GlyCosmos Portal

Submissions

interleukin 16

Summary

Gene Symbol

Il16

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

16170

PubChem

16170

Alliance of Genome Resources

MGI:1270855

Annotation

Keyword

Alternative promoter usage
Chemotaxis
Cytokine
Cytoplasm
Nucleus
Phosphoprotein
Reference proteome
Repeat
Secreted
Transcription regulation

Proteins

Displaying 1 entry
UniProt	Protein Name
O54824

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 19 in total

1

2

3

4

Next ›

Last »
GO Term	Evidence Code	PMID
signal transduction	IEA
positive regulation of gene expression	IDA	30089723
cytokine-mediated signaling pathway	IDA	30089723
cytokine-mediated signaling pathway	IBA
leukocyte chemotaxis	IDA	9637508

GO Hierarchy

biological process

immune system process [inference]

leukocyte migration [inference]

leukocyte chemotaxis

cellular process [inference]

signal transduction

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway

cell motility [inference]

cell migration [inference]

leukocyte migration [inference]

leukocyte chemotaxis

cell chemotaxis [inference]

leukocyte chemotaxis

locomotion [inference]

taxis [inference]

chemotaxis [inference]

cell chemotaxis [inference]

leukocyte chemotaxis

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte activation [inference]

positive regulation of neutrophil activation

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of neutrophil activation

regulation of neutrophil activation [inference]

positive regulation of neutrophil activation

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of interleukin-1 production [inference]

positive regulation of interleukin-1 alpha production

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of interleukin-1 production [inference]

positive regulation of interleukin-1 alpha production

regulation of chemokine production [inference]

positive regulation of chemokine production

regulation of interleukin-1 production [inference]

regulation of interleukin-1 alpha production [inference]

positive regulation of interleukin-1 alpha production

positive regulation of interleukin-1 production [inference]

positive regulation of interleukin-1 alpha production

regulation of interleukin-12 production [inference]

positive regulation of interleukin-12 production

regulation of interleukin-6 production [inference]

positive regulation of interleukin-6 production

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of interleukin-1 production [inference]

positive regulation of interleukin-1 alpha production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of interleukin-1 production [inference]

positive regulation of interleukin-1 alpha production

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of interleukin-1 production [inference]

positive regulation of interleukin-1 alpha production

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of interleukin-1 production [inference]

positive regulation of interleukin-1 alpha production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of interleukin-1 production [inference]

positive regulation of interleukin-1 alpha production

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of interleukin-1 production [inference]

positive regulation of interleukin-1 alpha production

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of interleukin-1 production [inference]

positive regulation of interleukin-1 alpha production

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of interleukin-1 production [inference]

positive regulation of interleukin-1 alpha production

regulation of chemokine production [inference]

positive regulation of chemokine production

regulation of interleukin-1 production [inference]

regulation of interleukin-1 alpha production [inference]

positive regulation of interleukin-1 alpha production

positive regulation of interleukin-1 production [inference]

positive regulation of interleukin-1 alpha production

regulation of interleukin-12 production [inference]

positive regulation of interleukin-12 production

regulation of interleukin-6 production [inference]

positive regulation of interleukin-6 production

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of interleukin-1 production [inference]

positive regulation of interleukin-1 alpha production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of interleukin-1 production [inference]

positive regulation of interleukin-1 alpha production

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of interleukin-1 production [inference]

positive regulation of interleukin-1 alpha production

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of interleukin-1 production [inference]

positive regulation of interleukin-1 alpha production

regulation of chemokine production [inference]

positive regulation of chemokine production

regulation of interleukin-1 production [inference]

regulation of interleukin-1 alpha production [inference]

positive regulation of interleukin-1 alpha production

positive regulation of interleukin-1 production [inference]

positive regulation of interleukin-1 alpha production

regulation of interleukin-12 production [inference]

positive regulation of interleukin-12 production

regulation of interleukin-6 production [inference]

positive regulation of interleukin-6 production

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of interleukin-1 production [inference]

positive regulation of interleukin-1 alpha production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of interleukin-1 production [inference]

positive regulation of interleukin-1 alpha production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of interleukin-1 production [inference]

positive regulation of interleukin-1 alpha production

regulation of localization [inference]

regulation of transport [inference]

regulation of monoatomic ion transport [inference]

regulation of metal ion transport [inference]

regulation of calcium ion transport

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of chemotaxis [inference]

positive regulation of positive chemotaxis [inference]

induction of positive chemotaxis

regulation of chemotaxis [inference]

positive regulation of chemotaxis [inference]

positive regulation of positive chemotaxis [inference]

induction of positive chemotaxis

regulation of positive chemotaxis [inference]

positive regulation of positive chemotaxis [inference]

induction of positive chemotaxis

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte activation [inference]

positive regulation of neutrophil activation

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of interleukin-1 production [inference]

positive regulation of interleukin-1 alpha production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of interleukin-1 production [inference]

positive regulation of interleukin-1 alpha production

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of interleukin-1 production [inference]

positive regulation of interleukin-1 alpha production

positive regulation of locomotion [inference]

positive regulation of chemotaxis [inference]

positive regulation of positive chemotaxis [inference]

induction of positive chemotaxis

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of interleukin-1 production [inference]

positive regulation of interleukin-1 alpha production

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of neutrophil activation

positive regulation of response to stimulus [inference]

positive regulation of defense response [inference]

positive regulation of inflammatory response

positive regulation of response to external stimulus [inference]

positive regulation of inflammatory response

positive regulation of chemotaxis [inference]

positive regulation of positive chemotaxis [inference]

induction of positive chemotaxis

positive regulation of multicellular organismal process [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of interleukin-1 production [inference]

positive regulation of interleukin-1 alpha production

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of neutrophil activation

regulation of response to stimulus [inference]

regulation of response to external stimulus [inference]

positive regulation of response to external stimulus [inference]

positive regulation of inflammatory response

positive regulation of chemotaxis [inference]

positive regulation of positive chemotaxis [inference]

induction of positive chemotaxis

regulation of inflammatory response [inference]

positive regulation of inflammatory response

regulation of chemotaxis [inference]

positive regulation of chemotaxis [inference]

positive regulation of positive chemotaxis [inference]

induction of positive chemotaxis

regulation of positive chemotaxis [inference]

positive regulation of positive chemotaxis [inference]

induction of positive chemotaxis

positive regulation of response to stimulus [inference]

positive regulation of defense response [inference]

positive regulation of inflammatory response

positive regulation of response to external stimulus [inference]

positive regulation of inflammatory response

positive regulation of chemotaxis [inference]

positive regulation of positive chemotaxis [inference]

induction of positive chemotaxis

regulation of response to stress [inference]

regulation of defense response [inference]

positive regulation of defense response [inference]

positive regulation of inflammatory response

regulation of inflammatory response [inference]

positive regulation of inflammatory response

regulation of cellular process [inference]

signal transduction

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of interleukin-1 production [inference]

positive regulation of interleukin-1 alpha production

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of interleukin-1 production [inference]

positive regulation of interleukin-1 alpha production

regulation of chemokine production [inference]

positive regulation of chemokine production

regulation of interleukin-1 production [inference]

regulation of interleukin-1 alpha production [inference]

positive regulation of interleukin-1 alpha production

positive regulation of interleukin-1 production [inference]

positive regulation of interleukin-1 alpha production

regulation of interleukin-12 production [inference]

positive regulation of interleukin-12 production

regulation of interleukin-6 production [inference]

positive regulation of interleukin-6 production

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of interleukin-1 production [inference]

positive regulation of interleukin-1 alpha production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of interleukin-1 production [inference]

positive regulation of interleukin-1 alpha production

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of interleukin-1 production [inference]

positive regulation of interleukin-1 alpha production

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of interleukin-1 production [inference]

positive regulation of interleukin-1 alpha production

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of neutrophil activation

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of neutrophil activation

regulation of neutrophil activation [inference]

positive regulation of neutrophil activation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of neutrophil activation

regulation of multicellular organismal process [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of interleukin-1 production [inference]

positive regulation of interleukin-1 alpha production

regulation of chemokine production [inference]

positive regulation of chemokine production

regulation of interleukin-1 production [inference]

regulation of interleukin-1 alpha production [inference]

positive regulation of interleukin-1 alpha production

positive regulation of interleukin-1 production [inference]

positive regulation of interleukin-1 alpha production

regulation of interleukin-12 production [inference]

positive regulation of interleukin-12 production

regulation of interleukin-6 production [inference]

positive regulation of interleukin-6 production

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of neutrophil activation

regulation of neutrophil activation [inference]

positive regulation of neutrophil activation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of neutrophil activation

positive regulation of multicellular organismal process [inference]

positive regulation of cytokine production [inference]

positive regulation of chemokine production

positive regulation of interleukin-1 production [inference]

positive regulation of interleukin-1 alpha production

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of neutrophil activation

Displaying entries **1 - 5** of 13 in total

1

2

3

Next ›

Last »
GO Term	Evidence Code	PMID
extracellular space	IEA
intracellular anatomical structure	IDA	9598300
cytosol	ISO
cytosol	IEA
plasma membrane	ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

nuclear body [inference]

nuclear speck

cell junction [inference]

anchoring junction [inference]

cell-substrate junction [inference]

focal adhesion

external encapsulating structure [inference]

extracellular matrix [inference]

collagen-containing extracellular matrix

Flemming body

Displaying entries **1 - 5** of 6 in total

1

2

Next ›

Last »
GO Term	Evidence Code	PMID
cytokine activity	IDA	9637508
cytokine activity	IBA
protein binding	IPI	15102471 9637508
CD4 receptor binding	ISO
CD4 receptor binding	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding [inference]

CD4 receptor binding

receptor ligand activity [inference]

cytokine activity

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

cytokine activity

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

cytokine activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

pro-interleukin-16

Functional Category

J: Translation, ribosomal structure and biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
cytokine activity

Displaying **all 2** entries
InterPro
PDZ domain
PDZ superfamily

Ortholog

Displaying entries **1 - 10** of 61 in total

1

2

3

4

5

…

Next ›

Last »
Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	3603	Xenbase:XB-GENE-489722	HUMAN24708
Xenopus tropicalis	16170	Xenbase:XB-GENE-489722
Drosophila melanogaster	23037	FB:FBgn0087007
Drosophila melanogaster	68070	FB:FBgn0087007
Rattus norvegicus	116996		RATNO18594
Sus scrofa	396589		PIGXX31819
Pan troglodytes	449644		PANTR10975
Canis lupus familiaris	488762		CANLF12114
Felis catus	493882		FELCA13559
Macaca mulatta	574100		MACMU40782

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements