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Guidelines

MIRAGE

helicase for meiosis 1

Summary

Gene Symbol

HFM1

Organism

Homo sapiens (human)

External Links

NCBI Gene

164045

PubChem

164045

Alliance of Genome Resources

HGNC:20193

JoGo

HFM1

TogoVar

HFM1

Annotation

Keyword

Alternative splicing
Disease variant
Helicase
Isomerase
Meiosis
Premature ovarian failure
Proteomics identification
Reference proteome
Zinc-finger

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A2PYH4	DNA 3'-5' helicase HFM1 SEC63 domain-containing protein 1
B4DYS5	DNA 3'-5' helicase HFM1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying 1 entry
GO Term	Evidence Code	PMID
resolution of meiotic recombination intermediates	IBA

GO Hierarchy

biological process

cellular process [inference]

cell cycle process [inference]

meiotic cell cycle process [inference]

meiosis I cell cycle process [inference]

resolution of meiotic recombination intermediates

reproductive process [inference]

meiotic cell cycle process [inference]

meiosis I cell cycle process [inference]

resolution of meiotic recombination intermediates

Displaying 1 entry
GO Term	Evidence Code	PMID
nucleus	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying entries **1 - 5** of 8 in total

1

2

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GO Term	Evidence Code	PMID
nucleic acid binding	IEA
DNA helicase activity	IBA
ATP binding	IEA
four-way junction helicase activity	IEA
ATP hydrolysis activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

catalytic activity, acting on a nucleic acid [inference]

helicase activity [inference]

DNA helicase activity

four-way junction helicase activity

single-stranded DNA helicase activity [inference]

single-stranded 3'-5' DNA helicase activity

double-stranded DNA helicase activity

3'-5' DNA helicase activity [inference]

single-stranded 3'-5' DNA helicase activity

forked DNA-dependent helicase activity

catalytic activity, acting on DNA [inference]

ATP-dependent activity, acting on DNA [inference]

DNA helicase activity

four-way junction helicase activity

single-stranded DNA helicase activity [inference]

single-stranded 3'-5' DNA helicase activity

double-stranded DNA helicase activity

3'-5' DNA helicase activity [inference]

single-stranded 3'-5' DNA helicase activity

forked DNA-dependent helicase activity

binding [inference]

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleic acid binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ATP-dependent activity [inference]

helicase activity [inference]

DNA helicase activity

four-way junction helicase activity

single-stranded DNA helicase activity [inference]

single-stranded 3'-5' DNA helicase activity

double-stranded DNA helicase activity

3'-5' DNA helicase activity [inference]

single-stranded 3'-5' DNA helicase activity

forked DNA-dependent helicase activity

ATP-dependent activity, acting on DNA [inference]

DNA helicase activity

four-way junction helicase activity

single-stranded DNA helicase activity [inference]

single-stranded 3'-5' DNA helicase activity

double-stranded DNA helicase activity

3'-5' DNA helicase activity [inference]

single-stranded 3'-5' DNA helicase activity

forked DNA-dependent helicase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

helicase

Functional Category

J: Translation, ribosomal structure and biogenesis
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
ATP binding
hydrolase activity
nucleotide binding

Displaying **all 9** entries
InterPro
C2 domain superfamily
DEAD/DEAH box helicase domain
Helicase superfamily 1/2, ATP-binding domain
Helicase, C-terminal domain-like
Immunoglobulin E-set
P-loop containing nucleoside triphosphate hydrolase
Sec63 domain
Winged helix DNA-binding domain superfamily
Winged helix-like DNA-binding domain superfamily

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0080866	primary ovarian insufficiency 9	Alliance of Genome Resources

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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GlyCosmos Portal v4.5.0

Last updated: April 6, 2026