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insulin-like growth factor binding protein 4

Summary

Gene Symbol

Igfbp4

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

16010

PubChem

16010

Alliance of Genome Resources

MGI:96439

Annotation

Keyword

Disulfide bond
Glycoprotein
Growth factor binding
Phosphoprotein
Reference proteome
Secreted
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
P47879

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
MAPK cascade	IGI	16675541
regulation of cell growth	IGI	16675541
regulation of glucose metabolic process	IGI	16675541
response to organic cyclic compound
regulation of growth	IGI	16675541

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

MAPK cascade

cell population proliferation [inference]

epithelial cell proliferation [inference]

type B pancreatic cell proliferation

response to stimulus [inference]

response to chemical [inference]

response to organic substance [inference]

response to organic cyclic compound

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of small molecule metabolic process [inference]

regulation of glucose metabolic process

regulation of primary metabolic process [inference]

regulation of carbohydrate metabolic process [inference]

regulation of glucose metabolic process

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of insulin-like growth factor receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of insulin-like growth factor receptor signaling pathway

positive regulation of insulin-like growth factor receptor signaling pathway

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of insulin-like growth factor receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of growth

regulation of cell growth

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of insulin-like growth factor receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of insulin-like growth factor receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of insulin-like growth factor receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of insulin-like growth factor receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of insulin-like growth factor receptor signaling pathway

positive regulation of insulin-like growth factor receptor signaling pathway

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of insulin-like growth factor receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

MAPK cascade

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of insulin-like growth factor receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of insulin-like growth factor receptor signaling pathway

positive regulation of insulin-like growth factor receptor signaling pathway

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of insulin-like growth factor receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of insulin-like growth factor receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of cellular component organization [inference]

regulation of cell growth

Displaying **all 3** entries
GO Term	Evidence Code	PMID
extracellular space	IDA	7510770 7679139
extracellular space	IBA
extracellular space	HDA	24006456

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular space

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein binding	IPI	18528331
insulin-like growth factor binding	IPI	7679139
insulin-like growth factor I binding	IBA
insulin-like growth factor II binding	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding

growth factor binding [inference]

insulin-like growth factor binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

insulin like growth factor binding protein 4

Functional Category

G: Carbohydrate transport and metabolism
L: Replication, recombination and repair
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
growth factor binding
insulin-like growth factor I binding
insulin-like growth factor II binding
insulin-like growth factor binding
regulation of insulin-like growth factor receptor signaling pathway

Displaying **all 6** entries
InterPro
Growth factor receptor cysteine-rich domain superfamily
Insulin-like growth factor-binding protein 4
Insulin-like growth factor-binding protein family 1-6, chordata
Insulin-like growth factor-binding protein, IGFBP
Thyroglobulin type-1 superfamily
Thyroglobulin type-1