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MIRAGE
hyperpolarization activated cyclic nucleotide gated potassium channel 1
Summary
- Gene Symbol
-
- Hcn1
- Organism
- Mus musculus (house mouse)
Annotation
- Keyword
-
- 3D-structure
- Cell membrane
- Glycoprotein
- Ligand-gated ion channel
- Potassium channel
- Reference proteome
- Sodium channel
- Transmembrane helix
- Voltage-gated channel
- cAMP-binding
- Proteins
| UniProt | Protein Name |
|---|---|
| O88704 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| regulation of membrane depolarization | ||
| regulation of membrane depolarization | ||
| regulation of membrane depolarization | ||
| neuronal action potential | ||
| cellular response to interferon-beta |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| plasma membrane | ||
| plasma membrane | ||
| plasma membrane | ||
| plasma membrane | ||
| cell surface |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| intracellular cAMP-activated cation channel activity | ||
| intracellular cAMP-activated cation channel activity | ||
| voltage-gated sodium channel activity | ||
| voltage-gated sodium channel activity | ||
| voltage-gated potassium channel activity |
GO Hierarchy
molecular function
transporter activity [inference]
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel
- Functional Category
-
- E: Amino acid transport and metabolism
- Q: Secondary metabolites biosynthesis, transport and catabolism
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| monoatomic ion channel activity |
| monoatomic ion transport |
| regulation of membrane depolarization |
| sodium ion transmembrane transport |
| voltage-gated potassium channel activity |
| InterPro |
|---|
| Cyclic nucleotide-binding domain superfamily |
| Cyclic nucleotide-binding domain |
| Cyclic nucleotide-binding, conserved site |
| RmlC-like jelly roll fold |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:13884 | sick sinus syndrome |
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 610 | FB:FBgn0263397 | ||
| 10021 | FB:FBgn0263397 | ||
| 15165 | Xenbase:XB-GENE-950265 | ||
| 15166 | FB:FBgn0263397 | ||
| 15168 | FB:FBgn0263397 | ||
| 57657 | FB:FBgn0263397 | ||
| 59266 | FB:FBgn0263397 | ||
| 84390 | Xenbase:XB-GENE-950265 | RATNO24523 | |
| 114244 | FB:FBgn0263397 | ||
| 114245 | FB:FBgn0263397 |
