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alanyl-tRNA synthetase 1

Summary

Gene Symbol

AARS1

Organism

Homo sapiens (human)

External Links

NCBI Gene

PubChem

Alliance of Genome Resources

HGNC:20

Annotation

Keyword

3D-structure
ATP-binding
Acetylation
Alternative splicing
Aminoacyl-tRNA synthetase
Charcot-Marie-Tooth disease
Cytoplasm
Direct protein sequencing
Disease variant
Epilepsy
Metal-binding
Methylation
Neurodegeneration
Phosphoprotein
Protein biosynthesis
Reference proteome
Ubl conjugation
Zinc
tRNA-binding

Proteins

Displaying 1 entry
UniProt	Protein Name
P49588	Alanyl-tRNA synthetase Renal carcinoma antigen NY-REN-42

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
cerebellar Purkinje cell layer development	IEA
tRNA aminoacylation for protein translation	TAS
negative regulation of signal transduction by p53 class mediator	IDA	38653238
tRNA modification	ISS
aminoacyl-tRNA metabolism involved in translational fidelity	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

tRNA processing

tRNA modification

RNA modification [inference]

tRNA modification

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing

tRNA modification

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation

alanyl-tRNA aminoacylation

aminoacyl-tRNA metabolism involved in translational fidelity

ncRNA processing [inference]

tRNA processing

tRNA modification

organonitrogen compound metabolic process [inference]

amino acid metabolic process [inference]

amino acid activation [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation

alanyl-tRNA aminoacylation

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid activation [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation

alanyl-tRNA aminoacylation

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

tRNA processing

tRNA modification

RNA modification [inference]

tRNA modification

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing

tRNA modification

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation

alanyl-tRNA aminoacylation

aminoacyl-tRNA metabolism involved in translational fidelity

ncRNA processing [inference]

tRNA processing

tRNA modification

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

tRNA processing

tRNA modification

RNA modification [inference]

tRNA modification

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing

tRNA modification

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation

alanyl-tRNA aminoacylation

aminoacyl-tRNA metabolism involved in translational fidelity

ncRNA processing [inference]

tRNA processing

tRNA modification

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

tRNA processing

tRNA modification

RNA modification [inference]

tRNA modification

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing

tRNA modification

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation

alanyl-tRNA aminoacylation

aminoacyl-tRNA metabolism involved in translational fidelity

ncRNA processing [inference]

tRNA processing

tRNA modification

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

tRNA processing

tRNA modification

RNA modification [inference]

tRNA modification

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing

tRNA modification

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation

alanyl-tRNA aminoacylation

aminoacyl-tRNA metabolism involved in translational fidelity

ncRNA processing [inference]

tRNA processing

tRNA modification

amino acid metabolic process [inference]

amino acid activation [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation

alanyl-tRNA aminoacylation

small molecule metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid activation [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation

alanyl-tRNA aminoacylation

organic substance metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid activation [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation

alanyl-tRNA aminoacylation

macromolecule metabolic process [inference]

macromolecule modification [inference]

RNA modification [inference]

tRNA modification

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

tRNA processing

tRNA modification

RNA modification [inference]

tRNA modification

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing

tRNA modification

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation

alanyl-tRNA aminoacylation

aminoacyl-tRNA metabolism involved in translational fidelity

ncRNA processing [inference]

tRNA processing

tRNA modification

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

tRNA processing

tRNA modification

RNA modification [inference]

tRNA modification

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing

tRNA modification

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation

alanyl-tRNA aminoacylation

aminoacyl-tRNA metabolism involved in translational fidelity

ncRNA processing [inference]

tRNA processing

tRNA modification

organonitrogen compound metabolic process [inference]

amino acid metabolic process [inference]

amino acid activation [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation

alanyl-tRNA aminoacylation

cellular process [inference]

cell death [inference]

programmed cell death [inference]

apoptotic process [inference]

neuron apoptotic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid activation [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation

alanyl-tRNA aminoacylation

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

tRNA processing

tRNA modification

RNA modification [inference]

tRNA modification

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing

tRNA modification

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation

alanyl-tRNA aminoacylation

aminoacyl-tRNA metabolism involved in translational fidelity

ncRNA processing [inference]

tRNA processing

tRNA modification

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

tRNA processing

tRNA modification

RNA modification [inference]

tRNA modification

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing

tRNA modification

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation

alanyl-tRNA aminoacylation

aminoacyl-tRNA metabolism involved in translational fidelity

ncRNA processing [inference]

tRNA processing

tRNA modification

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

tRNA processing

tRNA modification

RNA modification [inference]

tRNA modification

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing

tRNA modification

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation

alanyl-tRNA aminoacylation

aminoacyl-tRNA metabolism involved in translational fidelity

ncRNA processing [inference]

tRNA processing

tRNA modification

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

neuromuscular process [inference]

neuromuscular process controlling balance

developmental process [inference]

anatomical structure development [inference]

cerebellar Purkinje cell layer development

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation [inference]

regulation of translational elongation [inference]

regulation of cytoplasmic translational elongation [inference]

regulation of cytoplasmic translational fidelity

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation [inference]

regulation of translational elongation [inference]

regulation of cytoplasmic translational elongation [inference]

regulation of cytoplasmic translational fidelity

regulation of nitrogen compound metabolic process [inference]

regulation of amide metabolic process [inference]

regulation of translation [inference]

regulation of translational elongation [inference]

regulation of cytoplasmic translational elongation [inference]

regulation of cytoplasmic translational fidelity

regulation of protein metabolic process [inference]

regulation of translation [inference]

regulation of translational elongation [inference]

regulation of cytoplasmic translational elongation [inference]

regulation of cytoplasmic translational fidelity

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation [inference]

regulation of translational elongation [inference]

regulation of cytoplasmic translational elongation [inference]

regulation of cytoplasmic translational fidelity

regulation of protein metabolic process [inference]

regulation of translation [inference]

regulation of translational elongation [inference]

regulation of cytoplasmic translational elongation [inference]

regulation of cytoplasmic translational fidelity

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of translation [inference]

regulation of translational elongation [inference]

regulation of cytoplasmic translational elongation [inference]

regulation of cytoplasmic translational fidelity

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of hippo signaling

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of signal transduction by p53 class mediator

regulation of intracellular signal transduction [inference]

regulation of hippo signaling [inference]

positive regulation of hippo signaling

regulation of signal transduction by p53 class mediator [inference]

negative regulation of signal transduction by p53 class mediator

negative regulation of intracellular signal transduction [inference]

negative regulation of signal transduction by p53 class mediator

positive regulation of intracellular signal transduction [inference]

positive regulation of hippo signaling

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of hippo signaling

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of signal transduction by p53 class mediator

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of hippo signaling

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of hippo signaling

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of hippo signaling

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of signal transduction by p53 class mediator

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of signal transduction by p53 class mediator

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of signal transduction by p53 class mediator

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of hippo signaling

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of signal transduction by p53 class mediator

regulation of intracellular signal transduction [inference]

regulation of hippo signaling [inference]

positive regulation of hippo signaling

regulation of signal transduction by p53 class mediator [inference]

negative regulation of signal transduction by p53 class mediator

negative regulation of intracellular signal transduction [inference]

negative regulation of signal transduction by p53 class mediator

positive regulation of intracellular signal transduction [inference]

positive regulation of hippo signaling

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of hippo signaling

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of signal transduction by p53 class mediator

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of hippo signaling

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of signal transduction by p53 class mediator

regulation of intracellular signal transduction [inference]

regulation of hippo signaling [inference]

positive regulation of hippo signaling

regulation of signal transduction by p53 class mediator [inference]

negative regulation of signal transduction by p53 class mediator

negative regulation of intracellular signal transduction [inference]

negative regulation of signal transduction by p53 class mediator

positive regulation of intracellular signal transduction [inference]

positive regulation of hippo signaling

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of hippo signaling

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of signal transduction by p53 class mediator

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation [inference]

regulation of translational elongation [inference]

regulation of cytoplasmic translational elongation [inference]

regulation of cytoplasmic translational fidelity

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process

regulation of neuron apoptotic process [inference]

negative regulation of neuron apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of hippo signaling

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of signal transduction by p53 class mediator

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process

regulation of biological quality [inference]

regulation of translational fidelity [inference]

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
membrane	HDA	19946888
mitochondrion	IBA
nucleus	IDA	38512451
cytosol	IDA TAS
cytoplasm	IDA	38512451

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
zinc ion binding	IEA
aminoacyl-tRNA editing activity	IBA IDA	28493438
tRNA binding	IEA
ATP binding	IEA
amino acid binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

carboxylic ester hydrolase activity [inference]

aminoacyl-tRNA editing activity

Ser-tRNA(Ala) hydrolase activity

ligase activity [inference]

ligase activity, forming carbon-oxygen bonds [inference]

aminoacyl-tRNA ligase activity [inference]

alanine-tRNA ligase activity

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on RNA [inference]

catalytic activity, acting on a tRNA [inference]

aminoacyl-tRNA editing activity

Ser-tRNA(Ala) hydrolase activity

aminoacyl-tRNA ligase activity [inference]

alanine-tRNA ligase activity

binding [inference]

small molecule binding [inference]

organic acid binding [inference]

carboxylic acid binding [inference]

amino acid binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

carboxylic acid binding [inference]

amino acid binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

RNA binding [inference]

tRNA binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

alanine--tRNA ligase

Functional Category

J: Translation, ribosomal structure and biogenesis
K: Transcription
L: Replication, recombination and repair
T: Signal transduction mechanisms

Displaying **all 9** entries
Gene Ontology
ATP binding
alanine-tRNA ligase activity
alanyl-tRNA aminoacylation
aminoacyl-tRNA editing activity
ligase activity
metal ion binding
nucleotide binding
tRNA aminoacylation
zinc ion binding

Displaying **all 10** entries
InterPro
Alanine-tRNA ligase, class IIc, anti-codon-binding domain superfamily
Alanine-tRNA ligase, class IIc
Alanine-tRNA ligase, eukaryota/bacteria
Alanyl-tRNA synthetase, class IIc, N-terminal
Alanyl-tRNA synthetase, class IIc, core domain
Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL)
DHHA1 domain
Threonyl/alanyl tRNA synthetase, SAD
Threonyl/alanyl tRNA synthetase, class II-like, putative editing domain superfamily
Translation protein, beta-barrel domain superfamily

Disease

Disease Ontology

Displaying **all 9** entries
DO ID	Disease Name	Source
DOID:0050753	cerebellar ataxia	Alliance of Genome Resources
DOID:0080451	developmental and epileptic encephalopathy 29	Alliance of Genome Resources
DOID:0110177	Charcot-Marie-Tooth disease axonal type 2N	Alliance of Genome Resources
DOID:0111866	trichothiodystrophy	Alliance of Genome Resources
DOID:10223	dermatomyositis	Alliance of Genome Resources
DOID:10579	leukodystrophy	Alliance of Genome Resources
DOID:10595	Charcot-Marie-Tooth disease	Alliance of Genome Resources
DOID:10907	microcephaly	Alliance of Genome Resources
DOID:7319	axonal neuropathy	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of **117** in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	34156		FB:FBgn0027094
Caenorhabditis elegans	171985		WB:WBGene00000197
Mus musculus	234734		MGI:2384560	MOUSE58265
Rattus norvegicus	292023		RGD:1304832	RATNO14584
Danio rerio	324940		ZFIN:ZDB-GENE-030131-3663	DANRE14337
Pan troglodytes	454210	9598_0:004190		PANTR12746
Canis lupus familiaris	479656			CANLF15958
Bos taurus	510933			BOVIN10123
Macaca mulatta	709492			MACMU27494
Saccharomyces cerevisiae S288C	854513		SGD:S000005862

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Summary

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements