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Guidelines

MIRAGE

cathepsin D

Summary

Gene Symbol

CTSD

Organism

Homo sapiens (human)

External Links

NCBI Gene

1509

KEGG Gene ID

PubChem

1509

Alliance of Genome Resources

HGNC:2529

Annotation

Keyword

3D-structure
Alzheimer disease
Aspartyl protease
Direct protein sequencing
Disease variant
Disulfide bond
Glycoprotein
Lysosome
Neuronal ceroid lipofuscinosis
Proteomics identification
Reference proteome
Secreted
Signal
Zymogen

Proteins

Displaying **all 2** entries
UniProt	Protein Name
V9HWI3
P07339

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
autophagosome assembly
proteolysis	IDA
proteolysis	IMP
proteolysis	IBA
proteolysis	IEA

GO Hierarchy

biological process

immune system process [inference]

antigen processing and presentation [inference]

antigen processing and presentation of peptide or polysaccharide antigen via MHC class II [inference]

antigen processing and presentation of peptide antigen via MHC class II [inference]

antigen processing and presentation of exogenous peptide antigen via MHC class II

antigen processing and presentation of exogenous antigen [inference]

antigen processing and presentation of exogenous peptide antigen [inference]

antigen processing and presentation of exogenous peptide antigen via MHC class II

antigen processing and presentation of peptide antigen [inference]

antigen processing and presentation of exogenous peptide antigen [inference]

antigen processing and presentation of exogenous peptide antigen via MHC class II

antigen processing and presentation of peptide antigen via MHC class II [inference]

antigen processing and presentation of exogenous peptide antigen via MHC class II

cellular process [inference]

metabolic process [inference]

catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

protein metabolic process [inference]

proteolysis

protein catabolic process [inference]

lipoprotein metabolic process [inference]

lipoprotein catabolic process

insulin metabolic process [inference]

insulin catabolic process

receptor metabolic process [inference]

receptor recycling [inference]

insulin receptor recycling

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein catabolic process [inference]

lipoprotein metabolic process [inference]

lipoprotein catabolic process

insulin metabolic process [inference]

insulin catabolic process

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

vacuole organization [inference]

autophagosome organization [inference]

autophagosome assembly

organelle assembly [inference]

autophagosome assembly

cellular component assembly [inference]

organelle assembly [inference]

autophagosome assembly

execution phase of apoptosis

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of protein localization [inference]

regulation of establishment of protein localization

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

regulation of cellular process [inference]

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

Displaying entries **11 - 15** of 23 in total

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GO Term	Evidence Code	PMID
lysosome	IEA
lysosomal membrane	IDA
cytosol	IDA
endosome membrane	IDA
extracellular matrix	HDA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane

bounding membrane of organelle [inference]

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane

endosome membrane

membrane microdomain [inference]

membrane raft

external encapsulating structure [inference]

extracellular matrix

membrane-enclosed lumen [inference]

organelle lumen [inference]

vesicle lumen [inference]

cytoplasmic vesicle lumen [inference]

secretory granule lumen [inference]

specific granule lumen

intracellular organelle lumen [inference]

vacuolar lumen [inference]

lysosomal lumen

endosome lumen

cytoplasmic vesicle lumen [inference]

secretory granule lumen [inference]

specific granule lumen

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

pigment granule [inference]

melanosome

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

pigment granule [inference]

melanosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

pigment granule [inference]

melanosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
endopeptidase activity	IEA
aspartic-type endopeptidase activity	TAS
aspartic-type endopeptidase activity	IBA
aspartic-type endopeptidase activity	IEA
cysteine-type endopeptidase activity	TAS

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity

peptidase activity

endopeptidase activity

cysteine-type peptidase activity [inference]

cysteine-type endopeptidase activity

aspartic-type peptidase activity

aspartic-type endopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity

endopeptidase activity

cysteine-type peptidase activity [inference]

cysteine-type endopeptidase activity

aspartic-type peptidase activity

aspartic-type endopeptidase activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0110725	neuronal ceroid lipofuscinosis 10	Alliance of Genome Resources
DOID:1612	breast cancer	Alliance of Genome Resources
DOID:10652	Alzheimer's disease	Alliance of Genome Resources

Ortholog

Displaying **all 5** entries
Species	Gene ID	Alliance of Genome Resources
Saccharomyces cerevisiae S288C	855949	SGD:S000006075
Xenopus laevis	443721	Xenbase:XB-GENE-5907046
Mus musculus	13033	MGI:88562
Rattus norvegicus	171293	RGD:621511
Caenorhabditis elegans	181444	WB:WBGene00000217

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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GlyCosmos Portal v4.5.0

Last updated: April 6, 2026