cytochrome P450 family 7 subfamily A member 1

Summary
Gene Symbol
  • CYP7A1
Aliases
  • cholesterol 7 alpha-monooxygenase
  • cholesterol 7α-hydroxylase
Organism
Homo sapiens (human)
External Links
NCBI Gene
1581
HGNC
2651
KEGG Gene ID
hsa:1581
PubChem
1581
Alliance of Genome Resources
Annotation
Keyword
  • 3D-structure
  • Cholesterol metabolism
  • Heme
  • Microsome
  • Monooxygenase
  • Reference proteome
  • Transmembrane helix
Proteins
Displaying 1 entry
UniProt Protein Name
P22680
  • 24-hydroxycholesterol 7-alpha-hydroxylase
  • CYPVII
  • Cholesterol 7-alpha-hydroxylase
  • Cholesterol 7-alpha-monooxygenase
Gene Ontology (GO)
GO Hierarchy
GO Hierarchy
KEGG BRITE Database
Orthology
K00489
Name
cholesterol 7alpha-monooxygenase [EC:1.14.14.23]
References
Disease
Disease Ontology
Displaying entries 1 - 10 of 96 in total
DO ID Disease Name Source
DOID:0014667 disease of metabolism
DOID:0050629 Aicardi-Goutieres syndrome
DOID:0050674 congenital bile acid synthesis defect
DOID:0060262 gallbladder disease
DOID:0080199 colorectal carcinoma
DOID:0080547 metabolic dysfunction-associated steatohepatitis
DOID:0110741 type 1 diabetes mellitus 2
DOID:0110742 type 1 diabetes mellitus 3
DOID:0110743 type 1 diabetes mellitus 4
DOID:0110744 type 1 diabetes mellitus 5
The Human Phenotype Ontology
Displaying entries 1 - 10 of 15 in total
HPO ID HPO Term
HP:0001396 Cholestasis
HP:0001397 Hepatic steatosis
HP:0001403 Macrovesicular hepatic steatosis
HP:0001513 Obesity
HP:0001677 Coronary artery atherosclerosis
HP:0002155 Hypertriglyceridemia
HP:0003124 Hypercholesterolemia
HP:0003141 Increased LDL cholesterol concentration
HP:0004943 Accelerated atherosclerosis
HP:0006573 Acute hepatic steatosis
Displaying 1 entry
Disease ID Disease Name
ORPHA:209902
  • hypercholesterolemia due to cholesterol 7alpha-hydroxylase deficiency
LIPID MAPS Gene / Proteome Database
LMPD ID
LMP000667
Gene Name
cytochrome P450, family 7, subfamily A, polypeptide 1

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: August 19, 2024