GlyCosmos Portal

Annotation

Keyword

3D-structure
Alternative splicing
Direct protein sequencing
Disease variant
Heme
Lipid metabolism
Microsome
Monooxygenase
Pseudohermaphroditism
Reference proteome
Transmembrane helix

Proteins

Displaying **all 5** entries
UniProt	Protein Name
A8K6W3	CYPXIX Cytochrome P-450AROM Cytochrome P450 19A1 Estrogen synthase
Q8IYG4	CYPXIX Cytochrome P-450AROM Cytochrome P450 19A1 Estrogen synthase
P11511	CYPXIX Cytochrome P-450AROM Cytochrome P450 19A1 Estrogen synthase
Q8TCA4
Q05CU4	CYPXIX Cytochrome P450 19A1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
negative regulation of chronic inflammatory response	IEA
steroid biosynthetic process	TAS	2848247
estrogen biosynthetic process	TAS
androgen catabolic process	IDA	26482249
syncytium formation	TAS	27791094

GO Hierarchy

biological process

metabolic process [inference]

catabolic process [inference]

hormone catabolic process [inference]

androgen catabolic process

organic substance catabolic process [inference]

lipid catabolic process [inference]

steroid catabolic process [inference]

androgen catabolic process

organic cyclic compound catabolic process [inference]

steroid catabolic process [inference]

androgen catabolic process

biosynthetic process [inference]

hormone biosynthetic process [inference]

estrogen biosynthetic process

cellular biosynthetic process [inference]

ketone biosynthetic process [inference]

testosterone biosynthetic process

small molecule biosynthetic process [inference]

ketone biosynthetic process [inference]

testosterone biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process

testosterone biosynthetic process

steroid hormone biosynthetic process [inference]

estrogen biosynthetic process

ketone biosynthetic process [inference]

testosterone biosynthetic process

olefinic compound biosynthetic process [inference]

testosterone biosynthetic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process

testosterone biosynthetic process

steroid hormone biosynthetic process [inference]

estrogen biosynthetic process

organic hydroxy compound biosynthetic process [inference]

testosterone biosynthetic process

hormone metabolic process [inference]

androgen metabolic process [inference]

androgen catabolic process

estrogen metabolic process [inference]

estrogen biosynthetic process

hormone biosynthetic process [inference]

estrogen biosynthetic process

hormone catabolic process [inference]

androgen catabolic process

cellular metabolic process [inference]

cellular ketone metabolic process [inference]

ketone biosynthetic process [inference]

testosterone biosynthetic process

cellular biosynthetic process [inference]

ketone biosynthetic process [inference]

testosterone biosynthetic process

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process

testosterone biosynthetic process

steroid hormone biosynthetic process [inference]

estrogen biosynthetic process

steroid catabolic process [inference]

androgen catabolic process

androgen metabolic process [inference]

androgen catabolic process

estrogen metabolic process [inference]

estrogen biosynthetic process

sterol metabolic process

lipid biosynthetic process [inference]

steroid biosynthetic process

testosterone biosynthetic process

steroid hormone biosynthetic process [inference]

estrogen biosynthetic process

lipid catabolic process [inference]

steroid catabolic process [inference]

androgen catabolic process

small molecule metabolic process [inference]

cellular ketone metabolic process [inference]

ketone biosynthetic process [inference]

testosterone biosynthetic process

small molecule biosynthetic process [inference]

ketone biosynthetic process [inference]

testosterone biosynthetic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process

testosterone biosynthetic process

steroid hormone biosynthetic process [inference]

estrogen biosynthetic process

steroid catabolic process [inference]

androgen catabolic process

androgen metabolic process [inference]

androgen catabolic process

estrogen metabolic process [inference]

estrogen biosynthetic process

sterol metabolic process

lipid biosynthetic process [inference]

steroid biosynthetic process

testosterone biosynthetic process

steroid hormone biosynthetic process [inference]

estrogen biosynthetic process

lipid catabolic process [inference]

steroid catabolic process [inference]

androgen catabolic process

cellular ketone metabolic process [inference]

ketone biosynthetic process [inference]

testosterone biosynthetic process

olefinic compound metabolic process [inference]

olefinic compound biosynthetic process [inference]

testosterone biosynthetic process

organic cyclic compound metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process

testosterone biosynthetic process

steroid hormone biosynthetic process [inference]

estrogen biosynthetic process

steroid catabolic process [inference]

androgen catabolic process

androgen metabolic process [inference]

androgen catabolic process

estrogen metabolic process [inference]

estrogen biosynthetic process

sterol metabolic process

organic cyclic compound catabolic process [inference]

steroid catabolic process [inference]

androgen catabolic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process

testosterone biosynthetic process

steroid hormone biosynthetic process [inference]

estrogen biosynthetic process

organic substance catabolic process [inference]

lipid catabolic process [inference]

steroid catabolic process [inference]

androgen catabolic process

organic cyclic compound catabolic process [inference]

steroid catabolic process [inference]

androgen catabolic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process

testosterone biosynthetic process

steroid hormone biosynthetic process [inference]

estrogen biosynthetic process

ketone biosynthetic process [inference]

testosterone biosynthetic process

olefinic compound biosynthetic process [inference]

testosterone biosynthetic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process

testosterone biosynthetic process

steroid hormone biosynthetic process [inference]

estrogen biosynthetic process

organic hydroxy compound biosynthetic process [inference]

testosterone biosynthetic process

organic hydroxy compound metabolic process [inference]

sterol metabolic process

organic hydroxy compound biosynthetic process [inference]

testosterone biosynthetic process

cellular process [inference]

syncytium formation

cellular metabolic process [inference]

cellular ketone metabolic process [inference]

ketone biosynthetic process [inference]

testosterone biosynthetic process

cellular biosynthetic process [inference]

ketone biosynthetic process [inference]

testosterone biosynthetic process

reproductive process [inference]

developmental process involved in reproduction [inference]

reproductive structure development [inference]

gonad development [inference]

female gonad development

genitalia development [inference]

female genitalia development

uterus development

prostate gland growth

multicellular organismal process [inference]

organ growth [inference]

prostate gland growth

developmental process [inference]

developmental process involved in reproduction [inference]

reproductive structure development [inference]

gonad development [inference]

female gonad development

genitalia development [inference]

female genitalia development

uterus development

prostate gland growth

anatomical structure formation involved in morphogenesis [inference]

syncytium formation

anatomical structure development [inference]

animal organ development [inference]

gonad development [inference]

female gonad development

gland development [inference]

mammary gland development

genitalia development [inference]

female genitalia development

uterus development

reproductive structure development [inference]

gonad development [inference]

female gonad development

genitalia development [inference]

female genitalia development

uterus development

growth [inference]

developmental growth [inference]

organ growth [inference]

prostate gland growth

response to stimulus [inference]

response to chemical [inference]

response to organic substance [inference]

response to organic cyclic compound [inference]

response to estradiol

response to lipid [inference]

response to estradiol

response to oxygen-containing compound [inference]

response to estradiol

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

negative regulation of immune system process [inference]

negative regulation of leukocyte migration [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of macrophage chemotaxis

negative regulation of macrophage migration [inference]

negative regulation of macrophage chemotaxis

regulation of leukocyte migration [inference]

negative regulation of leukocyte migration [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of macrophage chemotaxis

negative regulation of macrophage migration [inference]

negative regulation of macrophage chemotaxis

regulation of leukocyte chemotaxis [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of macrophage chemotaxis

regulation of macrophage chemotaxis [inference]

negative regulation of macrophage chemotaxis

regulation of macrophage migration [inference]

regulation of macrophage chemotaxis [inference]

negative regulation of macrophage chemotaxis

negative regulation of macrophage migration [inference]

negative regulation of macrophage chemotaxis

regulation of signaling [inference]

positive regulation of signaling [inference]

positive regulation of hormone secretion [inference]

positive regulation of steroid hormone secretion [inference]

positive regulation of estradiol secretion

regulation of hormone secretion [inference]

positive regulation of hormone secretion [inference]

positive regulation of steroid hormone secretion [inference]

positive regulation of estradiol secretion

regulation of steroid hormone secretion [inference]

positive regulation of steroid hormone secretion [inference]

positive regulation of estradiol secretion

regulation of estradiol secretion [inference]

positive regulation of estradiol secretion

regulation of localization [inference]

regulation of transport [inference]

regulation of lipid transport [inference]

positive regulation of lipid transport [inference]

positive regulation of steroid hormone secretion [inference]

positive regulation of estradiol secretion

regulation of steroid hormone secretion [inference]

positive regulation of steroid hormone secretion [inference]

positive regulation of estradiol secretion

regulation of estradiol secretion [inference]

positive regulation of estradiol secretion

regulation of secretion [inference]

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of hormone secretion [inference]

positive regulation of steroid hormone secretion [inference]

positive regulation of estradiol secretion

regulation of secretion by cell [inference]

regulation of hormone secretion [inference]

positive regulation of hormone secretion [inference]

positive regulation of steroid hormone secretion [inference]

positive regulation of estradiol secretion

regulation of steroid hormone secretion [inference]

positive regulation of steroid hormone secretion [inference]

positive regulation of estradiol secretion

regulation of estradiol secretion [inference]

positive regulation of estradiol secretion

positive regulation of secretion by cell [inference]

positive regulation of hormone secretion [inference]

positive regulation of steroid hormone secretion [inference]

positive regulation of estradiol secretion

positive regulation of transport [inference]

positive regulation of lipid transport [inference]

positive regulation of steroid hormone secretion [inference]

positive regulation of estradiol secretion

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of hormone secretion [inference]

positive regulation of steroid hormone secretion [inference]

positive regulation of estradiol secretion

regulation of lipid localization [inference]

regulation of lipid transport [inference]

positive regulation of lipid transport [inference]

positive regulation of steroid hormone secretion [inference]

positive regulation of estradiol secretion

regulation of steroid hormone secretion [inference]

positive regulation of steroid hormone secretion [inference]

positive regulation of estradiol secretion

regulation of estradiol secretion [inference]

positive regulation of estradiol secretion

positive regulation of lipid localization [inference]

positive regulation of lipid transport [inference]

positive regulation of steroid hormone secretion [inference]

positive regulation of estradiol secretion

regulation of locomotion [inference]

negative regulation of locomotion [inference]

negative regulation of chemotaxis [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of macrophage chemotaxis

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of leukocyte migration [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of macrophage chemotaxis

negative regulation of macrophage migration [inference]

negative regulation of macrophage chemotaxis

regulation of chemotaxis [inference]

regulation of leukocyte chemotaxis [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of macrophage chemotaxis

regulation of macrophage chemotaxis [inference]

negative regulation of macrophage chemotaxis

negative regulation of chemotaxis [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of macrophage chemotaxis

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of leukocyte migration [inference]

negative regulation of leukocyte migration [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of macrophage chemotaxis

negative regulation of macrophage migration [inference]

negative regulation of macrophage chemotaxis

regulation of leukocyte chemotaxis [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of macrophage chemotaxis

regulation of macrophage chemotaxis [inference]

negative regulation of macrophage chemotaxis

regulation of macrophage migration [inference]

regulation of macrophage chemotaxis [inference]

negative regulation of macrophage chemotaxis

negative regulation of macrophage migration [inference]

negative regulation of macrophage chemotaxis

negative regulation of cell migration [inference]

negative regulation of leukocyte migration [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of macrophage chemotaxis

negative regulation of macrophage migration [inference]

negative regulation of macrophage chemotaxis

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of leukocyte migration [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of macrophage chemotaxis

negative regulation of macrophage migration [inference]

negative regulation of macrophage chemotaxis

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of hormone secretion [inference]

positive regulation of steroid hormone secretion [inference]

positive regulation of estradiol secretion

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of hormone secretion [inference]

positive regulation of steroid hormone secretion [inference]

positive regulation of estradiol secretion

positive regulation of secretion by cell [inference]

positive regulation of hormone secretion [inference]

positive regulation of steroid hormone secretion [inference]

positive regulation of estradiol secretion

positive regulation of transport [inference]

positive regulation of lipid transport [inference]

positive regulation of steroid hormone secretion [inference]

positive regulation of estradiol secretion

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of hormone secretion [inference]

positive regulation of steroid hormone secretion [inference]

positive regulation of estradiol secretion

positive regulation of multicellular organismal process [inference]

positive regulation of steroid hormone secretion [inference]

positive regulation of estradiol secretion

positive regulation of lipid localization [inference]

positive regulation of lipid transport [inference]

positive regulation of steroid hormone secretion [inference]

positive regulation of estradiol secretion

negative regulation of biological process [inference]

negative regulation of immune system process [inference]

negative regulation of leukocyte migration [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of macrophage chemotaxis

negative regulation of macrophage migration [inference]

negative regulation of macrophage chemotaxis

negative regulation of locomotion [inference]

negative regulation of chemotaxis [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of macrophage chemotaxis

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of leukocyte migration [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of macrophage chemotaxis

negative regulation of macrophage migration [inference]

negative regulation of macrophage chemotaxis

negative regulation of cellular process [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of leukocyte migration [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of macrophage chemotaxis

negative regulation of macrophage migration [inference]

negative regulation of macrophage chemotaxis

negative regulation of response to stimulus [inference]

negative regulation of defense response [inference]

negative regulation of inflammatory response [inference]

negative regulation of chronic inflammatory response

negative regulation of response to external stimulus [inference]

negative regulation of inflammatory response [inference]

negative regulation of chronic inflammatory response

negative regulation of chemotaxis [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of macrophage chemotaxis

regulation of response to stimulus [inference]

regulation of response to external stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of inflammatory response [inference]

negative regulation of chronic inflammatory response

negative regulation of chemotaxis [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of macrophage chemotaxis

regulation of inflammatory response [inference]

regulation of chronic inflammatory response [inference]

negative regulation of chronic inflammatory response

negative regulation of inflammatory response [inference]

negative regulation of chronic inflammatory response

regulation of chemotaxis [inference]

regulation of leukocyte chemotaxis [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of macrophage chemotaxis

regulation of macrophage chemotaxis [inference]

negative regulation of macrophage chemotaxis

negative regulation of chemotaxis [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of macrophage chemotaxis

negative regulation of response to stimulus [inference]

negative regulation of defense response [inference]

negative regulation of inflammatory response [inference]

negative regulation of chronic inflammatory response

negative regulation of response to external stimulus [inference]

negative regulation of inflammatory response [inference]

negative regulation of chronic inflammatory response

negative regulation of chemotaxis [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of macrophage chemotaxis

regulation of response to stress [inference]

regulation of defense response [inference]

negative regulation of defense response [inference]

negative regulation of inflammatory response [inference]

negative regulation of chronic inflammatory response

regulation of inflammatory response [inference]

regulation of chronic inflammatory response [inference]

negative regulation of chronic inflammatory response

negative regulation of inflammatory response [inference]

negative regulation of chronic inflammatory response

regulation of cellular process [inference]

regulation of cell communication [inference]

positive regulation of cell communication [inference]

positive regulation of hormone secretion [inference]

positive regulation of steroid hormone secretion [inference]

positive regulation of estradiol secretion

regulation of hormone secretion [inference]

positive regulation of hormone secretion [inference]

positive regulation of steroid hormone secretion [inference]

positive regulation of estradiol secretion

regulation of steroid hormone secretion [inference]

positive regulation of steroid hormone secretion [inference]

positive regulation of estradiol secretion

regulation of estradiol secretion [inference]

positive regulation of estradiol secretion

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of hormone secretion [inference]

positive regulation of steroid hormone secretion [inference]

positive regulation of estradiol secretion

positive regulation of secretion by cell [inference]

positive regulation of hormone secretion [inference]

positive regulation of steroid hormone secretion [inference]

positive regulation of estradiol secretion

negative regulation of cellular process [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of leukocyte migration [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of macrophage chemotaxis

negative regulation of macrophage migration [inference]

negative regulation of macrophage chemotaxis

regulation of secretion by cell [inference]

regulation of hormone secretion [inference]

positive regulation of hormone secretion [inference]

positive regulation of steroid hormone secretion [inference]

positive regulation of estradiol secretion

regulation of steroid hormone secretion [inference]

positive regulation of steroid hormone secretion [inference]

positive regulation of estradiol secretion

regulation of estradiol secretion [inference]

positive regulation of estradiol secretion

positive regulation of secretion by cell [inference]

positive regulation of hormone secretion [inference]

positive regulation of steroid hormone secretion [inference]

positive regulation of estradiol secretion

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of leukocyte migration [inference]

negative regulation of leukocyte migration [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of macrophage chemotaxis

negative regulation of macrophage migration [inference]

negative regulation of macrophage chemotaxis

regulation of leukocyte chemotaxis [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of macrophage chemotaxis

regulation of macrophage chemotaxis [inference]

negative regulation of macrophage chemotaxis

regulation of macrophage migration [inference]

regulation of macrophage chemotaxis [inference]

negative regulation of macrophage chemotaxis

negative regulation of macrophage migration [inference]

negative regulation of macrophage chemotaxis

negative regulation of cell migration [inference]

negative regulation of leukocyte migration [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of macrophage chemotaxis

negative regulation of macrophage migration [inference]

negative regulation of macrophage chemotaxis

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of leukocyte migration [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of macrophage chemotaxis

negative regulation of macrophage migration [inference]

negative regulation of macrophage chemotaxis

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of endocrine process [inference]

regulation of steroid hormone secretion [inference]

positive regulation of steroid hormone secretion [inference]

positive regulation of estradiol secretion

regulation of estradiol secretion [inference]

positive regulation of estradiol secretion

positive regulation of multicellular organismal process [inference]

positive regulation of steroid hormone secretion [inference]

positive regulation of estradiol secretion

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

androgen metabolic process [inference]

androgen catabolic process

estrogen metabolic process [inference]

estrogen biosynthetic process

hormone biosynthetic process [inference]

estrogen biosynthetic process

hormone catabolic process [inference]

androgen catabolic process

regulation of hormone secretion [inference]

positive regulation of hormone secretion [inference]

positive regulation of steroid hormone secretion [inference]

positive regulation of estradiol secretion

regulation of steroid hormone secretion [inference]

positive regulation of steroid hormone secretion [inference]

positive regulation of estradiol secretion

regulation of estradiol secretion [inference]

positive regulation of estradiol secretion

Displaying **all 4** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum	IDA
endoplasmic reticulum	IBA
endoplasmic reticulum membrane	TAS
membrane	TAS	2848247

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
iron ion binding	IEA
steroid hydroxylase activity	TAS
electron transfer activity	TAS	2848247
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	TAS	1371509
oxygen binding	TAS	2848247

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

monooxygenase activity [inference]

steroid hydroxylase activity

estrogen 2-hydroxylase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

aromatase activity

electron transfer activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

aromatase activity

estrogen 2-hydroxylase activity

binding [inference]

small molecule binding [inference]

oxygen binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

iron ion binding

organic cyclic compound binding [inference]

tetrapyrrole binding [inference]

heme binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

cytochrome

Functional Category

C: Energy production and conversion
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
heme binding
iron ion binding
metal ion binding
monooxygenase activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
oxidoreductase activity

Displaying **all 4** entries
InterPro
Cytochrome P450 superfamily
Cytochrome P450, E-class, group I
Cytochrome P450, conserved site
Cytochrome P450

Human Protein Atlas

ENSG00000137869

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K07434

Name

aromatase [EC:1.14.14.14]

References

2973313

Rhea

RHEA:38195

O₂ + androst-4-ene-3,17-dione

H₂O + H⁺ + formate + estrone

Enzyme

1.14.14.14

PMID

RHEA:38191

O₂ + testosterone

H₂O + H⁺ + formate + 17β-estradiol

Enzyme

1.14.14.14

PMID

Disease

Disease Ontology

Displaying entries **1 - 10** of 12 in total

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DO ID	Disease Name	Source
DOID:0090122	aromatase excess syndrome	Alliance of Genome Resources
DOID:10652	Alzheimer's disease	Alliance of Genome Resources
DOID:11476	osteoporosis	Alliance of Genome Resources
DOID:11612	polycystic ovary syndrome	Alliance of Genome Resources
DOID:12577	urethral obstruction	Alliance of Genome Resources
DOID:1380	endometrial cancer	Alliance of Genome Resources
DOID:13948	bladder neck obstruction	Alliance of Genome Resources
DOID:14654	prostatitis	Alliance of Genome Resources
DOID:1612	breast cancer	Alliance of Genome Resources
DOID:2394	ovarian cancer	Alliance of Genome Resources

The Human Phenotype Ontology

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HPO ID	HPO Term
HP:0000006	Autosomal dominant inheritance
HP:0000007	Autosomal recessive inheritance
HP:0000028	Cryptorchidism
HP:0000061	Ambiguous genitalia, female
HP:0000098	Tall stature
HP:0000138	Ovarian cyst
HP:0000771	Gynecomastia
HP:0000786	Primary amenorrhea
HP:0000815	Hypergonadotropic hypogonadism
HP:0000855	Insulin resistance

Displaying **all 3** entries
Disease ID	Disease Name
OMIM:613546	aromatase deficiency
OMIM:139300	aromatase excess syndrome
ORPHA:91	aromatase deficiency

PubChem Disease

GHR Health Conditions

MedGen Diseases

OMIM Phenotypes

KEGG Diseases

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP001780
Gene Name: cytochrome P450, family 19, subfamily A, polypeptide 1

Ortholog

Displaying entries **1 - 10** of **109** in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	1588	Xenbase:XB-GENE-953895
Mus musculus	13075		MOUSE61102
Rattus norvegicus	25147		RATNO40638
Danio rerio	30390		DANRE13628
Bos taurus	281740		BOVIN01347
Sus scrofa	403331		PIGXX14322
Sus scrofa	403332		PIGXX14322
Sus scrofa	403333		PIGXX14322
Pan troglodytes	453433		PANTR10315
Canis lupus familiaris	494003		CANLF12514

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

KEGG BRITE Database

PubChem Disease

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements