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adaptor related protein complex 2 subunit alpha 2

Summary

Gene Symbol

AP2A2

Organism

Homo sapiens (human)

External Links

NCBI Gene

161

PubChem

161

Alliance of Genome Resources

HGNC:562

Annotation

Keyword

Alternative splicing
Cell membrane
Coated pit
Endocytosis
Lipid-binding
Protein transport
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
O94973	100 kDa coated vesicle protein C Adaptor protein complex AP-2 subunit alpha-2 Adaptor-related protein complex 2 subunit alpha-2 Alpha-adaptin C Alpha2-adaptin Clathrin assembly protein complex 2 alpha-C large chain Huntingtin yeast partner J Huntingtin-interacting protein 9 Huntingtin-interacting protein J Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
postsynaptic neurotransmitter receptor internalization	NAS	31671891
vesicle-mediated transport	NAS	15941406
intracellular protein transport	IEA
clathrin-dependent endocytosis	IBA IDA IMP NAS TAS	12121421 22262466 23676497 29184887
synaptic vesicle endocytosis	IEA

GO Hierarchy

biological process

cellular process [inference]

vesicle-mediated transport

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor internalization [inference]

neurotransmitter receptor internalization [inference]

postsynaptic neurotransmitter receptor internalization

clathrin-dependent endocytosis

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

postsynaptic endocytosis [inference]

postsynaptic neurotransmitter receptor internalization

vesicle-mediated transport in synapse [inference]

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

postsynaptic endocytosis [inference]

postsynaptic neurotransmitter receptor internalization

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

localization [inference]

protein-containing complex localization [inference]

neurotransmitter receptor internalization [inference]

postsynaptic neurotransmitter receptor internalization

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

establishment of localization [inference]

transport [inference]

vesicle-mediated transport

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor internalization [inference]

neurotransmitter receptor internalization [inference]

postsynaptic neurotransmitter receptor internalization

clathrin-dependent endocytosis

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

postsynaptic endocytosis [inference]

postsynaptic neurotransmitter receptor internalization

vesicle-mediated transport in synapse [inference]

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

postsynaptic endocytosis [inference]

postsynaptic neurotransmitter receptor internalization

intracellular transport [inference]

intracellular protein transport

organic substance transport [inference]

protein transport [inference]

intracellular protein transport

nitrogen compound transport [inference]

protein transport [inference]

intracellular protein transport

import into cell [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor internalization [inference]

neurotransmitter receptor internalization [inference]

postsynaptic neurotransmitter receptor internalization

clathrin-dependent endocytosis

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

postsynaptic endocytosis [inference]

postsynaptic neurotransmitter receptor internalization

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular protein transport

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

postsynaptic endocytosis [inference]

postsynaptic neurotransmitter receptor internalization

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

biological regulation [inference]

regulation of biological quality [inference]

regulation of postsynaptic membrane neurotransmitter receptor levels [inference]

postsynaptic neurotransmitter receptor internalization

Displaying entries **6 - 10** of 13 in total

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GO Term	Evidence Code	PMID
endocytic vesicle membrane	TAS
plasma membrane	TAS
cytoplasmic side of plasma membrane	NAS	29184887
AP-2 adaptor complex	IBA IDA NAS TAS	12086608 12121421 23676497
clathrin-coated endocytic vesicle membrane	TAS

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

AP-type membrane coat adaptor complex [inference]

clathrin adaptor complex [inference]

AP-2 adaptor complex

plasma membrane protein complex [inference]

AP-2 adaptor complex

cellular anatomical entity [inference]

cytosol

membrane [inference]

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane [inference]

endolysosome membrane

coated vesicle membrane [inference]

clathrin-coated vesicle membrane [inference]

clathrin-coated endocytic vesicle membrane

endocytic vesicle membrane

clathrin-coated endocytic vesicle membrane

secretory granule membrane

ficolin-1-rich granule membrane

bounding membrane of organelle [inference]

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane [inference]

endolysosome membrane

endosome membrane [inference]

endolysosome membrane

coated vesicle membrane [inference]

clathrin-coated vesicle membrane [inference]

clathrin-coated endocytic vesicle membrane

endocytic vesicle membrane

clathrin-coated endocytic vesicle membrane

secretory granule membrane

ficolin-1-rich granule membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

coated vesicle [inference]

clathrin-coated vesicle [inference]

clathrin-coated endocytic vesicle

endocytic vesicle [inference]

clathrin-coated endocytic vesicle

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

coated vesicle [inference]

clathrin-coated vesicle [inference]

clathrin-coated endocytic vesicle

endocytic vesicle [inference]

clathrin-coated endocytic vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

coated vesicle [inference]

clathrin-coated vesicle [inference]

clathrin-coated endocytic vesicle

endocytic vesicle [inference]

clathrin-coated endocytic vesicle

side of membrane [inference]

cytoplasmic side of membrane [inference]

cytoplasmic side of plasma membrane

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	15598649 16902404 22262466 22323290 23676497 32296183 32353859 33060197 33961781 36217030
disordered domain specific binding	IEA
clathrin adaptor activity	IBA TAS	12121421
protein kinase binding	ISS
lipid binding	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding

enzyme binding [inference]

kinase binding [inference]

protein kinase binding

protein domain specific binding [inference]

disordered domain specific binding

lipid binding

molecular adaptor activity [inference]

protein-macromolecule adaptor activity [inference]

cargo adaptor activity [inference]

clathrin adaptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

ap-2 complex subunit alpha

Functional Category

O: Posttranslational modification, protein turnover, chaperones
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
clathrin adaptor activity
clathrin-dependent endocytosis

Displaying **all 9** entries
InterPro
Adaptor protein complex AP-2, alpha subunit
Armadillo-like helical
Armadillo-type fold
Clathrin adaptor, alpha-adaptin, appendage, C-terminal subdomain
Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain
Clathrin adaptor, appendage, Ig-like subdomain superfamily
Clathrin/coatomer adaptor, adaptin-like, N-terminal
Coatomer/calthrin adaptor appendage, C-terminal subdomain
TBP domain superfamily

Ortholog

Displaying entries **1 - 10** of 81 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	11772		MGI:101920	MOUSE57393
Drosophila melanogaster	33211		FB:FBgn0264855
Rattus norvegicus	81637		RGD:71015	RATNO20744
Xenopus tropicalis	407867		Xenbase:XB-GENE-486024
Pan troglodytes	450939	9598_0:002e9f
Canis lupus familiaris	475994			CANLF05896
Bos taurus	515216			BOVIN23744
Macaca mulatta	720875			MACMU09328
Xenopus laevis	734352		Xenbase:XB-GENE-865570
Saccharomyces cerevisiae S288C	852243		SGD:S000000133