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Guidelines

MIRAGE

DCC netrin 1 receptor

Summary

Gene Symbol

DCC

Organism

Homo sapiens (human)

External Links

NCBI Gene

1630

PubChem

1630

Alliance of Genome Resources

HGNC:2701

Annotation

Keyword

3D-structure
Apoptosis
Developmental protein
Disease variant
Disulfide bond
Glycoprotein
Immunoglobulin domain
Intellectual disability
Membrane
Phosphoprotein
Proteomics identification
Receptor
Reference proteome
Repeat
Signal
Transmembrane helix
Tumor suppressor
Ubl conjugation

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q49AK4
P43146	Colorectal cancer suppressor Immunoglobulin superfamily DCC subclass member 1 Tumor suppressor protein DCC

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
neuron migration	IBA
apoptotic process	IEA
axonogenesis	TAS	8861902
axon guidance	IBA
negative regulation of neuron projection development	TAS	19616629

GO Hierarchy

biological process

cellular process [inference]

cell adhesion [inference]

cell-cell adhesion

cell death [inference]

programmed cell death [inference]

apoptotic process

cell motility [inference]

cell migration [inference]

neuron migration

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

central nervous system neuron axonogenesis [inference]

central nervous system projection neuron axonogenesis [inference]

spinal cord ventral commissure morphogenesis

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

neuron projection guidance [inference]

developmental process [inference]

anatomical structure morphogenesis [inference]

cellular anatomical entity morphogenesis [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

central nervous system neuron axonogenesis [inference]

central nervous system projection neuron axonogenesis [inference]

spinal cord ventral commissure morphogenesis

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

postsynaptic modulation of chemical synaptic transmission

regulation of growth [inference]

regulation of cell growth [inference]

negative regulation of cell growth [inference]

negative regulation of collateral sprouting

regulation of extent of cell growth [inference]

regulation of collateral sprouting [inference]

negative regulation of collateral sprouting

negative regulation of growth [inference]

negative regulation of cell growth [inference]

negative regulation of collateral sprouting

negative regulation of developmental growth [inference]

negative regulation of collateral sprouting

regulation of developmental growth [inference]

negative regulation of developmental growth [inference]

negative regulation of collateral sprouting

regulation of collateral sprouting [inference]

negative regulation of collateral sprouting

negative regulation of biological process [inference]

negative regulation of growth [inference]

negative regulation of cell growth [inference]

negative regulation of collateral sprouting

negative regulation of developmental growth [inference]

negative regulation of collateral sprouting

negative regulation of cellular process [inference]

negative regulation of cell growth [inference]

negative regulation of collateral sprouting

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of collateral sprouting

negative regulation of cellular component organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development

negative regulation of axonogenesis [inference]

negative regulation of collateral sprouting

negative regulation of dendrite development

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of collateral sprouting

negative regulation of developmental growth [inference]

negative regulation of collateral sprouting

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of collateral sprouting

negative regulation of dendrite development

negative regulation of multicellular organismal process [inference]

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of collateral sprouting

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of axonogenesis [inference]

regulation of collateral sprouting [inference]

negative regulation of collateral sprouting

negative regulation of axonogenesis [inference]

negative regulation of collateral sprouting

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of collateral sprouting

regulation of cell development [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of collateral sprouting

regulation of neurogenesis [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of collateral sprouting

regulation of developmental growth [inference]

negative regulation of developmental growth [inference]

negative regulation of collateral sprouting

regulation of collateral sprouting [inference]

negative regulation of collateral sprouting

regulation of dendrite development [inference]

negative regulation of dendrite development

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of collateral sprouting

negative regulation of developmental growth [inference]

negative regulation of collateral sprouting

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of collateral sprouting

negative regulation of dendrite development

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of collateral sprouting

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of collateral sprouting

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

postsynaptic modulation of chemical synaptic transmission

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of collateral sprouting

regulation of cell development [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of collateral sprouting

regulation of neurogenesis [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of collateral sprouting

negative regulation of cellular process [inference]

negative regulation of cell growth [inference]

negative regulation of collateral sprouting

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of collateral sprouting

negative regulation of cellular component organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development

negative regulation of axonogenesis [inference]

negative regulation of collateral sprouting

negative regulation of dendrite development

regulation of cellular component organization [inference]

regulation of cell growth [inference]

negative regulation of cell growth [inference]

negative regulation of collateral sprouting

regulation of extent of cell growth [inference]

regulation of collateral sprouting [inference]

negative regulation of collateral sprouting

regulation of cell projection organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development

negative regulation of axonogenesis [inference]

negative regulation of collateral sprouting

negative regulation of dendrite development

regulation of plasma membrane bounded cell projection organization [inference]

regulation of neuron projection development [inference]

negative regulation of neuron projection development

negative regulation of axonogenesis [inference]

negative regulation of collateral sprouting

negative regulation of dendrite development

regulation of axonogenesis [inference]

regulation of collateral sprouting [inference]

negative regulation of collateral sprouting

negative regulation of axonogenesis [inference]

negative regulation of collateral sprouting

regulation of dendrite development [inference]

negative regulation of dendrite development

negative regulation of cellular component organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development

negative regulation of axonogenesis [inference]

negative regulation of collateral sprouting

negative regulation of dendrite development

regulation of multicellular organismal process [inference]

negative regulation of multicellular organismal process [inference]

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of collateral sprouting

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of collateral sprouting

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of collateral sprouting

Displaying entries **6 - 8** of 8 in total

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GO Term	Evidence Code	PMID
axonal growth cone
Schaffer collateral - CA1 synapse	IEA
postsynaptic density membrane	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

synaptic membrane [inference]

postsynaptic specialization membrane [inference]

postsynaptic density membrane

cell junction [inference]

synapse [inference]

Schaffer collateral - CA1 synapse

site of polarized growth [inference]

growth cone [inference]

axonal growth cone

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

axon

Displaying **all 2** entries
GO Term	Evidence Code	PMID
transmembrane signaling receptor activity	TAS	8861902
protein binding	IPI	11527412 12011067 16537496 18585357 19721007 20434207 21642953 22084112 26190107

GO Hierarchy

molecular function

binding [inference]

protein binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Neogenin

Functional Category

G: Carbohydrate transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 9** entries
InterPro
Fibronectin type III superfamily
Fibronectin type III
Immunoglobulin I-set
Immunoglobulin subtype 2
Immunoglobulin subtype
Immunoglobulin-like domain superfamily
Immunoglobulin-like domain
Immunoglobulin-like fold
Neogenin, C-terminal

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0111153	congenital mirror movement disorder	Alliance of Genome Resources
DOID:3748	esophagus squamous cell carcinoma	Alliance of Genome Resources
DOID:9256	colorectal cancer	Alliance of Genome Resources

Ortholog

Displaying entries **41 - 50** of 59 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Cercocebus atys	105592484		CERAT05322
Aotus nancymaae	105725293		AOTNA28051
Microcebus murinus	105860580		MICMU15909
Dipodomys ordii	105987617		DIPOR06690
Equus asinus asinus	106834507		EQUAS01426
Ictalurus punctatus	108260324		ICTPU23358
Cyprinus carpio carpio	109053098		CYPCA13856
Cyprinus carpio carpio	109070294		CYPCA19004
Vulpes vulpes	112919273		VULVU08283
Pseudonaja textilis	113444773		PSETE02303

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Last updated: December 8, 2025