GlyCosmos Portal

Submissions

complement factor B

Summary

Gene Symbol

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

14962

PubChem

14962

Alliance of Genome Resources

MGI:105975

Annotation

Keyword

Complement alternate pathway
Disulfide bond
Glycoprotein
Proteomics identification
Reference proteome
Repeat
Serine protease
Signal
Sushi
Zymogen

Proteins

Displaying **all 3** entries
UniProt	Protein Name
B8JJM6	C3/C5 convertase
B8JJM5	C3/C5 convertase
Q3UEG8	C3/C5 convertase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
proteolysis	IEA
complement activation, alternative pathway	IGI IMP TAS	27564415 6550027 9238044
response to bacterium	IBA
B cell proliferation		9238044
complement activation	IBA

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

complement activation

complement activation, alternative pathway

activation of immune response [inference]

complement activation

complement activation, alternative pathway

immune response [inference]

humoral immune response [inference]

complement activation

complement activation, alternative pathway

innate immune response [inference]

complement activation, alternative pathway

leukocyte activation [inference]

lymphocyte activation [inference]

B cell activation [inference]

B cell proliferation

lymphocyte proliferation [inference]

B cell proliferation

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

cellular process [inference]

cell activation [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

B cell activation [inference]

B cell proliferation

lymphocyte proliferation [inference]

B cell proliferation

cell population proliferation [inference]

leukocyte proliferation [inference]

mononuclear cell proliferation [inference]

lymphocyte proliferation [inference]

B cell proliferation

multicellular organismal process [inference]

cell activation [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

B cell activation [inference]

B cell proliferation

lymphocyte proliferation [inference]

B cell proliferation

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to bacterium

defense response to other organism [inference]

innate immune response [inference]

complement activation, alternative pathway

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

innate immune response [inference]

complement activation, alternative pathway

immune response [inference]

humoral immune response [inference]

complement activation

complement activation, alternative pathway

innate immune response [inference]

complement activation, alternative pathway

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium

defense response to other organism [inference]

innate immune response [inference]

complement activation, alternative pathway

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium

defense response to other organism [inference]

innate immune response [inference]

complement activation, alternative pathway

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

complement activation, alternative pathway

regulation of immune response [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

complement activation, alternative pathway

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

complement activation, alternative pathway

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

complement activation, alternative pathway

regulation of response to stimulus [inference]

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

complement activation, alternative pathway

regulation of immune response [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

complement activation, alternative pathway

Displaying 1 entry
GO Term	Evidence Code	PMID
extracellular region	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular region

Displaying 1 entry
GO Term	Evidence Code	PMID
serine-type endopeptidase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity [inference]

serine-type endopeptidase activity

serine-type peptidase activity [inference]

serine-type endopeptidase activity

serine hydrolase activity [inference]

serine-type peptidase activity [inference]

serine-type endopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity [inference]

serine-type endopeptidase activity

serine-type peptidase activity [inference]

serine-type endopeptidase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

Complement factor B

Functional Category

K: Transcription
L: Replication, recombination and repair
T: Signal transduction mechanisms

Displaying **all 7** entries
Gene Ontology
complement activation, alternative pathway
complement activation
hydrolase activity
immune system process
proteolysis
serine-type endopeptidase activity
serine-type peptidase activity

Displaying **all 10** entries
InterPro
Complement B/C2
Peptidase S1, PA clan
Peptidase S1A, chymotrypsin family
Serine proteases, trypsin domain
Serine proteases, trypsin family, histidine active site
Serine proteases, trypsin family, serine active site
Sushi/SCR/CCP domain
Sushi/SCR/CCP superfamily
von Willebrand factor A-like domain superfamily
von Willebrand factor, type A

Disease

Disease Ontology

Displaying entries **1 - 10** of 27 in total

1

2

3

Next ›

Last »
DO ID	Disease Name	Source
DOID:0050127	sinusitis	Alliance of Genome Resources
DOID:0080162	lupus nephritis	Alliance of Genome Resources
DOID:0080301	atypical hemolytic-uremic syndrome	Alliance of Genome Resources
DOID:0080750	erythema nodosum	Alliance of Genome Resources
DOID:0110026	age related macular degeneration 14	Alliance of Genome Resources
DOID:10887	lepromatous leprosy	Alliance of Genome Resources
DOID:10923	sickle cell anemia	Alliance of Genome Resources
DOID:10976	membranous glomerulonephritis	Alliance of Genome Resources
DOID:11400	pyelonephritis	Alliance of Genome Resources
DOID:12134	factor VIII deficiency	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 80 in total

1

2

3

4

5

…

Next ›

Last »
Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	629		HGNC:1037	HUMAN84093
Danio rerio	30489		ZFIN:ZDB-GENE-990415-34
Danio rerio	30604		ZFIN:ZDB-GENE-980526-487
Rattus norvegicus	294257	10116_1:005194
Ciona intestinalis	497244			CIOIN03737
Bos taurus	514076			BOVIN18745
Danio rerio	792472		ZFIN:ZDB-GENE-030131-2319
Equus caballus	100051124			HORSE19474
Sus scrofa	100124383			PIGXX31207
Oryctolagus cuniculus	100355944			RABIT02216

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements