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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
aldo-keto reductase family 1 member C1
Summary
- Gene Symbol
-
- AKR1C1
- Aliases
-
- DD1
- DDH
- HAKRC
- MBAB
- dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Cytoplasm
- Direct protein sequencing
- Lipid metabolism
- NADP
- Oxidoreductase
- Reference proteome
- Proteins
| UniProt | Protein Name |
|---|---|
| Q04828 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| bile acid metabolic process | ||
| positive regulation of reactive oxygen species metabolic process | ||
| daunorubicin metabolic process | ||
| doxorubicin metabolic process | ||
| cellular response to jasmonic acid stimulus |
GO Hierarchy
biological process
metabolic process [inference]
cellular process [inference]
response to stimulus [inference]
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| androstan-3-alpha,17-beta-diol dehydrogenase activity | ||
| carboxylic acid binding | ||
| alditol:NADP+ 1-oxidoreductase activity | ||
| 3beta-hydroxy-5beta-steroid dehydrogenase activity | ||
| oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor |
GO Hierarchy
- estradiol 17-beta-dehydrogenase [NAD(P)] activity
- testosterone dehydrogenase [NAD(P)] activity
- dihydrotestosterone 17-beta-dehydrogenase activity
- 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity
- 5alpha-androstane-3beta,17beta-diol dehydrogenase activity
- androstan-3-alpha,17-beta-diol dehydrogenase activity
- testosterone 17-beta-dehydrogenase (NADP+) activity
- 3beta-hydroxy-5beta-steroid dehydrogenase activity
- estradiol 17-beta-dehydrogenase [NAD(P)] activity
- testosterone dehydrogenase [NAD(P)] activity
- dihydrotestosterone 17-beta-dehydrogenase activity
- 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity
- 5alpha-androstane-3beta,17beta-diol dehydrogenase activity
- androstan-3-alpha,17-beta-diol dehydrogenase activity
- testosterone 17-beta-dehydrogenase (NADP+) activity
- indanol dehydrogenase activity
molecular function
catalytic activity [inference]
oxidoreductase activity [inference]
steroid dehydrogenase activity [inference]
steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
oxidoreductase activity, acting on CH-OH group of donors [inference]
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]
steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Rhea
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:3765 | pseudohermaphroditism | |
| DOID:381 | arthropathy | |
| DOID:3904 | bronchus carcinoma | |
| DOID:3905 | lung carcinoma | |
| DOID:3908 | lung non-small cell carcinoma | |
| DOID:4001 | ovarian carcinoma | |
| DOID:4007 | bladder carcinoma | |
| DOID:409 | liver disease | |
| DOID:4154 | dentinogenesis imperfecta | |
| DOID:4362 | cervical cancer |
LIPID MAPS Gene / Proteome Database
- LMPD ID
- LMP002152
- Gene Name
- aldo-keto reductase family 1, member C1
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 175047 | WB:WBGene00012722 | ||
| 39305 | FB:FBgn0036183 | ||
| 326033 | ZFIN:ZDB-GENE-030131-4758 | ||
| 447277 | Xenbase:XB-GENE-5895956 | ||
| 448368 | Xenbase:XB-GENE-5757727 | ||
| 779650 | Xenbase:XB-GENE-5844204 | ||
| 100127714 | Xenbase:XB-GENE-5895911 | ||
| 100085065 | ORNAN04476 | ||
| 101865536 | MACFA41893 | ||
| 102142023 | MACFA41893 |
