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cytochrome P450 family 2 subfamily C member 8

Summary

Gene Symbol

CYP2C8

Aliases

CPC8

Organism

Homo sapiens (human)

External Links

NCBI Gene

1558

HGNC

2622

KEGG Gene ID

hsa:1558

PubChem

1558

Alliance of Genome Resources

HGNC:2622

Annotation

Keyword

3D-structure
Alternative splicing
Direct protein sequencing
Heme
Membrane
Microsome
Monooxygenase
Phosphoprotein
Proteomics identification
Reference proteome
Steroid metabolism

Proteins

Displaying **all 2** entries
UniProt	Protein Name
B7Z1F5
P10632	CYPIIC8 Cytochrome P450 IIC2 Cytochrome P450 MP-12 Cytochrome P450 MP-20 Cytochrome P450 form 1 S-mephenytoin 4-hydroxylase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
epoxygenase P450 pathway	IBA IDA TAS	7574697
retinoic acid metabolic process	IDA	11093772
xenobiotic catabolic process	IDA	18619574
omega-hydroxylase P450 pathway
icosanoid biosynthetic process	IDA	15766564

GO Hierarchy

biological process

metabolic process [inference]

catabolic process [inference]

cellular catabolic process [inference]

xenobiotic catabolic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

hormone metabolic process [inference]

cellular metabolic process [inference]

organic acid metabolic process

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

arachidonic acid metabolic process [inference]

icosanoid biosynthetic process

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

long-chain fatty acid biosynthetic process

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

retinoic acid metabolic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

xenobiotic metabolic process

xenobiotic catabolic process

cellular catabolic process [inference]

xenobiotic catabolic process

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

long-chain fatty acid biosynthetic process

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process [inference]

lipid modification [inference]

lipid hydroxylation

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process

estrogen metabolic process

lipid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

long-chain fatty acid biosynthetic process

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process [inference]

lipid modification [inference]

lipid hydroxylation

small molecule metabolic process [inference]

alcohol metabolic process [inference]

primary alcohol metabolic process [inference]

retinol metabolic process

organic acid metabolic process

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

arachidonic acid metabolic process [inference]

icosanoid biosynthetic process

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

long-chain fatty acid biosynthetic process

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

retinoic acid metabolic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

demethylation [inference]

oxidative demethylation

organic substance metabolic process [inference]

organic acid metabolic process

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

arachidonic acid metabolic process [inference]

icosanoid biosynthetic process

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

long-chain fatty acid biosynthetic process

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

retinoic acid metabolic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

lipid metabolic process [inference]

steroid metabolic process

estrogen metabolic process

lipid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

long-chain fatty acid biosynthetic process

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process [inference]

lipid modification [inference]

lipid hydroxylation

olefinic compound metabolic process [inference]

arachidonic acid metabolic process [inference]

retinol metabolic process

organic cyclic compound metabolic process [inference]

steroid metabolic process

estrogen metabolic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

primary alcohol metabolic process [inference]

retinol metabolic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

arachidonic acid metabolic process [inference]

icosanoid biosynthetic process

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

long-chain fatty acid biosynthetic process

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

retinoic acid metabolic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

xenobiotic metabolic process

xenobiotic catabolic process

cellular catabolic process [inference]

xenobiotic catabolic process

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

icosanoid biosynthetic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

long-chain fatty acid biosynthetic process

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process [inference]

lipid modification [inference]

lipid hydroxylation

biological regulation [inference]

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

Displaying **all 4** entries
GO Term	Evidence Code	PMID
intracellular membrane-bounded organelle	IBA IDA
cytoplasm	IBA
endoplasmic reticulum membrane
plasma membrane	IDA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

membrane [inference]

plasma membrane

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle

intracellular organelle [inference]

intracellular membrane-bounded organelle

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
caffeine oxidase activity	IDA	18619574
retinoic acid 4-hydroxylase activity	IDA	11093772
monooxygenase activity	IDA TAS	15766564 19651758
iron ion binding	IEA
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

monooxygenase activity

arachidonic acid monooxygenase activity [inference]

arachidonic acid epoxygenase activity

steroid hydroxylase activity [inference]

estrogen 16-alpha-hydroxylase activity

retinoic acid 4-hydroxylase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

aromatase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [inference]

arachidonic acid monooxygenase activity [inference]

arachidonic acid epoxygenase activity

retinoic acid 4-hydroxylase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

aromatase activity

estrogen 16-alpha-hydroxylase activity

oxidoreductase activity, acting on CH or CH2 groups [inference]

oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor [inference]

caffeine oxidase activity

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

iron ion binding

organic cyclic compound binding [inference]

tetrapyrrole binding [inference]

heme binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000138115

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K17718

Name

cytochrome P450 family 2 subfamily C8 [EC:1.14.14.1]

References

3500169

Rhea

RHEA:17149

an organic molecule + O₂

H₂O + H⁺ + an alcohol

Enzyme

1.14.14.1

PMID

Disease

Disease Ontology

Displaying entries **1 - 10** of 73 in total

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DO ID	Disease Name	Source
DOID:0040085	bacterial sepsis	DisGeNET
DOID:0050590	severe congenital neutropenia	DisGeNET
DOID:0050635	alternating hemiplegia of childhood	DisGeNET
DOID:0050865	tongue squamous cell carcinoma	DisGeNET
DOID:0080144	childhood acute lymphocytic leukemia	DisGeNET
DOID:0080147	lymphoblastic lymphoma	DisGeNET
DOID:10159	osteonecrosis	DisGeNET
DOID:10283	prostate cancer	DisGeNET DisGeNET
DOID:10286	prostate carcinoma	DisGeNET DisGeNET
DOID:1073	renal hypertension	Alliance of Genome Resources

PubChem Disease

MedGen Diseases

DRUG METABOLISM, ALTERED, CYP2C8-RELATED

OMIM Phenotypes

DRUG METABOLISM, ALTERED, CYP2C8-RELATED

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

Ortholog

Displaying entries **1 - 10** of 89 in total

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Species	Gene ID	Alliance of Genome Resources
Caenorhabditis elegans	173787	WB:WBGene00015135
Caenorhabditis elegans	178695	WB:WBGene00016697
Caenorhabditis elegans	178704	WB:WBGene00018413
Caenorhabditis elegans	178706	WB:WBGene00018261
Caenorhabditis elegans	178752	WB:WBGene00016860
Caenorhabditis elegans	178803	WB:WBGene00019472
Caenorhabditis elegans	179148	WB:WBGene00015709
Caenorhabditis elegans	181850	WB:WBGene00015043
Caenorhabditis elegans	181851	WB:WBGene00015044
Caenorhabditis elegans	181852	WB:WBGene00015045

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

KEGG BRITE Database

PubChem Disease

International Collaboration

Acknowledgements