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MIRAGE

5-hydroxytryptamine (serotonin) receptor 6

Summary

Gene Symbol

Htr6

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

15565

PubChem

15565

Alliance of Genome Resources

MGI:1196627

Annotation

Keyword

Cell membrane
Disulfide bond
G-protein coupled receptor
Glycoprotein
Reference proteome
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q9R1C8	Serotonin receptor 6
Q14AW8

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 10** of 14 in total

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GO Term	Evidence Code	PMID
negative regulation of acetylcholine secretion, neurotransmission	ISO
negative regulation of glutamate secretion	ISO
negative regulation of gamma-aminobutyric acid secretion	ISO
learning	ISO
G protein-coupled serotonin receptor signaling pathway	IEA

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

adenylate cyclase-modulating G protein-coupled receptor signaling pathway

adenylate cyclase-activating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating serotonin receptor signaling pathway

G protein-coupled serotonin receptor signaling pathway

serotonin receptor signaling pathway [inference]

adenylate cyclase-activating serotonin receptor signaling pathway

cell motility [inference]

cell migration [inference]

forebrain cell migration [inference]

telencephalon cell migration [inference]

cerebral cortex cell migration

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

cognition [inference]

learning or memory [inference]

learning

behavior [inference]

learning or memory [inference]

learning

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of TOR signaling

regulation of intracellular signal transduction [inference]

regulation of TOR signaling [inference]

positive regulation of TOR signaling

positive regulation of intracellular signal transduction [inference]

positive regulation of TOR signaling

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of TOR signaling

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

negative regulation of signaling [inference]

negative regulation of synaptic transmission [inference]

negative regulation of synaptic transmission, cholinergic [inference]

negative regulation of acetylcholine secretion, neurotransmission

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic transmission, cholinergic [inference]

regulation of acetylcholine secretion, neurotransmission [inference]

negative regulation of acetylcholine secretion, neurotransmission

negative regulation of synaptic transmission, cholinergic [inference]

negative regulation of acetylcholine secretion, neurotransmission

regulation of neurotransmitter secretion [inference]

regulation of acetylcholine secretion, neurotransmission [inference]

negative regulation of acetylcholine secretion, neurotransmission

negative regulation of neurotransmitter secretion [inference]

negative regulation of acetylcholine secretion, neurotransmission

regulation of synaptic plasticity [inference]

long-term synaptic potentiation

negative regulation of synaptic transmission [inference]

negative regulation of synaptic transmission, cholinergic [inference]

negative regulation of acetylcholine secretion, neurotransmission

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

regulation of localization [inference]

regulation of transport [inference]

regulation of organic acid transport [inference]

negative regulation of organic acid transport [inference]

negative regulation of amino acid transport [inference]

positive regulation of organic acid transport [inference]

positive regulation of amino acid transport [inference]

positive regulation of gamma-aminobutyric acid secretion

regulation of amino acid transport [inference]

regulation of glutamate secretion [inference]

negative regulation of glutamate secretion

regulation of gamma-aminobutyric acid secretion [inference]

negative regulation of amino acid transport [inference]

positive regulation of amino acid transport [inference]

positive regulation of gamma-aminobutyric acid secretion

regulation of secretion [inference]

regulation of gamma-aminobutyric acid secretion [inference]

positive regulation of secretion [inference]

positive regulation of gamma-aminobutyric acid secretion

positive regulation of secretion by cell [inference]

positive regulation of catecholamine secretion [inference]

positive regulation of dopamine secretion

negative regulation of secretion [inference]

negative regulation of gamma-aminobutyric acid secretion

negative regulation of secretion by cell [inference]

negative regulation of glutamate secretion

negative regulation of neurotransmitter secretion [inference]

negative regulation of acetylcholine secretion, neurotransmission

regulation of secretion by cell [inference]

regulation of glutamate secretion [inference]

negative regulation of glutamate secretion

regulation of neurotransmitter secretion [inference]

regulation of acetylcholine secretion, neurotransmission [inference]

negative regulation of acetylcholine secretion, neurotransmission

negative regulation of neurotransmitter secretion [inference]

negative regulation of acetylcholine secretion, neurotransmission

regulation of catecholamine secretion [inference]

regulation of dopamine secretion [inference]

positive regulation of dopamine secretion

positive regulation of catecholamine secretion [inference]

positive regulation of dopamine secretion

negative regulation of secretion by cell [inference]

negative regulation of glutamate secretion

negative regulation of neurotransmitter secretion [inference]

negative regulation of acetylcholine secretion, neurotransmission

positive regulation of secretion by cell [inference]

positive regulation of catecholamine secretion [inference]

positive regulation of dopamine secretion

positive regulation of transport [inference]

positive regulation of organic acid transport [inference]

positive regulation of amino acid transport [inference]

positive regulation of gamma-aminobutyric acid secretion

positive regulation of secretion [inference]

positive regulation of gamma-aminobutyric acid secretion

positive regulation of secretion by cell [inference]

positive regulation of catecholamine secretion [inference]

positive regulation of dopamine secretion

positive regulation of amine transport [inference]

positive regulation of catecholamine secretion [inference]

positive regulation of dopamine secretion

positive regulation of amino acid transport [inference]

positive regulation of gamma-aminobutyric acid secretion

negative regulation of transport [inference]

negative regulation of organic acid transport [inference]

negative regulation of amino acid transport [inference]

negative regulation of secretion [inference]

negative regulation of gamma-aminobutyric acid secretion

negative regulation of secretion by cell [inference]

negative regulation of glutamate secretion

negative regulation of neurotransmitter secretion [inference]

negative regulation of acetylcholine secretion, neurotransmission

negative regulation of neurotransmitter transport [inference]

negative regulation of neurotransmitter secretion [inference]

negative regulation of acetylcholine secretion, neurotransmission

negative regulation of amine transport [inference]

negative regulation of acetylcholine secretion, neurotransmission

negative regulation of amino acid transport [inference]

regulation of neurotransmitter transport [inference]

regulation of neurotransmitter secretion [inference]

regulation of acetylcholine secretion, neurotransmission [inference]

negative regulation of acetylcholine secretion, neurotransmission

negative regulation of neurotransmitter secretion [inference]

negative regulation of acetylcholine secretion, neurotransmission

negative regulation of neurotransmitter transport [inference]

negative regulation of neurotransmitter secretion [inference]

negative regulation of acetylcholine secretion, neurotransmission

regulation of amine transport [inference]

regulation of acetylcholine secretion, neurotransmission [inference]

negative regulation of acetylcholine secretion, neurotransmission

regulation of catecholamine secretion [inference]

regulation of dopamine secretion [inference]

positive regulation of dopamine secretion

positive regulation of catecholamine secretion [inference]

positive regulation of dopamine secretion

negative regulation of amine transport [inference]

negative regulation of acetylcholine secretion, neurotransmission

negative regulation of amino acid transport [inference]

positive regulation of amine transport [inference]

positive regulation of catecholamine secretion [inference]

positive regulation of dopamine secretion

positive regulation of amino acid transport [inference]

positive regulation of gamma-aminobutyric acid secretion

regulation of amino acid transport [inference]

regulation of glutamate secretion [inference]

negative regulation of glutamate secretion

regulation of gamma-aminobutyric acid secretion [inference]

negative regulation of amino acid transport [inference]

positive regulation of amino acid transport [inference]

positive regulation of gamma-aminobutyric acid secretion

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of TOR signaling

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of TOR signaling

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

positive regulation of secretion by cell [inference]

positive regulation of catecholamine secretion [inference]

positive regulation of dopamine secretion

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of TOR signaling

positive regulation of transport [inference]

positive regulation of organic acid transport [inference]

positive regulation of amino acid transport [inference]

positive regulation of gamma-aminobutyric acid secretion

positive regulation of secretion [inference]

positive regulation of gamma-aminobutyric acid secretion

positive regulation of secretion by cell [inference]

positive regulation of catecholamine secretion [inference]

positive regulation of dopamine secretion

positive regulation of amine transport [inference]

positive regulation of catecholamine secretion [inference]

positive regulation of dopamine secretion

positive regulation of amino acid transport [inference]

positive regulation of gamma-aminobutyric acid secretion

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of synaptic transmission [inference]

negative regulation of synaptic transmission, cholinergic [inference]

negative regulation of acetylcholine secretion, neurotransmission

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of synaptic transmission [inference]

negative regulation of synaptic transmission, cholinergic [inference]

negative regulation of acetylcholine secretion, neurotransmission

negative regulation of secretion by cell [inference]

negative regulation of glutamate secretion

negative regulation of neurotransmitter secretion [inference]

negative regulation of acetylcholine secretion, neurotransmission

negative regulation of transport [inference]

negative regulation of organic acid transport [inference]

negative regulation of amino acid transport [inference]

negative regulation of secretion [inference]

negative regulation of gamma-aminobutyric acid secretion

negative regulation of secretion by cell [inference]

negative regulation of glutamate secretion

negative regulation of neurotransmitter secretion [inference]

negative regulation of acetylcholine secretion, neurotransmission

negative regulation of neurotransmitter transport [inference]

negative regulation of neurotransmitter secretion [inference]

negative regulation of acetylcholine secretion, neurotransmission

negative regulation of amine transport [inference]

negative regulation of acetylcholine secretion, neurotransmission

negative regulation of amino acid transport [inference]

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of TOR signaling

regulation of intracellular signal transduction [inference]

regulation of TOR signaling [inference]

positive regulation of TOR signaling

positive regulation of intracellular signal transduction [inference]

positive regulation of TOR signaling

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of TOR signaling

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

adenylate cyclase-modulating G protein-coupled receptor signaling pathway

adenylate cyclase-activating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating serotonin receptor signaling pathway

G protein-coupled serotonin receptor signaling pathway

serotonin receptor signaling pathway [inference]

adenylate cyclase-activating serotonin receptor signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of TOR signaling

regulation of intracellular signal transduction [inference]

regulation of TOR signaling [inference]

positive regulation of TOR signaling

positive regulation of intracellular signal transduction [inference]

positive regulation of TOR signaling

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of TOR signaling

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

negative regulation of cell communication [inference]

negative regulation of synaptic transmission [inference]

negative regulation of synaptic transmission, cholinergic [inference]

negative regulation of acetylcholine secretion, neurotransmission

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic transmission, cholinergic [inference]

regulation of acetylcholine secretion, neurotransmission [inference]

negative regulation of acetylcholine secretion, neurotransmission

negative regulation of synaptic transmission, cholinergic [inference]

negative regulation of acetylcholine secretion, neurotransmission

regulation of neurotransmitter secretion [inference]

regulation of acetylcholine secretion, neurotransmission [inference]

negative regulation of acetylcholine secretion, neurotransmission

negative regulation of neurotransmitter secretion [inference]

negative regulation of acetylcholine secretion, neurotransmission

regulation of synaptic plasticity [inference]

long-term synaptic potentiation

negative regulation of synaptic transmission [inference]

negative regulation of synaptic transmission, cholinergic [inference]

negative regulation of acetylcholine secretion, neurotransmission

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of TOR signaling

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

positive regulation of secretion by cell [inference]

positive regulation of catecholamine secretion [inference]

positive regulation of dopamine secretion

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of synaptic transmission [inference]

negative regulation of synaptic transmission, cholinergic [inference]

negative regulation of acetylcholine secretion, neurotransmission

negative regulation of secretion by cell [inference]

negative regulation of glutamate secretion

negative regulation of neurotransmitter secretion [inference]

negative regulation of acetylcholine secretion, neurotransmission

regulation of secretion by cell [inference]

regulation of glutamate secretion [inference]

negative regulation of glutamate secretion

regulation of neurotransmitter secretion [inference]

regulation of acetylcholine secretion, neurotransmission [inference]

negative regulation of acetylcholine secretion, neurotransmission

negative regulation of neurotransmitter secretion [inference]

negative regulation of acetylcholine secretion, neurotransmission

regulation of catecholamine secretion [inference]

regulation of dopamine secretion [inference]

positive regulation of dopamine secretion

positive regulation of catecholamine secretion [inference]

positive regulation of dopamine secretion

negative regulation of secretion by cell [inference]

negative regulation of glutamate secretion

negative regulation of neurotransmitter secretion [inference]

negative regulation of acetylcholine secretion, neurotransmission

positive regulation of secretion by cell [inference]

positive regulation of catecholamine secretion [inference]

positive regulation of dopamine secretion

regulation of biological quality [inference]

regulation of synaptic plasticity [inference]

long-term synaptic potentiation

Displaying **all 4** entries
GO Term	Evidence Code	PMID
dendrite	IBA ISO
synapse
plasma membrane	IBA ISS
cilium	IDA	22179047

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

cell junction [inference]

synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

cilium

neuron projection [inference]

dendrite

organelle [inference]

membrane-bounded organelle [inference]

cilium

Displaying **all 3** entries
GO Term	Evidence Code	PMID
neurotransmitter receptor activity	IBA
G protein-coupled serotonin receptor activity	IBA IDA ISO	11406289
protein binding	IPI	23027611 25078650

GO Hierarchy

molecular function

binding [inference]

protein binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity [inference]

G protein-coupled amine receptor activity [inference]

G protein-coupled serotonin receptor activity

neurotransmitter receptor activity

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:10652	Alzheimer's disease	Alliance of Genome Resources

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Last updated: February 17, 2025