cytochrome P450 family 11 subfamily B member 2
| UniProt | Protein Name |
|---|---|
| P19099 |
|
| GO Term | Evidence Code | PMID |
|---|---|---|
| regulation of blood volume by renal aldosterone | ||
| renal water homeostasis | ||
| C21-steroid hormone biosynthetic process | ||
| glucocorticoid biosynthetic process | ||
| mineralocorticoid biosynthetic process |
| GO Term | Evidence Code | PMID |
|---|---|---|
| mitochondrion | ||
| mitochondrion | ||
| mitochondrial inner membrane | ||
| mitochondrial inner membrane | ||
| mitochondrial inner membrane |
| GO Term | Evidence Code | PMID |
|---|---|---|
| steroid 11-beta-monooxygenase activity | ||
| steroid 11-beta-monooxygenase activity | ||
| steroid 11-beta-monooxygenase activity | ||
| iron ion binding | ||
| steroid hydroxylase activity |
| InterPro |
|---|
| Cytochrome P450 superfamily |
| Cytochrome P450, E-class, group I |
| Cytochrome P450, conserved site |
| Cytochrome P450 |
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0080626 | corticosterone methyloxidase deficiency 1 | |
| DOID:0110429 | dilated cardiomyopathy 1H | |
| DOID:10591 | pre-eclampsia | |
| DOID:10763 | hypertension | |
| DOID:446 | primary hyperaldosteronism | |
| DOID:9351 | diabetes mellitus | |
| DOID:9352 | type 2 diabetes mellitus |
| HPO ID | HPO Term |
|---|---|
| HP:0000007 | Autosomal recessive inheritance |
| HP:0000127 | Renal salt wasting |
| HP:0000360 | Tinnitus |
| HP:0000421 | Epistaxis |
| HP:0000811 | Abnormal external genitalia |
| HP:0000822 | Hypertension |
| HP:0000848 | Increased circulating renin level |
| HP:0001278 | Orthostatic hypotension |
| HP:0001290 | Generalized hypotonia |
| HP:0001324 | Muscle weakness |
| Disease ID | Disease Name |
|---|---|
| ORPHA:403 |
|
| OMIM:610600 |
|
| ORPHA:556030 |
|
| OMIM:203400 |
|
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 1584 | ZFIN:ZDB-GENE-070828-1 | ||
| 1585 | ZFIN:ZDB-GENE-070828-1 | ||
| 13072 | MOUSE15836 | ||
| 24294 | RATNO39602 | ||
| 110115 | MOUSE15834 | ||
| 282422 | BOVIN05626 | ||
| 353498 | RATNO39523 | ||
| 482071 | CANLF03261 | ||
| 500892 | RATNO39523 | ||
| 695914 | MACMU43723 |
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Supported by JST NBDC Grant Number JPMJND2204
Partly supported by NIH Common Fund Grant #1U01GM125267-01
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Last updated: December 8, 2025