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jagged 2

Summary

Gene Symbol

Jag2

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

16450

PubChem

16450

Alliance of Genome Resources

MGI:1098270

Annotation

Keyword

Calcium
Developmental protein
Disulfide bond
EGF-like domain
Glycoprotein
Notch signaling pathway
Phosphoprotein
Reference proteome
Repeat
Signal
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9QYE5

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 21 in total

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GO Term	Evidence Code	PMID
skeletal system development	IMP	15721140
in utero embryonic development	IMP	9531541
cell fate determination	NAS	10910909
respiratory system process	IMP	9531541
Notch signaling pathway	IEA

GO Hierarchy

biological process

immune system process [inference]

T cell selection [inference]

thymic T cell selection

leukocyte activation [inference]

lymphocyte activation [inference]

lymphocyte differentiation [inference]

T cell differentiation

gamma-delta T cell differentiation

T cell activation [inference]

T cell differentiation

gamma-delta T cell differentiation

gamma-delta T cell activation [inference]

gamma-delta T cell differentiation

cellular process [inference]

cell activation [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

lymphocyte differentiation [inference]

T cell differentiation

gamma-delta T cell differentiation

T cell activation [inference]

T cell differentiation

gamma-delta T cell differentiation

gamma-delta T cell activation [inference]

gamma-delta T cell differentiation

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Notch signaling pathway

cell death [inference]

programmed cell death [inference]

apoptotic process [inference]

apoptotic process involved in development [inference]

apoptotic process involved in morphogenesis [inference]

epithelial cell apoptotic process involved in palatal shelf morphogenesis

epithelial cell apoptotic process [inference]

epithelial cell apoptotic process involved in palatal shelf morphogenesis

cellular developmental process [inference]

cell fate determination

cell differentiation

leukocyte differentiation [inference]

mononuclear cell differentiation [inference]

lymphocyte differentiation [inference]

T cell differentiation

gamma-delta T cell differentiation

cell fate commitment [inference]

neuron fate commitment [inference]

inner ear receptor cell fate commitment [inference]

auditory receptor cell fate commitment

reproductive process [inference]

developmental process involved in reproduction [inference]

spermatogenesis

multicellular organismal reproductive process [inference]

gamete generation [inference]

male gamete generation [inference]

spermatogenesis

multicellular organismal process [inference]

cell activation [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

lymphocyte differentiation [inference]

T cell differentiation

gamma-delta T cell differentiation

T cell activation [inference]

T cell differentiation

gamma-delta T cell differentiation

gamma-delta T cell activation [inference]

gamma-delta T cell differentiation

system process [inference]

respiratory system process

nervous system process [inference]

sensory perception [inference]

sensory perception of mechanical stimulus [inference]

sensory perception of sound

multicellular organism development [inference]

embryo development [inference]

embryo development ending in birth or egg hatching [inference]

chordate embryonic development [inference]

in utero embryonic development

developmental process [inference]

developmental process involved in reproduction [inference]

spermatogenesis

anatomical structure morphogenesis [inference]

animal organ morphogenesis [inference]

odontogenesis [inference]

odontogenesis of dentin-containing tooth

embryonic morphogenesis [inference]

morphogenesis of embryonic epithelium

tissue morphogenesis [inference]

morphogenesis of an epithelium [inference]

morphogenesis of embryonic epithelium

anatomical structure development [inference]

multicellular organism development [inference]

embryo development [inference]

embryo development ending in birth or egg hatching [inference]

chordate embryonic development [inference]

in utero embryonic development

system development [inference]

skeletal system development

cellular developmental process [inference]

cell fate determination

cell differentiation

leukocyte differentiation [inference]

mononuclear cell differentiation [inference]

lymphocyte differentiation [inference]

T cell differentiation

gamma-delta T cell differentiation

cell fate commitment [inference]

neuron fate commitment [inference]

inner ear receptor cell fate commitment [inference]

auditory receptor cell fate commitment

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of Notch signaling pathway [inference]

positive regulation of Notch signaling pathway

positive regulation of signal transduction [inference]

positive regulation of Notch signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of Notch signaling pathway

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of Notch signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of Notch signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of Notch signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of Notch signaling pathway [inference]

positive regulation of Notch signaling pathway

positive regulation of signal transduction [inference]

positive regulation of Notch signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of Notch signaling pathway

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Notch signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of Notch signaling pathway [inference]

positive regulation of Notch signaling pathway

positive regulation of signal transduction [inference]

positive regulation of Notch signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of Notch signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of Notch signaling pathway

Displaying **all 4** entries
GO Term	Evidence Code	PMID
plasma membrane	TAS
plasma membrane	IDA	10910909
membrane	IDA	15886206
perinuclear region of cytoplasm	ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

perinuclear region of cytoplasm

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
Notch binding	ISO
Notch binding	IBA
Notch binding	IPI	10958687
calcium ion binding	IEA
protein binding	IPI	12496659 15788413

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding [inference]

Notch binding

receptor ligand activity [inference]

growth factor activity

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

growth factor activity

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

growth factor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

jagged

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
Notch binding
calcium ion binding
cell communication

Displaying **all 10** entries
InterPro
Delta/Serrate/lag-2 (DSL) protein
EGF-like calcium-binding domain
EGF-like calcium-binding, conserved site
EGF-like domain
EGF-like, conserved site
EGF-type aspartate/asparagine hydroxylation site
Growth factor receptor cysteine-rich domain superfamily
Jagged/Serrate protein
Notch ligand, N-terminal domain
VWFC domain

Ortholog

Displaying entries **1 - 10** of 73 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	182	FB:FBgn0004197
Homo sapiens	3714	Xenbase:XB-GENE-485160	HUMAN21614
Drosophila melanogaster	16449	FB:FBgn0004197
Xenopus tropicalis	16450	Xenbase:XB-GENE-485160
Drosophila melanogaster	29146	FB:FBgn0004197
Rattus norvegicus	29147		RATNO36910
Xenopus tropicalis	43275	Xenbase:XB-GENE-485160
Drosophila melanogaster	140421	FB:FBgn0004197
Danio rerio	140422		DANRE48583
Macaca mulatta	699003		MACMU40036