GlyCosmos Portal

Annotation

Keyword

3D-structure
Alternative splicing
Congenital adrenal hyperplasia
Direct protein sequencing
Disease variant
Heme
Mitochondrion inner membrane
Monooxygenase
Reference proteome
Steroid biosynthesis
Steroidogenesis
Transit peptide

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q8TDD0
P15538	CYPXIB1 Cytochrome P-450c11 Steroid 11-beta-hydroxylase, CYP11B1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 10** of 13 in total

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GO Term	Evidence Code	PMID
glucocorticoid biosynthetic process	IBA TAS
cortisol biosynthetic process	IDA IMP	19342457 2022736 8506298
aldosterone biosynthetic process	IBA IDA IMP	19342457 2256920
glucose homeostasis		16114325
cellular response to hormone stimulus	IEP	19342457

GO Hierarchy

biological process

immune system process [inference]

immune response

metabolic process [inference]

biosynthetic process [inference]

hormone biosynthetic process [inference]

C21-steroid hormone biosynthetic process

aldosterone biosynthetic process

mineralocorticoid biosynthetic process [inference]

aldosterone biosynthetic process

cellular biosynthetic process [inference]

C21-steroid hormone biosynthetic process

aldosterone biosynthetic process

ketone biosynthetic process [inference]

aldehyde biosynthetic process [inference]

aldosterone biosynthetic process

small molecule biosynthetic process [inference]

ketone biosynthetic process [inference]

alcohol biosynthetic process [inference]

primary alcohol biosynthetic process [inference]

tertiary alcohol biosynthetic process [inference]

cortisol biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

steroid hormone biosynthetic process [inference]

C21-steroid hormone biosynthetic process

aldosterone biosynthetic process

glucocorticoid biosynthetic process

cortisol biosynthetic process

mineralocorticoid biosynthetic process [inference]

aldosterone biosynthetic process

ketone biosynthetic process [inference]

aldehyde biosynthetic process [inference]

aldosterone biosynthetic process

olefinic compound biosynthetic process [inference]

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

steroid hormone biosynthetic process [inference]

C21-steroid hormone biosynthetic process

aldosterone biosynthetic process

glucocorticoid biosynthetic process

cortisol biosynthetic process

mineralocorticoid biosynthetic process [inference]

aldosterone biosynthetic process

organic hydroxy compound biosynthetic process [inference]

alcohol biosynthetic process [inference]

primary alcohol biosynthetic process [inference]

tertiary alcohol biosynthetic process [inference]

cortisol biosynthetic process

hormone metabolic process [inference]

C21-steroid hormone metabolic process [inference]

C21-steroid hormone biosynthetic process

aldosterone biosynthetic process

aldosterone metabolic process [inference]

aldosterone biosynthetic process

mineralocorticoid metabolic process [inference]

mineralocorticoid biosynthetic process [inference]

aldosterone biosynthetic process

aldosterone metabolic process [inference]

aldosterone biosynthetic process

hormone biosynthetic process [inference]

C21-steroid hormone biosynthetic process

aldosterone biosynthetic process

mineralocorticoid biosynthetic process [inference]

aldosterone biosynthetic process

cellular metabolic process [inference]

cellular aldehyde metabolic process [inference]

aldosterone metabolic process [inference]

aldosterone biosynthetic process

aldehyde biosynthetic process [inference]

aldosterone biosynthetic process

cellular ketone metabolic process [inference]

aldosterone metabolic process [inference]

aldosterone biosynthetic process

cortisol metabolic process

cortisol biosynthetic process

ketone biosynthetic process [inference]

cellular biosynthetic process [inference]

C21-steroid hormone biosynthetic process

aldosterone biosynthetic process

ketone biosynthetic process [inference]

aldehyde biosynthetic process [inference]

aldosterone biosynthetic process

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process [inference]

steroid hormone biosynthetic process [inference]

C21-steroid hormone biosynthetic process

aldosterone biosynthetic process

glucocorticoid biosynthetic process

cortisol biosynthetic process

mineralocorticoid biosynthetic process [inference]

aldosterone biosynthetic process

C21-steroid hormone metabolic process [inference]

C21-steroid hormone biosynthetic process

aldosterone biosynthetic process

aldosterone metabolic process [inference]

aldosterone biosynthetic process

glucocorticoid metabolic process [inference]

glucocorticoid biosynthetic process

cortisol biosynthetic process

cortisol metabolic process

cortisol biosynthetic process

mineralocorticoid metabolic process [inference]

mineralocorticoid biosynthetic process [inference]

aldosterone biosynthetic process

aldosterone metabolic process [inference]

aldosterone biosynthetic process

sterol metabolic process

cholesterol metabolic process

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

steroid hormone biosynthetic process [inference]

C21-steroid hormone biosynthetic process

aldosterone biosynthetic process

glucocorticoid biosynthetic process

cortisol biosynthetic process

mineralocorticoid biosynthetic process [inference]

aldosterone biosynthetic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

primary alcohol metabolic process [inference]

aldosterone metabolic process [inference]

aldosterone biosynthetic process

primary alcohol biosynthetic process [inference]

cortisol metabolic process

cortisol biosynthetic process

alcohol biosynthetic process [inference]

primary alcohol biosynthetic process [inference]

tertiary alcohol biosynthetic process [inference]

cortisol biosynthetic process

tertiary alcohol metabolic process [inference]

cortisol metabolic process

cortisol biosynthetic process

tertiary alcohol biosynthetic process [inference]

cortisol biosynthetic process

secondary alcohol metabolic process [inference]

cholesterol metabolic process

cellular ketone metabolic process [inference]

aldosterone metabolic process [inference]

aldosterone biosynthetic process

cortisol metabolic process

cortisol biosynthetic process

ketone biosynthetic process [inference]

small molecule biosynthetic process [inference]

ketone biosynthetic process [inference]

alcohol biosynthetic process [inference]

primary alcohol biosynthetic process [inference]

tertiary alcohol biosynthetic process [inference]

cortisol biosynthetic process

organic substance metabolic process [inference]

cellular aldehyde metabolic process [inference]

aldosterone metabolic process [inference]

aldosterone biosynthetic process

aldehyde biosynthetic process [inference]

aldosterone biosynthetic process

lipid metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process [inference]

steroid hormone biosynthetic process [inference]

C21-steroid hormone biosynthetic process

aldosterone biosynthetic process

glucocorticoid biosynthetic process

cortisol biosynthetic process

mineralocorticoid biosynthetic process [inference]

aldosterone biosynthetic process

C21-steroid hormone metabolic process [inference]

C21-steroid hormone biosynthetic process

aldosterone biosynthetic process

aldosterone metabolic process [inference]

aldosterone biosynthetic process

glucocorticoid metabolic process [inference]

glucocorticoid biosynthetic process

cortisol biosynthetic process

cortisol metabolic process

cortisol biosynthetic process

mineralocorticoid metabolic process [inference]

mineralocorticoid biosynthetic process [inference]

aldosterone biosynthetic process

aldosterone metabolic process [inference]

aldosterone biosynthetic process

sterol metabolic process

cholesterol metabolic process

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

steroid hormone biosynthetic process [inference]

C21-steroid hormone biosynthetic process

aldosterone biosynthetic process

glucocorticoid biosynthetic process

cortisol biosynthetic process

mineralocorticoid biosynthetic process [inference]

aldosterone biosynthetic process

cellular ketone metabolic process [inference]

aldosterone metabolic process [inference]

aldosterone biosynthetic process

cortisol metabolic process

cortisol biosynthetic process

ketone biosynthetic process [inference]

olefinic compound metabolic process [inference]

aldosterone metabolic process [inference]

aldosterone biosynthetic process

cortisol metabolic process

cortisol biosynthetic process

olefinic compound biosynthetic process [inference]

organic cyclic compound metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process [inference]

steroid hormone biosynthetic process [inference]

C21-steroid hormone biosynthetic process

aldosterone biosynthetic process

glucocorticoid biosynthetic process

cortisol biosynthetic process

mineralocorticoid biosynthetic process [inference]

aldosterone biosynthetic process

C21-steroid hormone metabolic process [inference]

C21-steroid hormone biosynthetic process

aldosterone biosynthetic process

aldosterone metabolic process [inference]

aldosterone biosynthetic process

glucocorticoid metabolic process [inference]

glucocorticoid biosynthetic process

cortisol biosynthetic process

cortisol metabolic process

cortisol biosynthetic process

mineralocorticoid metabolic process [inference]

mineralocorticoid biosynthetic process [inference]

aldosterone biosynthetic process

aldosterone metabolic process [inference]

aldosterone biosynthetic process

sterol metabolic process

cholesterol metabolic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

steroid hormone biosynthetic process [inference]

C21-steroid hormone biosynthetic process

aldosterone biosynthetic process

glucocorticoid biosynthetic process

cortisol biosynthetic process

mineralocorticoid biosynthetic process [inference]

aldosterone biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

steroid hormone biosynthetic process [inference]

C21-steroid hormone biosynthetic process

aldosterone biosynthetic process

glucocorticoid biosynthetic process

cortisol biosynthetic process

mineralocorticoid biosynthetic process [inference]

aldosterone biosynthetic process

ketone biosynthetic process [inference]

aldehyde biosynthetic process [inference]

aldosterone biosynthetic process

olefinic compound biosynthetic process [inference]

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

steroid hormone biosynthetic process [inference]

C21-steroid hormone biosynthetic process

aldosterone biosynthetic process

glucocorticoid biosynthetic process

cortisol biosynthetic process

mineralocorticoid biosynthetic process [inference]

aldosterone biosynthetic process

organic hydroxy compound biosynthetic process [inference]

alcohol biosynthetic process [inference]

primary alcohol biosynthetic process [inference]

tertiary alcohol biosynthetic process [inference]

cortisol biosynthetic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

primary alcohol metabolic process [inference]

aldosterone metabolic process [inference]

aldosterone biosynthetic process

primary alcohol biosynthetic process [inference]

cortisol metabolic process

cortisol biosynthetic process

alcohol biosynthetic process [inference]

primary alcohol biosynthetic process [inference]

tertiary alcohol biosynthetic process [inference]

cortisol biosynthetic process

tertiary alcohol metabolic process [inference]

cortisol metabolic process

cortisol biosynthetic process

tertiary alcohol biosynthetic process [inference]

cortisol biosynthetic process

secondary alcohol metabolic process [inference]

cholesterol metabolic process

sterol metabolic process

cholesterol metabolic process

organic hydroxy compound biosynthetic process [inference]

alcohol biosynthetic process [inference]

primary alcohol biosynthetic process [inference]

tertiary alcohol biosynthetic process [inference]

cortisol biosynthetic process

cellular process [inference]

C21-steroid hormone metabolic process [inference]

C21-steroid hormone biosynthetic process

aldosterone biosynthetic process

aldosterone metabolic process [inference]

aldosterone biosynthetic process

mineralocorticoid metabolic process [inference]

mineralocorticoid biosynthetic process [inference]

aldosterone biosynthetic process

aldosterone metabolic process [inference]

aldosterone biosynthetic process

cellular metabolic process [inference]

cellular aldehyde metabolic process [inference]

aldosterone metabolic process [inference]

aldosterone biosynthetic process

aldehyde biosynthetic process [inference]

aldosterone biosynthetic process

cellular ketone metabolic process [inference]

aldosterone metabolic process [inference]

aldosterone biosynthetic process

cortisol metabolic process

cortisol biosynthetic process

ketone biosynthetic process [inference]

cellular biosynthetic process [inference]

C21-steroid hormone biosynthetic process

aldosterone biosynthetic process

ketone biosynthetic process [inference]

aldehyde biosynthetic process [inference]

aldosterone biosynthetic process

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to inorganic substance [inference]

cellular response to metal ion [inference]

cellular response to potassium ion

cellular response to organic substance [inference]

cellular response to hormone stimulus

cellular response to peptide hormone stimulus

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus

cellular response to oxygen-containing compound [inference]

cellular response to potassium ion

cellular response to peptide [inference]

cellular response to peptide hormone stimulus

cellular response to salt [inference]

cellular response to potassium ion

homeostatic process [inference]

chemical homeostasis [inference]

carbohydrate homeostasis [inference]

glucose homeostasis

response to stimulus [inference]

immune response

response to endogenous stimulus [inference]

response to hormone [inference]

cellular response to hormone stimulus

cellular response to peptide hormone stimulus

response to peptide hormone [inference]

cellular response to peptide hormone stimulus

cellular response to endogenous stimulus [inference]

cellular response to hormone stimulus

cellular response to peptide hormone stimulus

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus

response to chemical [inference]

response to organic substance [inference]

response to hormone [inference]

cellular response to hormone stimulus

cellular response to peptide hormone stimulus

response to peptide hormone [inference]

cellular response to peptide hormone stimulus

response to organonitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus

response to peptide [inference]

response to peptide hormone [inference]

cellular response to peptide hormone stimulus

cellular response to peptide [inference]

cellular response to peptide hormone stimulus

cellular response to organic substance [inference]

cellular response to hormone stimulus

cellular response to peptide hormone stimulus

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus

response to inorganic substance [inference]

response to metal ion [inference]

response to potassium ion [inference]

cellular response to potassium ion

cellular response to metal ion [inference]

cellular response to potassium ion

cellular response to inorganic substance [inference]

cellular response to metal ion [inference]

cellular response to potassium ion

cellular response to chemical stimulus [inference]

cellular response to inorganic substance [inference]

cellular response to metal ion [inference]

cellular response to potassium ion

cellular response to organic substance [inference]

cellular response to hormone stimulus

cellular response to peptide hormone stimulus

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus

cellular response to oxygen-containing compound [inference]

cellular response to potassium ion

cellular response to peptide [inference]

cellular response to peptide hormone stimulus

cellular response to salt [inference]

cellular response to potassium ion

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus

response to peptide [inference]

response to peptide hormone [inference]

cellular response to peptide hormone stimulus

cellular response to peptide [inference]

cellular response to peptide hormone stimulus

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus

response to oxygen-containing compound [inference]

response to potassium ion [inference]

cellular response to potassium ion

response to peptide [inference]

response to peptide hormone [inference]

cellular response to peptide hormone stimulus

cellular response to peptide [inference]

cellular response to peptide hormone stimulus

cellular response to oxygen-containing compound [inference]

cellular response to potassium ion

cellular response to peptide [inference]

cellular response to peptide hormone stimulus

response to salt [inference]

response to potassium ion [inference]

cellular response to potassium ion

cellular response to salt [inference]

cellular response to potassium ion

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to inorganic substance [inference]

cellular response to metal ion [inference]

cellular response to potassium ion

cellular response to organic substance [inference]

cellular response to hormone stimulus

cellular response to peptide hormone stimulus

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to peptide hormone stimulus

cellular response to oxygen-containing compound [inference]

cellular response to potassium ion

cellular response to peptide [inference]

cellular response to peptide hormone stimulus

cellular response to salt [inference]

cellular response to potassium ion

biological regulation [inference]

regulation of biological quality [inference]

regulation of blood pressure

regulation of hormone levels [inference]

hormone metabolic process [inference]

C21-steroid hormone metabolic process [inference]

C21-steroid hormone biosynthetic process

aldosterone biosynthetic process

aldosterone metabolic process [inference]

aldosterone biosynthetic process

mineralocorticoid metabolic process [inference]

mineralocorticoid biosynthetic process [inference]

aldosterone biosynthetic process

aldosterone metabolic process [inference]

aldosterone biosynthetic process

hormone biosynthetic process [inference]

C21-steroid hormone biosynthetic process

aldosterone biosynthetic process

mineralocorticoid biosynthetic process [inference]

aldosterone biosynthetic process

Displaying **all 2** entries
GO Term	Evidence Code	PMID
mitochondrial inner membrane	IBA IC TAS	15026188 8506298
mitochondrion	IDA	2256920

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

organelle inner membrane [inference]

mitochondrial inner membrane

mitochondrial membrane [inference]

mitochondrial inner membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying **all 4** entries
GO Term	Evidence Code	PMID
steroid 11-beta-monooxygenase activity	IBA IDA IMP TAS	2022736 2256920 8506298
corticosterone 18-monooxygenase activity	IBA
iron ion binding	IEA
heme binding	IC	2256920

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

monooxygenase activity [inference]

steroid hydroxylase activity [inference]

steroid 11-beta-monooxygenase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen [inference]

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

iron ion binding

organic cyclic compound binding [inference]

tetrapyrrole binding [inference]

heme binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000160882

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K00497

Name

steroid 11beta-monooxygenase [EC:1.14.15.4]

References

Rhea

RHEA:15629

H⁺ + O₂ + a steroid

H₂O + an 11β-hydroxysteroid

Enzyme

1.14.15.4

PMID

Disease

Disease Ontology

Displaying entries **11 - 20** of 76 in total

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DO ID	Disease Name	Source
DOID:10493	adrenal cortical hypofunction	DisGeNET DisGeNET
DOID:10591	pre-eclampsia	DisGeNET
DOID:10688	hypertrophy of breast	DisGeNET
DOID:10763	hypertension	DisGeNET DisGeNET Alliance of Genome Resources
DOID:10793	chronic sphenoidal sinusitis	DisGeNET
DOID:10825	essential hypertension	DisGeNET DisGeNET
DOID:11383	cryptorchidism	DisGeNET
DOID:114	heart disease	DisGeNET DisGeNET Alliance of Genome Resources
DOID:11476	osteoporosis	DisGeNET
DOID:11603	infant gynecomastia	DisGeNET

The Human Phenotype Ontology

Displaying entries **1 - 10** of 51 in total

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HPO ID	HPO Term
HP:0000006	Autosomal dominant inheritance
HP:0000007	Autosomal recessive inheritance
HP:0000013	Hypoplasia of the uterus
HP:0000040	Long penis
HP:0000061	Ambiguous genitalia, female
HP:0000062	Ambiguous genitalia
HP:0000079	Abnormality of the urinary system
HP:0000127	Renal salt wasting
HP:0000147	Polycystic ovaries
HP:0000360	Tinnitus

Displaying **all 4** entries
Disease ID	Disease Name
ORPHA:90795	congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency
OMIM:202010	congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency
OMIM:103900	glucocorticoid-remediable aldosteronism
ORPHA:403	glucocorticoid-remediable aldosteronism

PubChem Disease

GHR Health Conditions

MedGen Diseases

OMIM Phenotypes

KEGG Diseases

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP002086
Gene Name: cytochrome P450, family 11, subfamily B, polypeptide 1

Ortholog

Displaying entries **31 - 40** of 56 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	13072	MGI:88584	MOUSE15836
Mus musculus	110115	MGI:88583	MOUSE15834
Rattus norvegicus	24294	RGD:2454	RATNO39602
Rattus norvegicus	353498		RATNO39523
Rattus norvegicus	500892	RGD:2453	RATNO39523
Rattus norvegicus	120093683		RATNO39523
Bos indicus x Bos taurus	113904044		BOBOX30679
Bos indicus x Bos taurus	113904046		BOBOX30679
Microcebus murinus	105867373		MICMU03622
Microcebus murinus	105867374		MICMU03622

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

KEGG BRITE Database

PubChem Disease

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements