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interleukin 1 receptor, type II

Summary

Gene Symbol

Il1r2

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

16178

PubChem

16178

Alliance of Genome Resources

MGI:96546

Annotation

Keyword

Cell membrane
Disulfide bond
Glycoprotein
Immunoglobulin domain
Receptor
Reference proteome
Repeat
Secreted
Signal
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q4FK69
P27931	CD121 antigen-like family member B IL-1 type II receptor Interleukin-1 receptor beta Interleukin-1 receptor type II

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

1

2

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Last »
GO Term	Evidence Code	PMID
negative regulation of protein processing	IMP	23395675
negative regulation of cytokine production involved in inflammatory response	IMP	23395675
negative regulation of interleukin-1 alpha production	IMP	23395675
cell surface receptor signaling pathway	IBA
negative regulation of interleukin-1-mediated signaling pathway	IPI	23395675

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing

protein maturation [inference]

protein processing

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing

protein maturation [inference]

protein processing

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing

protein maturation [inference]

protein processing

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing

protein maturation [inference]

protein processing

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway

cytokine-mediated signaling pathway

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 alpha production

negative regulation of cytokine production involved in inflammatory response

negative regulation of protein maturation [inference]

negative regulation of protein processing

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 alpha production

negative regulation of cytokine production involved in inflammatory response

regulation of interleukin-1 production [inference]

regulation of interleukin-1 alpha production [inference]

negative regulation of interleukin-1 alpha production

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 alpha production

regulation of cytokine production involved in inflammatory response [inference]

negative regulation of cytokine production involved in inflammatory response

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 alpha production

negative regulation of cytokine production involved in inflammatory response

negative regulation of protein maturation [inference]

negative regulation of protein processing

regulation of protein maturation [inference]

regulation of protein processing [inference]

negative regulation of protein processing

negative regulation of protein maturation [inference]

negative regulation of protein processing

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 alpha production

negative regulation of cytokine production involved in inflammatory response

negative regulation of protein maturation [inference]

negative regulation of protein processing

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 alpha production

negative regulation of cytokine production involved in inflammatory response

negative regulation of protein maturation [inference]

negative regulation of protein processing

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 alpha production

negative regulation of cytokine production involved in inflammatory response

negative regulation of protein maturation [inference]

negative regulation of protein processing

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 alpha production

negative regulation of cytokine production involved in inflammatory response

negative regulation of protein maturation [inference]

negative regulation of protein processing

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of protein processing

negative regulation of protein maturation [inference]

negative regulation of protein processing

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 alpha production

negative regulation of cytokine production involved in inflammatory response

negative regulation of protein maturation [inference]

negative regulation of protein processing

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of protein processing

negative regulation of protein maturation [inference]

negative regulation of protein processing

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 alpha production

negative regulation of cytokine production involved in inflammatory response

negative regulation of protein maturation [inference]

negative regulation of protein processing

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 alpha production

negative regulation of cytokine production involved in inflammatory response

regulation of interleukin-1 production [inference]

regulation of interleukin-1 alpha production [inference]

negative regulation of interleukin-1 alpha production

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 alpha production

regulation of cytokine production involved in inflammatory response [inference]

negative regulation of cytokine production involved in inflammatory response

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 alpha production

negative regulation of cytokine production involved in inflammatory response

negative regulation of protein maturation [inference]

negative regulation of protein processing

regulation of protein maturation [inference]

regulation of protein processing [inference]

negative regulation of protein processing

negative regulation of protein maturation [inference]

negative regulation of protein processing

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 alpha production

negative regulation of cytokine production involved in inflammatory response

negative regulation of protein maturation [inference]

negative regulation of protein processing

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 alpha production

negative regulation of cytokine production involved in inflammatory response

negative regulation of protein maturation [inference]

negative regulation of protein processing

regulation of nitrogen compound metabolic process [inference]

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of protein processing

negative regulation of protein maturation [inference]

negative regulation of protein processing

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis [inference]

negative regulation of protein processing

regulation of protein processing [inference]

negative regulation of protein processing

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of protein processing

negative regulation of protein maturation [inference]

negative regulation of protein processing

regulation of protein maturation [inference]

regulation of protein processing [inference]

negative regulation of protein processing

negative regulation of protein maturation [inference]

negative regulation of protein processing

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 alpha production

negative regulation of cytokine production involved in inflammatory response

regulation of interleukin-1 production [inference]

regulation of interleukin-1 alpha production [inference]

negative regulation of interleukin-1 alpha production

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 alpha production

regulation of cytokine production involved in inflammatory response [inference]

negative regulation of cytokine production involved in inflammatory response

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 alpha production

negative regulation of cytokine production involved in inflammatory response

negative regulation of protein maturation [inference]

negative regulation of protein processing

regulation of protein maturation [inference]

regulation of protein processing [inference]

negative regulation of protein processing

negative regulation of protein maturation [inference]

negative regulation of protein processing

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 alpha production

negative regulation of cytokine production involved in inflammatory response

negative regulation of protein maturation [inference]

negative regulation of protein processing

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 alpha production

negative regulation of cytokine production involved in inflammatory response

negative regulation of protein maturation [inference]

negative regulation of protein processing

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of protein processing

negative regulation of protein maturation [inference]

negative regulation of protein processing

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis [inference]

negative regulation of protein processing

regulation of protein processing [inference]

negative regulation of protein processing

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of protein processing

negative regulation of protein maturation [inference]

negative regulation of protein processing

regulation of protein maturation [inference]

regulation of protein processing [inference]

negative regulation of protein processing

negative regulation of protein maturation [inference]

negative regulation of protein processing

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis [inference]

negative regulation of protein processing

regulation of protein processing [inference]

negative regulation of protein processing

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of protein processing

negative regulation of protein maturation [inference]

negative regulation of protein processing

regulation of protein maturation [inference]

regulation of protein processing [inference]

negative regulation of protein processing

negative regulation of protein maturation [inference]

negative regulation of protein processing

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of cytokine-mediated signaling pathway [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of interleukin-1-mediated signaling pathway

regulation of interleukin-1-mediated signaling pathway [inference]

negative regulation of interleukin-1-mediated signaling pathway

negative regulation of signal transduction [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of interleukin-1-mediated signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of interleukin-1-mediated signaling pathway

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 alpha production

negative regulation of cytokine production involved in inflammatory response

negative regulation of protein maturation [inference]

negative regulation of protein processing

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 alpha production

negative regulation of cytokine production involved in inflammatory response

negative regulation of protein maturation [inference]

negative regulation of protein processing

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of protein processing

negative regulation of protein maturation [inference]

negative regulation of protein processing

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 alpha production

negative regulation of cytokine production involved in inflammatory response

negative regulation of protein maturation [inference]

negative regulation of protein processing

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of protein processing

negative regulation of protein maturation [inference]

negative regulation of protein processing

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of interleukin-1-mediated signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of interleukin-1-mediated signaling pathway

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 alpha production

negative regulation of cytokine production involved in inflammatory response

negative regulation of protein maturation [inference]

negative regulation of protein processing

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of interleukin-1-mediated signaling pathway

negative regulation of response to cytokine stimulus [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of interleukin-1-mediated signaling pathway

negative regulation of multicellular organismal process [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 alpha production

negative regulation of cytokine production involved in inflammatory response

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of cytokine-mediated signaling pathway [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of interleukin-1-mediated signaling pathway

regulation of interleukin-1-mediated signaling pathway [inference]

negative regulation of interleukin-1-mediated signaling pathway

negative regulation of signal transduction [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of interleukin-1-mediated signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of interleukin-1-mediated signaling pathway

negative regulation of response to cytokine stimulus [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of interleukin-1-mediated signaling pathway

regulation of response to cytokine stimulus [inference]

regulation of cytokine-mediated signaling pathway [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of interleukin-1-mediated signaling pathway

regulation of interleukin-1-mediated signaling pathway [inference]

negative regulation of interleukin-1-mediated signaling pathway

negative regulation of response to cytokine stimulus [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of interleukin-1-mediated signaling pathway

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway

cytokine-mediated signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of cytokine-mediated signaling pathway [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of interleukin-1-mediated signaling pathway

regulation of interleukin-1-mediated signaling pathway [inference]

negative regulation of interleukin-1-mediated signaling pathway

negative regulation of signal transduction [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of interleukin-1-mediated signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of interleukin-1-mediated signaling pathway

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 alpha production

negative regulation of cytokine production involved in inflammatory response

negative regulation of protein maturation [inference]

negative regulation of protein processing

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 alpha production

negative regulation of cytokine production involved in inflammatory response

regulation of interleukin-1 production [inference]

regulation of interleukin-1 alpha production [inference]

negative regulation of interleukin-1 alpha production

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 alpha production

regulation of cytokine production involved in inflammatory response [inference]

negative regulation of cytokine production involved in inflammatory response

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 alpha production

negative regulation of cytokine production involved in inflammatory response

negative regulation of protein maturation [inference]

negative regulation of protein processing

regulation of protein maturation [inference]

regulation of protein processing [inference]

negative regulation of protein processing

negative regulation of protein maturation [inference]

negative regulation of protein processing

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 alpha production

negative regulation of cytokine production involved in inflammatory response

negative regulation of protein maturation [inference]

negative regulation of protein processing

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 alpha production

negative regulation of cytokine production involved in inflammatory response

negative regulation of protein maturation [inference]

negative regulation of protein processing

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of interleukin-1-mediated signaling pathway

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 alpha production

negative regulation of cytokine production involved in inflammatory response

negative regulation of protein maturation [inference]

negative regulation of protein processing

regulation of multicellular organismal process [inference]

regulation of cytokine production [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 alpha production

negative regulation of cytokine production involved in inflammatory response

regulation of interleukin-1 production [inference]

regulation of interleukin-1 alpha production [inference]

negative regulation of interleukin-1 alpha production

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 alpha production

regulation of cytokine production involved in inflammatory response [inference]

negative regulation of cytokine production involved in inflammatory response

negative regulation of multicellular organismal process [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-1 production [inference]

negative regulation of interleukin-1 alpha production

negative regulation of cytokine production involved in inflammatory response

Displaying **all 4** entries
GO Term	Evidence Code	PMID
plasma membrane	IBA IEA
extracellular region	IEA
cell surface	IBA
cytoplasm	IDA	23395675

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

Displaying **all 3** entries
GO Term	Evidence Code	PMID
interleukin-1, type II, blocking receptor activity	IEA
interleukin-1 binding	IPI	23395675
interleukin-1 receptor activity	IBA IPI	23395675

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

growth factor binding [inference]

interleukin-1 binding

cytokine binding [inference]

interleukin-1 binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

cytokine receptor activity [inference]

interleukin-1 receptor activity

interleukin-1, type II, blocking receptor activity

immune receptor activity [inference]

cytokine receptor activity [inference]

interleukin-1 receptor activity

interleukin-1, type II, blocking receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

interleukin-1 receptor type 2

Functional Category

J: Translation, ribosomal structure and biogenesis
K: Transcription
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
cytokine-mediated signaling pathway
interleukin-1 binding
interleukin-1 receptor activity

Displaying **all 8** entries
InterPro
Immunoglobulin subtype
Immunoglobulin-like domain superfamily
Immunoglobulin-like domain
Immunoglobulin-like fold
Immunoglobulin
Interleukin-1 receptor family
Interleukin-1 receptor type I/II
Interleukin-1 receptor type II

Disease

Disease Ontology

Displaying **all 6** entries
DO ID	Disease Name	Source
DOID:0050686	organ system cancer	Alliance of Genome Resources
DOID:1324	lung cancer	Alliance of Genome Resources
DOID:1474	aggressive periodontitis	Alliance of Genome Resources
DOID:3910	lung adenocarcinoma	Alliance of Genome Resources
DOID:4947	cholangiocarcinoma	Alliance of Genome Resources
DOID:5041	esophageal cancer	Alliance of Genome Resources

Ortholog

Displaying entries **101 - 104** of **104** in total

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Species	Gene ID	OrthoDB
Peromyscus californicus insignis	128114790	564181_0:00194e
Psammomys obesus	129677554	48139_1:000271
Chionomys nivalis	130862231	269649_0:00458c
Peromyscus eremicus	131893692	42410_0:0040ed

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements