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G protein-coupled receptor kinase 3

Summary

Gene Symbol

GRK3

Organism

Homo sapiens (human)

External Links

NCBI Gene

157

PubChem

157

Alliance of Genome Resources

HGNC:290

Annotation

Keyword

ATP-binding
Cell projection
Reference proteome
Serine/threonine-protein kinase
Synapse
Ubl conjugation

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q8N433
P35626	Beta-adrenergic receptor kinase 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
desensitization of G protein-coupled receptor signaling pathway	IBA
signal transduction	TAS	8427589
G protein-coupled receptor signaling pathway	TAS
G protein-coupled receptor signaling pathway	IBA
receptor internalization	IDA	20074556

GO Hierarchy

biological process

cellular process [inference]

signal transduction

G protein-coupled receptor signaling pathway

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor internalization

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor internalization

import into cell [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor internalization

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of G protein-coupled receptor signaling pathway [inference]

desensitization of G protein-coupled receptor signaling pathway

negative regulation of signal transduction [inference]

negative adaptation of signaling pathway [inference]

desensitization of G protein-coupled receptor signaling pathway

negative regulation of G protein-coupled receptor signaling pathway [inference]

desensitization of G protein-coupled receptor signaling pathway

adaptation of signaling pathway [inference]

negative adaptation of signaling pathway [inference]

desensitization of G protein-coupled receptor signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative adaptation of signaling pathway [inference]

desensitization of G protein-coupled receptor signaling pathway

negative regulation of G protein-coupled receptor signaling pathway [inference]

desensitization of G protein-coupled receptor signaling pathway

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative adaptation of signaling pathway [inference]

desensitization of G protein-coupled receptor signaling pathway

negative regulation of G protein-coupled receptor signaling pathway [inference]

desensitization of G protein-coupled receptor signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative adaptation of signaling pathway [inference]

desensitization of G protein-coupled receptor signaling pathway

negative regulation of G protein-coupled receptor signaling pathway [inference]

desensitization of G protein-coupled receptor signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative adaptation of signaling pathway [inference]

desensitization of G protein-coupled receptor signaling pathway

negative regulation of G protein-coupled receptor signaling pathway [inference]

desensitization of G protein-coupled receptor signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of G protein-coupled receptor signaling pathway [inference]

desensitization of G protein-coupled receptor signaling pathway

negative regulation of signal transduction [inference]

negative adaptation of signaling pathway [inference]

desensitization of G protein-coupled receptor signaling pathway

negative regulation of G protein-coupled receptor signaling pathway [inference]

desensitization of G protein-coupled receptor signaling pathway

adaptation of signaling pathway [inference]

negative adaptation of signaling pathway [inference]

desensitization of G protein-coupled receptor signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative adaptation of signaling pathway [inference]

desensitization of G protein-coupled receptor signaling pathway

negative regulation of G protein-coupled receptor signaling pathway [inference]

desensitization of G protein-coupled receptor signaling pathway

regulation of cellular process [inference]

signal transduction

G protein-coupled receptor signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of G protein-coupled receptor signaling pathway [inference]

desensitization of G protein-coupled receptor signaling pathway

negative regulation of signal transduction [inference]

negative adaptation of signaling pathway [inference]

desensitization of G protein-coupled receptor signaling pathway

negative regulation of G protein-coupled receptor signaling pathway [inference]

desensitization of G protein-coupled receptor signaling pathway

adaptation of signaling pathway [inference]

negative adaptation of signaling pathway [inference]

desensitization of G protein-coupled receptor signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative adaptation of signaling pathway [inference]

desensitization of G protein-coupled receptor signaling pathway

negative regulation of G protein-coupled receptor signaling pathway [inference]

desensitization of G protein-coupled receptor signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative adaptation of signaling pathway [inference]

desensitization of G protein-coupled receptor signaling pathway

negative regulation of G protein-coupled receptor signaling pathway [inference]

desensitization of G protein-coupled receptor signaling pathway

Displaying **all 5** entries
GO Term	Evidence Code	PMID
cytosol	TAS
plasma membrane	TAS
cell projection	IEA
presynapse	IEA
postsynapse	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytosol

membrane [inference]

plasma membrane

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
G protein-coupled receptor binding	IBA
protein kinase activity	TAS	8427589
G protein-coupled receptor kinase activity	IBA
protein binding	IPI	23455922 28514442 33961781
ATP binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

protein kinase activity

protein serine/threonine kinase activity [inference]

G protein-coupled receptor kinase activity

beta-adrenergic receptor kinase activity

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity

protein serine/threonine kinase activity [inference]

G protein-coupled receptor kinase activity

beta-adrenergic receptor kinase activity

catalytic activity, acting on a protein [inference]

protein kinase activity

protein serine/threonine kinase activity [inference]

G protein-coupled receptor kinase activity

beta-adrenergic receptor kinase activity

binding [inference]

protein binding

signaling receptor binding [inference]

G protein-coupled receptor binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

G protein-coupled receptor kinase

Functional Category

E: Amino acid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 7** entries
Gene Ontology
ATP binding
G protein-coupled receptor binding
desensitization of G protein-coupled receptor signaling pathway
kinase activity
nucleotide binding
phosphorylation
transferase activity

Displaying entries **1 - 10** of 11 in total

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InterPro
AGC-kinase, C-terminal
GPCR kinase
PH-like domain superfamily
Pleckstrin homology domain
Protein kinase domain
Protein kinase, ATP binding site
Protein kinase-like domain superfamily
RGS domain superfamily
RGS domain
RGS, subdomain 2

Ortholog

Displaying entries **11 - 20** of 62 in total

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Species	Gene ID	Orthologous MAtrix
Callithrix jacchus	100396838	CALJA19393
Pongo abelii	100454669	PONAB21659
Ailuropoda melanoleuca	100475417	AILME09195
Pan troglodytes	100614029	PANTR26215
Loxodonta africana	100666578	LOXAF05234
Oreochromis niloticus	100707869	ORENI70196
Cavia porcellus	100730505	CAVPO03006
Otolemur garnettii	100966357	OTOGA11845
Pan paniscus	100984800	PANPA23513
Papio anubis	101003424	PAPAN11309