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keratin 8

Summary

Gene Symbol

Krt8

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

16691

PubChem

16691

Alliance of Genome Resources

MGI:96705

Annotation

Keyword

Acetylation
Coiled coil
Cytoplasm
Direct protein sequencing
Glycoprotein
Intermediate filament
Isopeptide bond
Keratin
Methylation
Nucleus
Phosphoprotein
Reference proteome
Ubl conjugation

Proteins

Displaying 1 entry
UniProt	Protein Name
P11679	Cytokeratin endo A Cytokeratin-8 Keratin-8 Type-II keratin Kb8

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
tumor necrosis factor-mediated signaling pathway	IMP	10747083
tumor necrosis factor-mediated signaling pathway	IGI	10747083
sarcomere organization	ISO
sarcomere organization	IEA
response to hydrostatic pressure	ISO

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway [inference]

tumor necrosis factor-mediated signaling pathway

extrinsic apoptotic signaling pathway

apoptotic signaling pathway [inference]

extrinsic apoptotic signaling pathway

cell death [inference]

programmed cell death [inference]

apoptotic process [inference]

epithelial cell apoptotic process [inference]

hepatocyte apoptotic process

actin filament-based process [inference]

actin cytoskeleton organization [inference]

actomyosin structure organization [inference]

sarcomere organization

cellular developmental process [inference]

cell differentiation [inference]

cell differentiation involved in embryonic placenta development

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

actin cytoskeleton organization [inference]

actomyosin structure organization [inference]

sarcomere organization

reproductive process [inference]

developmental process involved in reproduction [inference]

cell differentiation involved in embryonic placenta development

developmental process [inference]

developmental process involved in reproduction [inference]

cell differentiation involved in embryonic placenta development

cellular developmental process [inference]

cell differentiation [inference]

cell differentiation involved in embryonic placenta development

biological process involved in interspecies interaction between organisms [inference]

response to other organism

response to stimulus [inference]

response to stress [inference]

response to hydrostatic pressure

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism

response to abiotic stimulus [inference]

response to water [inference]

response to hydrostatic pressure

response to chemical [inference]

response to acid chemical [inference]

response to water [inference]

response to hydrostatic pressure

response to organic substance [inference]

response to water [inference]

response to hydrostatic pressure

response to inorganic substance [inference]

response to water [inference]

response to hydrostatic pressure

response to oxygen-containing compound [inference]

response to water [inference]

response to hydrostatic pressure

response to salt [inference]

response to water [inference]

response to hydrostatic pressure

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway [inference]

tumor necrosis factor-mediated signaling pathway

extrinsic apoptotic signaling pathway

apoptotic signaling pathway [inference]

extrinsic apoptotic signaling pathway

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GO Term	Evidence Code	PMID
nucleoplasm	IEA
cytoplasm	ISO
intermediate filament	ISO
intermediate filament	IDA	10747083
cell-cell junction	IDA	23266329

GO Hierarchy

cellular component

protein-containing complex [inference]

glycoprotein complex [inference]

dystrophin-associated glycoprotein complex

membrane protein complex [inference]

plasma membrane protein complex [inference]

dystrophin-associated glycoprotein complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane [inference]

sarcolemma

plasma membrane region [inference]

apicolateral plasma membrane

cell junction [inference]

anchoring junction [inference]

cell-cell junction

costamere

organelle [inference]

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

intermediate filament cytoskeleton

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

intermediate filament cytoskeleton

cell periphery

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

intermediate filament

keratin filament

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protein binding	IPI	10747083 12857878 24940650 25617501
protein-containing complex binding	ISO
protein-containing complex binding	IEA
scaffold protein binding	ISO
scaffold protein binding	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding

scaffold protein binding

protein-containing complex binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Keratin

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
intermediate filament organization
keratinization
structural constituent of skin epidermis

Displaying **all 4** entries
InterPro
Intermediate filament protein, conserved site
Intermediate filament, rod domain
Keratin type II head
Keratin, type II

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	1674	WB:WBGene00002058
Caenorhabditis elegans	2670	WB:WBGene00002058
Danio rerio	3848	ZFIN:ZDB-GENE-991110-23
Danio rerio	3849	ZFIN:ZDB-GENE-991110-23
Danio rerio	3852	ZFIN:ZDB-GENE-991110-23
Danio rerio	3855	ZFIN:ZDB-GENE-991110-23
Homo sapiens	3856	ZFIN:ZDB-GENE-991110-23	HUMAN12869
Caenorhabditis elegans	3858	WB:WBGene00002055
Caenorhabditis elegans	3872	WB:WBGene00002058
Caenorhabditis elegans	5630	WB:WBGene00002058

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements