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Guidelines

MIRAGE

DCC netrin 1 receptor

Summary

Gene Symbol

DCC

Organism

Homo sapiens (human)

External Links

NCBI Gene

1630

PubChem

1630

Alliance of Genome Resources

HGNC:2701

Annotation

Keyword

3D-structure
Apoptosis
Developmental protein
Disease variant
Disulfide bond
Glycoprotein
Immunoglobulin domain
Intellectual disability
Membrane
Phosphoprotein
Proteomics identification
Receptor
Reference proteome
Repeat
Signal
Transmembrane helix
Tumor suppressor
Ubl conjugation

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q49AK4
P43146	Colorectal cancer suppressor Immunoglobulin superfamily DCC subclass member 1 Tumor suppressor protein DCC

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
neuron migration	IBA
apoptotic process	IEA
axonogenesis	TAS	8861902
axon guidance	IBA
negative regulation of neuron projection development	TAS	19616629

GO Hierarchy

biological process

cellular process [inference]

cell adhesion [inference]

cell-cell adhesion

cell death [inference]

programmed cell death [inference]

apoptotic process

cell motility [inference]

cell migration [inference]

neuron migration

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

central nervous system neuron axonogenesis [inference]

central nervous system projection neuron axonogenesis [inference]

spinal cord ventral commissure morphogenesis

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

neuron projection guidance [inference]

developmental process [inference]

anatomical structure morphogenesis [inference]

cellular anatomical entity morphogenesis [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

central nervous system neuron axonogenesis [inference]

central nervous system projection neuron axonogenesis [inference]

spinal cord ventral commissure morphogenesis

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

postsynaptic modulation of chemical synaptic transmission

regulation of growth [inference]

regulation of cell growth [inference]

negative regulation of cell growth [inference]

negative regulation of collateral sprouting

regulation of extent of cell growth [inference]

regulation of collateral sprouting [inference]

negative regulation of collateral sprouting

negative regulation of growth [inference]

negative regulation of cell growth [inference]

negative regulation of collateral sprouting

negative regulation of developmental growth [inference]

negative regulation of collateral sprouting

regulation of developmental growth [inference]

negative regulation of developmental growth [inference]

negative regulation of collateral sprouting

regulation of collateral sprouting [inference]

negative regulation of collateral sprouting

negative regulation of biological process [inference]

negative regulation of growth [inference]

negative regulation of cell growth [inference]

negative regulation of collateral sprouting

negative regulation of developmental growth [inference]

negative regulation of collateral sprouting

negative regulation of cellular process [inference]

negative regulation of cell growth [inference]

negative regulation of collateral sprouting

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of collateral sprouting

negative regulation of cellular component organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development

negative regulation of axonogenesis [inference]

negative regulation of collateral sprouting

negative regulation of dendrite development

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of collateral sprouting

negative regulation of developmental growth [inference]

negative regulation of collateral sprouting

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of collateral sprouting

negative regulation of dendrite development

negative regulation of multicellular organismal process [inference]

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of collateral sprouting

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of axonogenesis [inference]

regulation of collateral sprouting [inference]

negative regulation of collateral sprouting

negative regulation of axonogenesis [inference]

negative regulation of collateral sprouting

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of collateral sprouting

regulation of cell development [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of collateral sprouting

regulation of neurogenesis [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of collateral sprouting

regulation of developmental growth [inference]

negative regulation of developmental growth [inference]

negative regulation of collateral sprouting

regulation of collateral sprouting [inference]

negative regulation of collateral sprouting

regulation of dendrite development [inference]

negative regulation of dendrite development

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of collateral sprouting

negative regulation of developmental growth [inference]

negative regulation of collateral sprouting

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of collateral sprouting

negative regulation of dendrite development

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of collateral sprouting

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of collateral sprouting

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

postsynaptic modulation of chemical synaptic transmission

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of collateral sprouting

regulation of cell development [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of collateral sprouting

regulation of neurogenesis [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of collateral sprouting

negative regulation of cellular process [inference]

negative regulation of cell growth [inference]

negative regulation of collateral sprouting

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of collateral sprouting

negative regulation of cellular component organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development

negative regulation of axonogenesis [inference]

negative regulation of collateral sprouting

negative regulation of dendrite development

regulation of cellular component organization [inference]

regulation of cell growth [inference]

negative regulation of cell growth [inference]

negative regulation of collateral sprouting

regulation of extent of cell growth [inference]

regulation of collateral sprouting [inference]

negative regulation of collateral sprouting

regulation of cell projection organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development

negative regulation of axonogenesis [inference]

negative regulation of collateral sprouting

negative regulation of dendrite development

regulation of plasma membrane bounded cell projection organization [inference]

regulation of neuron projection development [inference]

negative regulation of neuron projection development

negative regulation of axonogenesis [inference]

negative regulation of collateral sprouting

negative regulation of dendrite development

regulation of axonogenesis [inference]

regulation of collateral sprouting [inference]

negative regulation of collateral sprouting

negative regulation of axonogenesis [inference]

negative regulation of collateral sprouting

regulation of dendrite development [inference]

negative regulation of dendrite development

negative regulation of cellular component organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development

negative regulation of axonogenesis [inference]

negative regulation of collateral sprouting

negative regulation of dendrite development

regulation of multicellular organismal process [inference]

negative regulation of multicellular organismal process [inference]

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of collateral sprouting

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of collateral sprouting

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of collateral sprouting

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
cytosol	TAS
plasma membrane	TAS
plasma membrane	IBA
cell surface	IBA
axon	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

synaptic membrane [inference]

postsynaptic specialization membrane [inference]

postsynaptic density membrane

cell junction [inference]

synapse [inference]

Schaffer collateral - CA1 synapse

site of polarized growth [inference]

growth cone [inference]

axonal growth cone

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

axon

Displaying **all 2** entries
GO Term	Evidence Code	PMID
transmembrane signaling receptor activity	TAS	8861902
protein binding	IPI	11527412 12011067 16537496 18585357 19721007 20434207 21642953 22084112 26190107

GO Hierarchy

molecular function

binding [inference]

protein binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Neogenin

Functional Category

G: Carbohydrate transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 9** entries
InterPro
Fibronectin type III superfamily
Fibronectin type III
Immunoglobulin I-set
Immunoglobulin subtype 2
Immunoglobulin subtype
Immunoglobulin-like domain superfamily
Immunoglobulin-like domain
Immunoglobulin-like fold
Neogenin, C-terminal

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0111153	congenital mirror movement disorder	Alliance of Genome Resources
DOID:3748	esophagus squamous cell carcinoma	Alliance of Genome Resources
DOID:9256	colorectal cancer	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 59 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus laevis	1630	Xenbase:XB-GENE-5872596
Drosophila melanogaster	4756	FB:FBgn0011592
Mus musculus	13176	ZFIN:ZDB-GENE-011101-2	MOUSE24344
Drosophila melanogaster	18007	FB:FBgn0011592
Rattus norvegicus	25311	ZFIN:ZDB-GENE-011101-2	RATNO13778
Danio rerio	172233	ZFIN:ZDB-GENE-011101-2
Pan troglodytes	455425		PANTR16308
Canis lupus familiaris	483976		CANLF00103
Bos taurus	537176		BOVIN19787
Macaca mulatta	693352		MACMU17550

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Last updated: December 8, 2025