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Submissions

integrin alpha 2

Summary

Gene Symbol

Itga2

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

16398

PubChem

16398

Alliance of Genome Resources

MGI:96600

Annotation

Keyword

Calcium
Cell adhesion
Disulfide bond
Glycoprotein
Integrin
Magnesium
Metal-binding
Receptor
Reference proteome
Repeat
Signal
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q62469	CD49 antigen-like family member B Collagen receptor Platelet membrane glycoprotein Ia VLA-2 subunit alpha

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 58 in total

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GO Term	Evidence Code	PMID
response to hypoxia	IEA
positive regulation of leukocyte migration	ISO
positive regulation of leukocyte migration	IEA
substrate-dependent cell migration	ISO
substrate-dependent cell migration	IEA

GO Hierarchy

biological process

cellular process [inference]

cell adhesion [inference]

cell-substrate adhesion

cell-matrix adhesion

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cellular developmental process [inference]

cell differentiation [inference]

epithelial cell differentiation [inference]

hepatocyte differentiation

mesodermal cell differentiation

cell motility [inference]

cell migration [inference]

substrate-dependent cell migration

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to lipid [inference]

cellular response to estradiol stimulus

cellular response to organic cyclic compound [inference]

cellular response to estradiol stimulus

cellular response to oxygen-containing compound [inference]

cellular response to estradiol stimulus

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to mechanical stimulus

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

cell junction assembly [inference]

cell-substrate junction assembly [inference]

focal adhesion assembly

cell junction organization [inference]

cell junction assembly [inference]

cell-substrate junction assembly [inference]

focal adhesion assembly

cell-substrate junction organization [inference]

cell-substrate junction assembly [inference]

focal adhesion assembly

reproductive process [inference]

multi-organism reproductive process [inference]

female pregnancy

multicellular organismal process [inference]

multi-multicellular organism process [inference]

female pregnancy

developmental process [inference]

anatomical structure morphogenesis [inference]

animal organ morphogenesis [inference]

skin morphogenesis

anatomical structure development [inference]

animal organ development [inference]

gland development [inference]

mammary gland development

cellular developmental process [inference]

cell differentiation [inference]

epithelial cell differentiation [inference]

hepatocyte differentiation

mesodermal cell differentiation

response to stimulus [inference]

response to stress [inference]

response to hypoxia

response to osmotic stress [inference]

hypotonic response

response to external stimulus [inference]

detection of external stimulus [inference]

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of pain

response to mechanical stimulus [inference]

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of pain

cellular response to mechanical stimulus

response to extracellular stimulus [inference]

response to nutrient levels [inference]

response to nutrient [inference]

response to vitamin [inference]

response to L-ascorbic acid

cellular response to external stimulus [inference]

cellular response to mechanical stimulus

response to abiotic stimulus [inference]

response to osmotic stress [inference]

hypotonic response

detection of abiotic stimulus [inference]

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of pain

response to mechanical stimulus [inference]

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of pain

cellular response to mechanical stimulus

response to oxygen levels [inference]

response to decreased oxygen levels [inference]

response to hypoxia

cellular response to abiotic stimulus [inference]

cellular response to mechanical stimulus

response to endogenous stimulus [inference]

response to hormone [inference]

response to parathyroid hormone

response to activity [inference]

response to muscle activity

response to chemical [inference]

response to nutrient [inference]

response to vitamin [inference]

response to L-ascorbic acid

response to xenobiotic stimulus

response to organic substance [inference]

response to hormone [inference]

response to parathyroid hormone

response to carbohydrate [inference]

response to monosaccharide [inference]

response to L-ascorbic acid

response to organonitrogen compound [inference]

response to amine

response to organic cyclic compound [inference]

response to estradiol [inference]

cellular response to estradiol stimulus

response to L-ascorbic acid

cellular response to organic cyclic compound [inference]

cellular response to estradiol stimulus

response to lipid [inference]

response to estradiol [inference]

cellular response to estradiol stimulus

cellular response to lipid [inference]

cellular response to estradiol stimulus

cellular response to organic substance [inference]

cellular response to lipid [inference]

cellular response to estradiol stimulus

cellular response to organic cyclic compound [inference]

cellular response to estradiol stimulus

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to lipid [inference]

cellular response to estradiol stimulus

cellular response to organic cyclic compound [inference]

cellular response to estradiol stimulus

cellular response to oxygen-containing compound [inference]

cellular response to estradiol stimulus

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to amine

response to oxygen-containing compound [inference]

response to carbohydrate [inference]

response to monosaccharide [inference]

response to L-ascorbic acid

response to estradiol [inference]

cellular response to estradiol stimulus

cellular response to oxygen-containing compound [inference]

cellular response to estradiol stimulus

response to salt [inference]

response to L-ascorbic acid

detection of stimulus [inference]

detection of external stimulus [inference]

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of pain

detection of abiotic stimulus [inference]

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of pain

detection of stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of pain

detection of stimulus involved in sensory perception of pain [inference]

detection of mechanical stimulus involved in sensory perception of pain

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to lipid [inference]

cellular response to estradiol stimulus

cellular response to organic cyclic compound [inference]

cellular response to estradiol stimulus

cellular response to oxygen-containing compound [inference]

cellular response to estradiol stimulus

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to mechanical stimulus

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte migration

regulation of leukocyte migration [inference]

positive regulation of leukocyte migration

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of translation

positive regulation of collagen biosynthetic process

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation [inference]

positive regulation of translation

positive regulation of gene expression [inference]

positive regulation of translation

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of translation

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of translation

regulation of collagen biosynthetic process [inference]

positive regulation of collagen biosynthetic process

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of translation

positive regulation of collagen biosynthetic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of translation

positive regulation of protein metabolic process [inference]

positive regulation of translation

positive regulation of collagen metabolic process [inference]

positive regulation of collagen biosynthetic process

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of translation

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of amide metabolic process [inference]

positive regulation of translation

positive regulation of protein metabolic process [inference]

positive regulation of translation

regulation of collagen metabolic process [inference]

positive regulation of collagen metabolic process [inference]

positive regulation of collagen biosynthetic process

regulation of collagen biosynthetic process [inference]

positive regulation of collagen biosynthetic process

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of translation

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation [inference]

positive regulation of translation

positive regulation of gene expression [inference]

positive regulation of translation

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of translation

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of translation

regulation of nitrogen compound metabolic process [inference]

regulation of amide metabolic process [inference]

regulation of translation [inference]

positive regulation of translation

positive regulation of amide metabolic process [inference]

positive regulation of translation

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of amide metabolic process [inference]

positive regulation of translation

positive regulation of protein metabolic process [inference]

positive regulation of translation

regulation of protein metabolic process [inference]

regulation of translation [inference]

positive regulation of translation

positive regulation of protein metabolic process [inference]

positive regulation of translation

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation [inference]

positive regulation of translation

positive regulation of gene expression [inference]

positive regulation of translation

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of translation

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of translation

positive regulation of protein metabolic process [inference]

positive regulation of translation

regulation of protein metabolic process [inference]

regulation of translation [inference]

positive regulation of translation

positive regulation of protein metabolic process [inference]

positive regulation of translation

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of translation [inference]

positive regulation of translation

positive regulation of protein metabolic process [inference]

positive regulation of translation

regulation of localization [inference]

regulation of transport [inference]

positive regulation of transport [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis [inference]

positive regulation of phagocytosis, engulfment

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis [inference]

positive regulation of phagocytosis, engulfment

regulation of phagocytosis [inference]

positive regulation of phagocytosis [inference]

positive regulation of phagocytosis, engulfment

regulation of phagocytosis, engulfment [inference]

positive regulation of phagocytosis, engulfment

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of chemotaxis [inference]

positive regulation of positive chemotaxis

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

regulation of chemotaxis [inference]

positive regulation of chemotaxis [inference]

positive regulation of positive chemotaxis

regulation of positive chemotaxis [inference]

positive regulation of positive chemotaxis

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of leukocyte migration [inference]

positive regulation of leukocyte migration

regulation of epithelial cell migration [inference]

positive regulation of epithelial cell migration

regulation of smooth muscle cell migration [inference]

positive regulation of smooth muscle cell migration

positive regulation of cell migration [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte migration

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of translation

positive regulation of collagen biosynthetic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of translation

positive regulation of protein metabolic process [inference]

positive regulation of translation

positive regulation of collagen metabolic process [inference]

positive regulation of collagen biosynthetic process

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of translation

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of amide metabolic process [inference]

positive regulation of translation

positive regulation of protein metabolic process [inference]

positive regulation of translation

positive regulation of locomotion [inference]

positive regulation of chemotaxis [inference]

positive regulation of positive chemotaxis

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of smooth muscle cell proliferation

positive regulation of cell communication [inference]

positive regulation of transmission of nerve impulse

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of translation

positive regulation of cell adhesion

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization

positive regulation of endocytosis [inference]

positive regulation of phagocytosis [inference]

positive regulation of phagocytosis, engulfment

positive regulation of membrane invagination [inference]

positive regulation of phagocytosis, engulfment

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of response to stimulus [inference]

positive regulation of response to external stimulus [inference]

positive regulation of chemotaxis [inference]

positive regulation of positive chemotaxis

positive regulation of transport [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis [inference]

positive regulation of phagocytosis, engulfment

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system process [inference]

positive regulation of transmission of nerve impulse

positive regulation of muscle contraction [inference]

positive regulation of smooth muscle contraction

regulation of response to stimulus [inference]

regulation of response to external stimulus [inference]

positive regulation of response to external stimulus [inference]

positive regulation of chemotaxis [inference]

positive regulation of positive chemotaxis

regulation of chemotaxis [inference]

positive regulation of chemotaxis [inference]

positive regulation of positive chemotaxis

regulation of positive chemotaxis [inference]

positive regulation of positive chemotaxis

positive regulation of response to stimulus [inference]

positive regulation of response to external stimulus [inference]

positive regulation of chemotaxis [inference]

positive regulation of positive chemotaxis

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

regulation of cell communication [inference]

positive regulation of cell communication [inference]

positive regulation of transmission of nerve impulse

regulation of transmission of nerve impulse [inference]

positive regulation of transmission of nerve impulse

regulation of cell adhesion [inference]

positive regulation of cell adhesion

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of translation

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation [inference]

positive regulation of translation

positive regulation of gene expression [inference]

positive regulation of translation

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of translation

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of translation

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation [inference]

positive regulation of smooth muscle cell proliferation

regulation of smooth muscle cell proliferation [inference]

positive regulation of smooth muscle cell proliferation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of smooth muscle cell proliferation

positive regulation of cell communication [inference]

positive regulation of transmission of nerve impulse

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of translation

positive regulation of cell adhesion

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization

positive regulation of endocytosis [inference]

positive regulation of phagocytosis [inference]

positive regulation of phagocytosis, engulfment

positive regulation of membrane invagination [inference]

positive regulation of phagocytosis, engulfment

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

regulation of cellular component organization [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis [inference]

positive regulation of phagocytosis, engulfment

regulation of phagocytosis [inference]

positive regulation of phagocytosis [inference]

positive regulation of phagocytosis, engulfment

regulation of phagocytosis, engulfment [inference]

positive regulation of phagocytosis, engulfment

regulation of cell projection organization [inference]

positive regulation of cell projection organization

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization

positive regulation of endocytosis [inference]

positive regulation of phagocytosis [inference]

positive regulation of phagocytosis, engulfment

positive regulation of membrane invagination [inference]

positive regulation of phagocytosis, engulfment

regulation of membrane invagination [inference]

regulation of phagocytosis, engulfment [inference]

positive regulation of phagocytosis, engulfment

positive regulation of membrane invagination [inference]

positive regulation of phagocytosis, engulfment

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis [inference]

positive regulation of phagocytosis, engulfment

regulation of phagocytosis [inference]

positive regulation of phagocytosis [inference]

positive regulation of phagocytosis, engulfment

regulation of phagocytosis, engulfment [inference]

positive regulation of phagocytosis, engulfment

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of leukocyte migration [inference]

positive regulation of leukocyte migration

regulation of epithelial cell migration [inference]

positive regulation of epithelial cell migration

regulation of smooth muscle cell migration [inference]

positive regulation of smooth muscle cell migration

positive regulation of cell migration [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

regulation of multicellular organismal process [inference]

regulation of epithelial cell migration [inference]

positive regulation of epithelial cell migration

regulation of system process [inference]

regulation of nervous system process [inference]

positive regulation of nervous system process [inference]

positive regulation of transmission of nerve impulse

regulation of transmission of nerve impulse [inference]

positive regulation of transmission of nerve impulse

regulation of muscle system process [inference]

regulation of muscle contraction [inference]

regulation of smooth muscle contraction [inference]

positive regulation of smooth muscle contraction

positive regulation of muscle contraction [inference]

positive regulation of smooth muscle contraction

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system process [inference]

positive regulation of transmission of nerve impulse

positive regulation of muscle contraction [inference]

positive regulation of smooth muscle contraction

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GO Term	Evidence Code	PMID
plasma membrane	ISO
plasma membrane	TAS
focal adhesion	ISO
focal adhesion	IEA
integrin complex	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex [inference]

plasma membrane signaling receptor complex [inference]

integrin complex

integrin alpha2-beta1 complex

protein complex involved in cell adhesion [inference]

integrin complex

integrin alpha2-beta1 complex

membrane protein complex [inference]

plasma membrane protein complex [inference]

plasma membrane signaling receptor complex [inference]

integrin complex

integrin alpha2-beta1 complex

cellular anatomical entity [inference]

cell surface

membrane [inference]

plasma membrane

cell junction [inference]

anchoring junction [inference]

cell-substrate junction [inference]

focal adhesion

cell projection

plasma membrane bounded cell projection [inference]

neuron projection [inference]

axon

neuron projection terminus [inference]

axon terminus

side of membrane [inference]

external side of plasma membrane

presynapse

axon terminus

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GO Term	Evidence Code	PMID
amyloid-beta binding	IDA	21126803
integrin binding	ISO
integrin binding	IBA
integrin binding	IEA
collagen binding	ISO

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

integrin binding

laminin binding

cell adhesion molecule binding [inference]

integrin binding

cell adhesion mediator activity [inference]

cell-matrix adhesion mediator activity [inference]

collagen binding involved in cell-matrix adhesion

amide binding [inference]

peptide binding [inference]

amyloid-beta binding

ion binding [inference]

cation binding [inference]

metal ion binding

protein-containing complex binding

integrin binding

collagen binding

collagen binding involved in cell-matrix adhesion

extracellular matrix binding [inference]

laminin binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

collagen receptor activity

Gene Ontology information from NCBI Gene and UniProt.

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

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Guidelines

Summary

External Links

Annotation

International Collaboration

Acknowledgements