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adaptor related protein complex 2 subunit alpha 1

Summary

Gene Symbol

AP2A1

Organism

Homo sapiens (human)

External Links

NCBI Gene

160

PubChem

160

Alliance of Genome Resources

HGNC:561

Annotation

Keyword

Alternative splicing
Cell membrane
Coated pit
Endocytosis
Phosphoprotein
Protein transport
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
O95782	100 kDa coated vesicle protein A Adaptor protein complex AP-2 subunit alpha-1 Adaptor-related protein complex 2 subunit alpha-1 Alpha-adaptin A Alpha1-adaptin Clathrin assembly protein complex 2 alpha-A large chain Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
endocytosis	NAS	12036598
positive regulation of neuron projection development	IEA
Golgi to endosome transport	NAS	12036598
postsynaptic neurotransmitter receptor internalization	NAS	31671891
vesicle-mediated transport	NAS	15941406

GO Hierarchy

biological process

cellular process [inference]

vesicle-mediated transport

endocytosis

receptor-mediated endocytosis [inference]

receptor internalization [inference]

neurotransmitter receptor internalization [inference]

postsynaptic neurotransmitter receptor internalization

clathrin-dependent endocytosis

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

postsynaptic endocytosis [inference]

postsynaptic neurotransmitter receptor internalization

Golgi vesicle transport [inference]

post-Golgi vesicle-mediated transport [inference]

Golgi to endosome transport

vesicle-mediated transport in synapse [inference]

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

postsynaptic endocytosis [inference]

postsynaptic neurotransmitter receptor internalization

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport

cytosolic transport [inference]

Golgi to endosome transport

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

localization [inference]

protein-containing complex localization [inference]

neurotransmitter receptor internalization [inference]

postsynaptic neurotransmitter receptor internalization

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

establishment of localization [inference]

transport [inference]

vesicle-mediated transport

endocytosis

receptor-mediated endocytosis [inference]

receptor internalization [inference]

neurotransmitter receptor internalization [inference]

postsynaptic neurotransmitter receptor internalization

clathrin-dependent endocytosis

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

postsynaptic endocytosis [inference]

postsynaptic neurotransmitter receptor internalization

Golgi vesicle transport [inference]

post-Golgi vesicle-mediated transport [inference]

Golgi to endosome transport

vesicle-mediated transport in synapse [inference]

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

postsynaptic endocytosis [inference]

postsynaptic neurotransmitter receptor internalization

intracellular transport [inference]

intracellular protein transport

cytosolic transport [inference]

Golgi to endosome transport

organic substance transport [inference]

protein transport [inference]

intracellular protein transport

nitrogen compound transport [inference]

protein transport [inference]

intracellular protein transport

import into cell [inference]

endocytosis

receptor-mediated endocytosis [inference]

receptor internalization [inference]

neurotransmitter receptor internalization [inference]

postsynaptic neurotransmitter receptor internalization

clathrin-dependent endocytosis

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

postsynaptic endocytosis [inference]

postsynaptic neurotransmitter receptor internalization

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular protein transport

cytosolic transport [inference]

Golgi to endosome transport

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

postsynaptic endocytosis [inference]

postsynaptic neurotransmitter receptor internalization

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport

cytosolic transport [inference]

Golgi to endosome transport

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of hyaluronan biosynthetic process

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of hyaluronan biosynthetic process

regulation of polysaccharide biosynthetic process [inference]

regulation of hyaluronan biosynthetic process [inference]

negative regulation of hyaluronan biosynthetic process

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of hyaluronan biosynthetic process

regulation of carbohydrate biosynthetic process [inference]

regulation of polysaccharide biosynthetic process [inference]

regulation of hyaluronan biosynthetic process [inference]

negative regulation of hyaluronan biosynthetic process

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of hyaluronan biosynthetic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of hyaluronan biosynthetic process

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of hyaluronan biosynthetic process

negative regulation of carbohydrate metabolic process [inference]

negative regulation of hyaluronan biosynthetic process

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of hyaluronan biosynthetic process

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of hyaluronan biosynthetic process

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of hyaluronan biosynthetic process

regulation of polysaccharide biosynthetic process [inference]

regulation of hyaluronan biosynthetic process [inference]

negative regulation of hyaluronan biosynthetic process

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of hyaluronan biosynthetic process

regulation of nitrogen compound metabolic process [inference]

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of hyaluronan biosynthetic process

regulation of hyaluronan biosynthetic process [inference]

negative regulation of hyaluronan biosynthetic process

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of hyaluronan biosynthetic process

regulation of polysaccharide biosynthetic process [inference]

regulation of hyaluronan biosynthetic process [inference]

negative regulation of hyaluronan biosynthetic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of hyaluronan biosynthetic process

regulation of polysaccharide metabolic process [inference]

regulation of polysaccharide biosynthetic process [inference]

regulation of hyaluronan biosynthetic process [inference]

negative regulation of hyaluronan biosynthetic process

regulation of primary metabolic process [inference]

regulation of carbohydrate metabolic process [inference]

regulation of polysaccharide metabolic process [inference]

regulation of polysaccharide biosynthetic process [inference]

regulation of hyaluronan biosynthetic process [inference]

negative regulation of hyaluronan biosynthetic process

regulation of carbohydrate biosynthetic process [inference]

regulation of polysaccharide biosynthetic process [inference]

regulation of hyaluronan biosynthetic process [inference]

negative regulation of hyaluronan biosynthetic process

negative regulation of carbohydrate metabolic process [inference]

negative regulation of hyaluronan biosynthetic process

regulation of localization [inference]

regulation of transport [inference]

positive regulation of transport [inference]

positive regulation of endocytosis [inference]

positive regulation of receptor-mediated endocytosis

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of receptor-mediated endocytosis

regulation of receptor-mediated endocytosis [inference]

positive regulation of receptor-mediated endocytosis

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development

positive regulation of endocytosis [inference]

positive regulation of receptor-mediated endocytosis

positive regulation of transport [inference]

positive regulation of endocytosis [inference]

positive regulation of receptor-mediated endocytosis

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of hyaluronan biosynthetic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of hyaluronan biosynthetic process

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of hyaluronan biosynthetic process

negative regulation of carbohydrate metabolic process [inference]

negative regulation of hyaluronan biosynthetic process

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of hyaluronan biosynthetic process

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of hyaluronan biosynthetic process

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of hyaluronan biosynthetic process

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of hyaluronan biosynthetic process

regulation of polysaccharide biosynthetic process [inference]

regulation of hyaluronan biosynthetic process [inference]

negative regulation of hyaluronan biosynthetic process

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of hyaluronan biosynthetic process

positive regulation of cellular process [inference]

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development

positive regulation of endocytosis [inference]

positive regulation of receptor-mediated endocytosis

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of hyaluronan biosynthetic process

regulation of cellular component organization [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of receptor-mediated endocytosis

regulation of receptor-mediated endocytosis [inference]

positive regulation of receptor-mediated endocytosis

regulation of cell projection organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development

regulation of plasma membrane bounded cell projection organization [inference]

regulation of neuron projection development [inference]

positive regulation of neuron projection development

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development

positive regulation of endocytosis [inference]

positive regulation of receptor-mediated endocytosis

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of receptor-mediated endocytosis

regulation of receptor-mediated endocytosis [inference]

positive regulation of receptor-mediated endocytosis

regulation of biological quality [inference]

regulation of postsynaptic membrane neurotransmitter receptor levels [inference]

postsynaptic neurotransmitter receptor internalization

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	PMID
membrane	HDA	19946888
filopodium tip	IEA
postsynapse
apical plasma membrane	IEA
endocytic vesicle membrane	TAS

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

membrane coat [inference]

clathrin coat [inference]

clathrin vesicle coat [inference]

clathrin coat of trans-Golgi network vesicle

vesicle coat [inference]

clathrin vesicle coat [inference]

clathrin coat of trans-Golgi network vesicle

AP-type membrane coat adaptor complex [inference]

clathrin adaptor complex [inference]

AP-2 adaptor complex

plasma membrane protein complex [inference]

AP-2 adaptor complex

cellular anatomical entity [inference]

cytosol

membrane

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane [inference]

endolysosome membrane

coated vesicle membrane [inference]

clathrin-coated vesicle membrane [inference]

clathrin-coated endocytic vesicle membrane

endocytic vesicle membrane

clathrin-coated endocytic vesicle membrane

bounding membrane of organelle [inference]

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane [inference]

endolysosome membrane

endosome membrane [inference]

endolysosome membrane

coated vesicle membrane [inference]

clathrin-coated vesicle membrane [inference]

clathrin-coated endocytic vesicle membrane

endocytic vesicle membrane

clathrin-coated endocytic vesicle membrane

plasma membrane region [inference]

cell junction [inference]

synapse [inference]

glutamatergic synapse

filopodium tip

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

coated vesicle [inference]

clathrin-coated vesicle [inference]

clathrin-coated endocytic vesicle

endocytic vesicle [inference]

clathrin-coated endocytic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

coated vesicle [inference]

clathrin-coated vesicle [inference]

clathrin-coated endocytic vesicle

endocytic vesicle [inference]

clathrin-coated endocytic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

coated vesicle [inference]

clathrin-coated vesicle [inference]

clathrin-coated endocytic vesicle

endocytic vesicle [inference]

clathrin-coated endocytic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

side of membrane [inference]

cytoplasmic side of membrane [inference]

cytoplasmic side of plasma membrane

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protein binding	IPI	16262731 19116314 22262466 23676497
low-density lipoprotein particle receptor binding	IPI	26005850
protein-containing complex binding	IEA
clathrin adaptor activity	IBA TAS	12121421
protein kinase binding	ISS

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding [inference]

lipoprotein particle receptor binding [inference]

low-density lipoprotein particle receptor binding

enzyme binding [inference]

kinase binding [inference]

protein kinase binding

protein-containing complex binding

molecular adaptor activity [inference]

protein-macromolecule adaptor activity [inference]

cargo adaptor activity [inference]

clathrin adaptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

ap-2 complex subunit alpha

Functional Category

O: Posttranslational modification, protein turnover, chaperones
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
clathrin adaptor activity
clathrin-dependent endocytosis

Displaying **all 9** entries
InterPro
Adaptor protein complex AP-2, alpha subunit
Armadillo-like helical
Armadillo-type fold
Clathrin adaptor, alpha-adaptin, appendage, C-terminal subdomain
Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain
Clathrin adaptor, appendage, Ig-like subdomain superfamily
Clathrin/coatomer adaptor, adaptin-like, N-terminal
Coatomer/calthrin adaptor appendage, C-terminal subdomain
TBP domain superfamily

Ortholog

Displaying entries **11 - 20** of 76 in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Pongo abelii	100448524	9601_0:0046c2	PONAB14788
Ailuropoda melanoleuca	100466326		AILME14136
Sus scrofa	100520250		PIGXX28288
Anolis carolinensis	100559796		ANOCA08685
Nomascus leucogenys	100587068		NOMLE02499
Oreochromis niloticus	100700052		ORENI54698
Cavia porcellus	100723156		CAVPO19290
Cricetulus griseus	100772481		CRIGR21153
Otolemur garnettii	100945537		OTOGA02103
Pan paniscus	100990247	9597_0:004e22	PANPA21080

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OrthoDB (Group)

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Acknowledgements