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inositol polyphosphate phosphatase-like 1

Summary

Gene Symbol

Inppl1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

16332

PubChem

16332

Alliance of Genome Resources

MGI:1333787

Annotation

Keyword

3D-structure
Actin-binding
Cell adhesion
Cell membrane
Cell projection
Cytoskeleton
Hydrolase
Immunity
Lipid metabolism
Nucleus
Phosphoprotein
Reference proteome
SH2 domain
SH3-binding

Proteins

Displaying 1 entry
UniProt	Protein Name
Q6P549	Inositol polyphosphate phosphatase-like protein 1 Protein 51C SH2 domain-containing inositol 5'-phosphatase 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 28 in total

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GO Term	Evidence Code	PMID
phosphatidylinositol 3-kinase/protein kinase B signal transduction	IGI	28878342
endocytosis	IEA ISO
endochondral ossification	ISO ISS
negative regulation of insulin receptor signaling pathway	ISO
response to insulin	IMP	11343120

GO Hierarchy

biological process

immune system process

metabolic process [inference]

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

macromolecule biosynthetic process [inference]

gene expression

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

phosphatidylinositol metabolic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

dephosphorylation [inference]

phospholipid dephosphorylation [inference]

phosphatidylinositol dephosphorylation

inositol phosphate metabolic process [inference]

inositol trisphosphate metabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

phosphatidylinositol metabolic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

inositol phosphate metabolic process [inference]

inositol trisphosphate metabolic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

cellular lipid metabolic process

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

phosphatidylinositol metabolic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

lipid modification [inference]

phospholipid dephosphorylation [inference]

phosphatidylinositol dephosphorylation

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

phosphatidylinositol metabolic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

primary metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

glucose metabolic process

lipid metabolic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

cellular lipid metabolic process

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

phosphatidylinositol metabolic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

lipid modification [inference]

phospholipid dephosphorylation [inference]

phosphatidylinositol dephosphorylation

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

phosphatidylinositol metabolic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

small molecule metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

glucose metabolic process

alcohol metabolic process [inference]

polyol metabolic process [inference]

inositol phosphate metabolic process [inference]

inositol trisphosphate metabolic process

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

glucose metabolic process

lipid metabolic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

cellular lipid metabolic process

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

phosphatidylinositol metabolic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

lipid modification [inference]

phospholipid dephosphorylation [inference]

phosphatidylinositol dephosphorylation

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

phosphatidylinositol metabolic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

phosphatidylinositol metabolic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

inositol phosphate metabolic process [inference]

inositol trisphosphate metabolic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

gene expression

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

macromolecule biosynthetic process [inference]

gene expression

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

polyol metabolic process [inference]

inositol phosphate metabolic process [inference]

inositol trisphosphate metabolic process

cellular process [inference]

microtubule-based process [inference]

microtubule cytoskeleton organization [inference]

establishment of spindle localization [inference]

establishment of mitotic spindle localization [inference]

establishment of mitotic spindle orientation

establishment of spindle orientation [inference]

establishment of mitotic spindle orientation

microtubule cytoskeleton organization involved in mitosis [inference]

establishment of mitotic spindle localization [inference]

establishment of mitotic spindle orientation

cell adhesion

signal transduction [inference]

intracellular signal transduction [inference]

MAPK cascade [inference]

ERK1 and ERK2 cascade

phosphatidylinositol 3-kinase/protein kinase B signal transduction

cell death [inference]

programmed cell death [inference]

apoptotic process

vesicle-mediated transport [inference]

endocytosis

cell cycle process [inference]

spindle localization [inference]

establishment of spindle localization [inference]

establishment of mitotic spindle localization [inference]

establishment of mitotic spindle orientation

establishment of spindle orientation [inference]

establishment of mitotic spindle orientation

mitotic cell cycle process [inference]

microtubule cytoskeleton organization involved in mitosis [inference]

establishment of mitotic spindle localization [inference]

establishment of mitotic spindle orientation

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

phosphatidylinositol metabolic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

dephosphorylation [inference]

phospholipid dephosphorylation [inference]

phosphatidylinositol dephosphorylation

inositol phosphate metabolic process [inference]

inositol trisphosphate metabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

phosphatidylinositol metabolic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

inositol phosphate metabolic process [inference]

inositol trisphosphate metabolic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

cellular lipid metabolic process

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

phosphatidylinositol metabolic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

lipid modification [inference]

phospholipid dephosphorylation [inference]

phosphatidylinositol dephosphorylation

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

phosphatidylinositol metabolic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

microtubule cytoskeleton organization [inference]

establishment of spindle localization [inference]

establishment of mitotic spindle localization [inference]

establishment of mitotic spindle orientation

establishment of spindle orientation [inference]

establishment of mitotic spindle orientation

microtubule cytoskeleton organization involved in mitosis [inference]

establishment of mitotic spindle localization [inference]

establishment of mitotic spindle orientation

cellular component assembly [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

ruffle assembly

cell projection organization [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

ruffle assembly

plasma membrane bounded cell projection organization [inference]

ruffle organization [inference]

ruffle assembly

plasma membrane bounded cell projection assembly [inference]

ruffle assembly

supramolecular fiber organization [inference]

actin filament organization

multicellular organismal process [inference]

ossification [inference]

replacement ossification [inference]

endochondral ossification

post-embryonic development

response to stimulus [inference]

response to endogenous stimulus [inference]

response to hormone [inference]

response to peptide hormone [inference]

response to insulin

response to chemical [inference]

response to organic substance [inference]

response to hormone [inference]

response to peptide hormone [inference]

response to insulin

response to organonitrogen compound [inference]

response to peptide [inference]

response to peptide hormone [inference]

response to insulin

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to peptide [inference]

response to peptide hormone [inference]

response to insulin

response to oxygen-containing compound [inference]

response to peptide [inference]

response to peptide hormone [inference]

response to insulin

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis

import into cell [inference]

endocytosis

establishment of localization in cell [inference]

establishment of spindle localization [inference]

establishment of mitotic spindle localization [inference]

establishment of mitotic spindle orientation

establishment of spindle orientation [inference]

establishment of mitotic spindle orientation

establishment of organelle localization [inference]

establishment of spindle localization [inference]

establishment of mitotic spindle localization [inference]

establishment of mitotic spindle orientation

establishment of spindle orientation [inference]

establishment of mitotic spindle orientation

organelle localization [inference]

spindle localization [inference]

establishment of spindle localization [inference]

establishment of mitotic spindle localization [inference]

establishment of mitotic spindle orientation

establishment of spindle orientation [inference]

establishment of mitotic spindle orientation

establishment of organelle localization [inference]

establishment of spindle localization [inference]

establishment of mitotic spindle localization [inference]

establishment of mitotic spindle orientation

establishment of spindle orientation [inference]

establishment of mitotic spindle orientation

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

regulation of immune response

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication

regulation of DNA metabolic process [inference]

regulation of DNA replication [inference]

negative regulation of DNA replication

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication

regulation of DNA metabolic process [inference]

regulation of DNA replication [inference]

negative regulation of DNA replication

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication

regulation of DNA metabolic process [inference]

regulation of DNA replication [inference]

negative regulation of DNA replication

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication

regulation of DNA metabolic process [inference]

regulation of DNA replication [inference]

negative regulation of DNA replication

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

regulation of platelet-derived growth factor receptor signaling pathway [inference]

negative regulation of platelet-derived growth factor receptor signaling pathway

regulation of insulin-like growth factor receptor signaling pathway [inference]

negative regulation of insulin-like growth factor receptor signaling pathway

regulation of insulin receptor signaling pathway [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

regulation of localization [inference]

regulation of cellular localization [inference]

regulation of protein localization

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication

negative regulation of cellular component organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development

negative regulation of cellular response to insulin stimulus [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of cellular response to insulin stimulus [inference]

negative regulation of insulin receptor signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

regulation of platelet-derived growth factor receptor signaling pathway [inference]

negative regulation of platelet-derived growth factor receptor signaling pathway

regulation of insulin-like growth factor receptor signaling pathway [inference]

negative regulation of insulin-like growth factor receptor signaling pathway

regulation of insulin receptor signaling pathway [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of cellular response to insulin stimulus [inference]

negative regulation of insulin receptor signaling pathway

regulation of immune response

regulation of cellular response to insulin stimulus [inference]

negative regulation of cellular response to insulin stimulus [inference]

negative regulation of insulin receptor signaling pathway

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

MAPK cascade [inference]

ERK1 and ERK2 cascade

phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

regulation of platelet-derived growth factor receptor signaling pathway [inference]

negative regulation of platelet-derived growth factor receptor signaling pathway

regulation of insulin-like growth factor receptor signaling pathway [inference]

negative regulation of insulin-like growth factor receptor signaling pathway

regulation of insulin receptor signaling pathway [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication

regulation of DNA metabolic process [inference]

regulation of DNA replication [inference]

negative regulation of DNA replication

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of actin filament-based process [inference]

regulation of actin cytoskeleton organization [inference]

regulation of actin filament organization

regulation of cell population proliferation [inference]

negative regulation of cell population proliferation

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication

negative regulation of cellular component organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development

negative regulation of cellular response to insulin stimulus [inference]

negative regulation of insulin receptor signaling pathway

regulation of cellular component organization [inference]

regulation of cell projection organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development

regulation of plasma membrane bounded cell projection organization [inference]

regulation of neuron projection development [inference]

negative regulation of neuron projection development

regulation of organelle organization [inference]

regulation of cytoskeleton organization [inference]

regulation of actin cytoskeleton organization [inference]

regulation of actin filament organization

negative regulation of cellular component organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development

regulation of supramolecular fiber organization [inference]

regulation of actin filament organization

regulation of cellular localization [inference]

regulation of protein localization

regulation of cellular response to insulin stimulus [inference]

negative regulation of cellular response to insulin stimulus [inference]

negative regulation of insulin receptor signaling pathway

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
Golgi apparatus	IEA ISO
nuclear speck	ISS
plasma membrane	IDA	14502564
spindle pole	IEA
filopodium	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

basal plasma membrane

nuclear body [inference]

nuclear speck

cell projection [inference]

plasma membrane bounded cell projection [inference]

lamellipodium

actin-based cell projection [inference]

filopodium

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Displaying entries **6 - 7** of 7 in total

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1

2
GO Term	Evidence Code	PMID
inositol-polyphosphate 5-phosphatase activity	IBA ISO
SH2 domain binding	IEA ISO

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

phosphoric ester hydrolase activity [inference]

phosphatase activity [inference]

inositol phosphate phosphatase activity [inference]

inositol trisphosphate phosphatase activity [inference]

inositol-polyphosphate 5-phosphatase activity

phosphatidylinositol phosphate phosphatase activity [inference]

phosphatidylinositol trisphosphate phosphatase activity [inference]

phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity

phosphatidylinositol phosphate 5-phosphatase activity [inference]

phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity

binding [inference]

protein binding

cytoskeletal protein binding [inference]

actin binding

protein domain specific binding [inference]

lipid binding [inference]

phospholipid binding [inference]

phosphatidylinositol binding [inference]

phosphatidylinositol phosphate binding [inference]

phosphatidylinositol-3,4,5-trisphosphate binding

ion binding [inference]

anion binding [inference]

phosphatidylinositol-3,4,5-trisphosphate binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2

Functional Category

C: Energy production and conversion
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
SH3 domain binding
immune system process
inositol-polyphosphate 5-phosphatase activity
negative regulation of insulin-like growth factor receptor signaling pathway
phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity
regulation of immune response

Displaying **all 6** entries
InterPro
Endonuclease/exonuclease/phosphatase superfamily
Inositol polyphosphate-related phosphatase
SH2 domain superfamily
SH2 domain
Sterile alpha motif domain
Sterile alpha motif/pointed domain superfamily

Rhea

RHEA:25528

H₂O + a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)

phosphate + a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate)

Enzyme

3.1.3.86

PMID

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:10763	hypertension	Alliance of Genome Resources
DOID:9352	type 2 diabetes mellitus	Alliance of Genome Resources
DOID:9970	obesity	Alliance of Genome Resources

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP006572
Gene Name: inositol polyphosphate phosphatase-like 1

Ortholog

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	3636		HGNC:6080	HUMAN07974
Rattus norvegicus	65038	10116_1:000607	RGD:68396	RATNO17790
Danio rerio	325179		ZFIN:ZDB-GENE-030131-3904
Pan troglodytes	451403			PANTR03744
Canis lupus familiaris	485209			CANLF08305
Macaca mulatta	718421			MACMU10194
Bos taurus	783833			BOVIN07167
Equus caballus	100066037			HORSE38256
Taeniopygia guttata	100222899			TAEGU09778
Callithrix jacchus	100396447			CALJA04607

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

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Annotation

OrthoDB (Group)

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements