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Guidelines

MIRAGE

inner centromere protein

Summary

Gene Symbol

Incenp

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

16319

PubChem

16319

Alliance of Genome Resources

MGI:1313288

Annotation

Keyword

Alternative splicing
Centromere
Chromosome
Chromosome partition
Coiled coil
Cytoskeleton
Glycoprotein
Kinetochore
Microtubule
Mitosis
Nucleus
Phosphoprotein
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9WU62

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
mitotic cell cycle	NAS	17956729
mitotic cytokinesis	ISS
mitotic cytokinesis	ISO
mitotic cytokinesis	NAS	17956729
mitotic cytokinesis	IBA

GO Hierarchy

biological process

cellular process [inference]

microtubule-based process [inference]

microtubule cytoskeleton organization [inference]

spindle organization [inference]

mitotic spindle organization

microtubule cytoskeleton organization involved in mitosis [inference]

mitotic spindle organization

spindle midzone assembly [inference]

cell cycle [inference]

mitotic cell cycle

cell cycle process [inference]

cytokinesis [inference]

cytoskeleton-dependent cytokinesis [inference]

mitotic cytokinesis

spindle organization [inference]

mitotic spindle organization

chromosome segregation

spindle midzone assembly [inference]

meiotic cell cycle process [inference]

meiotic spindle midzone assembly

mitotic cell cycle process [inference]

microtubule cytoskeleton organization involved in mitosis [inference]

mitotic spindle organization

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

microtubule cytoskeleton organization [inference]

spindle organization [inference]

mitotic spindle organization

microtubule cytoskeleton organization involved in mitosis [inference]

mitotic spindle organization

cellular component assembly [inference]

spindle midzone assembly [inference]

reproductive process [inference]

meiotic cell cycle process [inference]

meiotic spindle midzone assembly

localization [inference]

establishment of localization [inference]

establishment of localization in cell [inference]

establishment of chromosome localization [inference]

metaphase chromosome alignment

establishment of organelle localization [inference]

establishment of chromosome localization [inference]

metaphase chromosome alignment

organelle localization [inference]

chromosome localization [inference]

establishment of chromosome localization [inference]

metaphase chromosome alignment

establishment of organelle localization [inference]

establishment of chromosome localization [inference]

metaphase chromosome alignment

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of cell cycle checkpoint [inference]

positive regulation of spindle checkpoint [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

regulation of intracellular signal transduction [inference]

regulation of cell cycle checkpoint [inference]

regulation of spindle checkpoint [inference]

positive regulation of spindle checkpoint [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

regulation of mitotic spindle checkpoint [inference]

regulation of mitotic cell cycle spindle assembly checkpoint [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

positive regulation of cell cycle checkpoint [inference]

positive regulation of spindle checkpoint [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

positive regulation of intracellular signal transduction [inference]

positive regulation of cell cycle checkpoint [inference]

positive regulation of spindle checkpoint [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of cell cycle checkpoint [inference]

positive regulation of spindle checkpoint [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

regulation of localization [inference]

regulation of metaphase plate congression [inference]

regulation of attachment of mitotic spindle microtubules to kinetochore [inference]

positive regulation of attachment of mitotic spindle microtubules to kinetochore

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of cell cycle checkpoint [inference]

positive regulation of spindle checkpoint [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of cell cycle checkpoint [inference]

positive regulation of spindle checkpoint [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

positive regulation of cell cycle [inference]

positive regulation of cell cycle process [inference]

positive regulation of cytokinesis [inference]

positive regulation of mitotic cytokinesis

positive regulation of chromosome segregation [inference]

positive regulation of attachment of spindle microtubules to kinetochore [inference]

positive regulation of attachment of mitotic spindle microtubules to kinetochore

positive regulation of mitotic cell cycle spindle assembly checkpoint

positive regulation of chromosome separation [inference]

positive regulation of mitotic sister chromatid separation

positive regulation of cell division [inference]

positive regulation of cytokinesis [inference]

positive regulation of mitotic cytokinesis

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of cell cycle checkpoint [inference]

positive regulation of spindle checkpoint [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of cell cycle checkpoint [inference]

positive regulation of spindle checkpoint [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

regulation of intracellular signal transduction [inference]

regulation of cell cycle checkpoint [inference]

regulation of spindle checkpoint [inference]

positive regulation of spindle checkpoint [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

regulation of mitotic spindle checkpoint [inference]

regulation of mitotic cell cycle spindle assembly checkpoint [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

positive regulation of cell cycle checkpoint [inference]

positive regulation of spindle checkpoint [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

positive regulation of intracellular signal transduction [inference]

positive regulation of cell cycle checkpoint [inference]

positive regulation of spindle checkpoint [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of cell cycle checkpoint [inference]

positive regulation of spindle checkpoint [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of cell cycle checkpoint [inference]

positive regulation of spindle checkpoint [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

regulation of intracellular signal transduction [inference]

regulation of cell cycle checkpoint [inference]

regulation of spindle checkpoint [inference]

positive regulation of spindle checkpoint [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

regulation of mitotic spindle checkpoint [inference]

regulation of mitotic cell cycle spindle assembly checkpoint [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

positive regulation of cell cycle checkpoint [inference]

positive regulation of spindle checkpoint [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

positive regulation of intracellular signal transduction [inference]

positive regulation of cell cycle checkpoint [inference]

positive regulation of spindle checkpoint [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of cell cycle checkpoint [inference]

positive regulation of spindle checkpoint [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of cell cycle checkpoint [inference]

positive regulation of spindle checkpoint [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

positive regulation of cell cycle [inference]

positive regulation of cell cycle process [inference]

positive regulation of cytokinesis [inference]

positive regulation of mitotic cytokinesis

positive regulation of chromosome segregation [inference]

positive regulation of attachment of spindle microtubules to kinetochore [inference]

positive regulation of attachment of mitotic spindle microtubules to kinetochore

positive regulation of mitotic cell cycle spindle assembly checkpoint

positive regulation of chromosome separation [inference]

positive regulation of mitotic sister chromatid separation

positive regulation of cell division [inference]

positive regulation of cytokinesis [inference]

positive regulation of mitotic cytokinesis

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

regulation of chromosome organization [inference]

regulation of sister chromatid segregation [inference]

regulation of mitotic sister chromatid segregation [inference]

regulation of mitotic cell cycle spindle assembly checkpoint [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

regulation of attachment of mitotic spindle microtubules to kinetochore [inference]

positive regulation of attachment of mitotic spindle microtubules to kinetochore

regulation of metaphase/anaphase transition of cell cycle [inference]

regulation of mitotic metaphase/anaphase transition [inference]

regulation of mitotic cell cycle spindle assembly checkpoint [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

regulation of nuclear division [inference]

regulation of mitotic nuclear division [inference]

regulation of mitotic cell cycle spindle assembly checkpoint [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

regulation of cell division [inference]

regulation of cytokinesis [inference]

positive regulation of cytokinesis [inference]

positive regulation of mitotic cytokinesis

regulation of mitotic cytokinesis [inference]

positive regulation of mitotic cytokinesis

positive regulation of cell division [inference]

positive regulation of cytokinesis [inference]

positive regulation of mitotic cytokinesis

regulation of cell cycle [inference]

regulation of mitotic cell cycle [inference]

regulation of mitotic nuclear division [inference]

regulation of mitotic cell cycle spindle assembly checkpoint [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

regulation of mitotic cell cycle phase transition [inference]

regulation of mitotic metaphase/anaphase transition [inference]

regulation of mitotic cell cycle spindle assembly checkpoint [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

regulation of mitotic spindle checkpoint [inference]

regulation of mitotic cell cycle spindle assembly checkpoint [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

regulation of cell cycle process [inference]

regulation of mitotic nuclear division [inference]

regulation of mitotic cell cycle spindle assembly checkpoint [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

regulation of cytokinesis [inference]

positive regulation of cytokinesis [inference]

positive regulation of mitotic cytokinesis

regulation of mitotic cytokinesis [inference]

positive regulation of mitotic cytokinesis

regulation of chromosome segregation [inference]

regulation of sister chromatid segregation [inference]

regulation of mitotic sister chromatid segregation [inference]

regulation of mitotic cell cycle spindle assembly checkpoint [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

regulation of attachment of mitotic spindle microtubules to kinetochore [inference]

positive regulation of attachment of mitotic spindle microtubules to kinetochore

regulation of metaphase/anaphase transition of cell cycle [inference]

regulation of mitotic metaphase/anaphase transition [inference]

regulation of mitotic cell cycle spindle assembly checkpoint [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

positive regulation of chromosome segregation [inference]

positive regulation of attachment of spindle microtubules to kinetochore [inference]

positive regulation of attachment of mitotic spindle microtubules to kinetochore

regulation of chromosome separation [inference]

regulation of mitotic sister chromatid separation [inference]

regulation of mitotic cell cycle spindle assembly checkpoint [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

positive regulation of mitotic sister chromatid separation

positive regulation of chromosome separation [inference]

positive regulation of mitotic sister chromatid separation

regulation of attachment of spindle microtubules to kinetochore [inference]

positive regulation of attachment of spindle microtubules to kinetochore [inference]

positive regulation of attachment of mitotic spindle microtubules to kinetochore

regulation of attachment of mitotic spindle microtubules to kinetochore [inference]

positive regulation of attachment of mitotic spindle microtubules to kinetochore

positive regulation of cell cycle process [inference]

positive regulation of cytokinesis [inference]

positive regulation of mitotic cytokinesis

positive regulation of chromosome segregation [inference]

positive regulation of attachment of spindle microtubules to kinetochore [inference]

positive regulation of attachment of mitotic spindle microtubules to kinetochore

positive regulation of mitotic cell cycle spindle assembly checkpoint

positive regulation of chromosome separation [inference]

positive regulation of mitotic sister chromatid separation

regulation of cell cycle phase transition [inference]

regulation of cell cycle checkpoint [inference]

regulation of spindle checkpoint [inference]

positive regulation of spindle checkpoint [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

regulation of mitotic spindle checkpoint [inference]

regulation of mitotic cell cycle spindle assembly checkpoint [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

positive regulation of cell cycle checkpoint [inference]

positive regulation of spindle checkpoint [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

regulation of mitotic cell cycle phase transition [inference]

regulation of mitotic metaphase/anaphase transition [inference]

regulation of mitotic cell cycle spindle assembly checkpoint [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

regulation of metaphase/anaphase transition of cell cycle [inference]

regulation of mitotic metaphase/anaphase transition [inference]

regulation of mitotic cell cycle spindle assembly checkpoint [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

positive regulation of cell cycle [inference]

positive regulation of cell cycle process [inference]

positive regulation of cytokinesis [inference]

positive regulation of mitotic cytokinesis

positive regulation of chromosome segregation [inference]

positive regulation of attachment of spindle microtubules to kinetochore [inference]

positive regulation of attachment of mitotic spindle microtubules to kinetochore

positive regulation of mitotic cell cycle spindle assembly checkpoint

positive regulation of chromosome separation [inference]

positive regulation of mitotic sister chromatid separation

Displaying entries **1 - 5** of 30 in total

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GO Term	Evidence Code	PMID
chromosome, centromeric region	ISS
chromosome, centromeric region	ISO	11084331
chromosome, centromeric region	IDA	12584241
kinetochore	ISS
kinetochore	ISO

GO Hierarchy

cellular component

protein-containing complex

microtubule associated complex [inference]

chromosome passenger complex

protein-DNA complex [inference]

chromatin [inference]

heterochromatin [inference]

pericentric heterochromatin

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

microtubule cytoskeleton

chromocenter

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

microtubule cytoskeleton

chromocenter

spindle midzone [inference]

meiotic spindle midzone

chromosomal region [inference]

chromosome, centromeric region

supramolecular complex [inference]

kinetochore

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

microtubule

synaptonemal structure [inference]

synaptonemal complex

Displaying **all 2** entries
GO Term	Evidence Code	PMID
molecular function activator activity	ISO
molecular function activator activity	IEA

GO Hierarchy

molecular function

molecular function regulator activity [inference]

molecular function activator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

inner centromere protein A

Functional Category

G: Carbohydrate transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
cell cycle
cell division
chromosome segregation
meiotic spindle midzone assembly
metaphase chromosome alignment
mitotic cytokinesis

Displaying **all 2** entries
InterPro
Chromosome passenger complex (CPC) protein INCENP N-terminal
Inner centromere protein, ARK-binding domain

Ortholog

Displaying entries **1 - 10** of 54 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	3619	Xenbase:XB-GENE-990398	HUMAN06531
Xenopus tropicalis	16319	Xenbase:XB-GENE-990398
Rattus norvegicus	293733		RATNO21025
Pan troglodytes	451248		PANTR03125
Canis lupus familiaris	483790		CANLF06180
Bos taurus	507693		BOVIN23262
Danio rerio	572121		DANRE28081
Macaca mulatta	722320		MACMU11537
Equus caballus	100059935		HORSE06126
Taeniopygia guttata	100220066		TAEGU25863

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Last updated: December 8, 2025