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Guidelines

MIRAGE

insulin-like growth factor 2 receptor

Summary

Gene Symbol

Igf2r

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

16004

PubChem

16004

Alliance of Genome Resources

MGI:96435

Annotation

Keyword

Acetylation
Disulfide bond
Endosome
Glycoprotein
Golgi apparatus
Methylation
Palmitate
Phosphoprotein
Receptor
Reference proteome
Repeat
Signal
Transmembrane helix
Transport

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q07113	300 kDa mannose 6-phosphate receptor Insulin-like growth factor 2 receptor Insulin-like growth factor II receptor M6P/IGF2 receptor
Q8C6V9

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
liver development	ISO
liver development	IEA
lysosomal transport	IBA
lysosomal transport	IEA
G protein-coupled receptor signaling pathway	ISO

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

cellular localization [inference]

intracellular transport [inference]

vacuolar transport [inference]

lysosomal transport

reproductive process [inference]

developmental process involved in reproduction [inference]

spermatogenesis

multicellular organismal reproductive process [inference]

gamete generation [inference]

male gamete generation [inference]

spermatogenesis

multicellular organismal process [inference]

post-embryonic development

developmental process [inference]

developmental process involved in reproduction [inference]

spermatogenesis

anatomical structure development [inference]

regeneration [inference]

animal organ regeneration

animal organ development [inference]

animal organ regeneration

gland development [inference]

liver development

biological process involved in interspecies interaction between organisms [inference]

biological process involved in symbiotic interaction [inference]

biological process involved in interaction with symbiont [inference]

modulation by host of symbiont process [inference]

modulation by host of viral process [inference]

positive regulation by host of viral process

response to stimulus [inference]

response to chemical [inference]

response to organic substance [inference]

response to lipid [inference]

response to retinoic acid

response to tetrachloromethane

response to oxygen-containing compound [inference]

response to retinoic acid

localization [inference]

establishment of localization [inference]

transport [inference]

intracellular transport [inference]

vacuolar transport [inference]

lysosomal transport

establishment of localization in cell [inference]

intracellular transport [inference]

vacuolar transport [inference]

lysosomal transport

cellular localization [inference]

intracellular transport [inference]

vacuolar transport [inference]

lysosomal transport

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

regulation of programmed cell death [inference]

regulation of apoptotic process

positive regulation of apoptotic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

Displaying entries **1 - 5** of 29 in total

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GO Term	Evidence Code	PMID
Golgi membrane	IEA
extracellular space	ISO
extracellular space	IEA
nucleus	IDA	12729502
nuclear envelope lumen	IDA	12729502

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

membrane coat [inference]

clathrin coat

cellular anatomical entity [inference]

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane

bounding membrane of organelle [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

organelle envelope lumen [inference]

nuclear envelope lumen

organelle subcompartment [inference]

Golgi apparatus subcompartment [inference]

trans-Golgi network

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

Golgi-associated vesicle [inference]

trans-Golgi network transport vesicle

transport vesicle [inference]

trans-Golgi network transport vesicle

coated vesicle [inference]

clathrin-coated vesicle [inference]

trans-Golgi network transport vesicle

endocytic vesicle

intracellular membrane-bounded organelle

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

Golgi-associated vesicle [inference]

trans-Golgi network transport vesicle

transport vesicle [inference]

trans-Golgi network transport vesicle

coated vesicle [inference]

clathrin-coated vesicle [inference]

trans-Golgi network transport vesicle

endocytic vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

Golgi-associated vesicle [inference]

trans-Golgi network transport vesicle

transport vesicle [inference]

trans-Golgi network transport vesicle

coated vesicle [inference]

clathrin-coated vesicle [inference]

trans-Golgi network transport vesicle

endocytic vesicle

perinuclear region of cytoplasm

Displaying entries **1 - 5** of 20 in total

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GO Term	Evidence Code	PMID
G-protein alpha-subunit binding	ISO
G-protein alpha-subunit binding	IEA
retinoic acid binding	ISO
retinoic acid binding	IEA
protein binding	ISS

GO Hierarchy

molecular function

binding [inference]

protein binding

G-protein alpha-subunit binding

growth factor binding [inference]

insulin-like growth factor binding

insulin-like growth factor II binding

lipid binding [inference]

isoprenoid binding [inference]

retinoid binding [inference]

retinoic acid binding

carbohydrate binding [inference]

monosaccharide binding [inference]

mannose binding

small molecule binding [inference]

organic acid binding [inference]

carboxylic acid binding [inference]

monocarboxylic acid binding [inference]

retinoic acid binding

monosaccharide binding [inference]

mannose binding

ion binding [inference]

anion binding [inference]

carboxylic acid binding [inference]

monocarboxylic acid binding [inference]

retinoic acid binding

protein-containing complex binding [inference]

retromer complex binding

molecular transducer activity [inference]

signaling receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Cation-independent mannose-6-phosphate receptor

Functional Category

I: Lipid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
insulin-like growth factor binding
lysosomal transport
mannose binding

Displaying **all 3** entries
InterPro
Cation-independent mannose-6-phosphate receptor repeat
MRH domain
Mannose-6-phosphate receptor binding domain superfamily

Ortholog

Displaying entries **1 - 10** of 75 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	3482	Xenbase:XB-GENE-480957	HUMAN87261
Xenopus tropicalis	16004	Xenbase:XB-GENE-480957
Rattus norvegicus	25151		RATNO19274
Xenopus tropicalis	43223	Xenbase:XB-GENE-480957
Bos taurus	281849		BOVIN36075
Sus scrofa	397214		PIGXX13132
Ovis aries	443500		SHEEP18946
Pan troglodytes	463112		PANTR39434
Canis lupus familiaris	484067		CANLF00254
Danio rerio	557061		DANRE18855

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Partly supported by NIH Common Fund Grant #1U01GM125267-01

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GlyCosmos Portal v4.4.0

Last updated: December 8, 2025