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cytochrome P450 family 3 subfamily A member 5

Summary

Gene Symbol

CYP3A5

Aliases

CP35
P450PCN3
PCN3

Organism

Homo sapiens (human)

External Links

NCBI Gene

1577

HGNC

2638

KEGG Gene ID

hsa:1577

PubChem

1577

Alliance of Genome Resources

HGNC:2638

Annotation

Keyword

3D-structure
Alternative splicing
Heme
Membrane
Microsome
Monooxygenase
Reference proteome
Signal
Steroid metabolism

Proteins

Displaying **all 2** entries
UniProt	Protein Name
B7Z3P6
P20815	CYPIIIA5 Cytochrome P450-PCN3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
lipid hydroxylation	IDA	14559847
xenobiotic metabolic process	TAS
steroid metabolic process	IDA	14559847
steroid metabolic process	IBA
estrogen metabolic process	IDA	12865317

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound catabolic process [inference]

alkaloid catabolic process

organonitrogen compound metabolic process [inference]

alkaloid metabolic process [inference]

alkaloid catabolic process

organonitrogen compound catabolic process [inference]

alkaloid catabolic process

catabolic process [inference]

cellular catabolic process [inference]

xenobiotic catabolic process

cellular nitrogen compound catabolic process [inference]

alkaloid catabolic process

organic substance catabolic process [inference]

organonitrogen compound catabolic process [inference]

alkaloid catabolic process

secondary metabolic process [inference]

toxin metabolic process [inference]

mycotoxin metabolic process [inference]

aflatoxin metabolic process

hormone metabolic process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

retinoic acid metabolic process

xenobiotic metabolic process

xenobiotic catabolic process

toxin metabolic process [inference]

mycotoxin metabolic process [inference]

aflatoxin metabolic process

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound catabolic process [inference]

alkaloid catabolic process

cellular catabolic process [inference]

xenobiotic catabolic process

cellular nitrogen compound catabolic process [inference]

alkaloid catabolic process

cellular lipid metabolic process [inference]

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process [inference]

lipid modification [inference]

lipid hydroxylation

heterocycle metabolic process [inference]

organic heteropentacyclic compound metabolic process [inference]

aflatoxin metabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process

estrogen metabolic process

cellular lipid metabolic process [inference]

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process [inference]

lipid modification [inference]

lipid hydroxylation

small molecule metabolic process [inference]

alcohol metabolic process [inference]

primary alcohol metabolic process [inference]

retinol metabolic process

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

retinoic acid metabolic process

demethylation [inference]

oxidative demethylation

organic substance metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

retinoic acid metabolic process

lipid metabolic process [inference]

steroid metabolic process

estrogen metabolic process

cellular lipid metabolic process [inference]

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process [inference]

lipid modification [inference]

lipid hydroxylation

olefinic compound metabolic process [inference]

retinol metabolic process

organic cyclic compound metabolic process [inference]

steroid metabolic process

estrogen metabolic process

organic heteropentacyclic compound metabolic process [inference]

aflatoxin metabolic process

organonitrogen compound metabolic process [inference]

alkaloid metabolic process [inference]

alkaloid catabolic process

organonitrogen compound catabolic process [inference]

alkaloid catabolic process

organic substance catabolic process [inference]

organonitrogen compound catabolic process [inference]

alkaloid catabolic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

primary alcohol metabolic process [inference]

retinol metabolic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

retinoic acid metabolic process

xenobiotic metabolic process

xenobiotic catabolic process

toxin metabolic process [inference]

mycotoxin metabolic process [inference]

aflatoxin metabolic process

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound catabolic process [inference]

alkaloid catabolic process

cellular catabolic process [inference]

xenobiotic catabolic process

cellular nitrogen compound catabolic process [inference]

alkaloid catabolic process

cellular lipid metabolic process [inference]

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process [inference]

lipid modification [inference]

lipid hydroxylation

heterocycle metabolic process [inference]

organic heteropentacyclic compound metabolic process [inference]

aflatoxin metabolic process

biological regulation [inference]

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

Displaying **all 2** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum membrane	TAS
intracellular membrane-bounded organelle	TAS	2732228

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle

intracellular organelle [inference]

intracellular membrane-bounded organelle

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
monooxygenase activity	ISS
monooxygenase activity	TAS
iron ion binding	IEA
protein binding	IPI	32814053
retinoic acid 4-hydroxylase activity	IDA	11093772

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity

monooxygenase activity

steroid hydroxylase activity [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [inference]

binding [inference]

protein binding

small molecule binding [inference]

oxygen binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

iron ion binding

organic cyclic compound binding [inference]

tetrapyrrole binding [inference]

heme binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Cytochrome

Functional Category

C: Energy production and conversion
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
heme binding
iron ion binding
metal ion binding
monooxygenase activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
oxidoreductase activity

Displaying **all 4** entries
InterPro
Cytochrome P450 superfamily
Cytochrome P450, E-class, group I
Cytochrome P450, conserved site
Cytochrome P450

KEGG BRITE Database

Orthology

K17690

Name

cytochrome P450 family 3 subfamily A5 [EC:1.14.14.1]

References

Rhea

RHEA:17149

an organic molecule + O₂

H₂O + H⁺ + an alcohol

Enzyme

1.14.14.1

PMID

Disease

Disease Ontology

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:0080630	B-lymphoblastic leukemia/lymphoma	Alliance of Genome Resources
DOID:10825	essential hypertension	Alliance of Genome Resources
DOID:8552	chronic myeloid leukemia	Alliance of Genome Resources
DOID:9952	acute lymphoblastic leukemia	Alliance of Genome Resources

The Human Phenotype Ontology

Displaying **all 4** entries
HPO ID	HPO Term
HP:0001426	Non-Mendelian inheritance
HP:0004421	Elevated systolic blood pressure
HP:0004972	Elevated mean arterial pressure
HP:0005117	Elevated diastolic blood pressure

Displaying 1 entry
Disease ID	Disease Name
OMIM:145500	essential hypertension, genetic

PubChem Disease

MedGen Diseases

Essential hypertension, genetic

OMIM Phenotypes

HYPERTENSION, ESSENTIAL

KEGG Diseases

High blood pressure

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP000454
Gene Name: cytochrome P450, family 3, subfamily A, polypeptide 5

Ortholog

Displaying entries **1 - 10** of **125** in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Danio rerio	1551	ZFIN:ZDB-GENE-060929-96
Xenopus tropicalis	1576	Xenbase:XB-GENE-984218
Xenopus tropicalis	1577	Xenbase:XB-GENE-984218
Drosophila melanogaster	6916	FB:FBgn0039519
Xenopus tropicalis	64816	Xenbase:XB-GENE-984218
Bos taurus	282214		BOVIN20916
Sus scrofa	403324		PIGXX20288
Canis lupus familiaris	415127		CANLF16239
Canis lupus familiaris	415129		CANLF16239
Canis lupus familiaris	479740		CANLF16240

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

KEGG BRITE Database

PubChem Disease

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements