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karyopherin subunit alpha 1

Summary

Gene Symbol

Kpna1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

16646

PubChem

16646

Alliance of Genome Resources

MGI:103560

Annotation

Keyword

Acetylation
Cytoplasm
Nucleus
Phosphoprotein
Protein transport
Reference proteome
Repeat
Ubl conjugation

Proteins

Displaying 1 entry
UniProt	Protein Name
Q60960	Importin alpha-S1 Karyopherin subunit alpha-1 Nucleoprotein interactor 1 RAG cohort protein 2 SRP1-beta

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
protein import into nucleus	ISS
NLS-bearing protein import into nucleus	ISO
NLS-bearing protein import into nucleus	IMP	27434733
NLS-bearing protein import into nucleus	IBA
skeletal muscle satellite cell proliferation	IMP	27434733

GO Hierarchy

biological process

cellular process [inference]

cell activation [inference]

skeletal muscle satellite cell activation [inference]

satellite cell activation involved in skeletal muscle regeneration

signal transduction [inference]

postsynaptic signal transduction [inference]

postsynapse to nucleus signaling pathway

cell population proliferation [inference]

muscle cell proliferation [inference]

striated muscle cell proliferation [inference]

skeletal muscle cell proliferation [inference]

skeletal muscle satellite cell proliferation

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein import into nucleus

NLS-bearing protein import into nucleus

nuclear transport [inference]

nucleocytoplasmic transport [inference]

import into nucleus [inference]

protein import into nucleus

NLS-bearing protein import into nucleus

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to nucleus [inference]

protein import into nucleus

NLS-bearing protein import into nucleus

establishment of protein localization to organelle [inference]

protein import into nucleus

NLS-bearing protein import into nucleus

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein import into nucleus

NLS-bearing protein import into nucleus

establishment of protein localization to organelle [inference]

protein import into nucleus

NLS-bearing protein import into nucleus

multicellular organismal process [inference]

cell activation [inference]

skeletal muscle satellite cell activation [inference]

satellite cell activation involved in skeletal muscle regeneration

developmental process [inference]

anatomical structure development [inference]

regeneration [inference]

tissue regeneration [inference]

skeletal muscle tissue regeneration

growth [inference]

developmental growth [inference]

tissue regeneration [inference]

skeletal muscle tissue regeneration

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to nucleus [inference]

protein import into nucleus

NLS-bearing protein import into nucleus

establishment of protein localization to organelle [inference]

protein import into nucleus

NLS-bearing protein import into nucleus

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein import into nucleus

NLS-bearing protein import into nucleus

establishment of protein localization to organelle [inference]

protein import into nucleus

NLS-bearing protein import into nucleus

establishment of localization [inference]

transport [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein import into nucleus

NLS-bearing protein import into nucleus

nuclear transport [inference]

nucleocytoplasmic transport [inference]

import into nucleus [inference]

protein import into nucleus

NLS-bearing protein import into nucleus

organic substance transport [inference]

protein transport [inference]

intracellular protein transport [inference]

protein import into nucleus

NLS-bearing protein import into nucleus

nitrogen compound transport [inference]

protein transport [inference]

intracellular protein transport [inference]

protein import into nucleus

NLS-bearing protein import into nucleus

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein import into nucleus

NLS-bearing protein import into nucleus

establishment of protein localization to organelle [inference]

protein import into nucleus

NLS-bearing protein import into nucleus

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein import into nucleus

NLS-bearing protein import into nucleus

nuclear transport [inference]

nucleocytoplasmic transport [inference]

import into nucleus [inference]

protein import into nucleus

NLS-bearing protein import into nucleus

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein import into nucleus

NLS-bearing protein import into nucleus

nuclear transport [inference]

nucleocytoplasmic transport [inference]

import into nucleus [inference]

protein import into nucleus

NLS-bearing protein import into nucleus

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to nucleus [inference]

protein import into nucleus

NLS-bearing protein import into nucleus

establishment of protein localization to organelle [inference]

protein import into nucleus

NLS-bearing protein import into nucleus

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein import into nucleus

NLS-bearing protein import into nucleus

establishment of protein localization to organelle [inference]

protein import into nucleus

NLS-bearing protein import into nucleus

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of Wnt signaling pathway [inference]

regulation of canonical Wnt signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of Wnt signaling pathway [inference]

regulation of canonical Wnt signaling pathway

regulation of cellular process [inference]

signal transduction [inference]

postsynaptic signal transduction [inference]

postsynapse to nucleus signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of Wnt signaling pathway [inference]

regulation of canonical Wnt signaling pathway

regulation of programmed cell death [inference]

regulation of apoptotic process

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
nucleus	ISS
nucleus	ISO
nucleus	IBA
nucleoplasm	ISO
nucleoplasm	NAS	7892216

GO Hierarchy

cellular component

protein-containing complex [inference]

nucleocytoplasmic transport complex [inference]

NLS-dependent protein nuclear import complex

cellular anatomical entity [inference]

cell junction [inference]

synapse [inference]

glutamatergic synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

dendrite

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

postsynaptic specialization [inference]

postsynaptic density

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GO Term	Evidence Code	PMID
protein binding	IPI	18716025 26420826
nuclear localization sequence binding	ISO
nuclear localization sequence binding	IBA
nuclear import signal receptor activity	ISO
nuclear import signal receptor activity	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding

amide binding [inference]

peptide binding [inference]

signal sequence binding [inference]

nuclear localization sequence binding

molecular carrier activity [inference]

nucleocytoplasmic carrier activity [inference]

nuclear import signal receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Importin subunit alpha

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
NLS-bearing protein import into nucleus
nuclear import signal receptor activity
nuclear localization sequence binding
protein import into nucleus

Displaying **all 7** entries
InterPro
Armadillo-like helical
Armadillo-type fold
Armadillo
Atypical Arm repeat
Importin subunit alpha
Importin-alpha, importin-beta-binding domain superfamily
Importin-alpha, importin-beta-binding domain

Ortholog

Displaying entries **1 - 10** of 88 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	3836		HUMAN71874
Xenopus tropicalis	16646	Xenbase:XB-GENE-1014184
Saccharomyces cerevisiae S288C	16650	SGD:S000005133
Rattus norvegicus	288064		RATNO03649
Pan troglodytes	460631		PANTR31988
Canis lupus familiaris	478585		CANLF13356
Bos taurus	539679		BOVIN14615
Danio rerio	572542		DANRE26035
Macaca mulatta	692082		MACMU30526
Monodelphis domestica	100013631		MONDO22949