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keratin 8

Summary

Gene Symbol

Krt8

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

16691

PubChem

16691

Alliance of Genome Resources

MGI:96705

Annotation

Keyword

Acetylation
Coiled coil
Cytoplasm
Direct protein sequencing
Glycoprotein
Intermediate filament
Isopeptide bond
Keratin
Methylation
Nucleus
Phosphoprotein
Reference proteome
Ubl conjugation

Proteins

Displaying 1 entry
UniProt	Protein Name
P11679	Cytokeratin endo A Cytokeratin-8 Keratin-8 Type-II keratin Kb8

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
tumor necrosis factor-mediated signaling pathway	IMP	10747083
tumor necrosis factor-mediated signaling pathway	IGI	10747083
sarcomere organization	ISO
sarcomere organization	IEA
response to hydrostatic pressure	ISO

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway [inference]

tumor necrosis factor-mediated signaling pathway

extrinsic apoptotic signaling pathway

apoptotic signaling pathway [inference]

extrinsic apoptotic signaling pathway

cell death [inference]

programmed cell death [inference]

apoptotic process [inference]

epithelial cell apoptotic process [inference]

hepatocyte apoptotic process

actin filament-based process [inference]

actin cytoskeleton organization [inference]

actomyosin structure organization [inference]

sarcomere organization

cellular developmental process [inference]

cell differentiation [inference]

cell differentiation involved in embryonic placenta development

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

actin cytoskeleton organization [inference]

actomyosin structure organization [inference]

sarcomere organization

reproductive process [inference]

developmental process involved in reproduction [inference]

cell differentiation involved in embryonic placenta development

developmental process [inference]

developmental process involved in reproduction [inference]

cell differentiation involved in embryonic placenta development

cellular developmental process [inference]

cell differentiation [inference]

cell differentiation involved in embryonic placenta development

biological process involved in interspecies interaction between organisms [inference]

response to other organism

response to stimulus [inference]

response to stress [inference]

response to hydrostatic pressure

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism

response to abiotic stimulus [inference]

response to water [inference]

response to hydrostatic pressure

response to chemical [inference]

response to acid chemical [inference]

response to water [inference]

response to hydrostatic pressure

response to organic substance [inference]

response to water [inference]

response to hydrostatic pressure

response to inorganic substance [inference]

response to water [inference]

response to hydrostatic pressure

response to oxygen-containing compound [inference]

response to water [inference]

response to hydrostatic pressure

response to salt [inference]

response to water [inference]

response to hydrostatic pressure

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway [inference]

tumor necrosis factor-mediated signaling pathway

extrinsic apoptotic signaling pathway

apoptotic signaling pathway [inference]

extrinsic apoptotic signaling pathway

Displaying entries **16 - 18** of 18 in total

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GO Term	Evidence Code	PMID
keratin filament	ISO
intermediate filament cytoskeleton	ISO
cell periphery	IDA	19487454

GO Hierarchy

cellular component

protein-containing complex [inference]

glycoprotein complex [inference]

dystrophin-associated glycoprotein complex

membrane protein complex [inference]

plasma membrane protein complex [inference]

dystrophin-associated glycoprotein complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane [inference]

sarcolemma

plasma membrane region [inference]

apicolateral plasma membrane

cell junction [inference]

anchoring junction [inference]

cell-cell junction

costamere

organelle [inference]

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

intermediate filament cytoskeleton

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

intermediate filament cytoskeleton

cell periphery

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

intermediate filament

keratin filament

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protein binding	IPI	10747083 12857878 24940650 25617501
protein-containing complex binding	ISO
protein-containing complex binding	IEA
scaffold protein binding	ISO
scaffold protein binding	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding

scaffold protein binding

protein-containing complex binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

keratin, type II cytoskeletal 8

Functional Category

C: Energy production and conversion
E: Amino acid transport and metabolism
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
intermediate filament organization
keratinization
structural constituent of skin epidermis

Displaying **all 4** entries
InterPro
Intermediate filament protein, conserved site
Intermediate filament, rod domain
Keratin type II head
Keratin, type II

Ortholog

Displaying entries **71 - 80** of 86 in total

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Species	Gene ID	Orthologous MAtrix
Dipodomys ordii	105997938	DIPOR20808
Equus asinus asinus	106835267	EQUAS16871
Callithrix jacchus	108591292	CALJA00578
Phascolarctos cinereus	110194112	PHACI29582
Pseudonaja textilis	113444915	PSETE17599
Vombatus ursinus	114040332	VOMUR29919
Chelonoidis abingdonii	116828515	CHEAB02680
Callithrix jacchus	118145472	CALJA03846
Callithrix jacchus	118151063	CALJA41965
Callithrix jacchus	118152126	CALJA41965

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements