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dynactin subunit 1
Summary
- Gene Symbol
-
- DCTN1
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Alternative splicing
- Amyotrophic lateral sclerosis
- Coiled coil
- Cytoskeleton
- Dynein
- Microtubule
- Mitosis
- Neuropathy
- Nucleus
- Parkinsonism
- Phosphoprotein
- Reference proteome
- Transport
- Ubl conjugation
- Proteins
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| establishment of mitotic spindle orientation | ||
| establishment of mitotic spindle orientation | ||
| mitotic cell cycle | ||
| nuclear migration | ||
| nervous system development |
GO Hierarchy
biological process
cellular process [inference]
localization [inference]
biological regulation [inference]
regulation of biological process [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| kinetochore | ||
| kinetochore | ||
| spindle pole | ||
| spindle pole | ||
| nuclear envelope |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| protein binding |
|
|
| microtubule binding | ||
| microtubule binding | ||
| tubulin binding | ||
| protein kinase binding |
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- Dynactin subunit 1
- Functional Category
-
- E: Amino acid transport and metabolism
- G: Carbohydrate transport and metabolism
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| cytoplasmic microtubule organization |
| microtubule plus-end binding |
| InterPro |
|---|
| CAP Gly-rich domain superfamily |
| CAP Gly-rich domain |
| Dynein associated protein |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0060193 | amyotrophic lateral sclerosis type 1 | |
| DOID:0060486 | Perry syndrome | |
| DOID:0111202 | autosomal dominant distal hereditary motor neuronopathy 14 |
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 1639 | Xenbase:XB-GENE-5933522 | ||
| 13191 | Xenbase:XB-GENE-5933522 | MOUSE50919 | |
| 29167 | Xenbase:XB-GENE-5933522 | RATNO30236 | |
| 459332 | PANTR27947 | ||
| 483106 | CANLF05224 | ||
| 500227 | RATNO30236 | ||
| 511045 | BOVIN02108 | ||
| 708290 | MACMU08236 | ||
| 100003026 | DANRE06232 | ||
| 100017556 | MONDO26179 |
