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inositol 1,4,5-trisphosphate receptor 1

Summary

Gene Symbol

Itpr1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

16438

PubChem

16438

Alliance of Genome Resources

MGI:96623

Annotation

Keyword

3D-structure
ATP-binding
Alternative splicing
Apoptosis
Calcium channel
Cytoplasm
Cytoplasmic vesicle
Direct protein sequencing
Disulfide bond
Endoplasmic reticulum
Isopeptide bond
Ligand-gated ion channel
Membrane
Metal-binding
Palmitate
Phosphoprotein
Receptor
Reference proteome
Repeat
Transmembrane helix
Ubl conjugation
Zinc

Proteins

Displaying **all 5** entries
UniProt	Protein Name
Q8BQN0
P11881	IP3 receptor isoform 1 Inositol 1,4,5 trisphosphate receptor Inositol 1,4,5-trisphosphate receptor type 1 Inositol 1,4,5-trisphosphate-binding protein P400 Protein PCD-6 Purkinje cell protein 1 Type 1 inositol 1,4,5-trisphosphate receptor
Q3UVA1
Q8C7X9
Q8C8N0

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 38 in total

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GO Term	Evidence Code	PMID
cell morphogenesis	IMP	32675284
response to hypoxia	ISO
response to hypoxia	IDA	19120137
calcium ion transport	IDA	16014380
phospholipase C-activating G protein-coupled receptor signaling pathway	IMP	26075576 31664108

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

phospholipase C-activating G protein-coupled receptor signaling pathway

phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway

G protein-coupled acetylcholine receptor signaling pathway [inference]

phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway

ion channel modulating, G protein-coupled receptor signaling pathway

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

calcium-mediated signaling

intrinsic apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

postsynaptic signal transduction [inference]

acetylcholine receptor signaling pathway [inference]

G protein-coupled acetylcholine receptor signaling pathway [inference]

phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway

ligand-gated ion channel signaling pathway

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organic cyclic compound [inference]

cellular response to cAMP

cellular response to organonitrogen compound [inference]

cellular response to cAMP

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to cAMP

cellular response to oxygen-containing compound [inference]

cellular response to cAMP

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

mitochondrial calcium ion transmembrane transport [inference]

calcium import into the mitochondrion

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

release of sequestered calcium ion into cytosol by endoplasmic reticulum

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

mitochondrial calcium ion transmembrane transport [inference]

calcium import into the mitochondrion

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

release of sequestered calcium ion into cytosol by endoplasmic reticulum

mitochondrial transmembrane transport [inference]

calcium import into the mitochondrion

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein homooligomerization [inference]

protein homotetramerization

protein tetramerization [inference]

protein homotetramerization

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein homooligomerization [inference]

protein homotetramerization

protein tetramerization [inference]

protein homotetramerization

reproductive process [inference]

fertilization [inference]

single fertilization

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

neuromuscular process [inference]

musculoskeletal movement [inference]

voluntary musculoskeletal movement

post-embryonic development

multicellular organismal movement [inference]

musculoskeletal movement [inference]

voluntary musculoskeletal movement

developmental process [inference]

anatomical structure morphogenesis [inference]

cell morphogenesis

anatomical structure development [inference]

regeneration [inference]

animal organ regeneration [inference]

liver regeneration

animal organ development [inference]

animal organ regeneration [inference]

liver regeneration

gland development [inference]

liver development [inference]

liver regeneration

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis [inference]

endoplasmic reticulum calcium ion homeostasis

regulation of cytosolic calcium ion concentration

regulation of postsynaptic cytosolic calcium ion concentration

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis [inference]

endoplasmic reticulum calcium ion homeostasis

regulation of cytosolic calcium ion concentration

regulation of postsynaptic cytosolic calcium ion concentration

monoatomic cation homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis [inference]

endoplasmic reticulum calcium ion homeostasis

regulation of cytosolic calcium ion concentration

regulation of postsynaptic cytosolic calcium ion concentration

calcium ion homeostasis [inference]

intracellular calcium ion homeostasis [inference]

endoplasmic reticulum calcium ion homeostasis

regulation of cytosolic calcium ion concentration

regulation of postsynaptic cytosolic calcium ion concentration

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis [inference]

endoplasmic reticulum calcium ion homeostasis

regulation of cytosolic calcium ion concentration

regulation of postsynaptic cytosolic calcium ion concentration

inorganic ion homeostasis [inference]

calcium ion homeostasis [inference]

intracellular calcium ion homeostasis [inference]

endoplasmic reticulum calcium ion homeostasis

regulation of cytosolic calcium ion concentration

regulation of postsynaptic cytosolic calcium ion concentration

response to stimulus [inference]

response to stress [inference]

response to hypoxia

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

response to abiotic stimulus [inference]

response to oxygen levels [inference]

response to decreased oxygen levels [inference]

response to hypoxia

response to endogenous stimulus [inference]

cellular response to endogenous stimulus [inference]

cellular response to organonitrogen compound [inference]

cellular response to cAMP

response to chemical [inference]

response to organic substance [inference]

response to organonitrogen compound [inference]

response to purine-containing compound [inference]

response to cAMP [inference]

cellular response to cAMP

cellular response to organonitrogen compound [inference]

cellular response to cAMP

response to organic cyclic compound [inference]

response to purine-containing compound [inference]

response to cAMP [inference]

cellular response to cAMP

cellular response to organic cyclic compound [inference]

cellular response to cAMP

response to organophosphorus [inference]

response to cAMP [inference]

cellular response to cAMP

cellular response to organic substance [inference]

cellular response to organic cyclic compound [inference]

cellular response to cAMP

cellular response to organonitrogen compound [inference]

cellular response to cAMP

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organic cyclic compound [inference]

cellular response to cAMP

cellular response to organonitrogen compound [inference]

cellular response to cAMP

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to cAMP

cellular response to oxygen-containing compound [inference]

cellular response to cAMP

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to purine-containing compound [inference]

response to cAMP [inference]

cellular response to cAMP

cellular response to organonitrogen compound [inference]

cellular response to cAMP

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to cAMP

response to oxygen-containing compound [inference]

response to cAMP [inference]

cellular response to cAMP

cellular response to oxygen-containing compound [inference]

cellular response to cAMP

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organic cyclic compound [inference]

cellular response to cAMP

cellular response to organonitrogen compound [inference]

cellular response to cAMP

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to cAMP

cellular response to oxygen-containing compound [inference]

cellular response to cAMP

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

calcium ion transport

calcium ion transmembrane transport [inference]

mitochondrial calcium ion transmembrane transport [inference]

calcium import into the mitochondrion

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

release of sequestered calcium ion into cytosol by endoplasmic reticulum

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

mitochondrial calcium ion transmembrane transport [inference]

calcium import into the mitochondrion

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

release of sequestered calcium ion into cytosol by endoplasmic reticulum

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

mitochondrial calcium ion transmembrane transport [inference]

calcium import into the mitochondrion

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

release of sequestered calcium ion into cytosol by endoplasmic reticulum

mitochondrial transport [inference]

mitochondrial calcium ion transmembrane transport [inference]

calcium import into the mitochondrion

mitochondrial transmembrane transport [inference]

calcium import into the mitochondrion

fluid transport [inference]

epithelial fluid transport

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

mitochondrial calcium ion transmembrane transport [inference]

calcium import into the mitochondrion

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

release of sequestered calcium ion into cytosol by endoplasmic reticulum

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

mitochondrial calcium ion transmembrane transport [inference]

calcium import into the mitochondrion

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

release of sequestered calcium ion into cytosol by endoplasmic reticulum

mitochondrial transmembrane transport [inference]

calcium import into the mitochondrion

transepithelial transport [inference]

epithelial fluid transport

organic substance transport [inference]

calcium ion transport

calcium ion transmembrane transport [inference]

mitochondrial calcium ion transmembrane transport [inference]

calcium import into the mitochondrion

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

release of sequestered calcium ion into cytosol by endoplasmic reticulum

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of calcium-mediated signaling

regulation of intracellular signal transduction [inference]

regulation of calcium-mediated signaling [inference]

negative regulation of calcium-mediated signaling

negative regulation of intracellular signal transduction [inference]

negative regulation of calcium-mediated signaling

positive regulation of signaling [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of calcium-mediated signaling

regulation of hormone secretion [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

regulation of peptide hormone secretion [inference]

regulation of insulin secretion [inference]

positive regulation of insulin secretion

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

regulation of localization [inference]

regulation of transport [inference]

regulation of monoatomic ion transport [inference]

regulation of metal ion transport [inference]

regulation of calcium ion transport [inference]

positive regulation of calcium ion transport

positive regulation of monoatomic ion transport [inference]

positive regulation of calcium ion transport

regulation of secretion [inference]

regulation of peptide secretion [inference]

positive regulation of peptide secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

regulation of peptide hormone secretion [inference]

regulation of insulin secretion [inference]

positive regulation of insulin secretion

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

positive regulation of secretion [inference]

positive regulation of peptide secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

positive regulation of secretion by cell [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

positive regulation of protein secretion [inference]

positive regulation of insulin secretion

regulation of secretion by cell [inference]

regulation of hormone secretion [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

regulation of peptide hormone secretion [inference]

regulation of insulin secretion [inference]

positive regulation of insulin secretion

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

regulation of protein secretion [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion

regulation of insulin secretion [inference]

positive regulation of insulin secretion

positive regulation of secretion by cell [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

positive regulation of protein secretion [inference]

positive regulation of insulin secretion

positive regulation of transport [inference]

positive regulation of monoatomic ion transport [inference]

positive regulation of calcium ion transport

positive regulation of secretion [inference]

positive regulation of peptide secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

positive regulation of secretion by cell [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

positive regulation of protein secretion [inference]

positive regulation of insulin secretion

positive regulation of protein transport [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion

regulation of protein transport [inference]

regulation of protein secretion [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion

regulation of insulin secretion [inference]

positive regulation of insulin secretion

positive regulation of protein transport [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion

regulation of peptide transport [inference]

regulation of peptide secretion [inference]

positive regulation of peptide secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

regulation of peptide hormone secretion [inference]

regulation of insulin secretion [inference]

positive regulation of insulin secretion

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

regulation of sequestering of calcium ion [inference]

negative regulation of sequestering of calcium ion [inference]

release of sequestered calcium ion into cytosol

release of sequestered calcium ion into cytosol by endoplasmic reticulum

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of protein secretion [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion

regulation of insulin secretion [inference]

positive regulation of insulin secretion

positive regulation of protein transport [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion

positive regulation of protein localization [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of epithelial cell proliferation [inference]

positive regulation of hepatocyte proliferation

positive regulation of cell communication [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development

positive regulation of secretion by cell [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

positive regulation of protein secretion [inference]

positive regulation of insulin secretion

positive regulation of protein localization [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion

positive regulation of transport [inference]

positive regulation of monoatomic ion transport [inference]

positive regulation of calcium ion transport

positive regulation of secretion [inference]

positive regulation of peptide secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

positive regulation of secretion by cell [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

positive regulation of protein secretion [inference]

positive regulation of insulin secretion

positive regulation of protein transport [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of calcium-mediated signaling

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of calcium-mediated signaling

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of sequestering of calcium ion [inference]

release of sequestered calcium ion into cytosol

release of sequestered calcium ion into cytosol by endoplasmic reticulum

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of calcium-mediated signaling

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of calcium-mediated signaling

regulation of intracellular signal transduction [inference]

regulation of calcium-mediated signaling [inference]

negative regulation of calcium-mediated signaling

negative regulation of intracellular signal transduction [inference]

negative regulation of calcium-mediated signaling

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of calcium-mediated signaling

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

phospholipase C-activating G protein-coupled receptor signaling pathway

phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway

G protein-coupled acetylcholine receptor signaling pathway [inference]

phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway

ion channel modulating, G protein-coupled receptor signaling pathway

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

calcium-mediated signaling

intrinsic apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

postsynaptic signal transduction [inference]

acetylcholine receptor signaling pathway [inference]

G protein-coupled acetylcholine receptor signaling pathway [inference]

phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway

ligand-gated ion channel signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of calcium-mediated signaling

regulation of intracellular signal transduction [inference]

regulation of calcium-mediated signaling [inference]

negative regulation of calcium-mediated signaling

negative regulation of intracellular signal transduction [inference]

negative regulation of calcium-mediated signaling

positive regulation of cell communication [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of calcium-mediated signaling

regulation of hormone secretion [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

regulation of peptide hormone secretion [inference]

regulation of insulin secretion [inference]

positive regulation of insulin secretion

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation [inference]

positive regulation of epithelial cell proliferation [inference]

positive regulation of hepatocyte proliferation

regulation of epithelial cell proliferation [inference]

positive regulation of epithelial cell proliferation [inference]

positive regulation of hepatocyte proliferation

regulation of hepatocyte proliferation [inference]

positive regulation of hepatocyte proliferation

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of epithelial cell proliferation [inference]

positive regulation of hepatocyte proliferation

positive regulation of cell communication [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development

positive regulation of secretion by cell [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

positive regulation of protein secretion [inference]

positive regulation of insulin secretion

positive regulation of protein localization [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of calcium-mediated signaling

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of sequestering of calcium ion [inference]

release of sequestered calcium ion into cytosol

release of sequestered calcium ion into cytosol by endoplasmic reticulum

regulation of cellular component organization [inference]

regulation of cell projection organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development

regulation of plasma membrane bounded cell projection organization [inference]

regulation of neuron projection development [inference]

positive regulation of neuron projection development

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development

regulation of sequestering of calcium ion [inference]

negative regulation of sequestering of calcium ion [inference]

release of sequestered calcium ion into cytosol

release of sequestered calcium ion into cytosol by endoplasmic reticulum

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of protein secretion [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion

regulation of insulin secretion [inference]

positive regulation of insulin secretion

positive regulation of protein transport [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion

positive regulation of protein localization [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion

regulation of secretion by cell [inference]

regulation of hormone secretion [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

regulation of peptide hormone secretion [inference]

regulation of insulin secretion [inference]

positive regulation of insulin secretion

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

regulation of protein secretion [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion

regulation of insulin secretion [inference]

positive regulation of insulin secretion

positive regulation of secretion by cell [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

positive regulation of protein secretion [inference]

positive regulation of insulin secretion

regulation of biological quality [inference]

positive regulation of cytosolic calcium ion concentration

regulation of hormone levels [inference]

regulation of hormone secretion [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

regulation of peptide hormone secretion [inference]

regulation of insulin secretion [inference]

positive regulation of insulin secretion

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

Displaying entries **1 - 5** of 39 in total

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GO Term	Evidence Code	PMID
nuclear envelope	ISO
nuclear envelope	IDA	16014380
nuclear inner membrane	IDA	16014380
nucleolus	IDA	16014380
cytoplasm	IDA	9858485

GO Hierarchy

cellular component

protein-containing complex

intracellular protein-containing complex [inference]

calcineurin complex

catalytic complex [inference]

phosphatase complex [inference]

protein serine/threonine phosphatase complex [inference]

calcineurin complex

cellular anatomical entity [inference]

cytoplasm

membrane

plasma membrane

organelle membrane [inference]

endoplasmic reticulum membrane

smooth endoplasmic reticulum membrane

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

transport vesicle membrane

secretory granule membrane

platelet dense granule membrane

organelle inner membrane [inference]

nuclear inner membrane

nuclear membrane [inference]

nuclear inner membrane

bounding membrane of organelle [inference]

transport vesicle membrane

secretory granule membrane

platelet dense granule membrane

smooth endoplasmic reticulum membrane

plasma membrane region [inference]

synaptic membrane

cell junction [inference]

synapse

envelope [inference]

organelle envelope [inference]

nuclear envelope

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

dendrite

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

sarcoplasmic reticulum

platelet dense tubular network

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

nucleolus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

sarcoplasmic reticulum

platelet dense tubular network

intracellular non-membrane-bounded organelle [inference]

nucleolus

postsynaptic specialization [inference]

postsynaptic density

cell body [inference]

neuronal cell body

Displaying entries **1 - 5** of 25 in total

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GO Term	Evidence Code	PMID
inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity	ISO
inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity	TAS	1648733
inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity	IDA	11955285 17327232 20813840 2554142 28416699 38099643
inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity	IMP	35568199
inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity	IGI	10570150

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity

monoatomic cation channel activity [inference]

calcium channel activity [inference]

ligand-gated calcium channel activity [inference]

calcium-release channel activity

inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity

inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels

ligand-gated monoatomic cation channel activity [inference]

ligand-gated calcium channel activity [inference]

calcium-release channel activity

inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity

inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels

ligand-gated monoatomic ion channel activity [inference]

intracellular ligand-gated monoatomic ion channel activity [inference]

calcium-release channel activity

inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity

inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels

ligand-gated monoatomic cation channel activity [inference]

ligand-gated calcium channel activity [inference]

calcium-release channel activity

inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity

inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels

monoatomic cation transmembrane transporter activity [inference]

monoatomic cation channel activity [inference]

calcium channel activity [inference]

ligand-gated calcium channel activity [inference]

calcium-release channel activity

inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity

inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels

ligand-gated monoatomic cation channel activity [inference]

ligand-gated calcium channel activity [inference]

calcium-release channel activity

inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity

inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels

metal ion transmembrane transporter activity [inference]

calcium ion transmembrane transporter activity [inference]

calcium channel activity [inference]

ligand-gated calcium channel activity [inference]

calcium-release channel activity

inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity

inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels

inorganic molecular entity transmembrane transporter activity [inference]

inorganic cation transmembrane transporter activity [inference]

metal ion transmembrane transporter activity [inference]

calcium ion transmembrane transporter activity [inference]

calcium channel activity [inference]

ligand-gated calcium channel activity [inference]

calcium-release channel activity

inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity

inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity

monoatomic cation channel activity [inference]

calcium channel activity [inference]

ligand-gated calcium channel activity [inference]

calcium-release channel activity

inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity

inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels

ligand-gated monoatomic cation channel activity [inference]

ligand-gated calcium channel activity [inference]

calcium-release channel activity

inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity

inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels

ligand-gated monoatomic ion channel activity [inference]

intracellular ligand-gated monoatomic ion channel activity [inference]

calcium-release channel activity

inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity

inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels

ligand-gated monoatomic cation channel activity [inference]

ligand-gated calcium channel activity [inference]

calcium-release channel activity

inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity

inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels

gated channel activity [inference]

ligand-gated channel activity [inference]

ligand-gated monoatomic ion channel activity [inference]

intracellular ligand-gated monoatomic ion channel activity [inference]

calcium-release channel activity

inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity

inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels

ligand-gated monoatomic cation channel activity [inference]

ligand-gated calcium channel activity [inference]

calcium-release channel activity

inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity

inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels

salt transmembrane transporter activity [inference]

calcium ion transmembrane transporter activity [inference]

calcium channel activity [inference]

ligand-gated calcium channel activity [inference]

calcium-release channel activity

inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity

inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels

binding [inference]

protein binding

enzyme binding [inference]

phosphatase binding [inference]

protein phosphatase binding

protein domain specific binding

identical protein binding

protein homodimerization activity

transmembrane transporter binding

protein dimerization activity [inference]

protein homodimerization activity

lipid binding [inference]

phospholipid binding [inference]

phosphatidylinositol binding

small molecule binding [inference]

alcohol binding [inference]

inositol 1,4,5 trisphosphate binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

inositol 1,4,5 trisphosphate binding

cation binding [inference]

metal ion binding

calcium ion binding

protein-containing complex binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

molecular function regulator activity [inference]

molecular function inhibitor activity [inference]

transporter inhibitor activity [inference]

channel inhibitor activity [inference]

ion channel inhibitor activity [inference]

calcium channel inhibitor activity

transporter regulator activity [inference]

channel regulator activity [inference]

channel inhibitor activity [inference]

ion channel inhibitor activity [inference]

calcium channel inhibitor activity

ion channel regulator activity [inference]

calcium channel regulator activity [inference]

calcium channel inhibitor activity

ion channel inhibitor activity [inference]

calcium channel inhibitor activity

transporter inhibitor activity [inference]

channel inhibitor activity [inference]

ion channel inhibitor activity [inference]

calcium channel inhibitor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

inositol 1,4,5-trisphosphate receptor,

Functional Category

E: Amino acid transport and metabolism
J: Translation, ribosomal structure and biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 8** entries
Gene Ontology
calcium channel activity
calcium ion transmembrane transport
calcium ion transport
calcium-mediated signaling
inositol 1,4,5 trisphosphate binding
monoatomic ion channel activity
monoatomic ion transport
release of sequestered calcium ion into cytosol

Displaying **all 6** entries
InterPro
Inositol 1,4,5-trisphosphate receptor
Inositol 1,4,5-trisphosphate/ryanodine receptor
MIR motif
RIH domain
RyR/IP3 receptor binding core, RIH domain superfamily
Ryanodine/Inositol 1,4,5-trisphosphate receptor

Ortholog

Displaying entries **1 - 10** of 60 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	3708	Xenbase:XB-GENE-920765	HUMAN68200
Drosophila melanogaster	3709	FB:FBgn0010051
Drosophila melanogaster	3710	FB:FBgn0010051
Xenopus tropicalis	16438	Xenbase:XB-GENE-920765
Drosophila melanogaster	16440	FB:FBgn0010051
Rattus norvegicus	25262	Xenbase:XB-GENE-920765	RATNO32094
Bos taurus	317697		BOVIN17442
Sus scrofa	397454		PIGXX04492
Pan troglodytes	460134		PANTR30309
Canis lupus familiaris	476548		CANLF07320

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Acknowledgements