptotic signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

regulation of apoptotic signaling pathway [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

regulation of extrinsic apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

regulation of apoptotic signaling pathway [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

regulation of extrinsic apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

positive regulation of protein folding

regulation of protein folding [inference]

positive regulation of protein folding

Displaying entries **1 - 5** of 18 in total

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GO Term	Evidence Code	PMID
acrosomal vesicle	ISO
extracellular region	ISO
extracellular space	ISO
extracellular space	IEA
endoplasmic reticulum	ISO

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

endoplasmic reticulum protein-containing complex [inference]

cellular anatomical entity [inference]

membrane [inference]

plasma membrane region [inference]

apical plasma membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endoplasmic reticulum lumen

myelin sheath

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

pigment granule [inference]

melanosome

secretory vesicle [inference]

secretory granule [inference]

acrosomal vesicle

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

smooth endoplasmic reticulum

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

pigment granule [inference]

melanosome

secretory vesicle [inference]

secretory granule [inference]

acrosomal vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

smooth endoplasmic reticulum

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

pigment granule [inference]

melanosome

secretory vesicle [inference]

secretory granule [inference]

acrosomal vesicle

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
protein disulfide isomerase activity	IBA
protein disulfide isomerase activity	IEA
protein binding	IPI	21093319 23395171 28437467
peptidase activity	ISO
protein-disulfide reductase activity	ISO

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on a sulfur group of donors [inference]

disulfide oxidoreductase activity [inference]

protein-disulfide reductase activity

protein-disulfide reductase (glutathione) activity

oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor [inference]

protein-disulfide reductase (glutathione) activity

hydrolase activity [inference]

peptidase activity

isomerase activity [inference]

intramolecular oxidoreductase activity [inference]

intramolecular oxidoreductase activity, transposing S-S bonds [inference]

protein disulfide isomerase activity

catalytic activity, acting on a protein [inference]

protein-disulfide reductase activity

protein-disulfide reductase (glutathione) activity

binding [inference]

protein binding

signaling receptor binding [inference]

MHC protein binding [inference]

MHC class I protein binding

identical protein binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

RNA binding [inference]

lncRNA binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Disulfide isomerase

Functional Category

E: Amino acid transport and metabolism
M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 2** entries
Gene Ontology
isomerase activity
response to endoplasmic reticulum stress

Displaying **all 5** entries
InterPro
Protein disulfide-isomerase, thioredoxin-like domain
Protein disulphide isomerase
Thioredoxin domain
Thioredoxin, conserved site
Thioredoxin-like superfamily

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	2923	Xenbase:XB-GENE-976328	HUMAN22732
Saccharomyces cerevisiae S288C	5034	SGD:S000002926
Saccharomyces cerevisiae S288C	9601	SGD:S000002926
Saccharomyces cerevisiae S288C	12304	SGD:S000002926
Xenopus tropicalis	14827	Xenbase:XB-GENE-976328
Rattus norvegicus	29468		RATNO28517
Saccharomyces cerevisiae S288C	64714	SGD:S000002926
Saccharomyces cerevisiae S288C	69191	SGD:S000002926
Saccharomyces cerevisiae S288C	180724	SGD:S000002926
Bos taurus	281803		BOVIN16862

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OrthoDB (Group)

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