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Guidelines

MIRAGE

macrophage stimulating 1 (hepatocyte growth factor-like)

Summary

Gene Symbol

Mst1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

15235

PubChem

15235

Alliance of Genome Resources

MGI:96080

Annotation

Keyword

Disulfide bond
Glycoprotein
Kringle
Reference proteome
Repeat
Secreted
Serine protease homolog
Signal

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q3UZ05	Macrophage stimulatory protein
P26928	Macrophage stimulatory protein

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 21 in total

1

2

3

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5

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GO Term	Evidence Code	PMID
chromatin remodeling	IEA
proteolysis	IEA
spermatogenesis	IEA
embryo implantation	IDA	12606483
positive regulation of gene expression	IMP	25049204

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

primary metabolic process [inference]

protein metabolic process [inference]

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

macromolecule modification [inference]

protein modification process

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

cellular process [inference]

microtubule-based process [inference]

microtubule-based movement [inference]

cilium movement [inference]

cilium movement involved in cell motility [inference]

flagellated sperm motility

cell motility [inference]

cilium or flagellum-dependent cell motility [inference]

cilium-dependent cell motility [inference]

flagellated sperm motility

sperm motility [inference]

flagellated sperm motility

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to hypoxia

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to type II interferon

cellular response to oxygen levels [inference]

cellular response to decreased oxygen levels [inference]

cellular response to hypoxia

cellular component organization or biogenesis [inference]

cellular component organization [inference]

protein-containing complex organization [inference]

protein-DNA complex organization [inference]

chromatin organization [inference]

chromatin remodeling

reproductive process [inference]

developmental process involved in reproduction [inference]

spermatogenesis

embryo implantation

multicellular organismal reproductive process [inference]

gamete generation [inference]

male gamete generation [inference]

spermatogenesis

sperm motility [inference]

flagellated sperm motility

developmental process [inference]

developmental process involved in reproduction [inference]

spermatogenesis

anatomical structure development [inference]

animal organ development [inference]

gland development [inference]

mammary gland development

growth [inference]

developmental growth [inference]

developmental growth involved in morphogenesis [inference]

mammary duct terminal end bud growth

response to stimulus [inference]

response to stress [inference]

response to hypoxia [inference]

cellular response to hypoxia

cellular response to stress [inference]

cellular response to hypoxia

response to abiotic stimulus [inference]

response to oxygen levels [inference]

response to decreased oxygen levels [inference]

response to hypoxia [inference]

cellular response to hypoxia

cellular response to decreased oxygen levels [inference]

cellular response to hypoxia

cellular response to oxygen levels [inference]

cellular response to decreased oxygen levels [inference]

cellular response to hypoxia

response to chemical [inference]

response to organic substance [inference]

response to cytokine [inference]

response to type II interferon [inference]

cellular response to type II interferon

cellular response to cytokine stimulus [inference]

cellular response to type II interferon

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to type II interferon

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to type II interferon

cellular response to oxygen levels [inference]

cellular response to decreased oxygen levels [inference]

cellular response to hypoxia

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to hypoxia

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to type II interferon

cellular response to oxygen levels [inference]

cellular response to decreased oxygen levels [inference]

cellular response to hypoxia

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

regulation of leukocyte migration [inference]

regulation of leukocyte chemotaxis [inference]

regulation of macrophage chemotaxis

regulation of macrophage migration [inference]

regulation of macrophage chemotaxis

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of gluconeogenesis

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

negative regulation of cellular biosynthetic process [inference]

negative regulation of gluconeogenesis

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of carbohydrate biosynthetic process [inference]

regulation of gluconeogenesis [inference]

negative regulation of gluconeogenesis

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of gluconeogenesis

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of gluconeogenesis

negative regulation of carbohydrate metabolic process [inference]

negative regulation of gluconeogenesis

negative regulation of small molecule metabolic process [inference]

negative regulation of gluconeogenesis

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of gluconeogenesis

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

negative regulation of cellular biosynthetic process [inference]

negative regulation of gluconeogenesis

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of phosphorus metabolic process [inference]

regulation of phosphate metabolic process [inference]

regulation of phosphorylation [inference]

regulation of protein phosphorylation [inference]

regulation of protein kinase activity [inference]

regulation of protein serine/threonine kinase activity [inference]

regulation of cAMP-dependent protein kinase activity

regulation of kinase activity [inference]

regulation of protein kinase activity [inference]

regulation of protein serine/threonine kinase activity [inference]

regulation of cAMP-dependent protein kinase activity

regulation of nitrogen compound metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

regulation of protein kinase activity [inference]

regulation of protein serine/threonine kinase activity [inference]

regulation of cAMP-dependent protein kinase activity

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

regulation of protein kinase activity [inference]

regulation of protein serine/threonine kinase activity [inference]

regulation of cAMP-dependent protein kinase activity

regulation of small molecule metabolic process [inference]

regulation of glucose metabolic process [inference]

regulation of gluconeogenesis [inference]

negative regulation of gluconeogenesis

negative regulation of small molecule metabolic process [inference]

negative regulation of gluconeogenesis

regulation of primary metabolic process [inference]

regulation of carbohydrate metabolic process [inference]

regulation of glucose metabolic process [inference]

regulation of gluconeogenesis [inference]

negative regulation of gluconeogenesis

regulation of carbohydrate biosynthetic process [inference]

regulation of gluconeogenesis [inference]

negative regulation of gluconeogenesis

negative regulation of carbohydrate metabolic process [inference]

negative regulation of gluconeogenesis

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

regulation of protein kinase activity [inference]

regulation of protein serine/threonine kinase activity [inference]

regulation of cAMP-dependent protein kinase activity

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of receptor signaling pathway via STAT [inference]

regulation of receptor signaling pathway via JAK-STAT

regulation of locomotion [inference]

regulation of chemotaxis [inference]

regulation of leukocyte chemotaxis [inference]

regulation of macrophage chemotaxis

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of leukocyte migration [inference]

regulation of leukocyte chemotaxis [inference]

regulation of macrophage chemotaxis

regulation of macrophage migration [inference]

regulation of macrophage chemotaxis

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of epithelial cell proliferation [inference]

positive regulation of mammary gland epithelial cell proliferation

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of developmental process [inference]

positive regulation of mammary gland epithelial cell proliferation

positive regulation of multicellular organismal process [inference]

positive regulation of mammary gland epithelial cell proliferation

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of gluconeogenesis

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of gluconeogenesis

negative regulation of carbohydrate metabolic process [inference]

negative regulation of gluconeogenesis

negative regulation of small molecule metabolic process [inference]

negative regulation of gluconeogenesis

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of gluconeogenesis

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of epithelial cell apoptotic process

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of receptor signaling pathway via STAT [inference]

regulation of receptor signaling pathway via JAK-STAT

regulation of response to external stimulus [inference]

regulation of chemotaxis [inference]

regulation of leukocyte chemotaxis [inference]

regulation of macrophage chemotaxis

regulation of developmental process [inference]

positive regulation of developmental process [inference]

positive regulation of mammary gland epithelial cell proliferation

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of receptor signaling pathway via STAT [inference]

regulation of receptor signaling pathway via JAK-STAT

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of gluconeogenesis

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

negative regulation of cellular biosynthetic process [inference]

negative regulation of gluconeogenesis

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of phosphorus metabolic process [inference]

regulation of phosphate metabolic process [inference]

regulation of phosphorylation [inference]

regulation of protein phosphorylation [inference]

regulation of protein kinase activity [inference]

regulation of protein serine/threonine kinase activity [inference]

regulation of cAMP-dependent protein kinase activity

regulation of kinase activity [inference]

regulation of protein kinase activity [inference]

regulation of protein serine/threonine kinase activity [inference]

regulation of cAMP-dependent protein kinase activity

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation [inference]

positive regulation of epithelial cell proliferation [inference]

positive regulation of mammary gland epithelial cell proliferation

regulation of epithelial cell proliferation [inference]

regulation of mammary gland epithelial cell proliferation [inference]

positive regulation of mammary gland epithelial cell proliferation

positive regulation of epithelial cell proliferation [inference]

positive regulation of mammary gland epithelial cell proliferation

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process

negative regulation of apoptotic process [inference]

negative regulation of epithelial cell apoptotic process

regulation of epithelial cell apoptotic process [inference]

negative regulation of epithelial cell apoptotic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of epithelial cell apoptotic process

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of epithelial cell proliferation [inference]

positive regulation of mammary gland epithelial cell proliferation

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of gluconeogenesis

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of epithelial cell apoptotic process

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of leukocyte migration [inference]

regulation of leukocyte chemotaxis [inference]

regulation of macrophage chemotaxis

regulation of macrophage migration [inference]

regulation of macrophage chemotaxis

regulation of multicellular organismal process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of mammary gland epithelial cell proliferation

regulation of molecular function [inference]

regulation of catalytic activity [inference]

regulation of transferase activity [inference]

regulation of kinase activity [inference]

regulation of protein kinase activity [inference]

regulation of protein serine/threonine kinase activity [inference]

regulation of cAMP-dependent protein kinase activity

Displaying **all 4** entries
GO Term	Evidence Code	PMID
extracellular space	ISS
extracellular space	ISO
extracellular space	IBA
vacuole	IDA	25049204

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular space

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole

Displaying entries **1 - 5** of 8 in total

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2

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GO Term	Evidence Code	PMID
endopeptidase activity	IBA
serine-type endopeptidase activity	IEA
enzyme binding	ISO
receptor tyrosine kinase binding	ISS
receptor tyrosine kinase binding	ISO

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

protein kinase activity [inference]

histone kinase activity

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity [inference]

histone kinase activity

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity

serine-type endopeptidase activity

serine-type peptidase activity [inference]

serine-type endopeptidase activity

serine hydrolase activity [inference]

serine-type peptidase activity [inference]

serine-type endopeptidase activity

catalytic activity, acting on a protein [inference]

protein kinase activity [inference]

histone kinase activity

peptidase activity [inference]

endopeptidase activity

serine-type endopeptidase activity

serine-type peptidase activity [inference]

serine-type endopeptidase activity

histone modifying activity [inference]

histone kinase activity

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

receptor tyrosine kinase binding

kinase binding [inference]

protein kinase binding [inference]

protein tyrosine kinase binding [inference]

receptor tyrosine kinase binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Hepatocyte growth factor

Functional Category

E: Amino acid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
proteolysis
serine-type endopeptidase activity
signaling receptor binding

Displaying **all 9** entries
InterPro
Kringle superfamily
Kringle, conserved site
Kringle-like fold
Kringle
PAN/Apple domain
Peptidase S1, PA clan, chymotrypsin-like fold
Peptidase S1, PA clan
Peptidase S1A, chymotrypsin family
Serine proteases, trypsin domain

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Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025