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CXADR Ig-like cell adhesion molecule

Summary

Gene Symbol

CXADR

Organism

Homo sapiens (human)

External Links

NCBI Gene

1525

PubChem

1525

Alliance of Genome Resources

HGNC:2559

Annotation

Keyword

3D-structure
Alternative splicing
Cell adhesion
Cell membrane
Disulfide bond
Glycoprotein
Host cell receptor for virus entry
Host-virus interaction
Immunoglobulin domain
Palmitate
Phosphoprotein
Reference proteome
Repeat
Secreted
Signal
Tight junction
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P78310	CVB3-binding protein Coxsackievirus B-adenovirus receptor HCVADR

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 18 in total

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GO Term	Evidence Code	PMID
mitochondrion organization	ISS
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	IDA	12869515 15800062
heart development	ISS
germ cell migration	ISS
epithelial structure maintenance	IMP	15304526

GO Hierarchy

biological process

immune system process [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

T cell activation [inference]

gamma-delta T cell activation

leukocyte migration [inference]

leukocyte chemotaxis [inference]

granulocyte chemotaxis [inference]

neutrophil chemotaxis

myeloid leukocyte migration [inference]

granulocyte migration [inference]

granulocyte chemotaxis [inference]

neutrophil chemotaxis

neutrophil migration [inference]

neutrophil chemotaxis

cellular process [inference]

cell activation [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

T cell activation [inference]

gamma-delta T cell activation

cell communication [inference]

cell communication involved in cardiac conduction [inference]

AV node cell to bundle of His cell communication

cell adhesion [inference]

cell-cell adhesion [inference]

homotypic cell-cell adhesion

cardiac muscle cell-cardiac muscle cell adhesion [inference]

AV node cell-bundle of His cell adhesion involved in cell communication

heterotypic cell-cell adhesion [inference]

AV node cell-bundle of His cell adhesion involved in cell communication

cell-cell adhesion via plasma-membrane adhesion molecules [inference]

heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules

cellular process involved in reproduction in multicellular organism [inference]

germ cell migration

actin filament-based process [inference]

actin cytoskeleton organization

cellular developmental process [inference]

cell development [inference]

muscle cell development [inference]

cardiac muscle cell development

cardiac cell development [inference]

cardiac muscle cell development

cell motility [inference]

cell migration [inference]

germ cell migration

leukocyte migration [inference]

leukocyte chemotaxis [inference]

granulocyte chemotaxis [inference]

neutrophil chemotaxis

myeloid leukocyte migration [inference]

granulocyte migration [inference]

granulocyte chemotaxis [inference]

neutrophil chemotaxis

neutrophil migration [inference]

neutrophil chemotaxis

cell chemotaxis [inference]

leukocyte chemotaxis [inference]

granulocyte chemotaxis [inference]

neutrophil chemotaxis

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

mitochondrion organization

cytoskeleton organization [inference]

actin cytoskeleton organization

cell junction organization [inference]

cell-cell junction organization

reproductive process [inference]

cellular process involved in reproduction in multicellular organism [inference]

germ cell migration

multicellular organismal process [inference]

cell activation [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

T cell activation [inference]

gamma-delta T cell activation

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

epithelial structure maintenance

developmental process [inference]

anatomical structure development [inference]

cell development [inference]

muscle cell development [inference]

cardiac muscle cell development

cardiac cell development [inference]

cardiac muscle cell development

animal organ development [inference]

heart development

cellular developmental process [inference]

cell development [inference]

muscle cell development [inference]

cardiac muscle cell development

cardiac cell development [inference]

cardiac muscle cell development

locomotion [inference]

taxis [inference]

chemotaxis [inference]

cell chemotaxis [inference]

leukocyte chemotaxis [inference]

granulocyte chemotaxis [inference]

neutrophil chemotaxis

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

epithelial structure maintenance

biological process involved in interspecies interaction between organisms [inference]

biological process involved in symbiotic interaction [inference]

biological process involved in interaction with host [inference]

movement in host [inference]

entry into host [inference]

viral entry into host cell

response to other organism [inference]

response to virus [inference]

defense response to virus

defense response to other organism [inference]

defense response to symbiont [inference]

defense response to virus

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

defense response to virus

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to virus [inference]

defense response to virus

defense response to other organism [inference]

defense response to symbiont [inference]

defense response to virus

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to virus [inference]

defense response to virus

defense response to other organism [inference]

defense response to symbiont [inference]

defense response to virus

localization [inference]

establishment of localization [inference]

transport [inference]

transepithelial transport

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of AV node cell action potential

regulation of action potential [inference]

regulation of cardiac muscle cell action potential [inference]

regulation of AV node cell action potential

regulation of biological quality [inference]

regulation of membrane potential [inference]

regulation of action potential [inference]

regulation of cardiac muscle cell action potential [inference]

regulation of AV node cell action potential

Displaying entries **1 - 5** of 26 in total

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GO Term	Evidence Code	PMID
acrosomal vesicle	ISS
extracellular region	IEA
extracellular space	IDA	14978041
nucleoplasm	IDA
cytoplasm	IDA	22003382

GO Hierarchy

cellular component

protein-containing complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

membrane microdomain [inference]

membrane raft

cell junction

synapse [inference]

neuromuscular junction

anchoring junction [inference]

cell-cell junction

adherens junction

cell-cell contact zone [inference]

intercalated disc

tight junction [inference]

bicellular tight junction

site of polarized growth [inference]

growth cone

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection

actin-based cell projection [inference]

filopodium

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule [inference]

acrosomal vesicle

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule [inference]

acrosomal vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule [inference]

acrosomal vesicle

cell body

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
virus receptor activity	IEA
signaling receptor binding	IPI	14978041
integrin binding	IPI	12869515
protein binding	IPI	11734628 17675666 32296183
beta-catenin binding	IPI	12297051

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding

integrin binding

beta-catenin binding

protein domain specific binding [inference]

PDZ domain binding

identical protein binding

cell adhesion molecule binding

integrin binding

cell adhesion mediator activity [inference]

cell-cell adhesion mediator activity [inference]

protein binding involved in heterotypic cell-cell adhesion [inference]

cell adhesive protein binding involved in AV node cell-bundle of His cell communication

connexin binding

exogenous protein binding [inference]

virus receptor activity

protein-containing complex binding [inference]

integrin binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Immunoglobulin

Functional Category

G: Carbohydrate transport and metabolism
M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 5** entries
InterPro
Immunoglobulin subtype 2
Immunoglobulin subtype
Immunoglobulin-like domain superfamily
Immunoglobulin-like domain
Immunoglobulin-like fold

Ortholog

Displaying entries **1 - 10** of 75 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	1525	Xenbase:XB-GENE-922483
Mus musculus	13052	Xenbase:XB-GENE-922483	MOUSE18651
Rattus norvegicus	89843	Xenbase:XB-GENE-922483	RATNO04836
Bos taurus	281733		BOVIN14297
Sus scrofa	397333		PIGXX05957
Canis lupus familiaris	403772		CANLF12765
Pan troglodytes	473920		PANTR25430
Macaca mulatta	716409		MACMU32800
Danio rerio	791793	Xenbase:XB-GENE-922483	DANRE01180
Equus caballus	100067795		HORSE24978