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salt inducible kinase 1

Summary

Gene Symbol

SIK1

Organism

Homo sapiens (human)

External Links

NCBI Gene

150094

PubChem

150094

Alliance of Genome Resources

HGNC:11142

Annotation

Keyword

ATP-binding
Biological rhythms
Cell cycle
Cytoplasm
Developmental protein
Differentiation
Disease variant
Epilepsy
Magnesium
Metal-binding
Nucleus
Phosphoprotein
Reference proteome
Serine/threonine-protein kinase
Tumor suppressor

Proteins

Displaying 1 entry
UniProt	Protein Name
P57059	Salt-inducible kinase 1 Serine/threonine-protein kinase SNF1-like kinase 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 19 in total

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GO Term	Evidence Code	PMID
regulation of sodium ion transport	ISS
chromatin remodeling	IEA
protein phosphorylation	ISS
protein phosphorylation	IDA	14976552
regulation of mitotic cell cycle	ISS

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

protein autophosphorylation

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation

protein autophosphorylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

protein autophosphorylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

protein autophosphorylation

macromolecule modification [inference]

protein modification process [inference]

protein phosphorylation

protein autophosphorylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

protein autophosphorylation

cellular process [inference]

signal transduction [inference]

intracellular signal transduction

cell death [inference]

programmed cell death [inference]

apoptotic process [inference]

anoikis

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation

protein autophosphorylation

cellular developmental process [inference]

cell differentiation [inference]

cardiocyte differentiation [inference]

cardiac muscle cell differentiation

muscle cell differentiation [inference]

striated muscle cell differentiation [inference]

cardiac muscle cell differentiation

cellular component organization or biogenesis [inference]

cellular component organization [inference]

protein-containing complex organization [inference]

protein-DNA complex organization [inference]

chromatin organization [inference]

chromatin remodeling

developmental process [inference]

cellular developmental process [inference]

cell differentiation [inference]

cardiocyte differentiation [inference]

cardiac muscle cell differentiation

muscle cell differentiation [inference]

striated muscle cell differentiation [inference]

cardiac muscle cell differentiation

rhythmic process

response to stimulus [inference]

response to external stimulus [inference]

entrainment of circadian clock [inference]

entrainment of circadian clock by photoperiod

response to abiotic stimulus [inference]

response to radiation [inference]

response to light stimulus [inference]

photoperiodism [inference]

entrainment of circadian clock by photoperiod

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of lipid biosynthetic process [inference]

negative regulation of triglyceride biosynthetic process

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

negative regulation of DNA-binding transcription factor activity [inference]

negative regulation of CREB transcription factor activity

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

negative regulation of DNA-binding transcription factor activity [inference]

negative regulation of CREB transcription factor activity

regulation of triglyceride biosynthetic process [inference]

negative regulation of triglyceride biosynthetic process

negative regulation of cellular biosynthetic process [inference]

regulation of carbohydrate biosynthetic process [inference]

regulation of gluconeogenesis [inference]

negative regulation of gluconeogenesis

regulation of lipid biosynthetic process [inference]

regulation of triglyceride biosynthetic process [inference]

negative regulation of triglyceride biosynthetic process

negative regulation of lipid biosynthetic process [inference]

negative regulation of triglyceride biosynthetic process

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of lipid biosynthetic process [inference]

negative regulation of triglyceride biosynthetic process

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of triglyceride metabolic process [inference]

negative regulation of triglyceride biosynthetic process

negative regulation of lipid metabolic process [inference]

negative regulation of lipid biosynthetic process [inference]

negative regulation of triglyceride biosynthetic process

negative regulation of triglyceride metabolic process [inference]

negative regulation of triglyceride biosynthetic process

negative regulation of carbohydrate metabolic process [inference]

negative regulation of gluconeogenesis

negative regulation of small molecule metabolic process [inference]

negative regulation of gluconeogenesis

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

negative regulation of DNA-binding transcription factor activity [inference]

negative regulation of CREB transcription factor activity

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of triglyceride metabolic process [inference]

negative regulation of triglyceride biosynthetic process

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

negative regulation of DNA-binding transcription factor activity [inference]

negative regulation of CREB transcription factor activity

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

negative regulation of DNA-binding transcription factor activity [inference]

negative regulation of CREB transcription factor activity

regulation of triglyceride biosynthetic process [inference]

negative regulation of triglyceride biosynthetic process

negative regulation of cellular biosynthetic process [inference]

regulation of triglyceride metabolic process [inference]

regulation of triglyceride biosynthetic process [inference]

negative regulation of triglyceride biosynthetic process

negative regulation of triglyceride metabolic process [inference]

negative regulation of triglyceride biosynthetic process

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

negative regulation of DNA-binding transcription factor activity [inference]

negative regulation of CREB transcription factor activity

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

negative regulation of DNA-binding transcription factor activity [inference]

negative regulation of CREB transcription factor activity

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

negative regulation of DNA-binding transcription factor activity [inference]

negative regulation of CREB transcription factor activity

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

negative regulation of DNA-binding transcription factor activity [inference]

negative regulation of CREB transcription factor activity

regulation of small molecule metabolic process [inference]

regulation of glucose metabolic process [inference]

regulation of gluconeogenesis [inference]

negative regulation of gluconeogenesis

negative regulation of small molecule metabolic process [inference]

negative regulation of gluconeogenesis

regulation of primary metabolic process [inference]

regulation of carbohydrate metabolic process [inference]

regulation of glucose metabolic process [inference]

regulation of gluconeogenesis [inference]

negative regulation of gluconeogenesis

regulation of carbohydrate biosynthetic process [inference]

regulation of gluconeogenesis [inference]

negative regulation of gluconeogenesis

negative regulation of carbohydrate metabolic process [inference]

negative regulation of gluconeogenesis

regulation of lipid metabolic process [inference]

negative regulation of lipid metabolic process [inference]

negative regulation of lipid biosynthetic process [inference]

negative regulation of triglyceride biosynthetic process

negative regulation of triglyceride metabolic process [inference]

negative regulation of triglyceride biosynthetic process

regulation of lipid biosynthetic process [inference]

regulation of triglyceride biosynthetic process [inference]

negative regulation of triglyceride biosynthetic process

negative regulation of lipid biosynthetic process [inference]

negative regulation of triglyceride biosynthetic process

regulation of triglyceride metabolic process [inference]

regulation of triglyceride biosynthetic process [inference]

negative regulation of triglyceride biosynthetic process

negative regulation of triglyceride metabolic process [inference]

negative regulation of triglyceride biosynthetic process

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

negative regulation of DNA-binding transcription factor activity [inference]

negative regulation of CREB transcription factor activity

regulation of localization [inference]

regulation of transport [inference]

regulation of monoatomic ion transport [inference]

regulation of metal ion transport [inference]

regulation of sodium ion transport

regulation of circadian rhythm [inference]

entrainment of circadian clock [inference]

entrainment of circadian clock by photoperiod

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of anoikis

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of lipid biosynthetic process [inference]

negative regulation of triglyceride biosynthetic process

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of triglyceride metabolic process [inference]

negative regulation of triglyceride biosynthetic process

negative regulation of lipid metabolic process [inference]

negative regulation of lipid biosynthetic process [inference]

negative regulation of triglyceride biosynthetic process

negative regulation of triglyceride metabolic process [inference]

negative regulation of triglyceride biosynthetic process

negative regulation of carbohydrate metabolic process [inference]

negative regulation of gluconeogenesis

negative regulation of small molecule metabolic process [inference]

negative regulation of gluconeogenesis

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of triglyceride metabolic process [inference]

negative regulation of triglyceride biosynthetic process

regulation of developmental process [inference]

regulation of cell differentiation

regulation of muscle cell differentiation [inference]

regulation of striated muscle cell differentiation [inference]

regulation of myotube differentiation

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

negative regulation of DNA-binding transcription factor activity [inference]

negative regulation of CREB transcription factor activity

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of triglyceride metabolic process [inference]

negative regulation of triglyceride biosynthetic process

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

negative regulation of DNA-binding transcription factor activity [inference]

negative regulation of CREB transcription factor activity

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

negative regulation of DNA-binding transcription factor activity [inference]

negative regulation of CREB transcription factor activity

regulation of triglyceride biosynthetic process [inference]

negative regulation of triglyceride biosynthetic process

negative regulation of cellular biosynthetic process [inference]

regulation of triglyceride metabolic process [inference]

regulation of triglyceride biosynthetic process [inference]

negative regulation of triglyceride biosynthetic process

negative regulation of triglyceride metabolic process [inference]

negative regulation of triglyceride biosynthetic process

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process [inference]

positive regulation of anoikis

regulation of anoikis [inference]

positive regulation of anoikis

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of anoikis

regulation of cell differentiation

regulation of muscle cell differentiation [inference]

regulation of striated muscle cell differentiation [inference]

regulation of myotube differentiation

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of anoikis

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of triglyceride metabolic process [inference]

negative regulation of triglyceride biosynthetic process

regulation of cell cycle [inference]

regulation of mitotic cell cycle

regulation of molecular function [inference]

negative regulation of molecular function [inference]

negative regulation of DNA-binding transcription factor activity [inference]

negative regulation of CREB transcription factor activity

regulation of DNA-binding transcription factor activity [inference]

negative regulation of DNA-binding transcription factor activity [inference]

negative regulation of CREB transcription factor activity

Displaying **all 5** entries
GO Term	Evidence Code	PMID
nucleus	IDA	16306228
nucleus	IBA
cytoplasm	ISS
cytoplasm	IDA	16306228
cytoplasm	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying entries **1 - 5** of 32 in total

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GO Term	Evidence Code	PMID
magnesium ion binding	ISS
magnesium ion binding	IDA	14976552
protein serine/threonine kinase activity	IDA	14976552 18348280
protein serine/threonine kinase activity	IBA
3-phosphoinositide-dependent protein kinase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

protein kinase activity [inference]

protein serine/threonine kinase activity

histone kinase activity [inference]

histone H2A kinase activity [inference]

histone H3 kinase activity [inference]

histone H4 kinase activity [inference]

histone H4S1 kinase activity

histone H2B kinase activity [inference]

histone H2AX kinase activity [inference]

histone H2AXS139 kinase activity

protein serine kinase activity

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity [inference]

protein serine/threonine kinase activity

histone kinase activity [inference]

histone H2A kinase activity [inference]

histone H3 kinase activity [inference]

histone H4 kinase activity [inference]

histone H4S1 kinase activity

histone H2B kinase activity [inference]

histone H2AX kinase activity [inference]

histone H2AXS139 kinase activity

protein serine kinase activity

catalytic activity, acting on a protein [inference]

protein kinase activity [inference]

protein serine/threonine kinase activity

histone kinase activity [inference]

histone H2A kinase activity [inference]

histone H3 kinase activity [inference]

histone H4 kinase activity [inference]

histone H4S1 kinase activity

histone H2B kinase activity [inference]

histone H2AX kinase activity [inference]

histone H2AXS139 kinase activity

protein serine kinase activity

histone modifying activity [inference]

histone kinase activity [inference]

histone H2A kinase activity [inference]

histone H3 kinase activity [inference]

histone H4 kinase activity [inference]

histone H4S1 kinase activity

histone H2B kinase activity [inference]

histone H2AX kinase activity [inference]

histone H2AXS139 kinase activity

binding [inference]

protein binding

transcription factor binding [inference]

DNA-binding transcription factor binding [inference]

cAMP response element binding protein binding

enzyme binding [inference]

kinase binding [inference]

protein kinase binding

histone deacetylase binding

14-3-3 protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding [inference]

magnesium ion binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Serine/threonine-protein kinase sik2

Functional Category

G: Carbohydrate transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
ATP binding
kinase activity
nucleotide binding
phosphorylation

Displaying **all 4** entries
InterPro
Protein kinase domain
Protein kinase-like domain superfamily
Serine/threonine-protein kinase, active site
Ubiquitin-associated domain

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0080465	developmental and epileptic encephalopathy 30	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 98 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	17691		MOUSE22836
Saccharomyces cerevisiae S288C	23235	SGD:S000002529
Saccharomyces cerevisiae S288C	23387	SGD:S000004086
Rattus norvegicus	59329		RATNO22327
Saccharomyces cerevisiae S288C	70661	SGD:S000002529
Saccharomyces cerevisiae S288C	81788	SGD:S000002529
Danio rerio	150094	ZFIN:ZDB-GENE-030131-9446
Saccharomyces cerevisiae S288C	235344	SGD:S000004086
Pan troglodytes	474029		PANTR25775
Canis lupus familiaris	487787		CANLF12915

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Acknowledgements