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5-hydroxytryptamine (serotonin) receptor 3A

Summary

Gene Symbol

Htr3a

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

15561

PubChem

15561

Alliance of Genome Resources

MGI:96282

Annotation

Keyword

3D-structure
Alternative splicing
Cell membrane
Disulfide bond
Glycoprotein
Ion channel
Ligand-gated ion channel
Postsynaptic cell membrane
Receptor
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P23979	5-hydroxytryptamine receptor 3 Serotonin receptor 3A Serotonin-gated ion channel receptor
Q8K1F4

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
serotonin receptor signaling pathway	ISO
serotonin receptor signaling pathway	IDA	38177669
chemical synaptic transmission	IBA
monoatomic ion transmembrane transport	IBA
ion transmembrane transport	IBA

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

signal transduction [inference]

serotonin receptor signaling pathway

serotonin-gated cation-selective signaling pathway

ligand-gated ion channel signaling pathway [inference]

serotonin-gated cation-selective signaling pathway

transmembrane transport [inference]

monoatomic ion transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic ion transmembrane transport

transmembrane transport [inference]

monoatomic ion transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport

biological regulation [inference]

regulation of biological process [inference]

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

regulation of cellular process [inference]

signal transduction [inference]

serotonin receptor signaling pathway

serotonin-gated cation-selective signaling pathway

ligand-gated ion channel signaling pathway [inference]

serotonin-gated cation-selective signaling pathway

regulation of biological quality [inference]

regulation of membrane potential

regulation of presynaptic membrane potential

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
plasma membrane	IBA
axon	ISO
cleavage furrow	ISO
cleavage furrow	IEA
presynaptic membrane	ISO

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex [inference]

serotonin receptor complex [inference]

serotonin-activated cation-selective channel complex

plasma membrane signaling receptor complex [inference]

neurotransmitter receptor complex [inference]

serotonin-activated cation-selective channel complex

membrane protein complex [inference]

plasma membrane protein complex [inference]

plasma membrane signaling receptor complex [inference]

neurotransmitter receptor complex [inference]

serotonin-activated cation-selective channel complex

transmembrane transporter complex

monoatomic ion channel complex [inference]

cation channel complex [inference]

serotonin-activated cation-selective channel complex

transporter complex [inference]

transmembrane transporter complex

monoatomic ion channel complex [inference]

cation channel complex [inference]

serotonin-activated cation-selective channel complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

cleavage furrow

synaptic membrane [inference]

cell junction [inference]

synapse

glutamatergic synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection

axon

cell body [inference]

neuronal cell body

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
excitatory extracellular ligand-gated monoatomic ion channel activity	IBA
serotonin-gated monoatomic cation channel activity	ISO	7565620
serotonin-gated monoatomic cation channel activity	IBA
identical protein binding	IPI	20023641 25119048 26724993 30401837 30401839
serotonin binding	ISO	7565620

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

monoatomic cation channel activity [inference]

ligand-gated monoatomic cation channel activity [inference]

serotonin-gated monoatomic cation channel activity

ligand-gated monoatomic ion channel activity [inference]

extracellular ligand-gated monoatomic ion channel activity [inference]

excitatory extracellular ligand-gated monoatomic ion channel activity

transmitter-gated monoatomic ion channel activity [inference]

ligand-gated monoatomic cation channel activity [inference]

serotonin-gated monoatomic cation channel activity

ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential

monoatomic cation transmembrane transporter activity [inference]

monoatomic cation channel activity [inference]

ligand-gated monoatomic cation channel activity [inference]

serotonin-gated monoatomic cation channel activity

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity [inference]

monoatomic cation channel activity [inference]

ligand-gated monoatomic cation channel activity [inference]

serotonin-gated monoatomic cation channel activity

ligand-gated monoatomic ion channel activity [inference]

extracellular ligand-gated monoatomic ion channel activity [inference]

excitatory extracellular ligand-gated monoatomic ion channel activity

transmitter-gated monoatomic ion channel activity [inference]

ligand-gated monoatomic cation channel activity [inference]

serotonin-gated monoatomic cation channel activity

ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential

gated channel activity [inference]

ligand-gated channel activity [inference]

ligand-gated monoatomic ion channel activity [inference]

extracellular ligand-gated monoatomic ion channel activity [inference]

excitatory extracellular ligand-gated monoatomic ion channel activity

transmitter-gated monoatomic ion channel activity [inference]

ligand-gated monoatomic cation channel activity [inference]

serotonin-gated monoatomic cation channel activity

ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential

transmitter-gated channel activity [inference]

transmitter-gated monoatomic ion channel activity [inference]

binding [inference]

protein binding [inference]

identical protein binding

ion binding [inference]

cation binding [inference]

serotonin binding

amine binding [inference]

serotonin binding

organic cyclic compound binding [inference]

serotonin binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

serotonin receptor activity [inference]

serotonin-gated monoatomic cation channel activity

neurotransmitter receptor activity [inference]

transmitter-gated channel activity [inference]

transmitter-gated monoatomic ion channel activity [inference]

postsynaptic neurotransmitter receptor activity [inference]

neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential [inference]

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

acetylcholine receptor subunit alpha

Functional Category

E: Amino acid transport and metabolism
T: Signal transduction mechanisms
X: Mobilome: prophages, transposons

Displaying **all 4** entries
Gene Ontology
extracellular ligand-gated monoatomic ion channel activity
ligand-gated monoatomic ion channel activity
monoatomic ion channel activity
monoatomic ion transport

Displaying **all 9** entries
InterPro
5-hydroxytryptamine 3 receptor, A subunit
5-hydroxytryptamine 3 receptor
Neuronal acetylcholine receptor
Neurotransmitter-gated ion-channel ligand-binding domain superfamily
Neurotransmitter-gated ion-channel ligand-binding domain
Neurotransmitter-gated ion-channel transmembrane domain superfamily
Neurotransmitter-gated ion-channel transmembrane domain
Neurotransmitter-gated ion-channel, conserved site
Neurotransmitter-gated ion-channel

Ortholog

Displaying entries **1 - 10** of 67 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	3359	Xenbase:XB-GENE-990708	HUMAN09460
Xenopus tropicalis	15561	Xenbase:XB-GENE-990708
Caenorhabditis elegans	57014	WB:WBGene00013655
Caenorhabditis elegans	58963	WB:WBGene00013655
Rattus norvegicus	79246	Xenbase:XB-GENE-990708	RATNO40683
Xenopus tropicalis	181009	Xenbase:XB-GENE-990708
Pan troglodytes	451556		PANTR04375
Canis lupus familiaris	489399		CANLF15271
Danio rerio	571641		DANRE21280
Bos taurus	617674		BOVIN06485