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hephaestin

Summary

Gene Symbol

Heph

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

15203

PubChem

15203

Alliance of Genome Resources

MGI:1332240

Annotation

Keyword

Alternative splicing
Calcium
Cell membrane
Disulfide bond
Glycoprotein
Iron transport
Metal-binding
Oxidoreductase
Phosphoprotein
Proteomics identification
Reference proteome
Repeat
Signal
Sodium
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A2AI62
Q9Z0Z4

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
iron ion transport	ISO
iron ion transport	TAS	5111764
erythrocyte differentiation	IMP
multicellular organismal-level iron ion homeostasis	IMP	9988272
positive regulation of iron export across plasma membrane	IDA	30647129

GO Hierarchy

biological process

cellular process [inference]

cellular developmental process [inference]

cell differentiation [inference]

myeloid cell differentiation [inference]

erythrocyte differentiation

multicellular organismal process [inference]

multicellular organismal-level homeostasis [inference]

multicellular organismal-level chemical homeostasis [inference]

multicellular organismal-level iron ion homeostasis

developmental process [inference]

cellular developmental process [inference]

cell differentiation [inference]

myeloid cell differentiation [inference]

erythrocyte differentiation

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

multicellular organismal-level chemical homeostasis [inference]

multicellular organismal-level iron ion homeostasis

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

monoatomic cation homeostasis [inference]

multicellular organismal-level iron ion homeostasis

inorganic ion homeostasis [inference]

multicellular organismal-level iron ion homeostasis

multicellular organismal-level chemical homeostasis [inference]

multicellular organismal-level iron ion homeostasis

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

transition metal ion transport [inference]

iron ion transport

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of transmembrane transport [inference]

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of iron ion transmembrane transport [inference]

positive regulation of iron export across plasma membrane

regulation of monoatomic ion transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of iron ion transmembrane transport [inference]

positive regulation of iron export across plasma membrane

regulation of monoatomic cation transmembrane transport [inference]

regulation of iron ion transmembrane transport [inference]

positive regulation of iron ion transmembrane transport [inference]

positive regulation of iron export across plasma membrane

regulation of iron export across plasma membrane [inference]

positive regulation of iron export across plasma membrane

positive regulation of cation transmembrane transport [inference]

positive regulation of iron ion transmembrane transport [inference]

positive regulation of iron export across plasma membrane

regulation of monoatomic ion transport [inference]

regulation of metal ion transport [inference]

regulation of iron ion transport [inference]

positive regulation of iron ion transport [inference]

positive regulation of iron ion transmembrane transport [inference]

positive regulation of iron export across plasma membrane

regulation of iron ion transmembrane transport [inference]

positive regulation of iron ion transmembrane transport [inference]

positive regulation of iron export across plasma membrane

regulation of iron export across plasma membrane [inference]

positive regulation of iron export across plasma membrane

regulation of monoatomic ion transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of iron ion transmembrane transport [inference]

positive regulation of iron export across plasma membrane

regulation of monoatomic cation transmembrane transport [inference]

regulation of iron ion transmembrane transport [inference]

positive regulation of iron ion transmembrane transport [inference]

positive regulation of iron export across plasma membrane

regulation of iron export across plasma membrane [inference]

positive regulation of iron export across plasma membrane

positive regulation of cation transmembrane transport [inference]

positive regulation of iron ion transmembrane transport [inference]

positive regulation of iron export across plasma membrane

positive regulation of monoatomic ion transport [inference]

positive regulation of iron ion transport [inference]

positive regulation of iron ion transmembrane transport [inference]

positive regulation of iron export across plasma membrane

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of iron ion transmembrane transport [inference]

positive regulation of iron export across plasma membrane

positive regulation of transport [inference]

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of iron ion transmembrane transport [inference]

positive regulation of iron export across plasma membrane

positive regulation of monoatomic ion transport [inference]

positive regulation of iron ion transport [inference]

positive regulation of iron ion transmembrane transport [inference]

positive regulation of iron export across plasma membrane

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of iron ion transmembrane transport [inference]

positive regulation of iron export across plasma membrane

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of iron ion transmembrane transport [inference]

positive regulation of iron export across plasma membrane

positive regulation of transport [inference]

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of iron ion transmembrane transport [inference]

positive regulation of iron export across plasma membrane

positive regulation of monoatomic ion transport [inference]

positive regulation of iron ion transport [inference]

positive regulation of iron ion transmembrane transport [inference]

positive regulation of iron export across plasma membrane

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of iron ion transmembrane transport [inference]

positive regulation of iron export across plasma membrane

regulation of cellular process [inference]

regulation of transmembrane transport [inference]

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of iron ion transmembrane transport [inference]

positive regulation of iron export across plasma membrane

regulation of monoatomic ion transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of iron ion transmembrane transport [inference]

positive regulation of iron export across plasma membrane

regulation of monoatomic cation transmembrane transport [inference]

regulation of iron ion transmembrane transport [inference]

positive regulation of iron ion transmembrane transport [inference]

positive regulation of iron export across plasma membrane

regulation of iron export across plasma membrane [inference]

positive regulation of iron export across plasma membrane

positive regulation of cation transmembrane transport [inference]

positive regulation of iron ion transmembrane transport [inference]

positive regulation of iron export across plasma membrane

positive regulation of cellular process [inference]

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of iron ion transmembrane transport [inference]

positive regulation of iron export across plasma membrane

Displaying entries **1 - 5** of 6 in total

1

2

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GO Term	Evidence Code	PMID
extracellular region
plasma membrane	IBA
basolateral plasma membrane	ISS
basolateral plasma membrane	ISO
perinuclear region of cytoplasm	ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular region

membrane [inference]

plasma membrane

plasma membrane region [inference]

basolateral plasma membrane

perinuclear region of cytoplasm

Displaying entries **1 - 5** of 6 in total

1

2

Next ›

Last »
GO Term	Evidence Code	PMID
ferroxidase activity	ISO
ferroxidase activity	IDA	14751926
ferroxidase activity	IBA
copper ion binding	ISO
copper ion binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on metal ions [inference]

oxidoreductase activity, acting on metal ions, oxygen as acceptor [inference]

ferroxidase activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

iron ion binding [inference]

ferrous iron binding

copper ion binding

Gene Ontology information from NCBI Gene and UniProt.

International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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