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cytochrome P450 family 3 subfamily A member 5

Summary

Gene Symbol

CYP3A5

Aliases

CP35
P450PCN3
PCN3

Organism

Homo sapiens (human)

External Links

NCBI Gene

1577

HGNC

2638

KEGG Gene ID

hsa:1577

PubChem

1577

Alliance of Genome Resources

HGNC:2638

Annotation

Keyword

3D-structure
Alternative splicing
Heme
Membrane
Microsome
Monooxygenase
Reference proteome
Signal
Steroid metabolism

Proteins

Displaying **all 2** entries
UniProt	Protein Name
B7Z3P6
P20815	CYPIIIA5 Cytochrome P450-PCN3

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
retinoic acid metabolic process	IDA	11093772
xenobiotic catabolic process	IDA	15039299
aflatoxin metabolic process
alkaloid catabolic process	IDA	15039299
lipid hydroxylation	IDA	14559847

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound catabolic process [inference]

alkaloid catabolic process

organonitrogen compound metabolic process [inference]

alkaloid metabolic process [inference]

alkaloid catabolic process

organonitrogen compound catabolic process [inference]

alkaloid catabolic process

catabolic process [inference]

cellular catabolic process [inference]

xenobiotic catabolic process

cellular nitrogen compound catabolic process [inference]

alkaloid catabolic process

organic substance catabolic process [inference]

organonitrogen compound catabolic process [inference]

alkaloid catabolic process

secondary metabolic process [inference]

toxin metabolic process [inference]

mycotoxin metabolic process [inference]

aflatoxin metabolic process

hormone metabolic process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

retinoic acid metabolic process

xenobiotic metabolic process

xenobiotic catabolic process

toxin metabolic process [inference]

mycotoxin metabolic process [inference]

aflatoxin metabolic process

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound catabolic process [inference]

alkaloid catabolic process

cellular catabolic process [inference]

xenobiotic catabolic process

cellular nitrogen compound catabolic process [inference]

alkaloid catabolic process

cellular lipid metabolic process [inference]

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process [inference]

lipid modification [inference]

lipid hydroxylation

heterocycle metabolic process [inference]

organic heteropentacyclic compound metabolic process [inference]

aflatoxin metabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process

estrogen metabolic process

cellular lipid metabolic process [inference]

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process [inference]

lipid modification [inference]

lipid hydroxylation

small molecule metabolic process [inference]

alcohol metabolic process [inference]

primary alcohol metabolic process [inference]

retinol metabolic process

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

retinoic acid metabolic process

demethylation [inference]

oxidative demethylation

organic substance metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

retinoic acid metabolic process

lipid metabolic process [inference]

steroid metabolic process

estrogen metabolic process

cellular lipid metabolic process [inference]

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process [inference]

lipid modification [inference]

lipid hydroxylation

olefinic compound metabolic process [inference]

retinol metabolic process

organic cyclic compound metabolic process [inference]

steroid metabolic process

estrogen metabolic process

organic heteropentacyclic compound metabolic process [inference]

aflatoxin metabolic process

organonitrogen compound metabolic process [inference]

alkaloid metabolic process [inference]

alkaloid catabolic process

organonitrogen compound catabolic process [inference]

alkaloid catabolic process

organic substance catabolic process [inference]

organonitrogen compound catabolic process [inference]

alkaloid catabolic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

primary alcohol metabolic process [inference]

retinol metabolic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

retinoic acid metabolic process

xenobiotic metabolic process

xenobiotic catabolic process

toxin metabolic process [inference]

mycotoxin metabolic process [inference]

aflatoxin metabolic process

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound catabolic process [inference]

alkaloid catabolic process

cellular catabolic process [inference]

xenobiotic catabolic process

cellular nitrogen compound catabolic process [inference]

alkaloid catabolic process

cellular lipid metabolic process [inference]

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process [inference]

lipid modification [inference]

lipid hydroxylation

heterocycle metabolic process [inference]

organic heteropentacyclic compound metabolic process [inference]

aflatoxin metabolic process

biological regulation [inference]

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

Displaying **all 2** entries
GO Term	Evidence Code	PMID
intracellular membrane-bounded organelle		2732228
endoplasmic reticulum membrane

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle

intracellular organelle [inference]

intracellular membrane-bounded organelle

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
oxidoreductase activity	IDA	15039299
retinoic acid 4-hydroxylase activity	IDA	11093772
oxygen binding		2732228
monooxygenase activity	ISS TAS
iron ion binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity

monooxygenase activity

steroid hydroxylase activity [inference]

retinoic acid 4-hydroxylase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [inference]

aromatase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [inference]

retinoic acid 4-hydroxylase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [inference]

aromatase activity

estrogen 16-alpha-hydroxylase activity

binding [inference]

protein binding

small molecule binding [inference]

oxygen binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

iron ion binding

organic cyclic compound binding [inference]

tetrapyrrole binding [inference]

heme binding

Gene Ontology information from NCBI Gene and UniProt.

KEGG BRITE Database

Orthology

K17690

Name

cytochrome P450 family 3 subfamily A5 [EC:1.14.14.1]

References

Rhea

RHEA:17149

an organic molecule + O₂

H₂O + H⁺ + an alcohol

Enzyme

1.14.14.1

PMID

Disease

Disease Ontology

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DO ID	Disease Name	Source
DOID:0050387	nonpapillary renal cell carcinoma	DisGeNET
DOID:0050589	inflammatory bowel disease	DisGeNET
DOID:0050590	severe congenital neutropenia	DisGeNET
DOID:0050741	alcohol dependence	DisGeNET
DOID:0050742	nicotine dependence	DisGeNET
DOID:0050819	obsolete Matthew-Wood syndrome	DisGeNET
DOID:0050865	tongue squamous cell carcinoma	DisGeNET
DOID:0050902	medulloblastoma	DisGeNET DisGeNET DisGeNET
DOID:0050908	myelodysplastic syndrome	DisGeNET
DOID:0060224	atrial fibrillation	DisGeNET

The Human Phenotype Ontology

Displaying **all 4** entries
HPO ID	HPO Term
HP:0001426	Non-Mendelian inheritance
HP:0004421	Elevated systolic blood pressure
HP:0004972	Elevated mean arterial pressure
HP:0005117	Elevated diastolic blood pressure

Displaying 1 entry
Disease ID	Disease Name
OMIM:145500	essential hypertension, genetic

PubChem Disease

MedGen Diseases

Essential hypertension, genetic

OMIM Phenotypes

HYPERTENSION, ESSENTIAL

KEGG Diseases

High blood pressure

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP000454
Gene Name: cytochrome P450, family 3, subfamily A, polypeptide 5

Ortholog

Displaying entries **1 - 10** of **157** in total

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Species	Gene ID	Alliance of Genome Resources
Caenorhabditis elegans	174522	WB:WBGene00014254
Caenorhabditis elegans	181462	WB:WBGene00008519
Caenorhabditis elegans	184472	WB:WBGene00008809
Caenorhabditis elegans	184473	WB:WBGene00008810
Caenorhabditis elegans	187068	WB:WBGene00010606
Caenorhabditis elegans	188355	WB:WBGene00011671
Caenorhabditis elegans	188356	WB:WBGene00011672
Caenorhabditis elegans	188357	WB:WBGene00011673
Caenorhabditis elegans	188358	WB:WBGene00011674
Caenorhabditis elegans	188359	WB:WBGene00011675

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

KEGG BRITE Database

PubChem Disease

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements