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hydroxysteroid (17-beta) dehydrogenase 2

Summary

Gene Symbol

Hsd17b2

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

15486

PubChem

15486

Alliance of Genome Resources

MGI:1096386

Annotation

Keyword

Endoplasmic reticulum
NAD
Oxidoreductase
Reference proteome
Signal-anchor
Steroid biosynthesis
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P51658	17-beta-hydroxysteroid dehydrogenase type 2 Testosterone 17-beta-dehydrogenase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
in utero embryonic development	IMP	18048640
placenta development	IMP	18048640
androgen biosynthetic process	ISO
estrogen biosynthetic process	ISS
estrogen biosynthetic process	ISO

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

hormone biosynthetic process [inference]

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

steroid hormone biosynthetic process [inference]

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

steroid hormone biosynthetic process [inference]

hormone metabolic process [inference]

androgen metabolic process

androgen biosynthetic process

estrogen metabolic process [inference]

estrogen biosynthetic process

hormone biosynthetic process [inference]

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process

steroid biosynthetic process [inference]

steroid hormone biosynthetic process [inference]

androgen metabolic process

androgen biosynthetic process

estrogen metabolic process [inference]

estrogen biosynthetic process

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

steroid hormone biosynthetic process [inference]

organic substance metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process

steroid biosynthetic process [inference]

steroid hormone biosynthetic process [inference]

androgen metabolic process

androgen biosynthetic process

estrogen metabolic process [inference]

estrogen biosynthetic process

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

steroid hormone biosynthetic process [inference]

organic cyclic compound metabolic process [inference]

steroid metabolic process

steroid biosynthetic process [inference]

steroid hormone biosynthetic process [inference]

androgen metabolic process

androgen biosynthetic process

estrogen metabolic process [inference]

estrogen biosynthetic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

steroid hormone biosynthetic process [inference]

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

steroid hormone biosynthetic process [inference]

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

steroid hormone biosynthetic process [inference]

multicellular organismal process [inference]

multicellular organism development [inference]

embryo development [inference]

embryo development ending in birth or egg hatching [inference]

chordate embryonic development [inference]

in utero embryonic development

developmental process [inference]

anatomical structure development [inference]

multicellular organism development [inference]

embryo development [inference]

embryo development ending in birth or egg hatching [inference]

chordate embryonic development [inference]

in utero embryonic development

animal organ development [inference]

placenta development

response to stimulus [inference]

response to chemical [inference]

response to organic substance [inference]

response to lipid [inference]

response to retinoic acid

response to oxygen-containing compound [inference]

response to retinoic acid

biological regulation [inference]

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

androgen metabolic process

androgen biosynthetic process

estrogen metabolic process [inference]

estrogen biosynthetic process

hormone biosynthetic process [inference]

Displaying **all 3** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum membrane	ISS
endoplasmic reticulum membrane	ISO
intracellular membrane-bounded organelle	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle

intracellular organelle [inference]

intracellular membrane-bounded organelle

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
estradiol 17-beta-dehydrogenase [NAD(P)] activity	ISO
estradiol 17-beta-dehydrogenase [NAD(P)] activity	IBA
estradiol 17-beta-dehydrogenase [NAD(P)] activity	IEA
testosterone dehydrogenase (NAD+) activity	ISO
testosterone dehydrogenase (NAD+) activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

steroid dehydrogenase activity [inference]

steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]

estradiol 17-beta-dehydrogenase [NAD(P)] activity

testosterone dehydrogenase [NAD(P)] activity [inference]

testosterone dehydrogenase (NAD+) activity

oxidoreductase activity, acting on CH-OH group of donors [inference]

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]

steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]

estradiol 17-beta-dehydrogenase [NAD(P)] activity

testosterone dehydrogenase [NAD(P)] activity [inference]

testosterone dehydrogenase (NAD+) activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Estradiol 17-beta-dehydrogenase 2

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
oxidoreductase activity
steroid metabolic process

Displaying **all 3** entries
InterPro
NAD(P)-binding domain superfamily
Short-chain dehydrogenase/reductase SDR
Short-chain dehydrogenase/reductase, conserved site

Ortholog

Displaying entries **1 - 10** of 82 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	622	FB:FBgn0033679
Homo sapiens	3294	Xenbase:XB-GENE-1011810	HUMAN29954
Drosophila melanogaster	8630	FB:FBgn0033679
Xenopus tropicalis	15486	Xenbase:XB-GENE-1011810
Saccharomyces cerevisiae S288C	27400	SGD:S000001386
Saccharomyces cerevisiae S288C	71911	SGD:S000001386
Rattus norvegicus	79243		RATNO15197
Drosophila melanogaster	117099	FB:FBgn0033679
Drosophila melanogaster	121214	FB:FBgn0033679
Drosophila melanogaster	286964	FB:FBgn0033679