GlyCosmos Portal

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iduronidase, alpha-L

Summary

Gene Symbol

Idua

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

15932

PubChem

15932

Alliance of Genome Resources

MGI:96418

Annotation

Keyword

Disulfide bond
Glycoprotein
Glycosidase
Lysosome
Proteomics identification
Reference proteome
Signal

Proteins

Displaying **all 3** entries
UniProt	Protein Name
Q3U1Z0
Q8BLF6
Q8BMG0

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 30 in total

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GO Term	Evidence Code	PMID
cell morphogenesis	IMP	9097952
carbohydrate metabolic process	IEA
glycosaminoglycan catabolic process	ISO
glycosaminoglycan catabolic process	IDA	16979922
glycosaminoglycan catabolic process	IMP	16979922 19751987 19834056 21873421 22580166

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan catabolic process

mucopolysaccharide metabolic process [inference]

heparin metabolic process [inference]

heparin catabolic process

dermatan sulfate metabolic process [inference]

dermatan sulfate catabolic process

protein metabolic process [inference]

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

proteoglycan catabolic process [inference]

heparan sulfate proteoglycan catabolic process

glycoprotein catabolic process [inference]

proteoglycan catabolic process [inference]

heparan sulfate proteoglycan catabolic process

protein catabolic process [inference]

glycoprotein catabolic process [inference]

proteoglycan catabolic process [inference]

heparan sulfate proteoglycan catabolic process

organonitrogen compound catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process

protein catabolic process [inference]

glycoprotein catabolic process [inference]

proteoglycan catabolic process [inference]

heparan sulfate proteoglycan catabolic process

catabolic process [inference]

cellular catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

dermatan sulfate catabolic process

sulfur compound catabolic process [inference]

small molecule catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

dermatan sulfate catabolic process

monosaccharide catabolic process [inference]

dermatan sulfate catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process

protein catabolic process [inference]

glycoprotein catabolic process [inference]

proteoglycan catabolic process [inference]

heparan sulfate proteoglycan catabolic process

carbohydrate catabolic process [inference]

monosaccharide catabolic process [inference]

dermatan sulfate catabolic process

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

dermatan sulfate catabolic process

carbohydrate derivative catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process

glycoprotein catabolic process [inference]

proteoglycan catabolic process [inference]

heparan sulfate proteoglycan catabolic process

amino disaccharide catabolic process [inference]

dermatan sulfate catabolic process

organonitrogen compound catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process

protein catabolic process [inference]

glycoprotein catabolic process [inference]

proteoglycan catabolic process [inference]

heparan sulfate proteoglycan catabolic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

dermatan sulfate catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

dermatan sulfate metabolic process [inference]

dermatan sulfate catabolic process

monocarboxylic acid catabolic process [inference]

dermatan sulfate catabolic process

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

dermatan sulfate catabolic process

sulfur compound metabolic process [inference]

heparin metabolic process [inference]

heparin catabolic process

dermatan sulfate metabolic process [inference]

dermatan sulfate catabolic process

sulfur compound catabolic process [inference]

cellular catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

dermatan sulfate catabolic process

sulfur compound catabolic process [inference]

primary metabolic process [inference]

carbohydrate metabolic process

monosaccharide metabolic process [inference]

dermatan sulfate metabolic process [inference]

dermatan sulfate catabolic process

monosaccharide catabolic process [inference]

dermatan sulfate catabolic process

carbohydrate catabolic process [inference]

monosaccharide catabolic process [inference]

dermatan sulfate catabolic process

protein metabolic process [inference]

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

proteoglycan catabolic process [inference]

heparan sulfate proteoglycan catabolic process

glycoprotein catabolic process [inference]

proteoglycan catabolic process [inference]

heparan sulfate proteoglycan catabolic process

protein catabolic process [inference]

glycoprotein catabolic process [inference]

proteoglycan catabolic process [inference]

heparan sulfate proteoglycan catabolic process

small molecule metabolic process [inference]

monosaccharide metabolic process [inference]

dermatan sulfate metabolic process [inference]

dermatan sulfate catabolic process

monosaccharide catabolic process [inference]

dermatan sulfate catabolic process

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

dermatan sulfate catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

dermatan sulfate metabolic process [inference]

dermatan sulfate catabolic process

monocarboxylic acid catabolic process [inference]

dermatan sulfate catabolic process

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

dermatan sulfate catabolic process

small molecule catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

dermatan sulfate catabolic process

monosaccharide catabolic process [inference]

dermatan sulfate catabolic process

organic substance metabolic process [inference]

carbohydrate metabolic process

monosaccharide metabolic process [inference]

dermatan sulfate metabolic process [inference]

dermatan sulfate catabolic process

monosaccharide catabolic process [inference]

dermatan sulfate catabolic process

carbohydrate catabolic process [inference]

monosaccharide catabolic process [inference]

dermatan sulfate catabolic process

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

dermatan sulfate catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

dermatan sulfate metabolic process [inference]

dermatan sulfate catabolic process

monocarboxylic acid catabolic process [inference]

dermatan sulfate catabolic process

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

dermatan sulfate catabolic process

macromolecule metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan catabolic process

mucopolysaccharide metabolic process [inference]

heparin metabolic process [inference]

heparin catabolic process

dermatan sulfate metabolic process [inference]

dermatan sulfate catabolic process

macromolecule catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process

protein catabolic process [inference]

glycoprotein catabolic process [inference]

proteoglycan catabolic process [inference]

heparan sulfate proteoglycan catabolic process

protein metabolic process [inference]

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

proteoglycan catabolic process [inference]

heparan sulfate proteoglycan catabolic process

glycoprotein catabolic process [inference]

proteoglycan catabolic process [inference]

heparan sulfate proteoglycan catabolic process

protein catabolic process [inference]

glycoprotein catabolic process [inference]

proteoglycan catabolic process [inference]

heparan sulfate proteoglycan catabolic process

carbohydrate derivative metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan catabolic process

mucopolysaccharide metabolic process [inference]

heparin metabolic process [inference]

heparin catabolic process

dermatan sulfate metabolic process [inference]

dermatan sulfate catabolic process

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

proteoglycan catabolic process [inference]

heparan sulfate proteoglycan catabolic process

glycoprotein catabolic process [inference]

proteoglycan catabolic process [inference]

heparan sulfate proteoglycan catabolic process

amino disaccharide metabolic process [inference]

dermatan sulfate metabolic process [inference]

dermatan sulfate catabolic process

amino disaccharide catabolic process [inference]

dermatan sulfate catabolic process

carbohydrate derivative catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process

glycoprotein catabolic process [inference]

proteoglycan catabolic process [inference]

heparan sulfate proteoglycan catabolic process

amino disaccharide catabolic process [inference]

dermatan sulfate catabolic process

organonitrogen compound metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan catabolic process

mucopolysaccharide metabolic process [inference]

heparin metabolic process [inference]

heparin catabolic process

dermatan sulfate metabolic process [inference]

dermatan sulfate catabolic process

protein metabolic process [inference]

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

proteoglycan catabolic process [inference]

heparan sulfate proteoglycan catabolic process

glycoprotein catabolic process [inference]

proteoglycan catabolic process [inference]

heparan sulfate proteoglycan catabolic process

protein catabolic process [inference]

glycoprotein catabolic process [inference]

proteoglycan catabolic process [inference]

heparan sulfate proteoglycan catabolic process

organonitrogen compound catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process

protein catabolic process [inference]

glycoprotein catabolic process [inference]

proteoglycan catabolic process [inference]

heparan sulfate proteoglycan catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process

protein catabolic process [inference]

glycoprotein catabolic process [inference]

proteoglycan catabolic process [inference]

heparan sulfate proteoglycan catabolic process

carbohydrate catabolic process [inference]

monosaccharide catabolic process [inference]

dermatan sulfate catabolic process

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

dermatan sulfate catabolic process

carbohydrate derivative catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process

glycoprotein catabolic process [inference]

proteoglycan catabolic process [inference]

heparan sulfate proteoglycan catabolic process

amino disaccharide catabolic process [inference]

dermatan sulfate catabolic process

organonitrogen compound catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process

protein catabolic process [inference]

glycoprotein catabolic process [inference]

proteoglycan catabolic process [inference]

heparan sulfate proteoglycan catabolic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

dermatan sulfate catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

dermatan sulfate metabolic process [inference]

dermatan sulfate catabolic process

monocarboxylic acid catabolic process [inference]

dermatan sulfate catabolic process

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

dermatan sulfate catabolic process

sulfur compound metabolic process [inference]

heparin metabolic process [inference]

heparin catabolic process

dermatan sulfate metabolic process [inference]

dermatan sulfate catabolic process

sulfur compound catabolic process [inference]

cellular catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

dermatan sulfate catabolic process

sulfur compound catabolic process [inference]

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

vacuole organization [inference]

lytic vacuole organization [inference]

lysosome organization

extracellular structure organization [inference]

extracellular matrix organization

external encapsulating structure organization [inference]

extracellular matrix organization

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

cognition [inference]

learning or memory [inference]

learning [inference]

associative learning [inference]

visual learning

memory

behavior [inference]

learning or memory [inference]

learning [inference]

associative learning [inference]

visual learning

memory

locomotory behavior

adult locomotory behavior

adult walking behavior

walking behavior [inference]

adult walking behavior

visual behavior [inference]

visual learning

adult behavior [inference]

adult locomotory behavior

adult walking behavior

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

cartilage homeostasis

developmental process [inference]

anatomical structure morphogenesis [inference]

cell morphogenesis

animal organ morphogenesis [inference]

skeletal system morphogenesis

appendage morphogenesis [inference]

limb morphogenesis

anatomical structure development [inference]

animal organ development [inference]

bone development

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

cartilage homeostasis

chemical homeostasis

response to stimulus [inference]

response to abiotic stimulus [inference]

response to radiation [inference]

response to light stimulus [inference]

visual behavior [inference]

visual learning

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of collagen catabolic process

positive regulation of collagen metabolic process [inference]

positive regulation of collagen catabolic process

regulation of catabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of collagen catabolic process

regulation of collagen catabolic process [inference]

positive regulation of collagen catabolic process

regulation of collagen metabolic process [inference]

regulation of collagen catabolic process [inference]

positive regulation of collagen catabolic process

positive regulation of collagen metabolic process [inference]

positive regulation of collagen catabolic process

regulation of localization [inference]

regulation of transport [inference]

regulation of secretion [inference]

negative regulation of secretion [inference]

negative regulation of secretion by cell [inference]

negative regulation of protein secretion [inference]

negative regulation of secretion of lysosomal enzymes

regulation of secretion by cell [inference]

regulation of protein secretion [inference]

negative regulation of protein secretion [inference]

negative regulation of secretion of lysosomal enzymes

regulation of secretion of lysosomal enzymes [inference]

negative regulation of secretion of lysosomal enzymes

negative regulation of secretion by cell [inference]

negative regulation of protein secretion [inference]

negative regulation of secretion of lysosomal enzymes

negative regulation of transport [inference]

negative regulation of secretion [inference]

negative regulation of secretion by cell [inference]

negative regulation of protein secretion [inference]

negative regulation of secretion of lysosomal enzymes

negative regulation of protein transport [inference]

negative regulation of protein secretion [inference]

negative regulation of secretion of lysosomal enzymes

regulation of protein transport [inference]

regulation of protein secretion [inference]

negative regulation of protein secretion [inference]

negative regulation of secretion of lysosomal enzymes

regulation of secretion of lysosomal enzymes [inference]

negative regulation of secretion of lysosomal enzymes

negative regulation of protein transport [inference]

negative regulation of protein secretion [inference]

negative regulation of secretion of lysosomal enzymes

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of protein secretion [inference]

negative regulation of protein secretion [inference]

negative regulation of secretion of lysosomal enzymes

regulation of secretion of lysosomal enzymes [inference]

negative regulation of secretion of lysosomal enzymes

negative regulation of protein transport [inference]

negative regulation of protein secretion [inference]

negative regulation of secretion of lysosomal enzymes

negative regulation of establishment of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of protein secretion [inference]

negative regulation of secretion of lysosomal enzymes

negative regulation of protein localization [inference]

negative regulation of establishment of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of protein secretion [inference]

negative regulation of secretion of lysosomal enzymes

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of collagen catabolic process

positive regulation of collagen metabolic process [inference]

positive regulation of collagen catabolic process

positive regulation of multicellular organismal process [inference]

positive regulation of bone resorption

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of secretion by cell [inference]

negative regulation of protein secretion [inference]

negative regulation of secretion of lysosomal enzymes

negative regulation of protein localization [inference]

negative regulation of establishment of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of protein secretion [inference]

negative regulation of secretion of lysosomal enzymes

negative regulation of transport [inference]

negative regulation of secretion [inference]

negative regulation of secretion by cell [inference]

negative regulation of protein secretion [inference]

negative regulation of secretion of lysosomal enzymes

negative regulation of protein transport [inference]

negative regulation of protein secretion [inference]

negative regulation of secretion of lysosomal enzymes

negative regulation of developmental process [inference]

negative regulation of cartilage development

negative regulation of multicellular organismal process [inference]

negative regulation of cartilage development

regulation of developmental process [inference]

negative regulation of developmental process [inference]

negative regulation of cartilage development

regulation of multicellular organismal development [inference]

regulation of cartilage development [inference]

negative regulation of cartilage development

regulation of cellular process [inference]

negative regulation of cellular process [inference]

negative regulation of secretion by cell [inference]

negative regulation of protein secretion [inference]

negative regulation of secretion of lysosomal enzymes

negative regulation of protein localization [inference]

negative regulation of establishment of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of protein secretion [inference]

negative regulation of secretion of lysosomal enzymes

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of protein secretion [inference]

negative regulation of protein secretion [inference]

negative regulation of secretion of lysosomal enzymes

regulation of secretion of lysosomal enzymes [inference]

negative regulation of secretion of lysosomal enzymes

negative regulation of protein transport [inference]

negative regulation of protein secretion [inference]

negative regulation of secretion of lysosomal enzymes

negative regulation of establishment of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of protein secretion [inference]

negative regulation of secretion of lysosomal enzymes

negative regulation of protein localization [inference]

negative regulation of establishment of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of protein secretion [inference]

negative regulation of secretion of lysosomal enzymes

regulation of secretion by cell [inference]

regulation of protein secretion [inference]

negative regulation of protein secretion [inference]

negative regulation of secretion of lysosomal enzymes

regulation of secretion of lysosomal enzymes [inference]

negative regulation of secretion of lysosomal enzymes

negative regulation of secretion by cell [inference]

negative regulation of protein secretion [inference]

negative regulation of secretion of lysosomal enzymes

regulation of multicellular organismal process [inference]

regulation of tissue remodeling [inference]

regulation of bone remodeling [inference]

regulation of bone resorption [inference]

positive regulation of bone resorption

positive regulation of multicellular organismal process [inference]

positive regulation of bone resorption

negative regulation of multicellular organismal process [inference]

negative regulation of cartilage development

regulation of multicellular organismal development [inference]

regulation of cartilage development [inference]

negative regulation of cartilage development

Displaying **all 3** entries
GO Term	Evidence Code	PMID
extracellular space	IDA	16979922
lysosome	IMP	19751987
lysosomal lumen	IMP	17101178 9660052

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular space

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

vacuolar lumen [inference]

lysosomal lumen

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

Displaying entries **1 - 5** of 7 in total

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2

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GO Term	Evidence Code	PMID
L-iduronidase activity	ISS
L-iduronidase activity	ISO
L-iduronidase activity	IDA	16979922 19751987 7698753
L-iduronidase activity	IMP	15979918 19751987 19834056 21873421
L-iduronidase activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on glycosyl bonds [inference]

hydrolase activity, hydrolyzing O-glycosyl compounds

L-iduronidase activity

binding [inference]

protein binding [inference]

signaling receptor binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Alpha-L-Iduronidase

Functional Category

G: Carbohydrate transport and metabolism
I: Lipid transport and metabolism
K: Transcription

Displaying **all 3** entries
Gene Ontology
L-iduronidase activity
hydrolase activity, acting on glycosyl bonds
hydrolase activity

Displaying **all 6** entries
InterPro
Alpha-L-iduronidase, C-terminal domain
Glycoside hydrolase superfamily
Glycoside hydrolase, family 39
Glycosyl hydrolases family 39, N-terminal catalytic domain
Glycosyl hydrolases family 39, active site
Immunoglobulin-like fold

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:10754	otitis media	Alliance of Genome Resources
DOID:12802	mucopolysaccharidosis I	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements